LOCUS       NM_011956               1448 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus nucleotide binding protein 2 (Nubp2), transcript
            variant 1, mRNA.
ACCESSION   NM_011956
VERSION     NM_011956.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   DiStasio,A., Paulding,D., Chaturvedi,P. and Stottmann,R.W.
  TITLE     Nubp2 is required for cranial neural crest survival in the mouse
  JOURNAL   Dev Biol 458 (2), 189-199 (2020)
   PUBMED   31733190
  REMARK    GeneRIF: Nubp2 is required for cranial neural crest survival in the
            mouse.
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Ververis,A., Christodoulou,A., Christoforou,M., Kamilari,C.,
            Lederer,C.W. and Santama,N.
  TITLE     A novel family of katanin-like 2 protein isoforms (KATNAL2),
            interacting with nucleotide-binding proteins Nubp1 and Nubp2, are
            key regulators of different MT-based processes in mammalian cells
  JOURNAL   Cell Mol Life Sci 73 (1), 163-184 (2016)
   PUBMED   26153462
  REMARK    GeneRIF: KATNAL2 isoforms interact with themselves, with each other
            and with Nubp1 and Nubp2.
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Kypri,E., Christodoulou,A., Maimaris,G., Lethan,M., Markaki,M.,
            Lysandrou,C., Lederer,C.W., Tavernarakis,N., Geimer,S.,
            Pedersen,L.B. and Santama,N.
  TITLE     The nucleotide-binding proteins Nubp1 and Nubp2 are negative
            regulators of ciliogenesis
  JOURNAL   Cell Mol Life Sci 71 (3), 517-538 (2014)
   PUBMED   23807208
  REMARK    GeneRIF: The nucleotide-binding proteins Nubp1 and Nubp2 are
            negative regulators of ciliogenesis.
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Schnatwinkel,C. and Niswander,L.
  TITLE     Nubp1 is required for lung branching morphogenesis and distal
            progenitor cell survival in mice
  JOURNAL   PLoS One 7 (9), e44871 (2012)
   PUBMED   23028652
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Christodoulou,A., Lederer,C.W., Surrey,T., Vernos,I. and Santama,N.
  TITLE     Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is
            implicated in the regulation of centrosome duplication
  JOURNAL   J Cell Sci 119 (Pt 10), 2035-2047 (2006)
   PUBMED   16638812
  REMARK    GeneRIF: KIFC5A interacts with nucleotide-binding proteins 1 and 2
            (Nubp1 and Nubp2). Nubp1 and Nubp2 also interact with each other.
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Sano,Y., Shimada,T., Nakashima,H., Nicholson,R.H., Eliason,J.F.,
            Kocarek,T.A. and Ko,M.S.
  TITLE     Random monoallelic expression of three genes clustered within 60 kb
            of mouse t complex genomic DNA
  JOURNAL   Genome Res 11 (11), 1833-1841 (2001)
   PUBMED   11691847
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Nakashima,H., Grahovac,M.J., Mazzarella,R., Fujiwara,H.,
            Kitchen,J.R., Threat,T.A. and Ko,M.S.
  TITLE     Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome
            17, and Nubp1, mapped to chromosome 16--establish a new gene family
            of nucleotide-binding proteins in eukaryotes
  JOURNAL   Genomics 60 (2), 152-160 (1999)
   PUBMED   10486206
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI735707.1, AF114169.1 and BU700400.1.
