LOCUS       NM_001004363            5634 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus NUAK family, SNF1-like kinase, 1 (Nuak1), mRNA.
ACCESSION   NM_001004363 XM_196007
VERSION     NM_001004363.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5634)
  AUTHORS   Lanfranchi,M., Yandiev,S., Meyer-Dilhet,G., Ellouze,S.,
            Kerkhofs,M., Dos Reis,R., Garcia,A., Blondet,C., Amar,A.,
            Kneppers,A., Polveche,H., Plassard,D., Foretz,M., Viollet,B.,
            Sakamoto,K., Mounier,R., Bourgeois,C.F., Raineteau,O., Goillot,E.
            and Courchet,J.
  TITLE     The AMPK-related kinase NUAK1 controls cortical axons branching by
            locally modulating mitochondrial metabolic functions
  JOURNAL   Nat Commun 15 (1), 2487 (2024)
   PUBMED   38514619
  REMARK    GeneRIF: The AMPK-related kinase NUAK1 controls cortical axons
            branching by locally modulating mitochondrial metabolic functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5634)
  AUTHORS   You,Y., Gao,C., Wu,J., Qu,H., Xiao,Y., Kang,Z., Li,J. and Hong,J.
  TITLE     Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte
            Synergistically Promote Liver Fibrosis
  JOURNAL   Int J Mol Sci 23 (21), 13084 (2022)
   PUBMED   36361872
  REMARK    GeneRIF: Enhanced Expression of ARK5 in Hepatic Stellate Cell and
            Hepatocyte Synergistically Promote Liver Fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5634)
  AUTHORS   Zhang,T., He,X., Caldwell,L., Goru,S.K., Ulloa Severino,L.,
            Tolosa,M.F., Misra,P.S., McEvoy,C.M., Christova,T., Liu,Y.,
            Atin,C., Zhang,J., Hu,C., Vukosa,N., Chen,X., Krizova,A.,
            Kirpalani,A., Gregorieff,A., Ni,R., Chan,K., Gill,M.K.,
            Attisano,L., Wrana,J.L. and Yuen,D.A.
  TITLE     NUAK1 promotes organ fibrosis via YAP and TGF-beta/SMAD signaling
  JOURNAL   Sci Transl Med 14 (637), eaaz4028 (2022)
   PUBMED   35320001
  REMARK    GeneRIF: NUAK1 promotes organ fibrosis via YAP and TGF-beta/SMAD
            signaling.
REFERENCE   4  (bases 1 to 5634)
  AUTHORS   Buensuceso,A., Fritz,J.L., Collins,O., Valdes,Y.R., Borrelli,M.J.,
            DiMattia,G.E. and Shepherd,T.G.
  TITLE     Loss of LKB1-NUAK1 signalling enhances NF-kappaB activity in a
            spheroid model of high-grade serous ovarian cancer
  JOURNAL   Sci Rep 12 (1), 3011 (2022)
   PUBMED   35194062
  REMARK    GeneRIF: Loss of LKB1-NUAK1 signalling enhances NF-kappaB activity
            in a spheroid model of high-grade serous ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5634)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5634)
  AUTHORS   Inazuka,F., Sugiyama,N., Tomita,M., Abe,T., Shioi,G. and Esumi,H.
  TITLE     Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1)
            prevents high fat diet-induced glucose intolerance
  JOURNAL   J Biol Chem 287 (20), 16379-16389 (2012)
   PUBMED   22418434
  REMARK    GeneRIF: a physiological role of NUAK1 is to suppress glucose
            uptake through negative regulation of insulin signaling in
            oxidative muscle.
REFERENCE   7  (bases 1 to 5634)
  AUTHORS   Hagglund,A.C., Dahl,L. and Carlsson,L.
  TITLE     Lhx2 is required for patterning and expansion of a distinct
            progenitor cell population committed to eye development
  JOURNAL   PLoS One 6 (8), e23387 (2011)
   PUBMED   21886788
REFERENCE   8  (bases 1 to 5634)
  AUTHORS   William,D.A., Saitta,B., Gibson,J.D., Traas,J., Markov,V.,
            Gonzalez,D.M., Sewell,W., Anderson,D.M., Pratt,S.C., Rappaport,E.F.
            and Kusumi,K.
  TITLE     Identification of oscillatory genes in somitogenesis from
            functional genomic analysis of a human mesenchymal stem cell model
  JOURNAL   Dev Biol 305 (1), 172-186 (2007)
   PUBMED   17362910
REFERENCE   9  (bases 1 to 5634)
  AUTHORS   Hirano,M., Kiyonari,H., Inoue,A., Furushima,K., Murata,T., Suda,Y.
            and Aizawa,S.
