LOCUS       NM_030699               5347 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus netrin G1 (Ntng1), transcript variant a, mRNA.
ACCESSION   NM_030699 XM_903203
VERSION     NM_030699.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5347)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 5347)
  AUTHORS   Sinclair-Wilson,A., Lawrence,A., Ferezou,I., Cartonnet,H.,
            Mailhes,C., Garel,S. and Lokmane,L.
  TITLE     Plasticity of thalamocortical axons is regulated by serotonin
            levels modulated by preterm birth
  JOURNAL   Proc Natl Acad Sci U S A 120 (33), e2301644120 (2023)
   PUBMED   37549297
REFERENCE   3  (bases 1 to 5347)
  AUTHORS   Lu,J., Chen,B., Levy,M., Xu,P., Han,B.X., Takatoh,J.,
            Thompson,P.M., He,Z., Prevosto,V. and Wang,F.
  TITLE     Somatosensory cortical signature of facial nociception and
            vibrotactile touch-induced analgesia
  JOURNAL   Sci Adv 8 (46), eabn6530 (2022)
   PUBMED   36383651
REFERENCE   4  (bases 1 to 5347)
  AUTHORS   Meltzer,S., Boulanger,K.C., Osei-Asante,E., Handler,A., Zhang,Q.,
            Sano,C., Itohara,S. and Ginty,D.D.
  TITLE     A role for axon-glial interactions and Netrin-G1 signaling in the
            formation of low-threshold mechanoreceptor end organs
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2210421119 (2022)
   PUBMED   36252008
  REMARK    GeneRIF: A role for axon-glial interactions and Netrin-G1 signaling
            in the formation of low-threshold mechanoreceptor end organs.
REFERENCE   5  (bases 1 to 5347)
  AUTHORS   Filova,I., Pysanenko,K., Tavakoli,M., Vochyanova,S., Dvorakova,M.,
            Bohuslavova,R., Smolik,O., Fabriciova,V., Hrabalova,P.,
            Benesova,S., Valihrach,L., Cerny,J., Yamoah,E.N., Syka,J.,
            Fritzsch,B. and Pavlinkova,G.
  TITLE     ISL1 is necessary for auditory neuron development and contributes
            toward tonotopic organization
  JOURNAL   Proc Natl Acad Sci U S A 119 (37), e2207433119 (2022)
   PUBMED   36074819
REFERENCE   6  (bases 1 to 5347)
  AUTHORS   Inaki,K., Nishimura,S., Nakashiba,T., Itohara,S. and Yoshihara,Y.
  TITLE     Laminar organization of the developing lateral olfactory tract
            revealed by differential expression of cell recognition molecules
  JOURNAL   J Comp Neurol 479 (3), 243-256 (2004)
   PUBMED   15457507
REFERENCE   7  (bases 1 to 5347)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 5347)
  AUTHORS   Yin,Y., Miner,J.H. and Sanes,J.R.
  TITLE     Laminets: laminin- and netrin-related genes expressed in distinct
            neuronal subsets
  JOURNAL   Mol Cell Neurosci 19 (3), 344-358 (2002)
   PUBMED   11906208
  REMARK    GeneRIF: selectively expressed in distinct neuronal subsets that
            include populations in forebrain, midbrain, hindbrain, spinal cord,
            and spinal ganglia
REFERENCE   9  (bases 1 to 5347)
  AUTHORS   Nakashiba,T., Nishimura,S., Ikeda,T. and Itohara,S.
  TITLE     Complementary expression and neurite outgrowth activity of netrin-G
            subfamily members
  JOURNAL   Mech Dev 111 (1-2), 47-60 (2002)
   PUBMED   11804778
REFERENCE   10 (bases 1 to 5347)
  AUTHORS   Nakashiba,T., Ikeda,T., Nishimura,S., Tashiro,K., Honjo,T.,
            Culotti,J.G. and Itohara,S.
  TITLE     Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian
            netrin that is functionally divergent from classical netrins
  JOURNAL   J Neurosci 20 (17), 6540-6550 (2000)
   PUBMED   10964959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB621591.1, AB038667.1 and AK034465.1.
