LOCUS       NM_001025074            8744 bp    mRNA    linear   ROD 06-DEC-2023
DEFINITION  Mus musculus neurotrophic tyrosine kinase, receptor, type 2
            (Ntrk2), transcript variant 1, mRNA.
ACCESSION   NM_001025074
VERSION     NM_001025074.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8744)
  AUTHORS   Honda A, Nozumi M, Ito Y, Natsume R, Kawasaki A, Nakatsu F, Abe M,
            Uchino H, Matsushita N, Ikeda K, Arita M, Sakimura K and Igarashi
            M.
  TITLE     Very-long-chain fatty acids are crucial to neuronal polarity by
            providing sphingolipids to lipid rafts
  JOURNAL   Cell Rep 42 (10), 113195 (2023)
   PUBMED   37816355
REFERENCE   2  (bases 1 to 8744)
  AUTHORS   Zhu ZA, Li YY, Xu J, Xue H, Feng X, Zhu YC and Xiong ZQ.
  TITLE     CDKL5 deficiency in adult glutamatergic neurons alters synaptic
            activity and causes spontaneous seizures via TrkB signaling
  JOURNAL   Cell Rep 42 (10), 113202 (2023)
   PUBMED   37777961
REFERENCE   3  (bases 1 to 8744)
  AUTHORS   Koutsioumpa C, Santiago C, Jacobs K, Lehnert BP, Barrera V,
            Hutchinson JN, Schmelyun D, Lehoczky JA, Paul DL and Ginty DD.
  TITLE     Skin-type-dependent development of murine mechanosensory neurons
  JOURNAL   Dev Cell 58 (20), 2032-2047 (2023)
   PUBMED   37607547
REFERENCE   4  (bases 1 to 8744)
  AUTHORS   Alitalo O, Gonzalez-Hernandez G, Rosenholm M, Kohtala P, Matsui N,
            Muller HK, Theilmann W, Klein A, Karkkainen O, Rozov S, Rantamaki T
            and Kohtala S.
  TITLE     Linking Hypothermia and Altered Metabolism with TrkB Activation
  JOURNAL   ACS Chem Neurosci 14 (17), 3212-3225 (2023)
   PUBMED   37551888
  REMARK    GeneRIF: Linking Hypothermia and Altered Metabolism with TrkB
            Activation.
REFERENCE   5  (bases 1 to 8744)
  AUTHORS   Tsai YY, Shen CL, D D, Tsai CY and Tarn WY.
  TITLE     Activation of TrkB signaling mitigates cerebellar anomalies caused
            by Rbm4-Bdnf deficiency
  JOURNAL   Commun Biol 6 (1), 910 (2023)
   PUBMED   37670183
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8744)
  AUTHORS   Chao MV.
  TITLE     Neurotrophin receptors: a window into neuronal differentiation
  JOURNAL   Neuron 9 (4), 583-593 (1992)
   PUBMED   1327010
  REMARK    Review article
REFERENCE   7  (bases 1 to 8744)
  AUTHORS   Barbacid M, Lamballe F, Pulido D and Klein R.
  TITLE     The trk family of tyrosine protein kinase receptors
  JOURNAL   Biochim Biophys Acta 1072 (2-3), 115-127 (1991)
   PUBMED   1751544
  REMARK    Review article
REFERENCE   8  (bases 1 to 8744)
  AUTHORS   Soppet D, Escandon E, Maragos J, Middlemas DS, Reid SW, Blair J,
            Burton LE, Stanton BR, Kaplan DR, Hunter T, Nikolics K and Parada
            LF.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
REFERENCE   9  (bases 1 to 8744)
  AUTHORS   Klein R, Martin-Zanca D, Barbacid M and Parada LF.
  TITLE     Expression of the tyrosine kinase receptor gene trkB is confined to
            the murine embryonic and adult nervous system
  JOURNAL   Development 109 (4), 845-850 (1990)
   PUBMED   2171894
REFERENCE   10 (bases 1 to 8744)
  AUTHORS   Klein R, Conway D, Parada LF and Barbacid M.
  TITLE     The trkB tyrosine protein kinase gene codes for a second neurogenic
            receptor that lacks the catalytic kinase domain
  JOURNAL   Cell 61 (4), 647-656 (1990)
   PUBMED   2160854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098737.1, AK147391.1 and AC154755.2.
            
            [WARNING] On Dec 8, 2023 this sequence was replaced by
            NM_001025074.3.
