LOCUS       NM_010947               4912 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus netrin 3 (Ntn3), mRNA.
ACCESSION   NM_010947
VERSION     NM_010947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4912)
  AUTHORS   Honeycutt,S.E., N'Guetta,P.Y., Hardesty,D.M., Xiong,Y.,
            Cooper,S.L., Stevenson,M.J. and O'Brien,L.L.
  TITLE     Netrin 1 directs vascular patterning and maturity in the developing
            kidney
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37818607
REFERENCE   2  (bases 1 to 4912)
  AUTHORS   Pan,W., Huang,X., Yu,Z., Ding,Q., Xia,L., Hua,J., Gu,B., Xiong,Q.,
            Yu,H., Wang,J., Xu,Z., Zeng,L., Bai,G. and Liu,H.
  TITLE     Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the
            Intra-epidermal Sprouting of Sensory Axons
  JOURNAL   Neurosci Bull 39 (5), 745-758 (2023)
   PUBMED   36587114
  REMARK    GeneRIF: Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating
            the Intra-epidermal Sprouting of Sensory Axons.
REFERENCE   3  (bases 1 to 4912)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4912)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (bases 1 to 4912)
  AUTHORS   Poliak,S., Morales,D., Croteau,L.P., Krawchuk,D., Palmesino,E.,
            Morton,S., Cloutier,J.F., Charron,F., Dalva,M.B., Ackerman,S.L.,
            Kao,T.J. and Kania,A.
  TITLE     Synergistic integration of Netrin and ephrin axon guidance signals
            by spinal motor neurons
  JOURNAL   Elife 4, e10841 (2015)
   PUBMED   26633881
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4912)
  AUTHORS   Loes,S., Luukko,K., Hals Kvinnsland,I., Salminen,M. and Kettunen,P.
  TITLE     Developmentally regulated expression of Netrin-1 and -3 in the
            embryonic mouse molar tooth germ
  JOURNAL   Dev Dyn 227 (4), 573-577 (2003)
   PUBMED   12889066
REFERENCE   7  (bases 1 to 4912)
  AUTHORS   Jiang,Y., Liu,M.T. and Gershon,M.D.
  TITLE     Netrins and DCC in the guidance of migrating neural crest-derived
            cells in the developing bowel and pancreas
  JOURNAL   Dev Biol 258 (2), 364-384 (2003)
   PUBMED   12798294
  REMARK    GeneRIF: Netrin-3 is expressed by the fetal mucosal epithelium and
            pancreas.
REFERENCE   8  (bases 1 to 4912)
  AUTHORS   Seaman,C. and Cooper,H.M.
  TITLE     Netrin-3 protein is localized to the axons of motor, sensory, and
            sympathetic neurons
  JOURNAL   Mech Dev 101 (1-2), 245-248 (2001)
   PUBMED   11231084
REFERENCE   9  (bases 1 to 4912)
  AUTHORS   Wang,H., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Tessier-Lavigne,M.
  TITLE     Netrin-3, a mouse homolog of human NTN2L, is highly expressed in
            sensory ganglia and shows differential binding to netrin receptors
  JOURNAL   J Neurosci 19 (12), 4938-4947 (1999)
   PUBMED   10366627
REFERENCE   10 (bases 1 to 4912)
  AUTHORS   PuschelPuschel,A.W.
  TITLE     Divergent properties of mouse netrins
  JOURNAL   Mech Dev 83 (1-2), 65-75 (1999)
   PUBMED   10381568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC094362.1.
