LOCUS       NM_021320               2411 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus netrin 4 (Ntn4), mRNA.
ACCESSION   NM_021320
VERSION     NM_021320.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Yang,H., Ting,X., Geng,Y.H., Xie,Y., Nierenberg,J.L., Huo,Y.F.,
            Zhou,Y.T., Huang,Y., Yu,Y.Q., Yu,X.Y., Li,X.F., Ziv,E., Zhang,H.,
            Fang,W.G., Shen,Y. and Tian,X.X.
  TITLE     The risk variant rs11836367 contributes to breast cancer onset and
            metastasis by attenuating Wnt signaling via regulating NTN4
            expression
  JOURNAL   Sci Adv 8 (23), eabn3509 (2022)
   PUBMED   35687692
  REMARK    GeneRIF: The risk variant rs11836367 contributes to breast cancer
            onset and metastasis by attenuating Wnt signaling via regulating
            NTN4 expression.
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Crespo-Garcia,S., Reichhart,N., Kociok,N., Skosyrski,S. and
            Joussen,A.M.
  TITLE     Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy
  JOURNAL   Int J Mol Sci 22 (9), 4481 (2021)
   PUBMED   33923095
  REMARK    GeneRIF: Anti-Inflammatory Role of Netrin-4 in Diabetic
            Retinopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Seya,D., Ihara,D., Shirai,M., Kawamura,T., Watanabe,Y. and
            Nakagawa,O.
  TITLE     A role of Hey2 transcription factor for right ventricle development
            through regulation of Tbx2-Mycn pathway during cardiac
            morphogenesis
  JOURNAL   Dev Growth Differ 63 (1), 82-92 (2021)
   PUBMED   33410138
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Lejmi,E., Leconte,L., Pedron-Mazoyer,S., Ropert,S., Raoul,W.,
            Lavalette,S., Bouras,I., Feron,J.G., Maitre-Boube,M., Assayag,F.,
            Feumi,C., Alemany,M., Jie,T.X., Merkulova,T., Poupon,M.F.,
            Ruchoux,M.M., Tobelem,G., Sennlaub,F. and Plouet,J.
  TITLE     Netrin-4 inhibits angiogenesis via binding to neogenin and
            recruitment of Unc5B
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12491-12496 (2008)
   PUBMED   18719102
  REMARK    GeneRIF: Netrin-4 significantly reduced pathological angiogenesis
            in Matrigel and laser-induced choroidal neovascularization models.
            Netrin-4, neogenin, and Unc5B receptor expression was up-regulated
            in choroidal neovessel EC after laser injury
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Schneiders,F.I., Maertens,B., Bose,K., Li,Y., Brunken,W.J.,
            Paulsson,M., Smyth,N. and Koch,M.
  TITLE     Binding of netrin-4 to laminin short arms regulates basement
            membrane assembly
  JOURNAL   J Biol Chem 282 (33), 23750-23758 (2007)
   PUBMED   17588941
  REMARK    GeneRIF: netrin-4 is a component of basement membranes and is
            integrated into the laminin polymer via interactions with the
            laminin gamma1 andgamma3 short arms.
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Liu,Y., Stein,E., Oliver,T., Li,Y., Brunken,W.J., Koch,M.,
            Tessier-Lavigne,M. and Hogan,B.L.
  TITLE     Novel role for Netrins in regulating epithelial behavior during
            lung branching morphogenesis
  JOURNAL   Curr Biol 14 (10), 897-905 (2004)
   PUBMED   15186747
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Koch,M., Murrell,J.R., Hunter,D.D., Olson,P.F., Jin,W., Keene,D.R.,
            Brunken,W.J. and Burgeson,R.E.
  TITLE     A novel member of the netrin family, beta-netrin, shares homology
            with the beta chain of laminin: identification, expression, and
            functional characterization
  JOURNAL   J Cell Biol 151 (2), 221-234 (2000)
   PUBMED   11038171
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Yin,Y., Sanes,J.R. and Miner,J.H.
  TITLE     Identification and expression of mouse netrin-4
  JOURNAL   Mech Dev 96 (1), 115-119 (2000)
   PUBMED   10940631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ068258.1, BB609851.1, BC119182.1, CX205916.1, CF537120.1 and
            AC151976.3.
