LOCUS       NM_133500               1747 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus netrin G2 (Ntng2), transcript variant a, mRNA.
ACCESSION   NM_133500
VERSION     NM_133500.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Yaguchi,K., Nishimura-Akiyoshi,S., Kuroki,S., Onodera,T. and
            Itohara,S.
  TITLE     Identification of transcriptional regulatory elements for Ntng1 and
            Ntng2 genes in mice
  JOURNAL   Mol Brain 7, 19 (2014)
   PUBMED   24642214
  REMARK    GeneRIF: The complementary expression patterns of Ntng1 and Ntng2
            are determined by transcriptional cis-regulatory elements widely
            scattered in these loci.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Zhang,W., Rajan,I., Savelieva,K.V., Wang,C.Y., Vogel,P., Kelly,M.,
            Xu,N., Hasson,B., Jarman,W. and Lanthorn,T.H.
  TITLE     Netrin-G2 and netrin-G2 ligand are both required for normal
            auditory responsiveness
  JOURNAL   Genes Brain Behav 7 (4), 385-392 (2008)
   PUBMED   17973922
  REMARK    GeneRIF: Mice in which netrin-G2 has been genetically inhibited do
            not startle to an acoustic stimulus, but otherwise perform normally
            through a behavioral test battery. There were no inner ear
            structural abnormalities.
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Nishimura-Akiyoshi,S., Niimi,K., Nakashiba,T. and Itohara,S.
  TITLE     Axonal netrin-Gs transneuronally determine lamina-specific
            subdendritic segments
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14801-14806 (2007)
   PUBMED   17785411
  REMARK    GeneRIF: Axonal Ntng2 transneuronally determines lamina-specific
            subdendritic segments.
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Kim,S., Burette,A., Chung,H.S., Kwon,S.K., Woo,J., Lee,H.W.,
            Kim,K., Kim,H., Weinberg,R.J. and Kim,E.
  TITLE     NGL family PSD-95-interacting adhesion molecules regulate
            excitatory synapse formation
  JOURNAL   Nat Neurosci 9 (10), 1294-1301 (2006)
   PUBMED   16980967
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Yin,Y., Miner,J.H. and Sanes,J.R.
  TITLE     Laminets: laminin- and netrin-related genes expressed in distinct
            neuronal subsets
  JOURNAL   Mol Cell Neurosci 19 (3), 344-358 (2002)
   PUBMED   11906208
  REMARK    GeneRIF: selectively expressed in distinct neuronal subsets that
            include populations in forebrain, midbrain, hindbrain, spinal cord,
            and spinal ganglia
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Nakashiba,T., Nishimura,S., Ikeda,T. and Itohara,S.
  TITLE     Complementary expression and neurite outgrowth activity of netrin-G
            subfamily members
  JOURNAL   Mech Dev 111 (1-2), 47-60 (2002)
   PUBMED   11804778
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC141258.1, AB052336.1,
            BM934422.1 and AL772379.11.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_133500.3.
            
            On Apr 3, 2015 this sequence version replaced NM_133500.1.
            
            Summary: The protein encoded by this gene belongs to a subclass of
            the netrin family called netrin-G proteins. Unlike classic netrins,
            which act as diffusible chemoattractants, netrin-Gs are
            glycosylphosphatidylinositol-anchored membrane proteins that
            interact with specific transmembrane proteins. In mouse, this gene
            is preferentially expressed in the cerebral cortex, habenular
            nucleus and superior colliculus. Knockout mutant mice display a
            lack of behavioral startle in response to acoustic stimuli.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (a) lacks two in-frame exons in
            the 3' coding region compared to variant b. It encodes isoform a,
            which is shorter than isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141258.1, AB052336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BC141258.1         1-59
            60-1652             AB052336.1         1-1593
            1653-1702           BM934422.1         1-50                c
            1703-1747           AL772379.11        44568-44612         c