            
            On May 1, 2005 this sequence version replaced NM_010947.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094362.1, AK141856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.31 cM"
     gene            1..4912
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /note="netrin 3"
                     /db_xref="GeneID:18209"
                     /db_xref="MGI:MGI:1341188"
     exon            1..1329
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1518
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1668
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1719
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1794
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..4911
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2537
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /note="major polyA site"
     regulatory      4048..4053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /note="hexamer: AATAAA"
     polyA_site      4073
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
     regulatory      4559..4564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /note="hexamer: AATAAA"
     polyA_site      4585
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
ORIGIN      
        1 ctcgctgcag ccaggagaag ccggcagccc gggcgcccca ggccccgccc gcccaaggcc
       61 cttcccggga ggccgggaga cctgctcctc ctggccctcc gtgggtgagt gctggcggcc
      121 ggcggcgggt ggggcctccg cgggcggagg caccgggagc gggggcgacg cctgtcaacg
      181 cttcaggcct agcaggagga ctcgccaaca tccctgctcc tgtgctcggc cccgggcgtg
      241 ccggtggctg ctcccacttc tgggcctgtg ctgggggccg ccctggtgct ctgctatctt
      301 ggcactgcag acccggcacg cagagtagcg gactaggctc tctcttcgag ggcagactcg
      361 ttaggcggaa gctggctggt tgacttacag cggccacggc catgcccacc tggctctggg
      421 ggctgctgct gaccgcgggc acgctctccg ctgcactgag cccagggctg ccggcctctg
      481 ccgacccctg ctatgatgag gcgagggagc ctcgctcttg tattcctggc cttgtgaacg
      541 ctgctctggg ccgagaggtg ctggcgtcca gcacgtgcgg gaggtcggcc aatcgcgtct
      601 gcgattcctc ggacccgcag cgggcacact ctgcagacct cctgacctct gctccgggca
      661 ctgcaagtcc tctctgttgg cgctccgatt tgctgcaaca ggcacctttc aacgtaaccc
      721 tcacagtgcc cctggggaag gcttttgagc tggtcttcgt gagcctgcgc ttctgctcag
      781 ctcctccaac ctccgtggcc ctgcttaagt cgcaggacca tggccgcagc tgggtcccct
      841 tgggcttctt ctcttccagc tgtaccctgg actatggccg tctgcctgct cctgctgatg
      901 gcccttctgg tccagggcca gaagccctct gctttccagc cccccaggct cagcctgatg
      961 gtggaggcct tctggccttc agtgtgcagg atggcagccc acagggcctg gatctggaca
     1021 acagccccgt gctccaagac tgggtgactg ccacagatat tcgcatagta ctcacaaggc
     1081 ctgccattca gggagacacc agggacggtg gggtgacagt cccctactcc tactcagcca
     1141 ctgagcttca ggtgggaggt cgatgcaagt gcaatgggca tgcctcacgg tgtctgttgg
     1201 acacccatgg ccacctggtc tgcgactgcc agcatggtac agagggccct gattgcagcc
     1261 gctgcaagcc cttctactgc gacaggccat ggcagcgggc tacagggcag gaagcccacg
     1321 cttgccttgc ttgctcctgc aacggccatg cgcgaagatg ccgcttcaac atggagctct
     1381 accgactgtc cggccgccgc agtgggggcg tgtgcctcaa ctgccggcac aatacagctg
     1441 gtcgtcactg ccactactgc cgggagggct tctatcgtga tccaggccgt gtcctgagtg
     1501 accgtcgtgc ttgcagagct tgtgactgcc acccagttgg tgctgctggc aaaacctgta
     1561 accagaccac aggccagtgt ccctgtaagg atggtgttac tggcctcacc tgtaaccgct
     1621 gtgccccagg tttccagcag agccgttctc ctgtggcacc ttgcgttaag actcctgtcc
     1681 ctggacccac cgaagaaagc agtcctgtgg agccacagga ctgtgagtca cattgcagac
     1741 ctgcgcgtgg cagttaccga atcagcctga agaagttctg ccggaaggac tatgcggtgc
     1801 aggtggcagt gggtgcacgc ggtgaggccc gcggctcgtg gacacgcttt ccggtagcgg
     1861 tgcttgctgt gttccgcagc ggcgaggaac gcgctcgacg cgggagcagc gcgctgtggg
     1921 taccaactct agacgcggcc tgcggttgcc cgcgcctcct gcccggccgg cgttacttgc