            
            On Sep 24, 2013 this sequence version replaced NM_001025074.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147391.1, SRR9219379.14795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               CJ098737.1         2-204
            204-5641            AK147391.1         2-5439
            5642-5642           AC154755.2         173476-173476
            5643-8744           AK147391.1         5440-8541
FEATURES             Location/Qualifiers
     source          1..8744
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 31.2 cM"
     gene            1..8744
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /note="neurotrophic tyrosine kinase, receptor, type 2"
                     /db_xref="GeneID:18212"
                     /db_xref="MGI:MGI:97384"
     exon            1..317
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            318..873
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     CDS             662..3127
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; BDNF/NT-3 growth factors receptor; trkB
                     tyrosine kinase; neurotrophic tyrosine receptor kinase
                     type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform a
                     precursor"
                     /protein_id="NP_001020245.1"
                     /db_xref="CCDS:CCDS26573.1"
                     /db_xref="GeneID:18212"
                     /db_xref="MGI:MGI:97384"
                     /translation="MSPWLKWHGPAMARLWGLCLLVLGFWRASLACPTSCKCSSARIW
                     CTEPSPGIVAFPRLEPNSVDPENITEILIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAYKAFLKNSNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLK
                     TLQETKSSPDTQDLYCLNESSKNMPLANLQIPNCGLPSARLAAPNLTVEEGKSVTLSC
                     SVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNY
                     PEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLVML
                     LLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIP
                     VIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI
                     LVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDL
                     NKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCL
                     VGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGV
                     VLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKN
                     IKSIHTLLQNLAKASPVYLDILG"
     exon            874..948
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1020
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1089
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1244
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1381
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1514
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1820
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1856
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1954
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2054
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2243
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2374
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2547
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2782
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2941
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..8744
                     /gene="Ntrk2"
                     /gene_synonym="GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctggaggg tgctatgcta tgcgtgtgtg cgtgtgtgtg cgcgcgcgcg tgtgtgagcg
       61 tgtgtgtttt tggatttcat actaattttc tggagtttct gcccctgctc tgcgtcagcc
