LOCUS       NM_001361702            1469 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus neurotensin receptor 2 (Ntsr2), transcript variant 2,
            mRNA.
ACCESSION   NM_001361702 XM_006515012
VERSION     NM_001361702.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1469)
  AUTHORS   Manning,C.E., Eagle,A.L., Kwiatkowski,C.C., Achargui,R.,
            Woodworth,H., Potter,E., Ohnishi,Y., Leinninger,G.M. and
            Robison,A.J.
  TITLE     Hippocampal Subgranular Zone FosB Expression Is Critical for
            Neurogenesis and Learning
  JOURNAL   Neuroscience 406, 225-233 (2019)
   PUBMED   30902680
REFERENCE   2  (bases 1 to 1469)
  AUTHORS   Woodworth,H.L., Perez-Bonilla,P.A., Beekly,B.G., Lewis,T.J. and
            Leinninger,G.M.
  TITLE     Identification of Neurotensin Receptor Expressing Cells in the
            Ventral Tegmental Area across the Lifespan
  JOURNAL   eNeuro 5 (1) (2018)
   PUBMED   29464190
  REMARK    GeneRIF: Study shows that neurotensin receptor 2 expression remains
            constant throughout lifespan, and is predominantly expressed within
            glia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1469)
  AUTHORS   Woodworth,H.L., Batchelor,H.M., Beekly,B.G., Bugescu,R.,
            Brown,J.A., Kurt,G., Fuller,P.M. and Leinninger,G.M.
  TITLE     Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental
            Dopamine Neurons that Coordinates Energy Balance
  JOURNAL   Cell Rep 20 (8), 1881-1892 (2017)
   PUBMED   28834751
REFERENCE   4  (bases 1 to 1469)
  AUTHORS   Suzuki,M., Kobayashi,M., Ohno,T., Kanamori,S., Tateishi,S.,
            Murai,A. and Horio,F.
  TITLE     Genetic dissection of the fatty liver QTL Fl1sa by using congenic
            mice and identification of candidate genes in the liver and
            epididymal fat
  JOURNAL   BMC Genet 17 (1), 145 (2016)
   PUBMED   27855657
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1469)
  AUTHORS   McCullough,K.M., Choi,D., Guo,J., Zimmerman,K., Walton,J.,
            Rainnie,D.G. and Ressler,K.J.
  TITLE     Molecular characterization of Thy1 expressing fear-inhibiting
            neurons within the basolateral amygdala
  JOURNAL   Nat Commun 7, 13149 (2016)
   PUBMED   27767183
  REMARK    GeneRIF: Molecular characterization of Thy1 expressing
            fear-inhibiting neurons within the basolateral amygdala identify
            and validate Ntsr2-expressing neurons as a putative 'Fear-Off'
            population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1469)
  AUTHORS   Martin,S., Vincent,J.P. and Mazella,J.
  TITLE     Recycling ability of the mouse and the human neurotensin type 2
            receptors depends on a single tyrosine residue
  JOURNAL   J Cell Sci 115 (Pt 1), 165-173 (2002)
   PUBMED   11801734
  REMARK    GeneRIF: Recycling ability depends on a single tyrosine residue
REFERENCE   7  (bases 1 to 1469)
  AUTHORS   Sun,Y.J., Maeno,H., Aoki,S. and Wada,K.
  TITLE     Mouse neurotensin receptor 2 gene (Ntsr2): genomic organization,
            transcriptional regulation and genetic mapping on chromosome 12
  JOURNAL   Brain Res Mol Brain Res 95 (1-2), 167-171 (2001)
   PUBMED   11687289
  REMARK    GeneRIF: transcriptional regulation; maps to chromosome 12
REFERENCE   8  (bases 1 to 1469)
  AUTHORS   Dubuc,I., Sarret,P., Labbe-Jullie,C., Botto,J.M., Honore,E.,
            Bourdel,E., Martinez,J., Costentin,J., Vincent,J.P., Kitabgi,P. and
            Mazella,J.
  TITLE     Identification of the receptor subtype involved in the analgesic
            effect of neurotensin
  JOURNAL   J Neurosci 19 (1), 503-510 (1999)
   PUBMED   9870978
REFERENCE   9  (bases 1 to 1469)
  AUTHORS   Botto,J.M., Sarret,P., Vincent,J.P. and Mazella,J.
  TITLE     Identification and expression of a variant isoform of the
            levocabastine-sensitive neurotensin receptor in the mouse central
            nervous system
  JOURNAL   FEBS Lett 400 (2), 211-214 (1997)
   PUBMED   9001400
REFERENCE   10 (bases 1 to 1469)
  AUTHORS   Mazella,J., Botto,J.M., Guillemare,E., Coppola,T., Sarret,P. and
            Vincent,J.P.