  TITLE     A new serine/threonine protein kinase, Omphk1, essential to ventral
            body wall formation
  JOURNAL   Dev Dyn 235 (8), 2229-2237 (2006)
   PUBMED   16715502
  REMARK    GeneRIF: Omphk1 expression is also found in each tissue associated
            with the ventral body wall closure: the primary body wall composed
            of primitive ectoderm and each component of the secondary body wall
            [Omphk1]
REFERENCE   10 (bases 1 to 5634)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150314.5, CF534664.1, CJ106400.1, BC082328.1, CJ247195.1,
            AI450794.1 and BB808457.1.
            
            On Feb 5, 2019 this sequence version replaced NM_001004363.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082328.1, SRR7652917.335479.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC150314.5         152568-152597       c
            31-71               CF534664.1         1-41
            72-197              CJ106400.1         2-127
            198-5223            BC082328.1         1-5026
            5224-5227           CJ247195.1         49-52
            5228-5566           AI450794.1         67-405              c
            5567-5634           BB808457.1         314-381
FEATURES             Location/Qualifiers
     source          1..5634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.42 cM"
     gene            1..5634
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /note="NUAK family, SNF1-like kinase, 1"
                     /db_xref="GeneID:77976"
                     /db_xref="MGI:MGI:1925226"
     exon            1..554
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2288
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /EC_number="2.7.11.1"
                     /note="ZNUAK family, SNF1-like kinase, 1; omphalocele
                     kinase 1; AMPK-related protein kinase 5"
                     /codon_start=1
                     /product="NUAK family SNF1-like kinase 1"
                     /protein_id="NP_001004363.1"
                     /db_xref="CCDS:CCDS24079.1"
                     /db_xref="GeneID:77976"
                     /db_xref="MGI:MGI:1925226"
                     /translation="MEGAAVSAAGDGPAVETGLPGSPLEAVAGATAAPVEPRKPHGVK
                     RHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIR
                     REIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFF
                     RQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPL
                     YASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQ
                     PSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALPDSESPLLARIID
                     WHHRSTGLQAEAEAKMKGLAKPGASEVVLERQRSLKKSKKENDFPQSGQDSVPESPSK
                     LSSKRPKGILKKRSNSEHRSHSTGFIEGIVSPALPSPFKMEQDLCRTAIPLPSSPEAD
                     MSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISGGLSSPPP
                     DPARGTSHSLSCRRKGILKHSSRYSDGGTDPALTRPEMPTLESLSPPGVPSDGISRSY
                     SRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAENFLQLQDFETPHNRPRPQ
                     YLKRLADSSFSLLTDMDDVTQVYKKALEICSKLN"
     exon            555..675
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..827
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..893
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1013
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1146
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..5634
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5337..5342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /note="hexamer: AATAAA"
     polyA_site      5363
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /note="major polyA site"
