LOCUS       NM_008746               2978 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus neurotrophic tyrosine kinase, receptor, type 3
            (Ntrk3), transcript variant 1, mRNA.
ACCESSION   NM_008746 XM_979968 XM_981510
VERSION     NM_008746.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2978)
  AUTHORS   Zhang,L., Nagel,M., Olson,W.P., Chesler,A.T. and O'Connor,D.H.
  TITLE     Trigeminal innervation and tactile responses in mouse tongue
  JOURNAL   Cell Rep 43 (9), 114665 (2024)
   PUBMED   39215998
REFERENCE   2  (bases 1 to 2978)
  AUTHORS   Baltar,J., Miranda,R.M., Cabral,M., Rebelo,S., Grahammer,F.,
            Huber,T.B., Reguenga,C. and Monteiro,F.A.
  TITLE     Neph1 is required for neurite branching and is negatively regulated
            by the PRRXL1 homeodomain factor in the developing spinal cord
            dorsal horn
  JOURNAL   Neural Dev 19 (1), 13 (2024)
   PUBMED   39049046
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2978)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2978)
  AUTHORS   Sharma,D., Feng,X., Wang,B., Yasin,B., Bekker,A., Hu,H. and
            Tao,Y.X.
  TITLE     NT-3 contributes to chemotherapy-induced neuropathic pain through
            TrkC-mediated CCL2 elevation in DRG neurons
  JOURNAL   EMBO Rep 25 (5), 2375-2390 (2024)
   PUBMED   38594391
  REMARK    GeneRIF: NT-3 contributes to chemotherapy-induced neuropathic pain
            through TrkC-mediated CCL2 elevation in DRG neurons.
REFERENCE   5  (bases 1 to 2978)
  AUTHORS   Jeon,S.M., Pradeep,A., Chang,D., McDonough,L., Chen,Y.,
            Latremoliere,A., Crawford,L.K. and Caterina,M.J.
  TITLE     Skin Reinnervation by Collateral Sprouting Following Spared Nerve
            Injury in Mice
  JOURNAL   J Neurosci 44 (15), e1494232024 (2024)
   PUBMED   38471780
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2978)
  AUTHORS   Schimmang,T., Minichiello,L., Vazquez,E., San Jose,I., Giraldez,F.,
            Klein,R. and Represa,J.
  TITLE     Developing inner ear sensory neurons require TrkB and TrkC
            receptors for innervation of their peripheral targets
  JOURNAL   Development 121 (10), 3381-3391 (1995)
   PUBMED   7588071
REFERENCE   7  (bases 1 to 2978)
  AUTHORS   Pernas-Alonso,R., Schaffner,A.E., Hansen,C.T., Barker,J.L. and di
            Porzio,U.
  TITLE     Acetylcholine esterase and peripherin mRNA level decrease in
            wobbler mouse
  JOURNAL   Neuroreport 6 (4), 597-600 (1995)
   PUBMED   7605908
REFERENCE   8  (bases 1 to 2978)
  AUTHORS   Tojo,H., Kaisho,Y., Nakata,M., Matsuoka,K., Kitagawa,M., Abe,T.,
            Takami,K., Yamamoto,M., Shino,A., Igarashi,K. et al.
  TITLE     Targeted disruption of the neurotrophin-3 gene with lacZ induces
            loss of trkC-positive neurons in sensory ganglia but not in spinal
            cords
  JOURNAL   Brain Res 669 (2), 163-175 (1995)
   PUBMED   7712171
REFERENCE   9  (bases 1 to 2978)
  AUTHORS   Chao,M.V.
  TITLE     Neurotrophin receptors: a window into neuronal differentiation
  JOURNAL   Neuron 9 (4), 583-593 (1992)
   PUBMED   1327010
  REMARK    Review article
REFERENCE   10 (bases 1 to 2978)
  AUTHORS   Barbacid,M., Lamballe,F., Pulido,D. and Klein,R.
  TITLE     The trk family of tyrosine protein kinase receptors
  JOURNAL   Biochim Biophys Acta 1072 (2-3), 115-127 (1991)
   PUBMED   1751544
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108420.8, AC121082.13, AC115868.12 and AK164887.1.