            
            On Jul 17, 2009 this sequence version replaced NM_030699.1.
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038667.1, SRR1660817.91398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-564               BB621591.1         1-564
            565-778             AB038667.1         332-545
            779-4288            AB038667.1         556-4065
            4289-5347           AK034465.1         3586-4644
FEATURES             Location/Qualifiers
     source          1..5347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 48.47 cM"
     gene            1..5347
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /note="netrin G1"
                     /db_xref="GeneID:80883"
                     /db_xref="MGI:MGI:1934028"
     exon            1..573
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1341
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1096..2715
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /note="isoform a precursor is encoded by transcript
                     variant a; laminet-1"
                     /codon_start=1
                     /product="netrin-G1 isoform a precursor"
                     /protein_id="NP_109624.1"
                     /db_xref="CCDS:CCDS38604.1"
                     /db_xref="GeneID:80883"
                     /db_xref="MGI:MGI:1934028"
                     /translation="MYLSRFLSIHALWVTVSSVMQPYLFVWGHYDVCKSLIYTEEGKV
                     WDYTACQPESTDMTKYLKVKLDPPDITCGDPPESFCAMGNPYMCNNECDASTPELAHP
                     PELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQM
                     ILEKSLDYGRTWQPYQYYATDCLHAFHMDPKSVKDLSQHTVLEIICTEEYSTGYSTNS
                     KIIHFEIKDRFAFFAGPRLRNMASLYGQLDTTKKLRDFFTVTDLRIRLLRPAVGEIFV
                     DELHLARYFYAISDIKVRGRCKCNLHATSCLYDNSKLTCECEHNTTGPDCGKCKKNYQ
                     GRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTR
                     GQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCD
                     ECLPGNSWYYGCQPNVCDNELLHCQNGGTCQNNVRCACPDAYTGILCEKLRCEEAGSC
                     GSESGQGAPPRGSPALLLLTMLLGTAGPLVF"
     exon            1342..1982
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2155
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2182
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2350
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2485
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..5347
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4264..4269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /note="hexamer: AATAAA"
     polyA_site      4288
                     /gene="Ntng1"
                     /gene_synonym="A930010C08Rik; Lmnt1"
                     /note="major polyA site"
ORIGIN      
        1 gaaattgctt cgagaggatc ttcttggcgc caaggctaat tgtcctgatt tatgtcgctt
       61 ctgacaaaaa agaaaaaaaa aaagacctaa cgtcttcatc tgaaataaaa tgaaagcggt
      121 gccaagcggg atagagccgc ctggctgctg gttctgatcc cctgggatcc agggggggaa
      181 aatcgttctg cagcttaaaa gaaaagaaag gaatagaaac agagaagaga gagagagaga
      241 gagagaaaaa aaacccacag taaaagttta aggcgagaag tggtggcggc ggcggcggcg