  TITLE     Structure, functional expression, and cerebral localization of the
            levocabastine-sensitive neurotensin/neuromedin N receptor from
            mouse brain
  JOURNAL   J Neurosci 16 (18), 5613-5620 (1996)
   PUBMED   8795617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122228.4.
            
            On Oct 13, 2022 this sequence version replaced NM_001361702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005368.1, ERR3363658.4201315.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-648               AC122228.4         68778-69425
            649-864             AC122228.4         71899-72114
            865-955             AC122228.4         73667-73757
            956-1469            AC122228.4         75011-75524
FEATURES             Location/Qualifiers
     source          1..1469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 7.98 cM"
     gene            1..1469
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /note="neurotensin receptor 2"
                     /db_xref="GeneID:18217"
                     /db_xref="MGI:MGI:108018"
     exon            1..648
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..993
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /note="isoform 2 is encoded by transcript variant 2;
                     neurotensin receptor type 2; low affinity neurotensin
                     receptor; low-affinity levocabastine-sensitive neurotensin
                     receptor"
                     /codon_start=1
                     /product="neurotensin receptor type 2 isoform 2"
                     /protein_id="NP_001348631.1"
                     /db_xref="GeneID:18217"
                     /db_xref="MGI:MGI:108018"
                     /translation="METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFA
                     LGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWV
                     FGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVW
                     VASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLP
                     LALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGV
                     QASLEPSWLCMSSAGCRTMPAGSCTATSPMMDGLMSSMTSITISTW"
     exon            649..864
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /inference="alignment:Splign:2.1.0"
     exon            865..955
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1469
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /note="hexamer: AATAAA"
     polyA_site      1469
                     /gene="Ntsr2"
                     /gene_synonym="NT-R-2; NT2R; NTR2; NTRL"
                     /note="major polyA site"
ORIGIN      
        1 agatcaggcc accacgagac agagatggag accagcagcc tgtggccccc gaggcccagc
       61 cccagtgcag ggctgagcct ggaggcgcgg ctgggcgtgg acactcgcct ctgggccaag
      121 gtgctgttca ccgcgctcta ttcgctcatc ttcgcgcttg gcacagccgg caatgcgctg
      181 tccgtgcacg tggtgctgaa ggcgcgggcg ggtcgccccg ggcgcctgcg ctaccacgtg
      241 ctcagcctgg cactgtcagc cctgctgcta ctgctgatca gcgtgcccat ggagctctac
      301 aacttcgtgt ggtcccacta cccctgggtc ttcggcgatc tcggctgtcg tggctattac
      361 ttcgtgcgtg agctgtgcgc ctacgccacg gtgctgagcg tggccagcct gagcgcagag
      421 cgctgcctgg ccgtgtgcca gccgctgcgc gcccgccgcc tgctcacccc gcgccgcacc
      481 cgccgcctgc tgtcactagt ctgggtcgcc tctctgggcc ttgccctgcc catggcggtt
      541 atcatgggac agaagcacga aatggagagg gccgacgggg agcctgagcc tgcctcgcgt
      601 gtgtgcacgg tgctagtaag tcgcgccacg ctccaggtct tcatccaggt gaacgtgctg
      661 gtctccttcg ttctcccctt ggcactcact gcttttctga atgggatcac tgtcaaccac
      721 ctggtggccc tctactccca ggtaccatca gcttctgccc aagtcaactc catccccagc
      781 cgcctggagc tcctgagtga ggaaggcctc ctgggcttca tcacatggag aaagaccctc
      841 tccctggggg tccaagccag cctggagcca tcgtggctgt gtatgtcatc tgctggctgc
      901 cgtaccatgc ccgcaggctc atgtactgct acatccccga tgatggatgg actgatgagc
      961 tctatgactt ctatcactat ttctacatgg tgaccaacac gctcttctat gtcagctcgg
     1021 cagtgacccc agtcctctac aacgccgtgt cttcctcctt cagaaagctc tttctggaat
     1081 ctctcagttc cctgtgtggt gaacagcgct ccgtggtgcc cttaccccaa gaagccccag
     1141 agtcaactac tagtacgtac agtttccggc tttggggatc cccaagaaac cccagcctgg
     1201 gtgaaataca agtgtgaaga gaacaaacaa tggctgcttg ggacacaccc atcagataag
     1261 ccatgccatt actaacagtc taagcggacc tactgaccca gcgcagtcat tgaccagtgc
     1321 atactgcagg caagccacgt aacacctcct gccctcaact tcccacctgt gcaaccaagg
     1381 tgtagaatag gacgaattgc ctagtgatga aggtgcccag tgccaggcct ggtacagaac
     1441 cagtactcaa taaattttag ctggtgcta
//
