LOCUS       NM_001163662            2418 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus nucleobindin 1 (Nucb1), transcript variant 1, mRNA.
ACCESSION   NM_001163662
VERSION     NM_001163662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2418)
  AUTHORS   Nasri,A., Kowaluk,M., Widenmaier,S.B. and Unniappan,S.
  TITLE     Nesfatin-1 and nesfatin-1-like peptide attenuate hepatocyte lipid
            accumulation and nucleobindin-1 disruption modulates lipid
            metabolic pathways
  JOURNAL   Commun Biol 7 (1), 623 (2024)
   PUBMED   38802487
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2418)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2418)
  AUTHORS   Nasri,A., Sands,J. and Unniappan,S.
  TITLE     Suppressive action of nesfatin-1 and nesfatin-1-like peptide on
            cortisol synthesis in human adrenal cortex cells
  JOURNAL   Sci Rep 14 (1), 3985 (2024)
   PUBMED   38368491
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2418)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 2418)
  AUTHORS   Siletti,K., Tarchini,B. and Hudspeth,A.J.
  TITLE     Daple coordinates organ-wide and cell-intrinsic polarity to pattern
            inner-ear hair bundles
  JOURNAL   Proc Natl Acad Sci U S A 114 (52), E11170-E11179 (2017)
   PUBMED   29229865
REFERENCE   6  (bases 1 to 2418)
  AUTHORS   Dho,S.E., Jacob,S., Wolting,C.D., French,M.B., Rohrschneider,L.R.
            and McGlade,C.J.
  TITLE     The mammalian numb phosphotyrosine-binding domain. Characterization
            of binding specificity and identification of a novel PDZ
            domain-containing numb binding protein, LNX
  JOURNAL   J Biol Chem 273 (15), 9179-9187 (1998)
   PUBMED   9535908
REFERENCE   7  (bases 1 to 2418)
  AUTHORS   Zhong,W., Feder,J.N., Jiang,M.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Asymmetric localization of a mammalian numb homolog during mouse
            cortical neurogenesis
  JOURNAL   Neuron 17 (1), 43-53 (1996)
   PUBMED   8755477
REFERENCE   8  (bases 1 to 2418)
  AUTHORS   Miura,K., Hirai,M., Kanai,Y. and Kurosawa,Y.
  TITLE     Organization of the human gene for nucleobindin (NUC) and its
            chromosomal assignment to 19q13.2-q13.4
  JOURNAL   Genomics 34 (2), 181-186 (1996)
   PUBMED   8661046
REFERENCE   9  (bases 1 to 2418)
  AUTHORS   Kanai,Y., Takeda,O., Kanai,Y., Miura,K. and Kurosawa,Y.
  TITLE     Novel autoimmune phenomena induced in vivo by a new DNA binding
            protein Nuc: a study on MRL/n mice
  JOURNAL   Immunol Lett 39 (1), 83-89 (1993)
   PUBMED   8144193
REFERENCE   10 (bases 1 to 2418)
  AUTHORS   Miura,K., Titani,K., Kurosawa,Y. and Kanai,Y.
  TITLE     Molecular cloning of nucleobindin, a novel DNA-binding protein that
            contains both a signal peptide and a leucine zipper structure
  JOURNAL   Biochem Biophys Res Commun 187 (1), 375-380 (1992)
   PUBMED   1520323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151602.4.
            
            On Nov 29, 2022 this sequence version replaced NM_001163662.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164088.1, AK160981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC151602.4         80075-80141
            68-209              AC151602.4         80617-80758
            210-317             AC151602.4         87179-87286
            318-450             AC151602.4         88749-88881
            451-554             AC151602.4         90559-90662
            555-740             AC151602.4         91554-91739
            741-831             AC151602.4         91974-92064
            832-890             AC151602.4         94851-94909
            891-983             AC151602.4         95150-95242
            984-1076            AC151602.4         95319-95411
            1077-1247           AC151602.4         95676-95846
            1248-1344           AC151602.4         96251-96347
            1345-2418           AC151602.4         96515-97588
FEATURES             Location/Qualifiers
     source          1..2418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.33 cM"
     gene            1..2418
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /note="nucleobindin 1"
                     /db_xref="GeneID:18220"
                     /db_xref="MGI:MGI:97388"
     exon            1..67
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            68..209
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1457
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="nucleobindin-1 isoform 1 precursor"
                     /protein_id="NP_001157134.1"
                     /db_xref="CCDS:CCDS52247.1"
                     /db_xref="GeneID:18220"
                     /db_xref="MGI:MGI:97388"