      121 ctcacgtcac ttcgccagca gtagcagagg cggcggcggc ggcggccgcc ggttagagcc
      181 cagtcgctgc ttcagctgct gttgctgctt ctgcagcgct ctgctccctg cgcttgctac
      241 gggaggccgg ggaagccgcg cggacagtcc tcggtggcct gggccggcac tgtcctgcta
      301 ccgcagttgc tccccagccc tgaggtgcgc accgatatcg atattcgtgc cggtttagcg
      361 gttctgcgac ccaaagagtc cagggagatc caccgagtgg tgcctggcgt ataggactat
      421 gcagccgcct tgtggctcgg agcagcggcc cgcgatgtcc cagccactgt gaaccatttg
      481 gtcagcgcca acctgctcag ccccagcacc gacaggctca gcctctggta cgctccactc
      541 cgcgggaggc caccagcacc aagcagcaag agggcgcagg gaaggcctcc cccctccggc
      601 gggggacgcc tggctcagcg tagggacacg cactccgact gactggcact ggcagctcgg
      661 gatgtcgccc tggctgaagt ggcatggacc cgccatggcg cggctctggg gcttatgcct
      721 gctggtcttg ggcttctgga gggcctctct cgcctgcccg acgtcctgca aatgcagttc
      781 cgctaggatt tggtgtactg agccttctcc aggcatcgtg gcattcccga ggttggaacc
      841 taacagcgtt gacccggaga acatcacgga aattctcatt gcaaaccaga aaaggctaga
      901 aatcatcaat gaagatgacg ttgaagctta cgtggggctg agaaacctta caattgtgga
      961 ttccggctta aagtttgtgg cttacaaagc gtttctgaaa aacagcaacc tgcggcacat
     1021 aaatttcaca cgaaacaagc tgacgagttt gtccaggaga catttccgcc accttgactt
     1081 gtctgacctg atcctgacgg gtaatccgtt cacgtgctcc tgcgacatca tgtggctcaa
     1141 gactctccag gagactaaat ccagccccga cactcaggat ttgtactgcc tcaatgagag
     1201 cagcaagaac atgcccctgg cgaacctgca gatacccaat tgtggtctgc catctgcacg
     1261 tctggctgct cctaacctca ccgtggagga aggaaagtct gtgacccttt cctgcagtgt
     1321 ggggggtgac ccactcccca ccttgtactg ggacgttggg aatttggttt ccaagcacat
     1381 gaatgaaaca agccacacac agggctcctt aaggataacg aacatttcat ctgatgacag
     1441 tggaaagcaa atctcttgtg tggcagaaaa ccttgtagga gaagatcaag attctgtgaa
     1501 cctcactgtg cattttgcgc caactatcac gtttctcgag tctccaacct cagatcacca
     1561 ctggtgcatt ccattcactg tgagaggcaa ccccaagcct gcgcttcagt ggttctacaa
     1621 tggggccata ctgaatgagt ccaagtacat ctgtactaag atccacgtca ccaatcacac
     1681 ggagtaccat ggctgcctcc agctggataa ccccactcat atgaataacg gagactacac
     1741 cctgatggcc aagaacgagt atgggaagga tgagagacag atctccgctc acttcatggg
     1801 ccggcctgga gtcgactacg agacaaaccc aaattaccct gaagtcctct atgaagactg
     1861 gaccacgcca actgacattg gggatactac gaacaaaagt aatgaaatcc cctccacgga
     1921 tgttgctgac caaagcaatc gggagcatct ctcggtctat gccgtggtgg tgattgcatc
     1981 tgtggtggga ttctgcctgc tggtgatgtt gctcctgctc aagttggcga gacattccaa
     2041 gtttggcatg aaaggcccag cttcggtcat cagcaacgac gatgactctg ccagccccct
     2101 ccaccacatc tccaatggga gtaacactcc atcttcttcg gagggcggtc ccgacgctgt
     2161 cattattgga atgaccaaga ttcctgttat tgaaaacccc cagtactttg gcatcaccaa
     2221 cagtcagctc aagccagaca catttgttca gcatatcaag agacacaaca tcgttctgaa
     2281 gagggaactt ggggaaggag ccttcgggaa agttttcctt gccgagtgct acaacctctg
     2341 cccagagcag gataagatcc tggtggctgt gaagacgctg aaggacgcca gcgacaatgc
     2401 acgcaaggac tttcatcggg aagctgagct gctgaccaac ctccagcacg agcacattgt
     2461 caagttctac ggtgtctgtg tggagggcga cccactcatc atggtctttg agtacatgaa
     2521 gcacggggac ctcaacaagt tccttagggc acacgggccc gacgcagtgc tgatggcaga
     2581 gggtaacccg cccacagagc tgacgcagtc gcagatgctg cacatcgctc agcaaatcgc
     2641 agcaggtatg gtctacctgg cgtcccaaca ctttgtgcac cgtgacctgg ccacccggaa
     2701 ctgcctggtg ggagagaacc tgctggtgaa aattggggac tttgggatgt cccgagatgt
     2761 gtacagcacc gactactatc gggtcggtgg ccacacaatg ttgcccatcc gatggatgcc
     2821 tccagagagc atcatgtaca ggaaattcac caccgagagc gacgtctgga gcctgggcgt
     2881 tgtgttgtgg gagatcttca cctacggcaa gcagccctgg tatcagctat cgaacaatga
     2941 ggtgatagag tgcatcaccc agggaagagt ccttcagcgg cctcgaacgt gtccccagga