      301 gcgcggggaa gctgcgagcg gagaaggttg ccgagacctc ggaaggcggc gatttggttc
      361 ctaatcccac tgtatttttg gagggagagg cacctttctc atcctccctt cctctccgcc
      421 cacccctctc cctccccctc atctacctgt caaagtcact gatcttttgc attttggaag
      481 aggacgtcaa cgggaaggaa ttccccctgt cagggtcccg gctccgagag ggggcgacgc
      541 gcgacaaggc tgccccaggg gcaagagacc aaggttgctg gtgccagaag agggaagaga
      601 aaagattgaa gggaaacaga tacaggacga tagacaccat ccctttgctt ctgatgctga
      661 tacttcagct catctgagga gccctgatga acccagaaca gcaaggatca ctcaggatta
      721 ttggatgtac aacgggagag ccgtcacttt gctaaattat tatctgctcc tggacatctt
      781 tcacaaaagt caaatagata tgttctacga ggagaaatgg ctgcaagctg ttaatgccta
      841 acagataagc atgttaggct tctaccaaag tcctcagcat acctgaccgc atagaatatt
      901 tcaatctgtc acatttggtt ttggaatctg ctttgagatc tcagcctatt tttttataca
      961 tatacagacc tacctacata aagatacata tagacacgtg cacacacaca cacacacaca
     1021 catataagat actcatgtat atttaaaaga gacactgatt gcatagaaga cacgaagatt
     1081 gccaagattt tagagatgta tttgtcaaga ttcctgtcga tccatgccct gtgggtgaca
     1141 gtgtcctctg tgatgcagcc ctaccttttc gtgtggggac attatgatgt atgtaagagc
     1201 ctgatttaca cagaagaagg caaagtttgg gattacacag cctgccagcc ggaatccacg
     1261 gacatgacca agtatctgaa agtgaaactg gaccctccgg atattacctg tggagaccct
     1321 ccagagtcct tctgtgcaat gggcaaccct tacatgtgca ataatgagtg tgatgcgagt
     1381 acccctgaac tggcacaccc tcctgagctg atgtttgatt ttgaaggaag acatccctcc
     1441 acattttggc agtctgctac ttggaaggag taccccaaac ctctccaggt taacatcact
     1501 ctgtcttgga gcaaaaccat tgaactcaca gacaacatag ttattacctt tgaatcgggg
     1561 cgtccagacc aaatgatcct agagaaatct ctcgactacg gacgaacatg gcagccctat
     1621 cagtattatg ccacagactg cctccatgca ttccacatgg acccgaaatc cgtgaaggat
     1681 ttatctcagc acacggtctt ggaaatcatt tgcacggaag agtactccac tgggtactcc
     1741 acgaatagca aaataatcca cttcgagatc aaagacaggt ttgcgttttt cgctggacct
     1801 cggctacgaa atatggcttc cctctatgga cagctggata caaccaagaa actcagagat
     1861 ttcttcactg tcacagacct gaggatcagg ctgttgagac ccgccgttgg ggaaatattt
     1921 gtagatgaac tacatttggc acgttacttt tatgcgatct cagacataaa ggtgcgagga
     1981 aggtgcaagt gcaacctgca tgccacttcg tgtttgtatg acaacagcaa actgacatgt
     2041 gaatgtgagc acaacactac aggtcccgac tgtgggaaat gcaagaagaa ctaccagggc
     2101 cgaccttgga gccccggctc atacctcccc atccccaaag gcaccgcaaa cacctgtatc
     2161 cccagcattt ccagtatcgg taactgtgaa tgcttcggcc actccaatcg gtgcagttat
     2221 atcgatctgc taaacacagt catttgcgtg agctgtaaac acaacactag agggcagcac
     2281 tgtgagttat gcaggctggg ctacttcaga aatgcttctg cacagctgga cgatgagaat
     2341 gtgtgcatag agtgttattg taaccctttg ggctcaatcc atgatcgttg taatggctca
     2401 ggattttgtg agtgtaagac tggaacaaca gggcctaaat gtgatgagtg tctgccagga
     2461 aattcctggt actacggctg tcaacctaat gtctgcgaca atgagctcct gcactgccag
     2521 aatggaggga cctgccagaa caatgtgcgc tgcgcgtgcc cagacgccta caccggcatc
     2581 ctctgtgaga agctacggtg cgaagaggcg ggcagctgtg gctccgaatc cggccaggga
     2641 gcacccccgc ggggctcccc agcactgctg ctgctgacca tgctgctggg gactgccggt
     2701 cccctggtgt tctaggggtc acacccagcc ctccgacagg cctgtgctgt ggggaagcaa
     2761 acacaaccca agcgattgcc actgacatag aaaacacgca cacccactcc aacacagtgt