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.57 cM"
     gene            1..1747
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /note="netrin G2"
                     /db_xref="GeneID:171171"
                     /db_xref="MGI:MGI:2159341"
     exon            1..272
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1652
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /note="isoform a precursor is encoded by transcript
                     variant a; laminet 2"
                     /codon_start=1
                     /product="netrin-G2 isoform a precursor"
                     /protein_id="NP_598007.1"
                     /db_xref="CCDS:CCDS15851.1"
                     /db_xref="GeneID:171171"
                     /db_xref="MGI:MGI:2159341"
                     /translation="MLRLLALFLHCLPLVSGDYDICKSWVTTDEGPTWEFYACQPKVM
                     RLKDYVKVKVEPSGITCGDPPERFCSHENPYLCSNECDASNPDLAHPPRLMFDREDEG
                     LATYWQSVTWSRYPSPLEANITLSWNKSVELTDDVVVTFEYGRPTVMVLEKSLDNGRT
                     WQPYQFYAEDCMEAFGMSARRARDMSPSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDR
                     FAIFAGPDLRNMDNLYTRMESAKGLKEFFTFTDLRMRLLRPALGGTYVQRENLYKYFY
                     AISNIEVIGRCKCNLHANLCTVREGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGSYL
                     PLPHGSPNACAAAGSAFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLG
                     YYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGAVGPKCDDCLPTHYWRQ
                     GCYPNVCDDDQLLCQNGGTCQQNQRCACPPGYTGIRCEQPRCDLADDAGPDCDRAPGI
                     VPRPDTLLGCLLLLGLAARLAC"
     exon            273..916
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1089
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1116
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1284
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1419
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1747
                     /gene="Ntng2"
                     /gene_synonym="2610016D08Rik; Lmnt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccccacca ccacttctcc agtgccgctc tgggccccac ccattcggac tgcgcagcca
       61 tgctgcgcct gctggctctc ttcctgcact gcctcccgct ggtctctggg gactatgaca
      121 tctgcaaatc ctgggtgacc acagatgagg gccccacctg ggaattctat gcctgccagc
      181 ccaaggtgat gcgcctgaag gattatgtca aggtcaaagt ggagccctca ggcatcacgt
      241 gcggagaccc ccctgaaagg ttctgttccc atgagaaccc ctacctgtgc agtaatgagt
      301 gtgatgcctc caatcccgac ctggcccacc cgccccggct tatgtttgac agggaagatg
      361 agggactggc tacctactgg caaagcgtca cgtggagtcg ctaccccagt ccactagagg
      421 ccaacatcac cctctcatgg aacaagagcg tggagttgac agacgacgtg gtggtgactt
      481 ttgagtatgg ccggcccacg gtcatggtcc tcgagaagtc cctggacaat ggccgcacct
      541 ggcagcccta ccagttctat gcagaggact gcatggaggc cttcggcatg tctgcccgac
      601 gtgcccgaga catgtcaccc tccagcgccc accgggtgct ctgcaccgag gagtactcac
      661 gctgggcagg gtccaagaaa gagaagcatg tgcgctttga ggtaagggac cgctttgcca
      721 tctttgccgg ccctgacctg cgtaacatgg acaacctgta cacgaggatg gagagcgcca
      781 agggcctcaa ggagttcttc accttcactg acctgcgcat gcgcctgctg cgtcctgcgc
      841 tgggtggcac ctacgtgcag cgagagaacc tctacaagta cttctatgcc atctccaata
      901 tcgaagtcat tggcaggtgt aagtgcaacc tgcatgccaa cctgtgcaca gtgcgagagg
      961 gcagcctgca gtgtgagtgt gaacacaaca ccacgggccc cgactgtggc aggtgcaaga
     1021 agaacttccg cacacgcgcc tggcgagctg gctcctacct gccgctgccc cacggctctc
     1081 ccaatgcctg tgcggccgcg ggctccgcct ttggcaactg cgagtgctac ggccactcca
     1141 accgttgcag ctacattgac ttcctgaacg tggtgacctg cgtcagctgt aaacacaaca
     1201 ctcgaggcca acactgtcag cactgccgcc tgggctacta tcgcaatggc tccgcagagc
     1261 tggatgatga gaacgtctgc attgaatgta actgtaacca gatcggctct gtgcacgatc
     1321 gatgcaatga gacaggcttc tgcgagtgca gggagggcgc agtggggccc aagtgcgacg
     1381 actgccttcc tacacactac tggcgccaag gatgctatcc caatgtgtgc gacgatgacc
     1441 agctgctctg ccagaatggc ggcacctgcc agcagaacca acgctgcgcc tgcccgcccg
     1501 gctacaccgg cattcgctgt gagcagcccc gctgtgacct cgccgacgac gctggcccgg
     1561 actgtgaccg cgcgccaggc atcgtcccgc gccccgacac cctgctcgga tgcctgctgc
     1621 tgctcgggct ggccgcccgt ctggcctgct gagcccgttc taagggtcca ggggtccctg
     1681 gcccggcggc gacacgggtg cggccgagct gctcccaggt gctactcgca gagtcctccc
     1741 gccctcc
//