     1981 tgctgggagg tgggccgggg gctgcagctg ggagcacagc gggccgggga caggggctca
     2041 gtgctgcccg tggaagcctc gtgctgcctt ggagagacgc ctggacccgg cgcctgcgga
     2101 ggctgcagag gagagagcgg cgggggcgct gcgggaccgc ctgaatctgc aagctgggcg
     2161 tggactgggc ggactcagct ctcttatcac tgggcgcggc gcgttcatca gagcactagg
     2221 ctggaagtgt cacgtgcatc gccatctaat ttccccctac ccccatcccc gcttgaaacc
     2281 tatttggcga taccctaccc ccaacttaga ggagtatgat ggcccctaag agctatctgg
     2341 aggctcctag ggcagctcag aggaccctga tcttatccct cttggctgat acccgacgtc
     2401 tcttaaaggt gtgaacccgc ctattcccag gggatgctag gatgatccct ctggggtttg
     2461 agcacatccc acgggccaat gtgattcatc aactctctga tgctgtgata cactagagtt
     2521 ctccaacctc tccaaaacca ctgttgccac cataattgcc tgtacaccgc tgcaggggct
     2581 gtggctcaat tgcacagcca agacagcgac gtctctgccc tccagccggg aatgtacaaa
     2641 gagtattgta ggctcccctg tccagtgtca tggatcttgt ccccatatcc attctggcct
     2701 gcctctgccg gtcacgtgac cgtgtcccca tccgcagctg catcactgcc tgtgtcccat
     2761 atctttcttg ttccgttgta cccttttctg gggtccatcc agctgtcgct ttctaccacg
     2821 actcctacca gtcttggcct cttggctcca tgacacaggt cctgccccta gctaggagcc
     2881 ctacactcta tccgctcaag actggacgtc gagaaggggc agatcaggtc cacgtgtgac
     2941 cggaccagag gcgacttcca cgggcagccg tcggagttct agtcgtccgt gactttgcct
     3001 tacaccaggc gctagggtcc ccacctcttt aggcgagccc ccgcccctta gcgcgggaac
     3061 cgctgtttgg ctagcgcatg ctcccgactt ggccgccgcc gggcgcaaat gcgcatgctc
     3121 agagccggca gcactgagac gcggggcact cggggtgggc agcccgcaag cgcgtgcttg
     3181 tggggcgggg ccgcctacgc gcgtgcgcag aaagtccagt gcggtccagc ggagagccga
     3241 agggagaggt gcggtgcggc gcgccgaggt gggtgcgcgg cgggggcgtg gcggctggac
     3301 gcggggtgtg ggggtgtcac tgccacggtg cgctgaccgg cggcacggat gtactgaggg
     3361 aggggggcac gggttgtgct ccgtgtcttg gtcgctgcgg gttagggggc tccagagtct
     3421 aatgctgcgt gcgtgacgtg ggccccggag tcagaaccct ttgggcaggc ccggctttcc
     3481 tcgatcatcc ctgccttctc tgggctctgt gtcgtgggca agaactgcct ctgtgtcaac
     3541 cttcccttgg ggcactttcc gtccctgcgg aataggaaat cctctttctg tattcgttcg
     3601 aaattgcagc agtgttcata tacctttgcc ctcggagacc tgcaacaacc caggcccttc
     3661 acttgccaaa gatgacacaa ctgcccacct gaagcttagg gactttccca gcctgagagc
     3721 cctatccagc cagtgtccct gacatgcctt ggtcacctgt gccttagctt ggccctgtgc
     3781 ttcaggagtt ttgaataaca gctggagggc agagctggca ccacacgggg tgggctgcac
     3841 atgacagaag tcagtctgct gggtgctggc agcctgacca cagattttcc ttgacagacc
     3901 tgactcagtt cagaaatagt gctctggcct tcttggatgg ggactcactg ggctaacttt
     3961 aaaggccaaa gattgtctag cccagcccgg acatatgcag gcataggttg gccatttggg
     4021 cggttgtgtt gctgtctttc caaggtaaat aaaggatttt ccttgtctca ccatgttctg
     4081 ctggaaggtc agcaagctac tcccaggcag ttggtacaac tgtcccatgg catgcgttgc
     4141 catgtcatct acttggggac aatgactcca ttctcatttt cacacccctg tccccaatag
     4201 gcacctgtca ttgttcactg aattgttgtg gagatggctg tatttgtgtt ctctcaagct
     4261 ctatctgatg tcagttctgg gttggtgtca agaccaaccc agacgacaaa tggttaagaa
     4321 atttcaaata tttgatagtg accattcata ttgagtgcta tgagggctct gtgtgcttcc
     4381 ttgatgatta atcctcacct aatctcccca gtactcagat aaagacttag ggtagtgaca
     4441 gctgtattta gaatctagtc tgcgtgtgga taggcctgga gccacatcgt gttgtccctg
     4501 ttcccccatg gtctggcatt cagttagcca ggcactctct taagtgcttg ttggagggaa
     4561 taaagatgcc actttttgaa tgctacatgt caactagtga actagcaatg tagtggcttt
     4621 tggctggatt aagggtgacc ttttgggttt gcagaagtac tctagtaatc taggtagggt
     4681 tttcataaca acaatcaaat ttacctccct gggagtgcaa actcacctgc ctgtgttccc
     4741 tactagctct gagtaaccac ccttgccagg actgtctggc aagtctcagt gaccttgggc
     4801 acacagcatt gctcctaatc cttattagag actgagccaa cctctgaaga catagtaaag
     4861 tgtttaaagt acacaagaca atgaagtggg ttgtaaaaaa aaaaaaaaaa aa
//
