LOCUS       NM_001113554            3444 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus NudC domain containing 1 (Nudcd1), transcript variant
            2, mRNA.
ACCESSION   NM_001113554
VERSION     NM_001113554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3444)
  AUTHORS   Rao,W., Xie,G., Zhang,Y., Wang,S., Wang,Y., Zhang,H., Song,F.,
            Zhang,R., Yin,Q., Shen,L. and Ge,H.
  TITLE     OVA66, a tumor associated protein, induces oncogenic transformation
            of NIH3T3 cells
  JOURNAL   PLoS One 9 (3), e85705 (2014)
   PUBMED   24633332
  REMARK    GeneRIF: results indicate that OVA66 is important in oncogenic
            transformation, promoting proliferation, cell migration and
            reducing apoptosis via hyperactivating PI3K/AKT and ERK1/2 MAPK
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3444)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   3  (bases 1 to 3444)
  AUTHORS   Yan,Y., Phan,L., Yang,F., Talpaz,M., Yang,Y., Xiong,Z., Ng,B.,
            Timchenko,N.A., Wu,C.J., Ritz,J., Wang,H. and Yang,X.F.
  TITLE     A novel mechanism of alternative promoter and splicing regulates
            the epitope generation of tumor antigen CML66-L
  JOURNAL   J Immunol 172 (1), 651-660 (2004)
   PUBMED   14688378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF521132.1, AK083587.1 and AC127312.4.
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the coding region, as compared to variant 1. The resulting
            isoform (2) lacks an internal amino acid, as compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF521132.1, SRR7345562.1109115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               AF521132.1         2-676
            676-1299            AK083587.1         258-881
            1300-2600           AF521132.1         1301-2601
            2601-3444           AC127312.4         35678-36521         c
FEATURES             Location/Qualifiers
     source          1..3444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.91 cM"
     gene            1..3444
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /note="NudC domain containing 1"
                     /db_xref="GeneID:67429"
                     /db_xref="MGI:MGI:1914679"
     exon            1..646
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..2277
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     chronic myelogenous leukemia tumor antigen 66; nudC
                     domain-containing protein 1"
                     /codon_start=1
                     /product="nudC domain-containing protein 1 isoform 2"
                     /protein_id="NP_001107026.1"
                     /db_xref="CCDS:CCDS88761.1"
                     /db_xref="GeneID:67429"
                     /db_xref="MGI:MGI:1914679"
                     /translation="MEAANCSLRVKRPLLDPRFEGYKLSLEPLPCYQLELDAAVAEVK
                     LRDDQYTLEHMHAFGMYNYLHCDAWYQDSVYYIDNLGRIMNLTVMLDTALGKPREVFR
                     LPTDVTAYDNRLCASIHFTSPSWVTLSDGTGRLYVIGTGDRGNSPEKWEIMFNEELGN
                     PFIIIHSISLLKAEEHSVAILLLRIEKEELDLKGSGFYVSLEWVVVTKKKEDSKKYEI
                     TKHHVLRGKSVPHYAAIEPNGNGLMIVSYKSFKVISGDQDLEENMDEDRPEKIKEPLY
                     YWQQSEDDLTVTVRLPESSTKEDIQIQFLPDNINIKLKDIQVLEGKLYSSIDHEGSTW
                     TIKENDSLEISLIKKNEGLMWPELVVGDKQGELLRDPAQCAAIAERLMHLTSDELNPN
                     PDKEKPACNAQELEECDIFFEESSSLCRFDGNTLQTTHVVNLGSNQYLFSVIVDPKEM
                     PCFCLRHDVDALLWQPHCSKQDDMWEHIATFNALGYVQASKRDKKFFACAPNYSYAAL
                     CECLRRVFIYRQPTPMSTVLYNRKEGRHVGQVAKQQVASLETNDPILGFQATNERLFV
                     LTTKNLFLIRVNTEN"
     exon            647..801
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            802..984
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1165
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1348
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1553
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1698
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1824
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1984
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..3444
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3420..3425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /note="hexamer: AATAAA"
     polyA_site      3444
                     /gene="Nudcd1"
                     /gene_synonym="4921532K09Rik; Cml66; CML66-L"
