LOCUS       NM_021431               2649 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nudix hydrolase 11 (Nudt11), mRNA.
ACCESSION   NM_021431 XM_974350 XM_978336
VERSION     NM_021431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2649)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2649)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2649)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   4  (bases 1 to 2649)
  AUTHORS   Hua,L.V., Hidaka,K., Pesesse,X., Barnes,L.D. and Shears,S.B.
  TITLE     Paralogous murine Nudt10 and Nudt11 genes have differential
            expression patterns but encode identical proteins that are
            physiologically competent diphosphoinositol polyphosphate
            phosphohydrolases
  JOURNAL   Biochem J 373 (Pt 1), 81-89 (2003)
   PUBMED   12689335
  REMARK    GeneRIF: High levels are expressed primarily in brain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX465866.13 and BC071274.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_978336.1, XM_974350.1, NM_021431.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071274.1, AB041576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               BX465866.13        31739-31934
            197-2649            BC071274.1         1-2453
FEATURES             Location/Qualifiers
     source          1..2649
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 2.68 cM"
     gene            1..2649
                     /gene="Nudt11"
                     /gene_synonym="DIPP3; Dipp3a; DIPP3b; Nudt10"
                     /note="nudix hydrolase 11"
                     /db_xref="GeneID:58242"
                     /db_xref="MGI:MGI:1930957"
     exon            1..898
                     /gene="Nudt11"
                     /gene_synonym="DIPP3; Dipp3a; DIPP3b; Nudt10"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..899
                     /gene="Nudt11"
                     /gene_synonym="DIPP3; Dipp3a; DIPP3b; Nudt10"
                     /EC_number="3.6.1.52"
                     /EC_number="3.6.1.60"
                     /note="nudix-type motif 11; Diphosphoinositol
                     polyphosphate phosphohydrolase 3-alpha; nudix (nucleoside
                     diphosphate linked moiety X)-type motif 11; DIPP-3-alpha;
                     DIPP3-alpha; Diadenosine 5',5'''-P1,P6-hexaphosphate
                     hydrolase 3-alpha; Nucleoside diphosphate-linked moiety X
                     motif 10; Nudix motif 10; DIPP3-beta; DIPP-3-beta; nudix
                     motif 11; nucleoside diphosphate-linked moiety X motif 11;
                     diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta;
                     diadenosine hexaphosphate hydrolase (AMP-forming)"
                     /codon_start=1
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     3-beta"
                     /protein_id="NP_067406.2"
                     /db_xref="CCDS:CCDS29955.1"
                     /db_xref="GeneID:58242"
                     /db_xref="MGI:MGI:1930957"
                     /translation="MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDR
                     WIVPGGGMEPEEEPDGAAVREVYEEAGVKGKLGRLLGVFEQNQDRKHRTYVFVLTVTE
                     LLEDWEDSVSIGRKREWFKIEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSAAPSPP
                     ESEP"
     exon            899..2623
                     /gene="Nudt11"
                     /gene_synonym="DIPP3; Dipp3a; DIPP3b; Nudt10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt11"
                     /gene_synonym="DIPP3; Dipp3a; DIPP3b; Nudt10"
