LOCUS       NP_035077                580 aa            linear   ROD 07-MAY-2024
DEFINITION  netrin-3 precursor [Mus musculus].
ACCESSION   NP_035077
VERSION     NP_035077.1
DBSOURCE    REFSEQ: accession NM_010947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 580)
  AUTHORS   Honeycutt,S.E., N'Guetta,P.Y., Hardesty,D.M., Xiong,Y.,
            Cooper,S.L., Stevenson,M.J. and O'Brien,L.L.
  TITLE     Netrin 1 directs vascular patterning and maturity in the developing
            kidney
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37818607
REFERENCE   2  (residues 1 to 580)
  AUTHORS   Pan,W., Huang,X., Yu,Z., Ding,Q., Xia,L., Hua,J., Gu,B., Xiong,Q.,
            Yu,H., Wang,J., Xu,Z., Zeng,L., Bai,G. and Liu,H.
  TITLE     Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the
            Intra-epidermal Sprouting of Sensory Axons
  JOURNAL   Neurosci Bull 39 (5), 745-758 (2023)
   PUBMED   36587114
  REMARK    GeneRIF: Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating
            the Intra-epidermal Sprouting of Sensory Axons.
REFERENCE   3  (residues 1 to 580)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 580)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (residues 1 to 580)
  AUTHORS   Poliak,S., Morales,D., Croteau,L.P., Krawchuk,D., Palmesino,E.,
            Morton,S., Cloutier,J.F., Charron,F., Dalva,M.B., Ackerman,S.L.,
            Kao,T.J. and Kania,A.
  TITLE     Synergistic integration of Netrin and ephrin axon guidance signals
            by spinal motor neurons
  JOURNAL   Elife 4, e10841 (2015)
   PUBMED   26633881
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 580)
  AUTHORS   Loes,S., Luukko,K., Hals Kvinnsland,I., Salminen,M. and Kettunen,P.
  TITLE     Developmentally regulated expression of Netrin-1 and -3 in the
            embryonic mouse molar tooth germ
  JOURNAL   Dev Dyn 227 (4), 573-577 (2003)
   PUBMED   12889066
REFERENCE   7  (residues 1 to 580)
  AUTHORS   Jiang,Y., Liu,M.T. and Gershon,M.D.
  TITLE     Netrins and DCC in the guidance of migrating neural crest-derived
            cells in the developing bowel and pancreas
  JOURNAL   Dev Biol 258 (2), 364-384 (2003)
   PUBMED   12798294
  REMARK    GeneRIF: Netrin-3 is expressed by the fetal mucosal epithelium and
            pancreas.
REFERENCE   8  (residues 1 to 580)
  AUTHORS   Seaman,C. and Cooper,H.M.
  TITLE     Netrin-3 protein is localized to the axons of motor, sensory, and
            sympathetic neurons
  JOURNAL   Mech Dev 101 (1-2), 245-248 (2001)
   PUBMED   11231084
REFERENCE   9  (residues 1 to 580)
  AUTHORS   Wang,H., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Tessier-Lavigne,M.
  TITLE     Netrin-3, a mouse homolog of human NTN2L, is highly expressed in
            sensory ganglia and shows differential binding to netrin receptors
  JOURNAL   J Neurosci 19 (12), 4938-4947 (1999)
   PUBMED   10366627
REFERENCE   10 (residues 1 to 580)
  AUTHORS   PuschelPuschel,A.W.
  TITLE     Divergent properties of mouse netrins
  JOURNAL   Mech Dev 83 (1-2), 65-75 (1999)
   PUBMED   10381568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC094362.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094362.1, AK141856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.31 cM"
     Protein         1..580
                     /product="netrin-3 precursor"
                     /note="netrin-2-like protein"
                     /calculated_mol_wt=60211
     sig_peptide     1..17
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1A3.1)"
                     /calculated_mol_wt=1831
     mat_peptide     18..580
                     /product="Netrin-3. /id=PRO_0000017086"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1A3.1)"
                     /calculated_mol_wt=60211
     Region          34..253
                     /region_name="Laminin_N"
                     /note="Laminin N-terminal (Domain VI); cl02806"
                     /db_xref="CDD:470680"
     Site            104
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1A3.1)"
     Region          254..299
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(255,257,264,274,276,285)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          311..362
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(311,313,320,338,341,350)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          373..422
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(374,376,386,393,395,404)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1A3.1)"
     Region          456..562
                     /region_name="NTR_netrin-1_like"
                     /note="NTR domain, Netrin-1-like subfamily; The C-terminal
                     NTR domain of netrins is also called domain C in the
                     context of C. elegans netrin UNC-6. Netrins are secreted
                     proteins that function as tropic cues in the direction of
                     axon growth and cell migration...; cd03579"
                     /db_xref="CDD:239634"
     Region          500..502
                     /region_name="Cell attachment site, atypical.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1A3.1)"
     CDS             1..580
                     /gene="Ntn3"
                     /gene_synonym="Ntn2l"
                     /coded_by="NM_010947.3:402..2144"
                     /db_xref="CCDS:CCDS28478.1"
                     /db_xref="GeneID:18209"
                     /db_xref="MGI:MGI:1341188"
ORIGIN      
        1 mptwlwglll tagtlsaals pglpasadpc ydeareprsc ipglvnaalg revlasstcg
       61 rsanrvcdss dpqrahsadl ltsapgtasp lcwrsdllqq apfnvtltvp lgkafelvfv
      121 slrfcsappt svallksqdh grswvplgff sssctldygr lpapadgpsg pgpealcfpa
      181 pqaqpdgggl lafsvqdgsp qgldldnspv lqdwvtatdi rivltrpaiq gdtrdggvtv
      241 pysysatelq vggrckcngh asrclldthg hlvcdcqhgt egpdcsrckp fycdrpwqra
      301 tgqeahacla cscngharrc rfnmelyrls grrsggvcln crhntagrhc hycregfyrd
      361 pgrvlsdrra cracdchpvg aagktcnqtt gqcpckdgvt gltcnrcapg fqqsrspvap
      421 cvktpvpgpt eesspvepqd ceshcrparg syrislkkfc rkdyavqvav gargeargsw
      481 trfpvavlav frsgeerarr gssalwvptl daacgcprll pgrrylllgg gpgaaagsta
      541 grgqglsaar gslvlpwrda wtrrlrrlqr rerrgrcgta
//