                     /note="major polyA site"
ORIGIN      
        1 agcacatcga aaggagcctg ggctgggccc gggtcccggc cctgaggacc acgggcatag
       61 ctcaccacca tcaccgcggg cgagggccgt cccttcccag cgacgaaatg acccttgcgc
      121 tgacgaccgt tacctaccac actcttcggc tgcccggact tagaccctca gtagctcggg
      181 cacctaagca cacagaaagc tagaccacgc atttccgggg cgggatctgg ccaccctgcc
      241 tataatgtga gaattcaact agcgcgggcc gccttctggt cgctcggccc tctgggtaag
      301 gaagtccaga gtctgttagc tgacgtgggt tcagggatca aaaaactaca tttcccagca
      361 ttgcaacaga accaaatttc tcatggacac tacacttccc agaagagacg tggcgccgca
      421 gagtcgtctg ggatgggaac cacgccgttt cccagcctca gttccaggag tgaagcgcgg
      481 acctttcaac aagagcttta ttgattctct tgctgggatc gggggaacgc gatggaggcg
      541 gccaattgct ctctgcgggt gaaaagacct ctgctggatc cccgcttcga gggctacaag
      601 ctgtctctcg aaccgctgcc ctgctaccag ctggagcttg atgcagctgt ggcagaagta
      661 aaacttcgag atgaccagta tacattagaa cacatgcatg cttttgggat gtataattat
      721 ctgcactgtg atgcctggta tcaagacagt gtctactaca ttgataacct tggaagaatt
      781 atgaacttaa cagtgatgct ggacaccgcc ttaggaaaac cccgagaggt gttccgcctt
      841 cctacagatg tgacagcata tgacaatcgt ctttgtgcat ctatccattt cacatcccct
      901 tcctgggtta ccttgtcaga tggaactgga agactgtatg tcattggaac aggtgaccgt
      961 ggaaacagtc ctgaaaaatg ggagattatg tttaatgaag agcttgggaa cccttttatt
     1021 ataattcaca gtatctcact gctgaaagct gaagaacatt cagtggctat cctgcttctt
     1081 cgaatagaga aggaggaatt ggacctgaaa ggaagtggtt tctatgtttc tttggagtgg
     1141 gtcgttgtca ctaagaagaa agaagatagt aaaaagtatg aaattacaaa gcatcatgtt
     1201 ctccgtggaa agtcagtgcc acattatgct gcaattgaac ctaatggaaa tggtctaatg
     1261 attgtatctt acaagtcctt caaggttatt tcgggagatc aggatcttga agagaatatg
     1321 gatgaagaca ggccagagaa aatcaaagaa cctctgtatt actggcaaca aagtgaggat
     1381 gatttgacag taacggtcag gcttccagaa agcagtacta aggaagatat tcaaatacaa
     1441 tttttgcctg ataatatcaa cattaagctg aaggatatcc aagttttgga aggaaaactc
     1501 tattcatcta ttgatcacga aggcagcaca tggacaatta aagagaatga tagcttggag
     1561 atttctttga ttaagaagaa tgaaggactg atgtggcctg agctggtggt tggtgataaa
     1621 caaggtgaac ttttaagaga ccctgcccaa tgtgctgcaa tagcagaacg cttgatgcac
     1681 ctgacctctg atgaactgaa tccaaatcca gataaggaaa agcctgcatg taatgctcaa
     1741 gaattagaag aatgtgatat tttctttgaa gagagctcca gtttatgcag atttgatggc
     1801 aatacattac aaacaactca tgtggtgaat cttggcagca accagtacct gttctcagtc
     1861 attgtggatc ctaaagaaat gccgtgcttc tgtctacgcc atgatgtcga tgctctcctc
     1921 tggcaaccac actgcagcaa gcaggacgac atgtgggagc acattgccac cttcaatgcc
     1981 ctaggttacg tccaagcctc aaagagagac aagaaatttt ttgcatgtgc tccaaactac
     2041 tcgtatgcag ccctttgtga gtgccttcgc cgagtattca tctatcggca gcccaccccc
     2101 atgtccactg tgctgtacaa caggaaggaa ggcaggcatg tggggcaagt tgctaagcag
     2161 caggtagcaa gcctagaaac caatgatcct attttaggct ttcaggcaac aaatgagaga
     2221 ttatttgttc tcactaccaa aaacctcttt ttaataagag taaatacgga gaattaatcc
     2281 tccaacattt gtctaaaaag tatccagtgg tacctggagg gctgaacagt tgtactataa
     2341 cttgataagt tttagcatga taaatgagaa taccttttat gaagttttat ttttaaagga
     2401 tactggaaat gtattcagta gattatgaat ctgtaaaagc tgtggataga cgaagctaca
     2461 ggattagaga acaccggctt ctgtaaaaat atggagatat tagcaaatat agttattttt
     2521 taaaacctga gatcgaatct catcttttat atgaaacata caattcagtg tttacaaata
     2581 aaaatattta tcatgtactt agctcattgt ttagattggt acagtcatta tgtagaatgt
     2641 ttgggtagta gtaaaatact gagtattata aaagtatttt aatgggctga agtctatata
     2701 cagaattgct ttaagtctgt atagatttgt aagaatacag cagttttgac aatatttgct
     2761 ttcaaccctt gttttacagc aagcagaaat ttatttatgt ctttcctgta ccacattgga
     2821 aaaggttata cattttccat tattgcataa caaagttcaa caaaactcag gtctaagagt
     2881 ttattccagt acatgggaaa ctaaagctgg agagttagca gttcaaggct agccagggcc
     2941 acatagcaag accttatctc aaaacaaaag caatttaagg tttatggttt ttcacgcttc
     3001 tctgagatgt ctcttgtcct ctagtagtct aagctctgct tcctgacatc atacagaaac
     3061 acattctaga gcaaactagg gtacaagagg ttggagagcc tggtttctca ttttttgcta
     3121 agaatatgga caaaatgagt cgcatggcta cgtctaaaca gacagtaggt ctgtgacaca
     3181 ttagagccct tgttgggaca gtcacacaga atagatttta acgcatttgt ctaagttccc
     3241 cttacttttc tgacagttta tcctatttac acatgagttt ttttcccaca aatatttgtg
     3301 gttcagactt cctctccaaa cttccttcaa tttgtatcca gtatggattg ttgtgttttt
     3361 attttcatac taccagaagc tcatgtttta gaatgttctc aagagcttaa gaggcagcaa
     3421 ataaagatta tgtcgtggac aata
//