     regulatory      5609..5614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /note="hexamer: AATAAA"
     polyA_site      5634
                     /gene="Nuak1"
                     /gene_synonym="B230104P22Rik; Omphk1"
                     /note="major polyA site"
ORIGIN      
        1 accctctccc ctccttctcg ccaacaccac cgcctcccct gacatcgctg ccacctcgcc
       61 ggacgctccg cagattgccg cggctggcca gggggcggtg cgccgagcgt gcgcgcccgg
      121 gacgccagat gtgcagtcgc cgccgccgcc gccgctagtg ccccagcggc agccagagcc
      181 aggtcgggtc gtctcagcaa tgctgctgcg ggggcgacct tgaacgcacc ccggtttccc
      241 tcggtgggga ccaccccgag cccctgtgcc gggacctgcc ctctccaact cggctcgccc
      301 tgcgcttggt catggaaggg gcggcagtgt ccgcggcagg ggatggccct gctgtagaga
      361 ccggcttgcc gggctctccg ctggaggcgg tggccggggc gactgcagcc ccagtggagc
      421 ccaggaagcc gcacggggtg aagcgacatc accacaaaca caacttgaag catcgctatg
      481 agctgcaaga gaccctgggc aaaggtacct acggcaaagt caagagagcc accgagaggt
      541 tttcaggccg agtggttgct ataaaatcca tccgtaagga caaaattaag gacgagctag
      601 acatggttca catcagacga gagattgaga tcatgtcatc cctcaaccat cctcatatca
      661 tcagtattta tgaagtgttt gagaacaaag ataagattgt gatcatcatg gaatatgcca
      721 gcaaaggaga gctgtatgat tacatcagtg agcgcaggcg cctcagcgag agggagacca
      781 gacacttctt ccggcagatt gtgtctgccg tgcattactg tcacaagaat ggtgtggtcc
      841 accgggactt gaagctggag aacatactgc ttgatgacaa ctgcaacatt aagattgctg
      901 actttgggct ctccaacctg taccagaagg acaagttctt gcaaacattt tgtgggagcc
      961 cactctatgc gtcgcccgag attgtcaacg gcaggcctta ccgagggcca gaggtggaca
     1021 gctgggccct gggtgtcttg ctttacactc tcatttatgg aacgatgccc ttcgatggct
     1081 ttgatcacaa aaacctcatc cggcagatca gcagcggaga gtaccgggag cccacacaac
     1141 cctcagatgc tcggggactc atccggtgga tgctgatggt gaatcccgat cgcagagcca
     1201 ccatcgagga catcgccaac cattggtggg tgaactgggg ctacaagagc agcgtctgtg
     1261 actgtgatgc ccttcctgac tctgagtctc cactcttggc acggatcatc gattggcatc
     1321 accgttccac ggggctgcag gctgaggctg aagccaagat gaagggtctg gccaaacccg
     1381 gggcctctga ggttgtgttg gagcggcagc ggtcactgaa gaagtccaag aaagagaacg
     1441 actttcccca gtctggccag gactccgtac ctgaaagccc atccaagctg agttccaaga
     1501 ggcccaaggg catcctgaag aaacggagca acagcgaaca ccgctcccac agcactggct
     1561 ttatcgaagg cattgtgagc cctgccttac catccccttt caaaatggag caagatttgt
     1621 gccggactgc catccccctc cccagctccc ccgaggcaga tatgtcaggg aagctcagcc
     1681 tcaaacagtc tgccacgatg cccaagaaag gcatcttgaa aaagacccag cagagagaat
     1741 ctggctacta ttcatcccca gagcgcagcg agtcctcgga actgctggac agcaacgatg
     1801 tggtcatcag tggtggcctc tcgtcccctc ccccagaccc agccagggga acttcccaca
     1861 gcctgtcctg ccggaggaag ggcatcttaa aacatagtag caggtactca gatggtggca
     1921 cagaccctgc cctcacccgc cctgaaatgc ccacactgga atccttgtca cctcccggtg
     1981 tcccctccga tggcatctct cggagctaca gtcgcccgtc cagtatcatc agtgatgaca
     2041 gtgtcctgtc cagcgactct ttcgacttgt tagagcttca agagaaccgg ccagcccgcc
     2101 agcgcatccg cagctgcgtc tctgctgaaa acttcctcca gcttcaggac tttgagacac
     2161 cacacaaccg gccccggccc cagtacctga agcggctggc agacagtagc ttctcccttc
     2221 tcactgatat ggacgatgtg actcaggtgt ataagaaagc gctggagatc tgcagcaagc
     2281 tcaactagcc cttcagggca cagaggatgg gatgggtggg tgggtgaggc caagggagaa
     2341 ggggaacaga actcagcctg aaggctggtt acctctttgc tggtcaaggc aacggattgg
     2401 gaaaggacta gtaatgtctg gcctggccag tttacacagc cttgagtcag cacctaaaag
     2461 ggatagaaac cattctttac cagttctgcc tgtgccagtt agaatggggg tcctaactgg
     2521 cattcccagg tgacatctca cgggggaggt ggtgttggcc agcaagaaat gggaagcggc
     2581 attatgggga agggtgtgtt tcctagaagt catctagatg tttctggagg aggggaagaa
     2641 agactgagac catctgcttt ggatggatcc attagcaagc ctggtctgac tacacagggg