                     /note="hexamer: AATAAA"
     polyA_site      2623
                     /gene="Nudt11"
                     /gene_synonym="DIPP3; Dipp3a; DIPP3b; Nudt10"
                     /note="major polyA site"
ORIGIN      
        1 ggcgatccgg agggcgggga ccgcgcacgg tccactccgg ggctgtgcgg aggcgcgggc
       61 tctgggctcc cggctccggg cggcggaagc ggcgcctcca atcaggcggc gggctcgcga
      121 ccctcggcgc gcccggccgg tgccgcccgc cccgcggact gactgacgcg ccggctcgcc
      181 cccgcccccg cgcccgcccg cccgcccgcc cccgcctcgt ctccgctggc tcggcacaga
      241 ctgcgctccg ctccactccg ctctcctctc ctctcctcca gcctcgccgg gccctctccc
      301 tgccagcctt tgctcctcgg ctgcgcggcg gcagcggccc gctcgctagg cagctgcaag
      361 cgacctcaga ggcggcggcg gcggcggcgg cggcgtcggg gaggatgaag tgcaagccga
      421 accagacgcg gacctacgac cccgagggct tcaagaagcg cgccgcgtgc ctgtgcttcc
      481 gcagcgagcg cgaggacgag gtgctgctgg tgagcagcag ccgctacccc gaccgctgga
      541 tcgtgccggg agggggcatg gagcccgagg aggagccgga cggcgcggcg gtgcgcgagg
      601 tgtacgagga ggcgggagtc aaggggaagt tgggccgctt gctgggcgtc ttcgagcaga
      661 accaggaccg caagcaccgg acctacgtgt tcgtgctcac cgtcaccgag ctgctggagg
      721 attgggaaga ctcggtcagc atcggcagga agcgcgagtg gttcaagatc gaagatgcca
      781 tcaaggtcct gcagtgccac aagcccgtgc acgccgagta cctggagaaa ctgaagctgg
      841 gcggctcccc tactaatggg aactcggccg ccccgtcccc gccagagagc gagccctaat
      901 gaaccgaggc atgctcaaga tcacactgaa atcatcattg atgtgaaccc agtatccagt
      961 ggtattgtca agttcaccgg agcaccatta aggttgccaa ggagaccgct cattctggtt
     1021 ttccttctac atcttggaac actcttctgt ctatcttacc aacgtttttt gctctggttg
     1081 ttgtactatt gtgtgtgaac ggacttaatt cagcacctat agcctttcgt tgtgcttttc
     1141 tgatgtgtct gctttcttca ttacaccttt gagagcaatg actatttttc cttactctgc
     1201 atattctgca tccaagacac tacttgaaat atggttggca tcactggagg tctttgattc
     1261 tattagtatt ttgtaatctc tttgtggcta aacatttccc tcccaatctg gtgctagtag
     1321 agtatccgct gtctaagcac cacgtgtgta gctcatgtgt attcggtgtt gcagaaacat
     1381 ttcaggacag tttgagatgt tccagaacaa gaattagtat tcatttatat gtcataccac
     1441 acaatggctg gcatggtttt aatattatgt catcatttag ggtaacattt tatagaatta
     1501 gtccttcacc taacaacttt agtgtttttg tactgttgct aatttgctta aaattttatt
     1561 caaaaggtat cacttggtat aaaggtaatt gtaacacatt acaatgaaaa cctattgtga
     1621 gtttttataa aaaataaatt ttaaattaat atacaaagaa taatacattt aatttttttt
     1681 gcagtgctct acttctgaaa tgtcacctta acatttcctt gcagaaaatt ctggggttgt
     1741 ttttgttgtt gttgttgttg tttacagatt caatattctg tattatttga tgatgagcac
     1801 gaaaaaaaaa aaacctgcta ctgaagcagt tttcagagct aattgtgcca tttagttgct
     1861 taagtgtctt ttgcctctct cactttttca gttggctgtg gttctcatcc ctttcctagt
     1921 acagtggtct ggctggctcc tcagtaccac aagctctctg catgtttatg cagaggagag
     1981 tgagtgctaa attggtgtcc cttagaaagg cttcagggaa agagactgct gtaaagggga
     2041 atgcaaaata aagagtttaa atgaggaagc tcagtttgac tctttccaga agaataactt
     2101 tatgccaagg acaaagacat ttcagagttt tgtcacaggg tgtgtgatgt caacactctt
     2161 actcagctca tcctgagggt tccaaagagg ttctgatatg gctggtggtt gtgtctcgct
     2221 ttttcattat aaaccattag atttggaaag gcctgaactc caatttagtg ttaacaccct
     2281 tcctcatggt accagtgaaa tgtattgtgt ccccatatct tacagacgtt aaaataaaac
     2341 cacacattct aatttgctgg agtttctatt tgtgacatgt actatgtgga tgtgctttct
     2401 aaagaaaccc ttatctttta gaaaactgta ctgaaaattt acagagatgc tactgttatt
     2461 tgcttcaata taatcagggt ggtatacgtt tgtacataga tgaaacaaga ctgactctga
     2521 cttgataatt gttgaagctg tgtgatagat gtttgagaat tcattattct ctatactttt
     2581 gtatatgttt gaaattttcc ataataaaaa ttgtaaaact gtaaaaaaaa aaaaaaaaaa
     2641 aaaaaaaaa
//
