LOCUS       NM_001356585            1018 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Mus musculus nudix hydrolase 1 (Nudt1), transcript variant 4, mRNA.
ACCESSION   NM_001356585 XM_006504657
VERSION     NM_001356585.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1018)
  AUTHORS   Li J, Zhang H, Wang ZH, Li YX, Zhang LQ, Cui J, Li DN, Wang ZH, Liu
            Q, Liu Z, Iwakuma T and Cai JP.
  TITLE     8-oxo-dGTP curbs tumor development via S phase arrest and
            AIF-mediated apoptosis
  JOURNAL   Free Radic Biol Med 196, 53-64 (2023)
   PUBMED   36640852
REFERENCE   2  (bases 1 to 1018)
  AUTHORS   Huang B, Lyu Z, Qian Q, Chen Y, Zhang J, Li B, Li Y, Liang J, Liu
            Q, Li Y, Chen R, Lian M, Xiao X, Miao Q, Wang Q, Fang J, Lian Z, Li
            Y, Tang R, Helleday T, Gershwin ME, You Z and Ma X.
  TITLE     NUDT1 promotes the accumulation and longevity of CD103+ TRM cells
            in primary biliary cholangitis
  JOURNAL   J Hepatol 77 (5), 1311-1324 (2022)
   PUBMED   35753523
  REMARK    GeneRIF: NUDT1 promotes the accumulation and longevity of CD103(+)
            TRM cells in primary biliary cholangitis.
REFERENCE   3  (bases 1 to 1018)
  AUTHORS   Li J, Wang ZH, Dang YM, Li DN, Liu Z, Dai DP and Cai JP.
  TITLE     MTH1 suppression enhances the stemness of MCF7 through upregulation
            of STAT3
  JOURNAL   Free Radic Biol Med 188, 447-458 (2022)
   PUBMED   35809767
REFERENCE   4  (bases 1 to 1018)
  AUTHORS   Karsten S.
  TITLE     Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach
            to treat inflammatory diseases
  JOURNAL   Basic Clin Pharmacol Toxicol 131 (2), 95-103 (2022)
   PUBMED   35708697
  REMARK    GeneRIF: Targeting the DNA repair enzymes MTH1 and OGG1 as a novel
            approach to treat inflammatory diseases.
            Review article
REFERENCE   5  (bases 1 to 1018)
  AUTHORS   Mizuno Y, Abolhassani N, Mazzei G, Saito T, Saido TC, Yamasaki R,
            Kira JI and Nakabeppu Y.
  TITLE     Deficiency of MTH1 and/or OGG1 increases the accumulation of
            8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse
            model of Alzheimer's disease, accompanied by accelerated
            microgliosis and reduced anxiety-like behavior
  JOURNAL   Neurosci Res 177, 118-134 (2022)
   PUBMED   34838904
REFERENCE   6  (bases 1 to 1018)
  AUTHORS   Nakabeppu Y.
  TITLE     Molecular genetics and structural biology of human MutT homolog,
            MTH1
  JOURNAL   Mutat Res 477 (1-2), 59-70 (2001)
   PUBMED   11376687
REFERENCE   7  (bases 1 to 1018)
  AUTHORS   Shimokawa H, Fujii Y, Furuichi M, Sekiguchi M and Nakabeppu Y.
  TITLE     Functional significance of conserved residues in the
            phosphohydrolase module of Escherichia coli MutT protein
  JOURNAL   Nucleic Acids Res 28 (17), 3240-3249 (2000)
   PUBMED   10954591
REFERENCE   8  (bases 1 to 1018)
  AUTHORS   Igarashi H, Tsuzuki T, Kakuma T, Tominaga Y and Sekiguchi M.
  TITLE     Organization and expression of the mouse MTH1 gene for preventing
            transversion mutation
  JOURNAL   J Biol Chem 272 (6), 3766-3772 (1997)
   PUBMED   9013634
REFERENCE   9  (bases 1 to 1018)
  AUTHORS   Kakuma T, Nishida J, Tsuzuki T and Sekiguchi M.
