LOCUS       NM_018766               3916 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Mus musculus neurotensin receptor 1 (Ntsr1), mRNA.
ACCESSION   NM_018766 XM_914674
VERSION     NM_018766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3916)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (bases 1 to 3916)
  AUTHORS   Lu,D., Uldry Lavergne,C.G., Choi,S., Park,J., Kim,J., Zhao,S.,
            Desimone,Q., Lendaro,E., Chen,B., Han,B.X., Wang,F. and
            Goldstein,N.
  TITLE     General anesthesia activates a central anxiolytic center in the
            BNST
  JOURNAL   Cell Rep 43 (11), 114909 (2024)
   PUBMED   39460938
REFERENCE   3  (bases 1 to 3916)
  AUTHORS   Gu,M., Li,X., Liang,S., Zhu,J., Sun,P., He,Y., Yu,H., Li,R.,
            Zhou,Z., Lyu,J., Li,S.C., Budinger,E., Zhou,Y., Jia,H., Zhang,J.
            and Chen,X.
  TITLE     Rabies virus-based labeling of layer 6 corticothalamic neurons for
            two-photon imaging in vivo
  JOURNAL   iScience 26 (5), 106625 (2023)
   PUBMED   37250327
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3916)
  AUTHORS   Ehrlich,A.T., Couvineau,P., Schamiloglu,S., Wojcik,S., Da Fonte,D.,
            Mezni,A., von Zastrow,M., Bender,K.J., Bouvier,M. and Kieffer,B.L.
  TITLE     Visualization of real-time receptor endocytosis in dopamine neurons
            enabled by NTSR1-Venus knock-in mice
  JOURNAL   Front Cell Neurosci 16, 1076599 (2022)
   PUBMED   36523815
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3916)
  AUTHORS   Pauli,J.L., Chen,J.Y., Basiri,M.L., Park,S., Carter,M.E., Sanz,E.,
            McKnight,G.S., Stuber,G.D. and Palmiter,R.D.
  TITLE     Molecular and anatomical characterization of parabrachial neurons
            and their axonal projections
  JOURNAL   Elife 11, e81868 (2022)
   PUBMED   36317965
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3916)
  AUTHORS   Markel,P.D., Bennett,B., Beeson,M., Gordon,L. and Johnson,T.E.
  TITLE     Confirmation of quantitative trait loci for ethanol sensitivity in
            long-sleep and short-sleep mice
  JOURNAL   Genome Res 7 (2), 92-99 (1997)
   PUBMED   9049627
REFERENCE   7  (bases 1 to 3916)
  AUTHORS   Erwin,V.G., Markel,P.D., Johnson,T.E., Gehle,V.M. and Jones,B.C.
  TITLE     Common quantitative trait loci for alcohol-related behaviors and
            central nervous system neurotensin measures: hypnotic and
            hypothermic effects
  JOURNAL   J Pharmacol Exp Ther 280 (2), 911-918 (1997)
   PUBMED   9023306
REFERENCE   8  (bases 1 to 3916)
  AUTHORS   Mazella,J., Botto,J.M., Guillemare,E., Coppola,T., Sarret,P. and
            Vincent,J.P.
  TITLE     Structure, functional expression, and cerebral localization of the
            levocabastine-sensitive neurotensin/neuromedin N receptor from
            mouse brain
  JOURNAL   J Neurosci 16 (18), 5613-5620 (1996)
   PUBMED   8795617
REFERENCE   9  (bases 1 to 3916)
  AUTHORS   Williamson,C.M., Dutton,E.R., Abbott,C.M., Beechey,C.V., Ball,S.T.
            and Peters,J.
  TITLE     Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1,
            Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal
            imprinting region of mouse chromosome 2 are not monoallelically
            expressed
  JOURNAL   Genet Res 65 (2), 83-93 (1995)
   PUBMED   7781998
REFERENCE   10 (bases 1 to 3916)
  AUTHORS   Laurent,P., Clerc,P., Mattei,M.G., Forgez,P., Dumont,X.,
            Ferrara,P., Caput,D. and Rostene,W.
  TITLE     Chromosomal localization of mouse and human neurotensin receptor
            genes
  JOURNAL   Mamm Genome 5 (5), 303-306 (1994)
   PUBMED   8075503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB017027.1.
