LOCUS       NM_001130479            1703 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus nucleobindin 2 (Nucb2), transcript variant 1, mRNA.
ACCESSION   NM_001130479
VERSION     NM_001130479.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Chang,J.W., Lin,Y.Y., Tsai,C.H., Liu,S.C., He,X.Y., Wu,Y.S.,
            Huang,C.C. and Tang,C.H.
  TITLE     Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in
            rheumatoid arthritis
  JOURNAL   Biochem Pharmacol 215, 115687 (2023)
   PUBMED   37481139
  REMARK    GeneRIF: Nesfatin-1 stimulates BMP5 expression and
            osteoclastogenesis in rheumatoid arthritis.
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Ahn,C., Sun,S., Ha,J. and Yang,H.
  TITLE     Nesfatin-1 regulates steroidogenesis in mouse Leydig cells
  JOURNAL   Peptides 166, 171036 (2023)
   PUBMED   37269882
  REMARK    GeneRIF: Nesfatin-1 regulates steroidogenesis in mouse Leydig
            cells.
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Zhang,R., Liang,H., Liu,G., Jiang,W., Tang,Z., Fan,Q., Nie,Z.,
            Hu,H., Kang,G. and Xie,S.
  TITLE     Nesfatin-1, a novel energy-regulating peptide, alleviates pulmonary
            fibrosis by blocking TGF-beta1/Smad pathway in an
            AMPKalpha-dependent manner
  JOURNAL   Int Immunopharmacol 120, 110369 (2023)
   PUBMED   37224650
  REMARK    GeneRIF: Nesfatin-1, a novel energy-regulating peptide, alleviates
            pulmonary fibrosis by blocking TGF-beta1/Smad pathway in an
            AMPKalpha-dependent manner.
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Caroleo,M., Carbone,E.A., Arcidiacono,B., Greco,M., Primerano,A.,
            Mirabelli,M., Fazia,G., Rania,M., Hribal,M.L., Gallelli,L.,
            Foti,D.P., De Fazio,P., Segura-Garcia,C. and Brunetti,A.
  TITLE     Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients
            with Binge Eating Disorder? Toward a Neurobiological Pathway
  JOURNAL   Nutrients 15 (2), 348 (2023)
   PUBMED   36678225
  REMARK    GeneRIF: Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese
            Patients with Binge Eating Disorder? Toward a Neurobiological
            Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Jin,X., Guan,K., Chen,Z., Sun,Y., Huo,H., Wang,J. and Dong,H.
  TITLE     The protective effects of nesfatin-1 in neurological dysfunction
            after spinal cord injury by inhibiting neuroinflammation
  JOURNAL   Brain Behav 12 (11), e2778 (2022)
   PUBMED   36271663
  REMARK    GeneRIF: The protective effects of nesfatin-1 in neurological
            dysfunction after spinal cord injury by inhibiting
            neuroinflammation.
REFERENCE   6  (bases 1 to 1703)
  AUTHORS   Gonzalez,R., Tiwari,A. and Unniappan,S.
  TITLE     Pancreatic beta cells colocalize insulin and pronesfatin
            immunoreactivity in rodents
  JOURNAL   Biochem Biophys Res Commun 381 (4), 643-648 (2009)
   PUBMED   19248766
  REMARK    GeneRIF: These results indicate that the insulin producing beta
            cells colocalize pronesfatin in the islets of both mice and rats.
REFERENCE   7  (bases 1 to 1703)
  AUTHORS   Nonogaki,K., Ohba,Y., Sumii,M. and Oka,Y.
  TITLE     Serotonin systems upregulate the expression of hypothalamic NUCB2
            via 5-HT2C receptors and induce anorexia via a leptin-independent
            pathway in mice
  JOURNAL   Biochem Biophys Res Commun 372 (1), 186-190 (2008)
   PUBMED   18477467
  REMARK    GeneRIF: 5-HT systems upregulate the expression of hypothalamic
            NUCB2 via 5-HT2C receptors, and induce anorexia via a
            leptin-independent pathway in mice.
REFERENCE   8  (bases 1 to 1703)
  AUTHORS   Lin,P., Li,F., Zhang,Y.W., Huang,H., Tong,G., Farquhar,M.G. and
            Xu,H.
  TITLE     Calnuc binds to Alzheimer's beta-amyloid precursor protein and
            affects its biogenesis
  JOURNAL   J Neurochem 100 (6), 1505-1514 (2007)
   PUBMED   17348862
REFERENCE   9  (bases 1 to 1703)
  AUTHORS   Nesselhut,J., Jurgan,U., Onken,E., Gotz,H., Barnikol,H.U.,
            Hirschfeld,G., Barnikol-Watanabe,S. and Hilschmann,N.