            
            On Apr 9, 2009 this sequence version replaced NM_021320.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF281278.1, BC119184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               CJ068258.1         1-506
            507-907             BB609851.1         378-778
            908-1361            BC119182.1         590-1043
            1362-1764           CX205916.1         173-575
            1765-2015           CF537120.1         359-609
            2016-2174           BC119182.1         1698-1856
            2175-2411           AC151976.3         44302-44538         c
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.59 cM"
     gene            1..2411
                     /gene="Ntn4"
                     /note="netrin 4"
                     /db_xref="GeneID:57764"
                     /db_xref="MGI:MGI:1888978"
     exon            1..460
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..2292
                     /gene="Ntn4"
                     /note="beta-netrin"
                     /codon_start=1
                     /product="netrin-4 precursor"
                     /protein_id="NP_067295.2"
                     /db_xref="CCDS:CCDS24128.1"
                     /db_xref="GeneID:57764"
                     /db_xref="MGI:MGI:1888978"
                     /translation="MGSCARLLLLWGCSAVAAGLNGVAGANSRCEKACNPRMGNLALG
                     RKLRADTMCGQNATELFCFYSENADLTCRQPKCDKCNAAHSHLAHPPSAMADSSFRFP
                     RTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYF
                     ATNCSATFGLEDDVVKKGAICTSRYSNPFPCTGGEVIFRALSPPYDIENPYSAKVQEQ
                     LKITNLRVRLLKRQSCPCQINDLNAKPHHFMHYAVYDFIVKGSCFCNGHADQCLPVEG
                     FRPIKAPGAFHVVHGRCMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPNECRTCKC
                     NGHADTCHFDVNVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDAC
                     KACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPCD
                     CAGSCDPLTGDCISSNADVDWYHEVPAFHSMHNKSEPSWEWEDEQGFSALRHSGKCEC
                     KEQVLGNPKAFCGMKYSYVLKIKILSAHDKGSHAEVNVKIKKVLKSTKLKILRGKRTL
                     YPESWTNRGCTCPILNPGLEYLVAGHEDVRTGKLIVNMKSFVQHWKPALGRRVMHILK
                     RDCV"
     exon            461..990
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1269
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1396
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1585
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1799
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1915
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1984
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2155
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2411
                     /gene="Ntn4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2349..2354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntn4"
                     /note="hexamer: AATGAA"
     regulatory      2368..2373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntn4"
                     /note="hexamer: AATAAA"
     polyA_site      2374
                     /gene="Ntn4"
                     /note="major polyA site"
     polyA_site      2399
                     /gene="Ntn4"
ORIGIN      
        1 gagaaggacg ggaccgagcc tcggcggcca cagaaggtgg gaaaagcgga ggaggacagc
       61 cgggaggcgg cggcggccgg gaagtgaaag gtctcgcaaa gttcagcgtc ggctgcgggc
      121 gccgagccct gggcgagcgg cgcacccgcc ctcagggccg ctcagccggc agcggccagg
      181 ccggctatga tcccggggct cccgccgctg ctgagctgcc cgggccccgc caggccggtg
      241 cgcgacggtc accccgccgc ctggcgcggc cccggcccgc ggctctgtgc ccacggtgcc
      301 cactgagcga gcctggcgct ccgggaggag gaagaaccac agagcccccg gtgctcccga
      361 ggaccactgc cgcttcatcc cacccgctcc cgcagctgcc cggccatggg gagctgcgca
      421 cggctgctgc tgctctgggg ctgctccgcg gtggccgcag gcttgaatgg agtagccgga
      481 gcgaactccc gctgtgagaa agcatgcaac cctcgcatgg gaaacttggc tttgggaaga
      541 aagctccggg cagacacaat gtgtggccag aacgccaccg aactcttctg cttctacagt
      601 gagaatgctg acctcacttg ccggcagccc aagtgtgata aatgcaacgc tgcccattct
      661 cacctggctc acccaccctc tgccatggca gactcatcct tcaggtttcc ccggacatgg
      721 tggcagtctg cagaggatgt gcacagggaa aagattcagc tagacctgga agcagaattc
      781 tacttcactc acctaattat ggtgttcaag tctcccaggc ctgcagccat ggtgctggac
      841 cggtcccagg actttgggaa gacctggaag ccttacaagt actttgcaac aaactgctcg
      901 gctacttttg gcctggaaga tgatgttgtc aagaagggag ctatttgcac gtctagatac
      961 tcaaatcctt tcccgtgcac cggaggagag gttattttca gagccctgtc accaccatac
     1021 gacatagaaa acccttacag tgccaaagtg caggagcagc tgaagatcac caacctccga
     1081 gtgcggctgc tcaagcgaca gtcctgccct tgtcagataa acgacctgaa cgcaaaacct
     1141 caccatttta tgcactacgc agtctatgac ttcatcgtca agggcagctg cttctgcaac
     1201 ggccacgctg accagtgctt acctgtggag ggcttcagac ccatcaaggc cccgggagcg
     1261 ttccacgtgg tccacgggag gtgtatgtgt aagcacaaca cagcaggcag ccactgccag
     1321 cactgtgcac cattgtacaa tgaccggccc tgggaggcag cggacggcag aacaggggct
     1381 cctaacgaat gcagaacttg caagtgcaat gggcacgcgg acacctgtca cttcgacgtc
     1441 aacgtgtggg aggcgtcggg gaaccgcagc ggcggtgtct gcaacaactg tcagcacaac
     1501 actgagggtc agcactgtca acgctgtaag cccggtttct accgcgacct cagaagaccc
     1561 ttctctgccc ctgacgcttg caaagcgtgt tcctgccacc cggttggatc ggcgatcctt
     1621 cctttcagct cagtgacctt ctgcgacccc agcaatggtg actgcccctg caagcctggg
     1681 gtggcggggc cacattgcga cagatgcatg gtgggatact ggggctttgg agactacggc
     1741 tgcagacctt gcgattgtgc ggggagctgc gacccgctca cgggagactg catcagcagt
     1801 aacgctgatg tagactggta ccacgaagtc cccgcctttc actcgatgca caataagagt
     1861 gagcccagct gggaatggga ggatgagcaa ggattttctg ccctccgaca ctcaggtaaa
     1921 tgtgaatgta aggaacaggt gttaggaaac cccaaagcct tctgtggaat gaagtattca
     1981 tatgtgttaa aaatcaagat cttatcagcc cacgacaaag gctcccatgc cgaagtcaat
     2041 gtgaagatta agaaagtctt aaagtccacc aaactgaaga tcttacgagg caagagaacg
     2101 ctatacccag agtcctggac taacagaggc tgcacctgtc caatcctcaa tccaggattg
     2161 gagtacctgg tcgctggcca cgaggacgta agaacaggca aattaattgt gaatatgaaa
     2221 agctttgtcc agcactggaa accagctctt ggcagaagag tcatgcacat cttaaaaaga
     2281 gactgcgtgt agcactgaag gtcttaagca cacaagggct tttctctggg tagcagatac
     2341 acaagtctaa tgaaaaagag acctcaaaat aaaactggaa tattttttaa gtgccaaaat
     2401 gtaggggggg g
//
