LOCUS       NP_067295                628 aa            linear   ROD 30-APR-2024
DEFINITION  netrin-4 precursor [Mus musculus].
ACCESSION   NP_067295
VERSION     NP_067295.2
DBSOURCE    REFSEQ: accession NM_021320.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 628)
  AUTHORS   Yang,H., Ting,X., Geng,Y.H., Xie,Y., Nierenberg,J.L., Huo,Y.F.,
            Zhou,Y.T., Huang,Y., Yu,Y.Q., Yu,X.Y., Li,X.F., Ziv,E., Zhang,H.,
            Fang,W.G., Shen,Y. and Tian,X.X.
  TITLE     The risk variant rs11836367 contributes to breast cancer onset and
            metastasis by attenuating Wnt signaling via regulating NTN4
            expression
  JOURNAL   Sci Adv 8 (23), eabn3509 (2022)
   PUBMED   35687692
  REMARK    GeneRIF: The risk variant rs11836367 contributes to breast cancer
            onset and metastasis by attenuating Wnt signaling via regulating
            NTN4 expression.
REFERENCE   3  (residues 1 to 628)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 628)
  AUTHORS   Crespo-Garcia,S., Reichhart,N., Kociok,N., Skosyrski,S. and
            Joussen,A.M.
  TITLE     Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy
  JOURNAL   Int J Mol Sci 22 (9), 4481 (2021)
   PUBMED   33923095
  REMARK    GeneRIF: Anti-Inflammatory Role of Netrin-4 in Diabetic
            Retinopathy.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 628)
  AUTHORS   Seya,D., Ihara,D., Shirai,M., Kawamura,T., Watanabe,Y. and
            Nakagawa,O.
  TITLE     A role of Hey2 transcription factor for right ventricle development
            through regulation of Tbx2-Mycn pathway during cardiac
            morphogenesis
  JOURNAL   Dev Growth Differ 63 (1), 82-92 (2021)
   PUBMED   33410138
REFERENCE   6  (residues 1 to 628)
  AUTHORS   Lejmi,E., Leconte,L., Pedron-Mazoyer,S., Ropert,S., Raoul,W.,
            Lavalette,S., Bouras,I., Feron,J.G., Maitre-Boube,M., Assayag,F.,
            Feumi,C., Alemany,M., Jie,T.X., Merkulova,T., Poupon,M.F.,
            Ruchoux,M.M., Tobelem,G., Sennlaub,F. and Plouet,J.
  TITLE     Netrin-4 inhibits angiogenesis via binding to neogenin and
            recruitment of Unc5B
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12491-12496 (2008)
   PUBMED   18719102
  REMARK    GeneRIF: Netrin-4 significantly reduced pathological angiogenesis
            in Matrigel and laser-induced choroidal neovascularization models.
            Netrin-4, neogenin, and Unc5B receptor expression was up-regulated
            in choroidal neovessel EC after laser injury
REFERENCE   7  (residues 1 to 628)
  AUTHORS   Schneiders,F.I., Maertens,B., Bose,K., Li,Y., Brunken,W.J.,
            Paulsson,M., Smyth,N. and Koch,M.
  TITLE     Binding of netrin-4 to laminin short arms regulates basement
            membrane assembly
  JOURNAL   J Biol Chem 282 (33), 23750-23758 (2007)
   PUBMED   17588941
  REMARK    GeneRIF: netrin-4 is a component of basement membranes and is
            integrated into the laminin polymer via interactions with the
            laminin gamma1 andgamma3 short arms.
REFERENCE   8  (residues 1 to 628)
  AUTHORS   Liu,Y., Stein,E., Oliver,T., Li,Y., Brunken,W.J., Koch,M.,
            Tessier-Lavigne,M. and Hogan,B.L.