     2701 ctagcaagac tccagcaacc tgagtgtgaa ttggtgatca attggtaatg tctgtactgt
     2761 ggtctgagtt tagtagacta ggcacaccag ggagcattga gtgagtacca ataactgcca
     2821 gggaatcagg accggaggca acagcatacc tgccctggct aagccctggg agttaggtta
     2881 aagcaggctg ttttaaagaa aaacagttaa ctctttcatg gcacagcatg acatgtgtta
     2941 atttgctcct ggaccttgag tagaagacag ggcttgctta gagagtgaat atgctgaact
     3001 ctgctaccga aataagtctg gtggtggtga ctttctggtt ttctgggatc tgcctcttct
     3061 ttctcctctc tcttgccttg ttcttcttta gtgggatctt ctgaaggtga gcaggaataa
     3121 agatggcagt gtgagagccc agggctttgt gtgtaatggg gcacagagct gctggggcct
     3181 ttgctcagtg aatggactga cggtgaagca tgccagcaag gggcgactta acactttctt
     3241 aaatatctca gtattaactg gaaccccgcc tcttggcttc tcacctgcac aaggacagga
     3301 tgctactctg agtctccaaa gcatcactgg ctcagccata ggccccattc accccaagtg
     3361 tggaatcttg actgtagaag agttgcttct agggagttag tatgtaggtg aaatatgtgg
     3421 ccgagggaaa gcccagtttg acagaaggtt cttgtctcgc caggccttag tattctgcct
     3481 cgtggttttg atctccctca ttttggggga ataaacaagt tccattcatc catccttcca
     3541 tccatccatc catccatcca tccatccatc cacagaataa gatgttgaga gagcagagtg
     3601 tggggggagg aggcttaggg acgtttcctc gggagccatc cagatggctc tggaggaggc
     3661 agaaaggagg tgtatggggt gacaggatgc ttaaaaatgt tccagctagt tatctaatct
     3721 ctgaacacta agattacagg tgatgtcatc ccctcagagg ggaccctggg gacactgggg
     3781 gcgggggtgg gggggattga agtggtcttt ctgggctgac cacggaatcc actggcttag
     3841 tcaaattaga atccttcttc taaggtggct gccttgtggg agcctctcag acagggttgg
     3901 gggaggatgc atccgtcact gcactgagga cagttgtcag ggagatgctg ctctatacag
     3961 cagaaggctg ctttgcatca ctgtgtttgg gccccgcgct ttcctttggg ctgaagtgag
     4021 caggatgtag tgggaagctg cttcgattct tttccttcag tttcacctcc tacctgaact
     4081 gtggcagggg ctaaaaggga ggaaaatcta taggtagaga agtggctctg gcgcttggag
     4141 gtgtatagac ggcagcatgt aacctctgaa tcctcccgct ccctgcctcc tctcgtgaac
     4201 aaccccgcct gctgctacac tgctggcccc tgagcaggca gctggtctcg ggtgtagcag
     4261 ccattgctgg ttgatggaat ttttcccttt tgccagctga ttgtgtctgt ttagtattcc
     4321 ccaccatgca gttgactcca ttaggaaaac cacgcccttc ggctttctcc ccttctcgat
     4381 caccagggtc accagtgtgt tctcttttgg cgggactctc aaagacaagg ggttggggag
     4441 gggaaaccaa atgtttcaca ccaagaacag aggctctcgg gtgtggggtg tgtcctccgt
     4501 tccagggctg acactgagtt gagtccaggt ctgccttgat ctggaggtct caggcacctg
     4561 cagtggctat gagggctgct tcccacgggt ggaggctgga gacgtggctg agtggtttcc
     4621 caaggccctc cccgcccccc tcagttctga tacctgcttc tagctgagat gctgactgtc
     4681 cctgcaggaa atgagttaga tcagagaata aagccctaaa aaaagcagtt tcccaatgga
     4741 gccctgttat ccctgccagt cagtccccag ccaaagaagg gatgcctgac tcatttccgc
     4801 ggagtcccca gtgagagaca cagatgaccc catgggcaga gtgggaaagt cgctgcgtga
     4861 gctgtcctcg tccttccttt gcttctaggg cacttctatt cttcgtttac acatctgcca
     4921 aagggggtgg agttgtactt cgttttacag gtaaatttca aggcacagtc agtttttaag
     4981 aaagtgctcc aagaccctag gcaacgtgac agttctcagt tccctctgaa ttttagtctc
     5041 tgctacctgg tgctctttac caaaggagct cgctgcaggg tgaaattcag gcgtgttctg
     5101 cccaggcctg ctgtcttgag tacaaatgtg aatgatggac tgactgcttg ttgccaaact
     5161 ggaaatgttt tgtagggatt tactggcatg gtatcattcc taggaagaag aagaaaaaaa
     5221 aaaggaaaaa gaaagaaaga aaaagggaca ggagagggag agaaacttga ctgcacattt
     5281 tttttttatt attaaatcca tgttgtgact tttatttaat ttctatattt tttggtaata
     5341 aaaagttgac tttttaattt gaatttgtct ttttttattt attggtctga aaggcatttc
     5401 aaaggtatta taataatata ttggtgtaat ttaattggtg cagcatgcct tctgggctcc
     5461 agtcaaagtt agtttttaac ttatttgatt ggtttgagaa cagcctacag ggagaggaag
     5521 agaagagctg gctaattacc ccaaagtgtt catctttcat tggaaactga atttttatca
     5581 tttttgtttc tgtttttatt ttaaattaaa taaattgcaa caaactgaac cagg
//