            
            On Nov 24, 2007 this sequence version replaced NM_008746.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY336094.1, SRR1660811.53247.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC108420.8         36642-36944
            304-378             AC108420.8         96987-97061
            379-450             AC108420.8         97680-97751
            451-519             AC121082.13        196474-196542       c
            520-677             AC121082.13        181395-181552       c
            678-820             AC121082.13        180196-180338       c
            821-962             AC121082.13        179655-179796       c
            963-1259            AC121082.13        178891-179187       c
            1260-1283           AC121082.13        171933-171956       c
            1284-1348           AC121082.13        170501-170565       c
            1349-1451           AC121082.13        169497-169599       c
            1452-1640           AC121082.13        74637-74825         c
            1641-1771           AC115868.12        27314-27444
            1772-1944           AC115868.12        36855-37027
            1945-2188           AC115868.12        40330-40573
            2189-2347           AC115868.12        88777-88935
            2348-2533           AC115868.12        94984-95169
            2534-2978           AK164887.1         256-700
FEATURES             Location/Qualifiers
     source          1..2978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 44.01 cM"
     gene            1..2978
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /note="neurotrophic tyrosine kinase, receptor, type 3"
                     /db_xref="GeneID:18213"
                     /db_xref="MGI:MGI:97385"
     exon            1..303
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2533
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; NT-3 growth factor receptor; trk-C; GP145-TrkC;
                     trkC tyrosine kinase; neurotrophin-3"
                     /codon_start=1
                     /product="NT-3 growth factor receptor isoform a precursor"
                     /protein_id="NP_032772.3"
                     /db_xref="CCDS:CCDS21371.1"
                     /db_xref="GeneID:18213"
                     /db_xref="MGI:MGI:97385"
                     /translation="MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEIN
                     CRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELY
                     TGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQN
                     FFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVN
                     LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSE
                     DNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLH
                     WLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTIN
                     GHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF
                     IMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRI
                     PVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK
                     MLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD
                     LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLAT
                     RNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW
                     SFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQ
                     QRLNIKEIYKILHALGKATPIYLDILG"
     exon            304..378
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            379..450
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            451..519
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            520..677
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            678..820
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            821..962
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1259
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1283
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1348
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1451
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1640
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1771
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1944