     2821 ataaaagaag agggcctaac tgaactaagc catatctctc agaaccggac agcacatcgc
     2881 acatcggagt tgagactgtt catcattgac tccagaggaa ttggcagctg ttgctattct
     2941 cactgcaaat ctcattgcca gctgcagagc tgattgcgga ttggaaaggc tgtgagagcg
     3001 cccccaagag gaaagacgga aaacaaactg atcaaccaac ctaaaaacat tcgctactct
     3061 accgtggtgc accctagtac cgctctgctc agtgtgtggg ccaaccaaat aaaagcattc
     3121 ttcgctgtca ggtgcattgt gggtataagg aaatctgtta caagctgcca tattggcctg
     3181 cttcagtccc cccgaccccc aaatcccttc caacctgtgc tttagtgaac gttgctctgt
     3241 aacccttgtt ggttgaaaga tttctttgtc tgatgttagt gatacacacg tgtaacagcc
     3301 ccctccaaag cgcaagccag tcatacccct gtatatttta gcagcactgc ggtcccagtg
     3361 ccagctcacg tccacttcac aagagtggtt agaggaaaag agaaagtgta tctatccttt
     3421 tgtattcaaa tgaagttatt tttcttgaaa taatgtaata tgtagatttt ttgtattatt
     3481 gccaatttat gttaccagac aatctgttaa tgtatctaat tcgaatcagc aaagactgac
     3541 tgatgtttga gtttttggtc ctctttggtt ttgtttcgtt tcgtcatgca gagatttctc
     3601 tgtaagggca acgagcgtgc tggcatcaaa gaatatcggt ttacatatag caagtgtaat
     3661 aagattccac caaaggacat tttaaatgtt ttttcttgtt gctttaacac tggaagattt
     3721 aaagaataaa aattcctgca gaaatgttat caggaaattg tatggccgtt tcttaagacg
     3781 aaaggagcaa ccacccagca gtttcccagt cacgtcactg atttttgtgt ggactgaaca
     3841 cagtcagctg acaactttaa taaccaggaa gacggattga tggtcactag cttggacaac
     3901 gtctgcaaaa tatgagacta ttttccacct gggaaaaaat tataaccaca aaaacagaga
     3961 gaaagaaata tctaagtgat tgccaagatt atgccaaagc ctgttggcag agcactaaga
     4021 gacttttatt tttaagtcat gctattttca cagatttatg gtgatcatgt gactctaggg
     4081 atgccgatct atgtatcctt ccaaatacag tgtttacatg gagtatcata agaggccacc
     4141 tggggaacca ggacagcagc agggaaattg agtgattagc aatttgactt tgaatatatt
     4201 ctaagtattt aaatgaaata tcaaaatata cagcagcaag tagacataac tgctgttcct
     4261 gaaaataaag tctgtttcaa gtactgccca aggtgtaata aattcttgtt tctgcctttt
     4321 attaggccaa ttactgtaca tgacagcaga gggagctggg cgggtggaga atcactgcaa
     4381 agtttttgga ggggctgaaa caatgtatgt tcaatcccgg cacactgcca ccctgcaggt
     4441 gacaaatgtg tcagcaatgg catctcttgg aatcagaaat aattatgagg ccaaaccaga
     4501 agattaaaga caatgaagtc ctacatgact tggtgggaca ataaccaatg acagtattag
     4561 gtcagaagcc tcgttccagg ctgaattctt caccctaccg ccagtctcgc ttgaaccagg
     4621 gggaagcagg gggaacaatg tcttctgaca aataaccgag tcaaaactag atgaaggaac
     4681 agcatgtctt attggttttg ttcccagaaa agccaattca aagaaggcaa taaaaggtaa
     4741 gcaggtaatt cctgctctgc ctgccacccc acgtccaagt cgattggatg tttgttattc
     4801 aaaccaacag catcttttga tataagaaat agggaaagat ggaaataaat tagcgccttg
     4861 gcttagtgcc agagtggcca accagaaatg gcagatttac attagaagca taaatagaaa
     4921 atcatattcc cagctcacca aagaatgcac atgaaaattc tgatcgcata cagagtgtga
     4981 gattacttct aatgaggtgg atttctgata ttaaaatgga gtttaagttg tcttatagtt
     5041 tattagcaca aaccaaaggc agactgtgtt atttctggca atggtgcact ttatcattat
     5101 ccagtcacac agctttgtca caatgatcag gaatcagacg ctgcacaatt caatacgtgg
     5161 gattccgaca gctaattctg aaatttaatg aaggcctgat ttaaatcaac tcatctgcat
     5221 tttatcttta tgaggctata agaatctaaa ttgaggagga atatcttgca ttcagtgtat
     5281 ttagatatag ttctctgatt ttcttgaagt gatgtgatct gcttttaata aaaattcact
     5341 tttaggt
//