            
            On Apr 5, 2007 this sequence version replaced NM_018766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017027.1, BC087730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3916              AB017027.1         2-3917
FEATURES             Location/Qualifiers
     source          1..3916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.04 cM"
     gene            1..3916
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /note="neurotensin receptor 1"
                     /db_xref="GeneID:18216"
                     /db_xref="MGI:MGI:97386"
     exon            1..1156
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..1717
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /note="NT-R-1"
                     /codon_start=1
                     /product="neurotensin receptor type 1"
                     /protein_id="NP_061236.1"
                     /db_xref="CCDS:CCDS17177.1"
                     /db_xref="GeneID:18216"
                     /db_xref="MGI:MGI:97386"
                     /translation="MHLNSSVQQGAPSEPGAQPFPHPQFGLETMLLALSLSNGSGNSS
                     ESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVH
                     YHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVA
                     SLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQH
                     PGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRG
                     VCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYI
                     SDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWR
                     RRRKKRPTFSRKPNSMSSNHAFSTSATRETLY"
     exon            1157..1373
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1464
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..3916
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3887..3892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /note="hexamer: AATAAA"
     polyA_site      3911
                     /gene="Ntsr1"
                     /gene_synonym="NT-1R; NTR-1; NTR1"
                     /note="major polyA site"
ORIGIN      
        1 aagcagaaga gggagaacga gggtgagcac gctgggcagc cgtgcgtgcg ctcctctctg
       61 cgccacaggc tcgcccaacg aagcacaagc cagcagggtc gcggtcctga ggacatcgct
      121 gccacccagg agtgcagaga accaaccaca gaatctggag gtcggtagca gccccgatct
      181 aggcaggctc ggagccaggg ggggtgccga ggaagaaccg gaaagcagat cccagactct
      241 gaaggagaaa gaagagtgga tccctgagcc ggcacgtctc gagccccaga gctcccagga
      301 tctcctggat agctggcttc gccgccggac ggcacgcccc ccttagcttc cacaccctct
      361 cctctgagcg cctcctcatc tgcccctgga gggactttca ccttcaaagg tgcaggacaa
      421 agccgcatat ctggcgccca ccatgcacct caacagctcc gtgcagcagg gagccccaag
      481 tgaacccggt gcccagccct tcccacatcc acagttcgga ctggagacga tgctcctggc
      541 gctcagcttg agcaatggtt ctggcaattc ctcagaatcc atcctggagc ccaacagcaa
      601 cctggacgtg aacactgaca tttattccaa ggtgctggtg accgctgtat acctggcact
      661 ttttgtggtg ggcactgtgg gcaactcggt gacagccttc actctagcgc ggaagaagtc
      721 gctgcagagc ctgcagagca ctgtgcatta ccacctgggt agcctggcac tgtctgacct
      781 gctcatcctg ctgctggcca tgcccgtgga gctgtacaac ttcatctggg tgcaccatcc
      841 ctgggccttt ggggatgctg gctgccgtgg ctactatttc ctgcgagatg cctgcaccta
      901 tgccacagcc ctcaatgtag ccagcctgag tgtggagcgc tacttggcca tctgccatcc
      961 cttcaaggcc aagaccctca tgtcccgcag ccgcaccaag aaattcatca gtgccatatg
     1021 gctagcctcg gcgctgctgg ctgtacccat gcttttcacc atgggcctgc agaaccgcag
     1081 tgccgatggc cagcaccctg gtggcctggt gtgcacaccc acggtggaca cagccaccgt