                     /translation="MPTSVPRGAPFLLLPPLLMLSAVLAVPVDRAAPPQEDSQATETP
                     DTGLYYHRYLQEVINVLETDGHFREKLQAANAEDIKSGKLSQELDFVSHNVRTKLDEL
                     KRQEVSRLRMLLKAKMDAKQEPNLQVDHMNLLKQFEHLDPQNQHTFEARDLELLIQTA
                     TRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLQEQQRRHREHPKV
                     NVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVY
                     DPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWKT
                     VEMSPAYTEEELKRFEEELAAREAELNARAQRLSQETEALGRSQDRLEAQKRELQQAV
                     LQMEQRKQQLQEQSAPPSKPDGQLQFRADTDDAPVPAPAGDQKDVPASEKKVPEQPPE
                     LPQLDSQHL"
     exon            210..317
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            318..450
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            451..554
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            555..740
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            741..831
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            832..890
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            891..983
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1076
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1247
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1344
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..2418
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /note="major polyA site"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
                     /note="hexamer: ATTAAA"
     polyA_site      2418
                     /gene="Nucb1"
                     /gene_synonym="B230337F23Rik; Calnuc; MTEST82; Nucb"
ORIGIN      
        1 aggagagaaa tcgccagaaa cctggcggag gttgctggcc ttaaaaaacg ccctcagcac
       61 tggagagacc agccacgatg cctacctcgg tgccccgcgg ggcccctttt cttctcctac
      121 cacctctact gatgctgtct gctgtgctgg cagtgcccgt ggaccgcgca gcacctcctc
      181 aggaggacag ccaggccact gagaccccgg acacgggcct gtactaccac cggtacctcc
      241 aggaggtcat caacgtgcta gagacagatg ggcacttccg ggagaagctg caggctgcca
      301 acgctgagga cattaagagt ggaaagctga gccaagagct ggacttcgtc agccacaacg
      361 tccgaaccaa gctggatgag ctcaagcgac aggaggtgtc gaggctgcgg atgctgctca
      421 aggccaagat ggatgcaaag caggagccca acttgcaggt ggaccacatg aacctcctga
      481 agcagtttga gcacctggac cctcagaacc agcacacgtt tgaggctcgg gacctagagc
      541 tgctgatcca gacggccacc cgagacctcg cccagtatga cgctgcacac catgaagagt
      601 tcaaacgcta cgagatgctc aaggaacatg agaggagacg atacctggag tctctgggag
      661 aggagcagcg gaaggaggcc gagaggaagc tccaagagca acagcgcaga caccgggaac
      721 accccaaagt caatgttcct ggcagccaag cccagttgaa ggaggtgtgg gaggagttgg
      781 atggattgga ccccaacagg ttcaacccca agaccttctt catactgcat gacatcaaca
      841 gtgatggtgt cctagatgag caagaactgg aagctctctt taccaaggag ctggagaagg
      901 tgtatgaccc gaagaatgag gaggatgaca tgagagagat ggaggaagaa cggcttcgca
      961 tgcgggagca cgtgatgaag aatgtggaca ccaaccagga ccggcttgtg accctggagg
     1021 agttcctggc atccacccag aggaaggagt tcggggacac tggggagggg tggaagacag
     1081 tggaaatgtc cccagcctac acagaggagg agctgaagcg ttttgaagag gagctggctg
     1141 cccgggaagc tgagctgaat gccagggccc agcgcctcag ccaggagaca gaggccctgg
     1201 ggcgctccca ggaccgcctg gaggcacaga agagagagct gcagcaggct gttctgcaga
     1261 tggagcagag gaagcagcaa ctgcaagaac agagcgctcc gccttccaaa cctgacgggc
     1321 agctgcagtt ccgtgcagac acagatgacg ctcctgtccc agctccagca ggtgaccaga
     1381 aagatgtgcc tgcttctgag aagaaggtcc cagagcagcc ccctgagctg ccacagctgg
     1441 attcccagca tttataactc ctcagagacc ccagccctca ggttcccaca gacagtgtgg
     1501 aagccagatg aagtggcctt gcagcctccc tggggaccaa cgccctcatg gcctcctggg
     1561 agcagaacag gggctaccct gttcctcaga tgtgcttctg ctggtctacc attctctgct
     1621 ctcagcctct gggtccaggt tctgcctccc tctctcgctc cctccctcca ctgtcaggga
     1681 ttaactacag gagctgaagt tgcaggagag ctcgctcacc tcacctggag tgcacactcc
     1741 aggcctgccc acctgcctac tttgctcttc tctgttccag gctcagcctc tctgcttcct
     1801 gtacctagtg tcactggatc acaggacctt ggcttagtgt ctctgactct gccttctgtg
     1861 gagccaatga tctcaattcc ttttggtggc tagaggccac caggatgtgg ggtgttcttc
     1921 aagtagctat cagctctgcc tgggactcct ggcctttacc accaccccat cagcctaccc
     1981 taactcccag gctcaatacc taccccatgg ccccaggagg tacccagata tggctacacc
     2041 cctagctgag gtccaaccct gctcagggct cctgaaaatt ggttcaccaa cttccctggc
     2101 ttcaggccac actgctgtgt cctgctctgt gccccagttc catccaaata tagcccggca
     2161 caaataaaca ttagtgtatc tgtgtgaata tcctgccctc ttccaagccc tgcctgcacg
     2221 cacgccacct gctcacctcc ctggtatcct agggcacatg actttccctg ccaggagact
     2281 tgccaggcgg ctttctgtgt gctcttgcca caagggcctc gctgcttcat ttttgccatg
     2341 ggaacagaaa acctaaacct gagcttgaaa aaaaaaagtt tactatctta aataattaaa
     2401 aatatatatt attaaggg
//