     3001 ggtgtatgag ctcatgcttg gatgctggca gcgggaacca cacacccgga agaacatcaa
     3061 gagcatccac accctccttc agaacttggc caaggcatct cccgtctacc tggatatcct
     3121 aggctagggt cctccttctg cccagaccgt ccttcccaag gccctcctca gactggccta
     3181 cacgacgaac ctcttgactg ccgctgacgt catgaccttg ctgtccttcg ctctgacagt
     3241 gttgacagga ccaggagcgg ctctttgggg gaggcagtgt gtgcttctcc atccacagac
     3301 agtattaact cgcttctggc attgtctctt tctctccctt gggtttgttt ctttcttttg
     3361 ccccttcccc ttttatcatt atttattcat ttatttattt tctggtcttc accgcttcac
     3421 ggccctcagt ctctccttga ccaatctggc ttctgcattc ctattaactg tacatagaca
     3481 aaggccttaa caaacctaat ttgttatatc agcagacact ccagtttgcc caccacaact
     3541 aacaatgcct tgttgtattc ctgcctttga cgtggatgaa aaaaagggaa aaaaaaatca
     3601 aacatctgac ttaagctgtc acttccgatg tacagacgtg gggcgtttct atggattcac
     3661 ttctatttat tatttattaa tttatttatt tatcactctt cttattgttt tctggtggtt
     3721 ttaacctatg tgtgagaagg aaaagttgtg tacaatctgg gaaaacttta tcagtgggaa
     3781 atgaaaacga gagcgagcaa gcgagcaaga gagggagaga gagagagaag cgttaccata
     3841 aaccacggca tgagcgagac agagacaagc catgggatca gtcgggagtc cgttgtgctt
     3901 aggaaaaccc agcagccatt agctggggga gcatgttcgg ctctgtcccc caagcacctt
     3961 tctgaggagg acacaggatg ttgaactctg cttcacgggc agagcttcta atgacagata
     4021 ctggcttgca ctggaaagac agttcccacg ggacctggac ggacaacaca tcctacattc
     4081 agacattgtg gtcgggcacg gtgacagagt tgatccgttt ctcaagtgtt atctaccaag
     4141 cttttgtgaa gttccatcga aggaggtaga ttcttgctca gatataattt caggaaaacc
     4201 cgagtccttg acaaagacag gagacgctct caatttggag gcaagtttct cttaccttga
     4261 actttttcag acagcaactc cgcccagccc ccatcttcca ctctcacctg tcttgtaact
     4321 gtgcaaacaa aagtgtgcat ggtctttgtc aattgatacc tatgtgcacg tgtgcagaaa
     4381 ctgttgttcc agctggggtg tctgattagg agggcagatc cataaaaggt ctaacctagg
     4441 caacttcggg aaaggagacc agatcagtag ctggaggcac tctccagtag gcggtgaggg
     4501 gtttactgag taggcatgct gaagcccgga tattcaccca tctcaaaccc cccgggctgc
     4561 aggacaggca caggccatcc ctgaggagaa ggggagccct tttgggatac cacctgaggt
     4621 tatgttcagt gtgctctggt caagtccctt gctcggggct ctgtttgggg agagtggttt
     4681 cattccaagg tactcattat tagtatgctg ttttgttaac tatactccat taaaaagtta
     4741 aaaaaaaaaa gaattaagcc ttgacactgt atggctgaca ggaggctgtg cccagactga
     4801 gcctggagat ttgcgcccgc acatggtcat tggttttccg aaaagagagg gtaaatttat
     4861 atagaaattt acaggtattt gggtagtcat ttagaccgag ggagaccagt gtttccattt
     4921 ctctgcgccc cctctgtgag gggaagttcg atacacttga cacctttata aacggagcca
     4981 gataggaagg gagtgactta attcacctta gaacatttca tttggtgttt atttctgaag
     5041 gtgcaagagc tctgtgtagg tttcatttgt gcccgagcat ttctggagca ctgtgttttc
     5101 tagcagaaac tccgagagcc agttctcaca atgaaacttt aaaacctgtg taaattgaca
     5161 gagagcagaa ggcgatccaa gaggcccact caagtgagtg gtggcacgag gcacatgcgg
     5221 tggccctttc tgttgtgctg gcccatgaga gatgggagct attttgtcct cttcgtccat
     5281 taaaacaaac ccctccagaa tacctatagt aatataatga aagccatatc tctgtgatct
     5341 ataccgtcag gtatagatca ttaaaggacc catggtactg tcaggcactg tggaaccgtg
     5401 aggcagcgga aaggcaaggg cacatttgta catgttcctc tagcttccgc cagccgtgac
     5461 ctatgaactc acataggccg gttgctccta gtctgacggg ctgccctggg aggaaaagct
     5521 gcaagatgct cagcagagag caaaggagag gatagtcttg gaaaaggcca aggttgggga
     5581 tgccatacag gattacacca aagggctgta ctgagaatgt gggagcattc cattccaggt
     5641 ttgtattttc ctcagcaaga aaaaagagca gatagaaggg cagaggagga tagagaggaa
     5701 gagaaaggag agggagaaga gagcagagaa gagagagaga gagagagaga gagagaatct
     5761 ttatactttt tggcaagtcc tcgaaggtct caaaatgaaa gtgtctatgc aagtgcaaat
     5821 ttttacagtt atttatacta attattatta ttgttattaa ttattattat tactagtctg