     1141 caaggtcgtc atccaggtta acaccttcat gtccttcctg tttcccatgc tgatcatctc
     1201 catcctaaac actgtgatag ccaacaaact gaccgtcatg gtgcaccagg ctgccgagca
     1261 gggccgtggt gtgtgcaccg tgggcaccca caacagttta gagcacagca cgttcaacat
     1321 gtccatcgag ccaggccgtg tccaggccct gcgccatgga gtcctcgtct tacgtgctgt
     1381 ggtaatcgcc tttgtggtct gctggctgcc ctaccacgtg cggcgcctca tgttctgcta
     1441 tatctcagat gaacagtgga ctacgttcct cttcgacttc taccactatt tctatatgct
     1501 gaccaacgct ctcttctacg tcagctcagc catcaatccc atcctttaca acctcgtctc
     1561 cgccaacttc cgccaggtct tcctgtccac actggcttgc ctctgtcctg ggtggcgccg
     1621 ccgccgaaag aagaggccaa cgttctccag gaagccaaac agcatgtcca gcaaccatgc
     1681 gttttccacc agcgccaccc gggaaaccct gtactaggcc atgaggaggt agcctgtgca
     1741 cagggcagca actcccccaa ccccccaccc ccaccccaaa gcctcccaag gttaagtagt
     1801 ggcccatcta agccatgccg gtgaggctgg ggcaccctca gcggaggctt ctttcttccc
     1861 agtttctctt tcttcccttc ctctggttct cccctcccta gtcctttatt cttgcccctt
     1921 atccctctcc tacctccacc tttaaaaaca gaaaagaggc ggtttctctc ctggccctac
     1981 aaaaggcctt taacaagaag aaattagcac tcaccaagga cggtctcctt tgttcccaga
     2041 ctaatggatg ttttagaagc aagaaatgaa agcaccacat tgggcctgga cagatgagct
     2101 gttgtaacca taacagcacc ttggaactgc actggcaggg cgagacagtg tctgatgttg
     2161 gacttgggtt cagagacaca ggctccatct cagccccttt atgcctctac tcctgccctg
     2221 gtccagcaga taccatagca ctctctgagc cttatgtcca gaccctttct tggcaggctg
     2281 gtacactgcc cttcccagag tggtccagag aagccccaaa attactgtgt aaggtccagg
     2341 gcccacagct ggaagctgtg ggaatccatg ccacacctgg atggctatgg cccactaaag
     2401 agaccccaat tcccacatgc ccaggaagga taaaagggct ggcctggaat caacacagga
     2461 caagcttcaa gtggctttgc acggggacct tcacctcttg gatctgcaga aggatggaag
     2521 ataagtgggg tccagcctcc ccagtccagg tggctttgct ggggacatgc atggttctgc
     2581 gtctcatata cagatgtata gactaaggtc tgacagcagc tggcttcagg ctgggacttc
     2641 tgagaagggg cactgagcca ggtcctcagc aagatgccag tgtctgagac tccacaggta
     2701 aggggaggcc aagcacccca gcatctagct ggccagcagc cctggactga ggcatatgtc
     2761 aatttgttaa ccagccgcca agcagccacc ctggcccagg ttctaggcgc ctggaaaagc
     2821 aggcaccctt catctctggg agctgtctcc aaacaagaca ggcccattca gcctccagcc
     2881 aacaagctgg ctgggcactt ggagacagtc ccaggatgcc atgcaccaac aaggtagaag
     2941 tagcaggaga gtcaagtgta gccttttgca aaagagcctt agctctgttg tctgggagag
     3001 agatggctgg acatgcagct gctctgtaag gatgaaattg ccacgggaca tgggaggctc
     3061 agtcacagcc caggctagcc tctgctccct ctgaactata aaacaatggg tgaaaagtca
     3121 gggtatctgt ggtcacccag agaaatgggg agggtgttca agtacttgaa ccccacaaaa
     3181 cactgctact agtaatgtga ttcctcaggc catcaagggc aggacctggg tgagtccgga
     3241 tcaaggctga caccaggaag atgtgatcac ccaagaggga agcccctcct cctaagaaat
     3301 gtctgcatgg gagcccctca cagccacctt gcccagtgag tgggtcaaag gctagcggtt
     3361 ggtcatgagg attttgactt agactcaagc caggcagccc agccccagga ctctaccctg
     3421 ggtttctaga ccttaagcca ttcttctgag ccttgatttc ctcatctcgg cggaccggga
     3481 ctgtcttgaa ggactcagcc tggagtacac agaagtggga cacctgaggc tgggtagagc
     3541 caatgccctc ttacatgatt cctcagaaat gtggtggcct cattataggg gtggtccagg
     3601 cagtcaccag aagtctctgc tgtagtctat agcatcttgt ctgtgtgctt ggtgtaatta
     3661 gggacataca tccatgcacc accagacaca cctgtgaccc tggctgggta tcctatgctc
     3721 tgggccaagt gaagatgaaa atagttctgg aggctgtcct gagcatcctg gctagagtct
     3781 catgagccca gtcgtgatgt ggaaacaagt cgtgtgcccc aaatatctgt cagaatgcca
     3841 cccaccctcc acacttcaat aaaagaacac cctcctcata tgtctcaata aagaataaag
     3901 gaagctgtgt atatcg
//