  TITLE     Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine
            5'-triphosphatase activity that prevents transversion mutation.
            cDNA cloning and tissue distribution
  JOURNAL   J Biol Chem 270 (43), 25942-25948 (1995)
   PUBMED   7592783
REFERENCE   10 (bases 1 to 1018)
  AUTHORS   Cai JP, Kakuma T, Tsuzuki T and Sekiguchi M.
  TITLE     cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents
            occurrence of spontaneous mutations due to oxidation of guanine
            nucleotides
  JOURNAL   Carcinogenesis 16 (10), 2343-2350 (1995)
   PUBMED   7586133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131670.5.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_001356585.2.
            
            On Oct 11, 2017 this sequence version replaced XM_006504657.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4819696.1,
                                           SRR11927937.4583162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC131670.5         36735-36896
            163-327             AC131670.5         49568-49732
            328-473             AC131670.5         50426-50571
            474-1018            AC131670.5         52706-53250
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..1018
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /note="nudix hydrolase 1"
                     /db_xref="GeneID:17766"
                     /db_xref="MGI:MGI:109280"
     exon            1..162
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..327
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..646
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /EC_number="3.6.1.56"
                     /note="7,8-dihydro-8-oxoguanine triphosphatase;
                     8-oxo-dGTPase; nudix motif 1; nucleoside
                     diphosphate-linked moiety X motif 1; mutT human homolog
                     (8-oxo-dGTPase); 8-oxo-7,8-dihydro-2'-dGTPase; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 1;
                     2-hydroxy-dATP diphosphatase; methylated purine nucleoside
                     triphosphate hydrolase"
                     /codon_start=1
                     /product="oxidized purine nucleoside triphosphate
                     hydrolase"
                     /protein_id="NP_001343514.1"
                     /db_xref="CCDS:CCDS19818.1"
                     /db_xref="GeneID:17766"
                     /db_xref="MGI:MGI:109280"
                     /translation="MSTSRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGET
                     IEDGAKRELLEESGLSVDTLHKVGHISFEFVGSPELMDVHIFSADHVHGTPTESEEMR
                     PQWFQLDQIPFADLWPDDSYWFPLLLQKKKFCGHFKFQDQDTILSYSLREVDSF"
     exon            328..473
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..1018
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagaattaa atatgtgctc cacgggcgta gcctgagaac aaaccgcagt cccgccaggg
       61 gacccggaac caaactgggc ccggctgcct gtcccgcagg gcgctcttcc actgccccgg
      121 ggtgcgccgt aatgtatgga atagcaccgc gcaggaggaa aggacccagg agagcatgag
      181 cacctccagg ctttataccc ttgtgctagt gctacagcct cagcgagttc tcctgggcat
      241 gaagaagagg ggctttggtg ctggccgctg gaatggcttc gggggcaagg tgcaggaagg
      301 agagaccatt gaggatgggg ctaagagaga gctgctggaa gaaagtggtc tgagcgtgga
      361 tacactgcac aaggtaggcc acatctcgtt tgaatttgtg ggctctcctg agctgatgga
      421 cgtgcatatc ttctcggctg accatgtgca cgggacgccc acagaaagtg aagaaatgcg
      481 ccctcagtgg ttccaactgg accagatccc ctttgccgac ctgtggccgg atgacagcta
      541 ctggttccca ctcctgcttc agaagaagaa gttctgtggg cacttcaagt tccaggatca
      601 ggacacgatc ctcagttact cgctgcgaga ggtggactca ttctaataca gaagtctggc
      661 tggttctggc cactcaggat gctacacagc cgcaagctgt cggaccaagg gcacaagcag
      721 gggctggtat tttctgtgtg cgaggggttg gggttgaaat gtgaaatgtc accaatacac
      781 caatgtttga attcttcgtc cccacatact ggtcctgttt tagaaggttg tggcaccttt
      841 aagagccaga gccctgctgg tggaactgag tcactggggg tcggagaatg gaggatgggc
      901 cttgctttat aggtgagcac cgcttactgt ctgctcacac tccggctact gtgtcagatt
      961 ttccacgatg gactgtatcc ccagatggat gagctgaaat aaaccgttgc tcctctaa
//