     5881 ttgtctcaag aatatgtgca gatttcagag cattaaagag tatttggttt cttttaaagt
     5941 agttgggtga gccaaggaca ccttaaaata attgtcactg ttcatctgct atcgcctttc
     6001 tcatggtatt ttaagtttta gaaaagaaac attcttgttc taaaacatat ccctctccat
     6061 agatgacaaa aaaaaatggt gttagcaaac cgaaacctcc cccgattcct gtctgacatc
     6121 cgatccattt ctcaactgct tgatgatttc cgagcgcttt ttgcatatgt tgtcaaaata
     6181 ttcatattat tttggtgagg gaatggagac tcagaaactc agaggacaaa cataagcttc
     6241 accgaagtct gtctgccaga tacaaactaa catacaaaca agacagccgg gaaggaaatg
     6301 tgctggtagc gtgtctgtgg agcagggtgg gggttagaac agaaggagac ctgggcagtg
     6361 cacgcagaag agatgttaca tcatgtgctt ctgctcctgg cttctgctga ctcccaactt
     6421 tgcgctcagc ctcatttaga aaacgcttca aacactgctc ttcagggttc tgtcagaact
     6481 cacacacacg tgctcacacc agccccgctt gtgacgtttt tatgtacttc tatataaata
     6541 tatacataat atatgttata aacacttgat ttatacatat acaaatgcac acatgtagtg
     6601 tgtttgtgtg tttatgtata aacatatagg ctcatggtaa tagaataatt ataagtaggg
     6661 tgcaatatga ataatttgct taatatttgc taagtaacca aaactttcca acgtcatgtg
     6721 gcagttcata tttccactct cagtgtgggt aaggatgggc tacaccacac tttcagctct
     6781 gtgcagccct tggatggaag atgtgttgaa aaaaaaatca catcttccct gaaacaactg
     6841 actgaaagcc atcctctaca ttgaatctgt tctctggctc tttgcaaagg agaaatgcag
     6901 acaaatggtc tccttgtgtc ccagtcctgg gaaggagaag tgggttttct cttcttgcac
     6961 atttgggccg tgctcacctt tcctggctct atgcccttta cactgggctc agagatgaag
     7021 cagtctagac ccaagctgca gggctgtagg gaggcaaatg tcttcgaggc tgatagcaaa
     7081 gcatccaaaa atctatagca agatgcgcag cttgaagtca ctcctcatcc acacggcaag
     7141 caagagccag ggcatgcagt gctgtccatc tctaggactg ggcagtgggg tccccggtca
     7201 agggcagtct ttccctaagc ctctcctttt gcaaatggca ctgccagcag tacctggcat
     7261 taagtcacga aaaatttcta aaatggcagc acagacccgt gtgccctcat tgctctgccc
     7321 ccacatgcct catcattaga gggctccagt tttcaaactt gactttccat ttggccctgt
     7381 atcgtggtta aaggaaatct caacagaggg atggccaatt gacctaaatc cccagatgtc
     7441 caagtttgca gtgaaagcca gttcttccca aatgtataac tggaatgtag ggactcaggt
     7501 tgtgatactt catacaggaa tctcagatgt tattgtaaag aactgggttg ggagggattc
     7561 atcactaagc caacaataat gcaggagggc gtggctgatc gttaagccaa tagtagtgca
     7621 ggagggcgtg gctgctgtga gggctggaat ccatctctgc tgctaaagtt cagggttctc
     7681 aactcttttc agctgttgca gcccttcact tctttccctt cggcgttatt tatttgtgta
     7741 tttatttatt tatttattta tttatctatc tatctatcaa cttttggtcc attcatcacc
     7801 aacataaagc aaaaacaatt ttttacatat atgtaaatgt gttgcaagtg aaacactgtg
     7861 aatctcacaa ccacctccta gcaactatgc tgccatcttg acgtgcgtct caggagtcga
     7921 gacgggaaaa gacgaggacg tcattttgca gcctacgcat tctgggccag gtccgtgttc
     7981 gttttatttc tttagtctgt gagttaagaa aacaatccga gtggagggtg acggatgttc
     8041 ggcaagttcg gtgaagcagc acgagctctt tgcagctata ggttcgagca agaagaaaaa
     8101 ccatgggaga tggagaaggg aaatttgatg gaggggtggg gtggggtggg ggctctgtct
     8161 tacagctcgt gtagcttact gttgcttaaa aatgtataca acagctggaa atgttttcaa
     8221 cacaaggtat ttgaaataaa tgtgaatctt aaatatgtac tcccttaagg aatgaacata
     8281 ttatggtgaa atattgctcc cccgcgtccc ctacaaatct gcctagagat gtggatacct
     8341 acatttgctt aagcatcaga ccagtgtttg tatatacccg ggccatacac actcatctcg
     8401 acgtctctct gcggatgtat ttccccttca ctggtgacct ggtatttaga actccgtctt
     8461 ttcagttggt ttatttccct ttaatgtgat gtctctgtgc cgattattac cggttcttac
     8521 ttgtttttgc aatccgtttt gaggtccagt gttttactga gactcattgc atcttggctg
     8581 atttcaaagt gacacccgaa tacagtgttt aaaaaaaaag tttgtttgta aatcatgtga
     8641 ccagcttctc tcaccctgac atggaatgtc tcttgtacta cagtgtattt aataataaaa
     8701 gaaaaaaatg atgtcttaca ataaataaca tcttccacaa gagg
//