            
            On Aug 12, 2009 this sequence version replaced NM_011956.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169896.1, AK003816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               BI735707.1         1-254
            255-1422            AF114169.1         233-1400
            1423-1448           BU700400.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1448
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /note="nucleotide binding protein 2"
                     /db_xref="GeneID:26426"
                     /db_xref="MGI:MGI:1347072"
     exon            1..72
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..872
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cytosolic Fe-S cluster assembly factor NUBP2
                     isoform 1"
                     /protein_id="NP_036086.1"
                     /db_xref="CCDS:CCDS28500.1"
                     /db_xref="GeneID:26426"
                     /db_xref="MGI:MGI:1347072"
                     /translation="MEAAAGERAEPGNLAGVRHIILVLSGKGGVGKSTISTELALALR
                     HQGKKVGILDVDLCGPSIPHMLRAQGKAVHQCDNGWVPVFVDQEQSISLMSVGFLLEN
                     PDEAVVWRGPKKHALIKQFVSDVAWGQLDYLVVDTPPGTSDEHMATMEALRPYRPLGA
                     LVVTTPQAVSIGDVRRELTFCKKTGLQVIGVIENMSGFTCPHCAECTNVFSSGSGEEL
                     ARLAGVPFLGSVPLDSQLTRSLEEGRDFIQEFPKSTAYSALTSIAQRVVHRMSALCS"
     exon            73..191
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /inference="alignment:Splign:2.1.0"
     exon            192..390
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /inference="alignment:Splign:2.1.0"
     exon            391..545
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /inference="alignment:Splign:2.1.0"
     exon            546..656
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /inference="alignment:Splign:2.1.0"
     exon            657..726
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1430
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /note="hexamer: TATAAA"
     polyA_site      1424
                     /gene="Nubp2"
                     /gene_synonym="D17Wsu11e"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggaag cggaagagag ccgcgaaaag caactagtag cggaatggag gctgctgccg
       61 gtgagcgtgc agaacccggg aacctggccg gggtgcgaca catcatcctt gttctttctg
      121 gaaagggtgg cgttgggaaa agcaccatct ccacggagtt ggccctggct ctgcgccacc
      181 agggcaagaa ggtgggaatc ctagatgtgg acctgtgcgg tcccagcata ccacacatgc
      241 tccgtgcaca aggcaaggcc gtgcaccagt gtgacaatgg ctgggtgcct gtctttgtgg
      301 atcaggagca gagcatctcc cttatgtctg tggggttcct gctggaaaac cctgatgagg
      361 ccgtggtgtg gagaggtccc aagaaacatg cactgataaa gcagtttgtg tctgacgtgg
      421 cctgggggca gctggattat ctggttgtgg acacacctcc agggacctct gatgagcaca
      481 tggccactat ggaagccctg cgcccctaca ggccccttgg ggctcttgta gtcaccacac
      541 cacaggcggt gtctattggg gatgtgaggc gggagctgac cttctgtaag aagactgggc
      601 tgcaggtgat aggggtcata gagaacatga gcggcttcac ctgcccacac tgcgctgagt
      661 gcaccaatgt cttctccagc ggcagtgggg aggagctggc ccggctggct ggagttccct
      721 ttttaggctc tgtccccctg gattcccaac ttaccaggag cttggaggaa gggcgtgact
      781 tcatccagga atttcccaaa agcactgcat attccgcact cacgtccata gcccagagag
      841 ttgtgcacag gatgtctgcc ctgtgctcct gaccgcctgg cagccttctg gtgctgcatg
      901 cctgtaggac ctttgggagc agaggccctc aggactgttt tgggacctgt agttgttggc
      961 ctgggcaatg gctggactat gcgattacat ccatgcagag atctgcaggc ccccatgtcc
     1021 ttggctgaca ctagcttcac caaactagtc tatagctgag gggatagcct gcgtcctgat
     1081 tccttgagat aatagcagcc ttaaccttta gcctataggc tttcgtccag ccctagtcac
     1141 ttctgcccca ggtcaacagg ctgctctcat agccacacca cacaggagct ggccagtgct
     1201 ttctcatcga gactgaccca cacatgctgt gttgtgtgcc ttttgtgaca ctgtggttta
     1261 ccggcacatc tggtaacttt acagaactct gctattaaac ataccgcccc gtcttaggaa
     1321 ggacccagca tccaagccct ttgtcctcag cgaggtgact cttgattccc ctacatttca
     1381 tgtctggaac aagcagtatt agtaaagatt ataaagggcc tgaagatgtg aaaaaaaaaa
     1441 aaaaaaaa
//