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2188
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2347
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2978
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2917..2922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /note="hexamer: AATGAA"
     polyA_site      2937
                     /gene="Ntrk3"
                     /gene_synonym="Ntrk3_tv3; TrkC"
                     /note="major polyA site"
ORIGIN      
        1 ccccaccccc ctctcctctc ctcctcctcc tcttttttag aagcagcgat cggagatgga
       61 tgtctctctt tgcccagcca agtgtagttt ctggcggatt ttcttgctgg gaagcgtctg
      121 gctggactat gtgggctccg tgctggcttg ccctgcaaat tgtgtctgca gcaagactga
      181 gatcaattgc cggcggccgg acgatgggaa cctcttccct ctcctggaag ggcaggattc
      241 agggaacagc aatgggaacg ccagcatcaa cattacggac atctcaagga atatcacttc
      301 catacacata gagaactggc gaggcctgca cacactcaat gctgtggaca tggagctcta
      361 cacgggactc cagaagctga ccatcaagaa ttctggactc cggaacatcc agcccagagc
      421 cttcgccaag aacccccact tgcgttatat aaacttgtca agtaaccggc tcaccacact
      481 ctcctggcag ctcttccaga cgctgagcct tcgggaattg agactggagc agaacttctt
      541 caactgcagc tgtgacatcc gctggatgca gctgtggcag gaacaggggg aggcgcggct
      601 ggacagccag agcctttact gcatcagtgc tgatggctcc caactccccc tcttccgcat
      661 gaacatcagt cagtgtgatc tcccagagat cagtgtgagc cacgtcaacc tgactgtccg
      721 agaaggagac aatgccgtga tcacttgcaa tggctctggc tctcctttgc ctgatgtgga
      781 ctggatagtc actgggctgc agtccatcaa cacccaccag accaatctga actggaccaa
      841 tgtacatgcc atcaacttga ccctggtgaa cgtgacgagc gaggacaatg gcttcaccct
      901 gacgtgcatt gcagagaacg tggtgggcat gagcaatgcc agtgttgctc tcactgtcta
      961 ctaccctcca cgtgtggtga gcctggtgga gcctgaggta cgcctggaac attgcattga
     1021 gtttgtggtg cgtggcaacc cgacacccac gctccactgg ctgtacaatg gacagccatt
     1081 gagggagtcc aagatcattc acatggacta ctaccaggag ggggaggtct cagagggctg
     1141 cctgctcttc aacaagccca cccactacaa caatggcaac tacaccctca ttgctaagaa
     1201 tgccctgggc acggccaacc agaccatcaa cggccacttc ctgaaggagc cctttccaga
     1261 gagcacagat ttctttgact ttgagtctga tgcgagccct acacctccta tcactgtgac
     1321 ccacaaacca gaggaagaca cttttggggt gtccatagca gtcggacttg ctgcctttgc
     1381 ctgcgtcctt ctggtggttc tctttatcat gatcaacaag tatggtcgcc ggtccaaatt
     1441 tggaatgaag ggtcctgtgg ctgttatcag tggagaggag gactcagcca gcccactgca
     1501 tcacatcaac catggcatca ctacaccatc atcgttggat gctgggcctg acacagtggt
     1561 cattggcatg acccgcatcc cagtcattga gaacccccag tacttccgtc agggtcacaa
     1621 ttgccacaag ccagacacat atgttcagca catcaagagg agagacatcg tgttgaagag
     1681 agaattgggt gagggagcct ttgggaaggt cttcctggct gagtgctaca atctaagccc
     1741 caccaaagac aagatgctag tggcagtgaa ggccctgaag gatcccacct tggctgccag
     1801 gaaggatttc cagagggagg ctgagctgct cacgaacctg cagcatgagc atattgtcaa
     1861 gttctatggg gtgtgtggtg atggtgaccc actcatcatg gtctttgaat acatgaagca
     1921 tggagacctt aacaagttcc tcagggccca tgggccagat gccatgatcc tcgtggatgg
     1981 acagccacgt caggccaagg gggagctagg gctctctcag atgctccaca tcgccagtca
     2041 gatagcctcg ggcatggtgt acctggcttc ccagcacttt gtacaccggg acctggccac
     2101 gaggaactgc ctggttggag ccaatctact agtgaagatt ggagattttg gcatgtccag
     2161 ggacgtctac agtactgatt actacagggt gggaggacac accatgctcc ccatccgctg
     2221 gatgccccct gaaagcataa tgtaccggaa gttcaccaca gagagtgatg tctggagctt
     2281 cggggttatt ctttgggaga tctttaccta tgggaagcaa ccatggttcc agctttccaa
     2341 cacggaggtc attgaatgca tcacccaagg ccgtgtcttg gagagaccca gagtctgccc
     2401 taaagaagtg tatgatgtca tgctggggtg ctggcagagg gaaccacagc agcggctgaa
     2461 tattaaggag atctacaaaa tcctccatgc tttggggaag gccaccccga tctacctgga
     2521 cattcttggc tagtggtgac tggtggccaa gcatttatac tctgttgcct cctctctccc
     2581 tgcttccttt cctctttttc ctcatctcaa ctcctttctt ccatttttga cggaaacgaa
     2641 catcttcata taaactcaag tgcctgctac acatacaaca ctgaatttaa acaaaacaaa
     2701 acaaaagaaa acaaaaaaaa ccaaacaaac aaaaagaaaa aacaaaagaa agaaaccctg
     2761 taaggcagtt tgacatatat atttatatat atatataact atctatctat ctatatctac
     2821 agagaattac cttctctaat acacagagaa gctgctgata cagaaaacag taagacatta
     2881 ataactgaga aaaaattaag tattattatt aacacaaatg aaattccctt gacttaagct
     2941 gtggcccgtg cttttttcag gtctggcttt tcggagat
//