  TITLE     Novel role for Netrins in regulating epithelial behavior during
            lung branching morphogenesis
  JOURNAL   Curr Biol 14 (10), 897-905 (2004)
   PUBMED   15186747
REFERENCE   9  (residues 1 to 628)
  AUTHORS   Koch,M., Murrell,J.R., Hunter,D.D., Olson,P.F., Jin,W., Keene,D.R.,
            Brunken,W.J. and Burgeson,R.E.
  TITLE     A novel member of the netrin family, beta-netrin, shares homology
            with the beta chain of laminin: identification, expression, and
            functional characterization
  JOURNAL   J Cell Biol 151 (2), 221-234 (2000)
   PUBMED   11038171
REFERENCE   10 (residues 1 to 628)
  AUTHORS   Yin,Y., Sanes,J.R. and Miner,J.H.
  TITLE     Identification and expression of mouse netrin-4
  JOURNAL   Mech Dev 96 (1), 115-119 (2000)
   PUBMED   10940631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ068258.1, BB609851.1, BC119182.1, CX205916.1, CF537120.1 and
            AC151976.3.
            
            On Apr 9, 2009 this sequence version replaced NP_067295.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF281278.1, BC119184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.59 cM"
     Protein         1..628
                     /product="netrin-4 precursor"
                     /note="beta-netrin"
                     /calculated_mol_wt=68006
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1879
     mat_peptide     20..628
                     /product="Netrin-4. /id=PRO_0000042117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JI33.2)"
                     /calculated_mol_wt=68006
     Region          34..260
                     /region_name="Laminin_N"
                     /note="Laminin N-terminal (Domain VI); pfam00055"
                     /db_xref="CDD:459653"
     Site            56
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JI33.2)"
     Site            163
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JI33.2)"
     Region          261..320
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(262,264,271,293,295,304)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          332..392
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(332,334,341,359,362,371)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JI33.2)"
     Region          395..446
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domai;
                     smart00180"
                     /db_xref="CDD:214543"
     Site            order(395,397,413,420,422,431)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Site            483
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JI33.2)"
     Region          517..626
                     /region_name="NTR_netrin-4_like"
                     /note="NTR domain, Netrin-4-like subfamily; composed of
                     the C-terminal NTR domains of netrin-4 (beta netrin) and
                     similar proteins. Netrins are secreted proteins that
                     function as tropic cues in the direction of axon growth
                     and cell migration during neural...; cd03578"
                     /db_xref="CDD:239633"
     CDS             1..628
                     /gene="Ntn4"
                     /coded_by="NM_021320.3:406..2292"
                     /db_xref="CCDS:CCDS24128.1"
                     /db_xref="GeneID:57764"
                     /db_xref="MGI:MGI:1888978"
ORIGIN      
        1 mgscarllll wgcsavaagl ngvagansrc ekacnprmgn lalgrklrad tmcgqnatel
       61 fcfysenadl tcrqpkcdkc naahshlahp psamadssfr fprtwwqsae dvhrekiqld
      121 leaefyfthl imvfksprpa amvldrsqdf gktwkpykyf atncsatfgl eddvvkkgai
      181 ctsrysnpfp ctggevifra lsppydienp ysakvqeqlk itnlrvrllk rqscpcqind
      241 lnakphhfmh yavydfivkg scfcnghadq clpvegfrpi kapgafhvvh grcmckhnta
      301 gshcqhcapl yndrpweaad grtgapnecr tckcnghadt chfdvnvwea sgnrsggvcn
      361 ncqhntegqh cqrckpgfyr dlrrpfsapd ackacschpv gsailpfssv tfcdpsngdc
      421 pckpgvagph cdrcmvgywg fgdygcrpcd cagscdpltg dcissnadvd wyhevpafhs
      481 mhnksepswe wedeqgfsal rhsgkcecke qvlgnpkafc gmkysyvlki kilsahdkgs
      541 haevnvkikk vlkstklkil rgkrtlypes wtnrgctcpi lnpgleylva ghedvrtgkl
      601 ivnmksfvqh wkpalgrrvm hilkrdcv
//