  TITLE     Golgi retention of human protein NEFA is mediated by its N-terminal
            Leu/Ile-rich region
  JOURNAL   FEBS Lett 509 (3), 469-475 (2001)
   PUBMED   11749975
REFERENCE   10 (bases 1 to 1703)
  AUTHORS   Taniguchi,N., Taniura,H., Niinobe,M., Takayama,C.,
            Tominaga-Yoshino,K., Ogura,A. and Yoshikawa,K.
  TITLE     The postmitotic growth suppressor necdin interacts with a
            calcium-binding protein (NEFA) in neuronal cytoplasm
  JOURNAL   J Biol Chem 275 (41), 31674-31681 (2000)
   PUBMED   10915798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163222.4, BY142521.1, AK160442.1, AK152672.1 and BF462404.1.
            
            On Aug 8, 2012 this sequence version replaced NM_001130479.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ222586.1, BC010459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC163222.4         142314-142318
            6-335               BY142521.1         1-330
            336-879             AK160442.1         184-727
            880-956             AK152672.1         118-194
            957-957             AC163222.4         165945-165945
            958-1152            AK152672.1         195-389
            1153-1183           AC163222.4         166966-166996
            1184-1504           AK152672.1         421-741
            1505-1505           AC163222.4         177934-177934
            1506-1685           AK152672.1         743-922
            1686-1703           BF462404.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 61.79 cM"
     gene            1..1703
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /note="nucleobindin 2"
                     /db_xref="GeneID:53322"
                     /db_xref="MGI:MGI:1858179"
     exon            1..116
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..287
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..431
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..539
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..666
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..770
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..956
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1047
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1106
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1199
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1289
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1460
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1542
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1689
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1637..1642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /note="hexamer: AATAAA"
     polyA_site      1656
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /note="hexamer: AATAAA"
     polyA_site      1689
                     /gene="Nucb2"
                     /gene_synonym="Calnuc; Nefa; Nesfatin-1"
                     /note="major polyA site"
ORIGIN      
        1 ggcacgcatt aggctgtgga tcagagcaag gcggagggcc gtgggcaggg aaaactggtg
       61 tgctcgcggc gggcatcagt cggcttagcc tcgcgcgccg ggaccctgca gagaagaaca
      121 caccagtcag tttttcaagg gaaaatcctg ggccaggagc caagtcctga tctctacaaa
      181 cttaatattg tgtagattat tttaccacct gagatctcag tggcctcatc tgtgcaagaa
      241 agagaaaatt aaataataaa aaagataaaa ccttggcctg tctgaagatg aggtggagga
      301 tcatccaagt acagtactgt tttctcttgg ttccgtgcat gctgaccgct ctggaagctg
      361 ttcctatcga tgtggacaag accaaagtac acaacactga gccagtggaa aatgcaagga
      421 tagagccacc agatactgga ctttattatg atgaatacct caagcaagtg attgaagtct
      481 tggaaacaga tccacatttc agagaaaagc tccagaaagc agacatagag gagataagga
      541 gcgggaggct gagtcaagag ctggacttag taagtcacaa agtgaggacg agactggatg
      601 agctgaagag gcaagaagta ggaagactgc ggatgctcat caaagctaag ctggatgccc
      661 ttcaagacac tggcatgaat caccaccttc ttctgaagca gtttgaacac ctgaaccacc
      721 agaatcctaa cacatttgaa tccagagatt tggatatgct aatcaaagca gctaccgcgg
      781 atctggagca atatgaccgg actcggcatg aagagtttaa gaagtacgag atgatgaagg
      841 aacacgagcg gagagagtat ttaaaaacgc tgagtgagga gaagaggaaa gaagaagagt
      901 ctaagtttga agagatgaag aggaagcacg aagaccaccc caaagttaat catcccggaa
      961 gcaaagatca actaaaagag gtttgggaag agactgatgg attggaccct aatgactttg
     1021 accccaagac atttttcaaa ttacatgatg ttaacaacga tggattcctg gatgaacaag
     1081 aattagaagc actattcaca agagagttgg agaaagtgta taacccacaa aatgcagagg
     1141 acgatatgat agaaatggaa gaggagaggc tcaggatgag agaacacgtc atgagtgaga
     1201 ttgataacaa caaagaccga ttggtgactc tggaggaatt cctgagagct acagagaaga
     1261 aagaattcct ggagcctgat agctgggaga cactggacca gcaacagtta ttcaccgagg
     1321 acgagcttaa agagtatgaa agcattattg ctatccaaga gaacgagctt aagaagaggg
     1381 cggaagagct gcagaaacag aaggaggatc tgcagcggca gcacgaccac ctcgaggcgc
     1441 agaagcagga gtatcatcag gccgtccagc acctggaaca gaagaaactt caacaaggca
     1501 ttgctccatc agggccagcg ggagagctga agtttgagcc acacacataa agtcctgatg
     1561 tctgccagaa cttggaagaa aaccgttgat tcaacatcta tttcatcttt caacatcctt
     1621 tcttttctct ccactcaata aatactttaa agcacatttg gaataaagga agagactttt
     1681 aagtgagaaa aaaaaaaaaa aaa
//
