LOCUS       NM_008744               5757 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus netrin 1 (Ntn1), mRNA.
ACCESSION   NM_008744
VERSION     NM_008744.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5757)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   2  (bases 1 to 5757)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5757)
  AUTHORS   Curran,B.M., Nickerson,K.R., Yung,A.R., Goodrich,L.V., Jaworski,A.,
            Tessier-Lavigne,M. and Ma,L.
  TITLE     Multiple guidance mechanisms control axon growth to generate
            precise T-shaped bifurcation during dorsal funiculus development in
            the spinal cord
  JOURNAL   Elife 13, 94109 (2024)
   PUBMED   39159057
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5757)
  AUTHORS   Yu,H.L., Liu,X., Yin,Y., Liu,X.N., Feng,Y.Y., Tahir,M.M.,
            Miao,X.Z., He,X.X., He,Z.X. and Zhu,X.J.
  TITLE     Netrin-1 Is an Important Mediator in Microglia Migration
  JOURNAL   Int J Mol Sci 25 (13), 7079 (2024)
   PUBMED   39000184
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5757)
  AUTHORS   Masuda,A., Nishida,K., Ajima,R., Saga,Y., Bakhtan,M., Klar,A.,
            Hirata,T. and Zhu,Y.
  TITLE     A global gene regulatory program and its region-specific regulator
            partition neurons into commissural and ipsilateral projection types
  JOURNAL   Sci Adv 10 (21), eadk2149 (2024)
   PUBMED   38781326
REFERENCE   6  (bases 1 to 5757)
  AUTHORS   Serafini,T., Colamarino,S.A., Leonardo,E.D., Wang,H.,
            Beddington,R., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Netrin-1 is required for commissural axon guidance in the
            developing vertebrate nervous system
  JOURNAL   Cell 87 (6), 1001-1014 (1996)
   PUBMED   8978605
REFERENCE   7  (bases 1 to 5757)
  AUTHORS   Ang,S.L., Jin,O., Rhinn,M., Daigle,N., Stevenson,L. and Rossant,J.
  TITLE     A targeted mouse Otx2 mutation leads to severe defects in
            gastrulation and formation of axial mesoderm and to deletion of
            rostral brain
  JOURNAL   Development 122 (1), 243-252 (1996)
   PUBMED   8565836
REFERENCE   8  (bases 1 to 5757)
  AUTHORS   Ishibashi,M., Ang,S.L., Shiota,K., Nakanishi,S., Kageyama,R. and
            Guillemot,F.
  TITLE     Targeted disruption of mammalian hairy and Enhancer of split
            homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix
            factors, premature neurogenesis, and severe neural tube defects
  JOURNAL   Genes Dev 9 (24), 3136-3148 (1995)
   PUBMED   8543157
REFERENCE   9  (bases 1 to 5757)
  AUTHORS   Skarnes,W.C., Moss,J.E., Hurtley,S.M. and Beddington,R.S.
  TITLE     Capturing genes encoding membrane and secreted proteins important
            for mouse development
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6592-6596 (1995)
   PUBMED   7604039
REFERENCE   10 (bases 1 to 5757)
  AUTHORS   Borit,A. and Sidman,R.L.
  TITLE     New mutant mouse with communicating hydrocephalus and secondary
            aqueductal stenosis
  JOURNAL   Acta Neuropathol 21 (4), 316-331 (1972)
   PUBMED   4116482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF537666.1, U65418.1, AI840271.1, BE652257.1, AL669842.11 and
            CF585515.1.
            
            On Aug 16, 2006 this sequence version replaced NM_008744.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.10822.1,
                                           SRR10223970.14020.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-699               CF537666.1         1-699
            700-1381            U65418.1           416-1097
            1382-1551           AI840271.1         256-425
            1552-1828           BE652257.1         1-277               c
            1829-5431           AL669842.11        59611-63213
            5432-5757           CF585515.1         2-327               c
FEATURES             Location/Qualifiers
     source          1..5757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 41.45 cM"
     gene            1..5757
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /note="netrin 1"
                     /db_xref="GeneID:18208"
                     /db_xref="MGI:MGI:105088"
     exon            1..217
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..1299
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..2096
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /codon_start=1
                     /product="netrin-1 precursor"
                     /protein_id="NP_032770.2"
                     /db_xref="CCDS:CCDS24864.1"
                     /db_xref="GeneID:18208"
                     /db_xref="MGI:MGI:105088"
                     /translation="MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDE
                     NGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNSSDPKKA
                     HPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMA
                     IYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLI
                     AFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYYYAV
                     SDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATARE
                     ANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMG
                     KPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAP
                     CIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKMNMKKYCRKDYAVQIHILKADKAG
                     DWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPD
                     QSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA"
     exon            1300..1488
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1638
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1692
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1767
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..5738
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5713..5718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /note="hexamer: AATAAA"
     polyA_site      5731
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccgcg tcgtcactcg ggaggaagag gcggcggcgg tggcggccgg ggccggggct
       61 ggggcagcgg cggccgcgcc gggcatggag ctggcaagcc cgcgttgaga caggacgctc
      121 ttgctagccg ccagcgagag gctctctgca gtccggcgcg cgggctcccc ggcttgggcc
      181 aggcaaactt ttctttctct tttgccatca cttagaggcg cctggtgcgg cgggcgaacc
      241 gactccttgg cgcggcgggg ccggggcaag ctggccacag catgatgcgc gctgtgtggg
      301 aggcgctggc ggcgctggcg gcggtggcgt gcctggtggg cgcggtgcgc ggcgggcccg
      361 ggcttagcat gttcgccggc caggcggcgc agcctgatcc ttgctcggat gagaatggac
      421 acccgcgccg ctgcatcccg gactttgtca acgcggcctt cggcaaggac gtgcgcgtgt
      481 ccagcacctg cggccggccc ccggcgcgct actgcgtggt gagcgagcgt ggtgaagagc
      541 ggctgcgctc ctgtcacctc tgcaactctt cggatcccaa gaaagcgcac ccgcccgcct
      601 tcctcaccga cctcaataac ccgcacaacc tgacgtgctg gcagtccgag aactacctgc
      661 agttcccgca caacgtgacg ctcactctgt cgctcggcaa gaagtttgag gtgacctatg
      721 tgagcctgca attctgctcg ccgcggccag agtccatggc catctacaag tccatggact
      781 acgggcgcac gtgggtgccc ttccagttct attccacgca gtgccgcaaa atgtacaacc
      841 ggccgcaccg cgcgcctatc accaaacaga acgagcagga ggccgtgtgc accgactcgc
      901 acaccgacat gcgcccgctc tctggcgggc tgatcgcttt cagcacgctg gacgggcggc
      961 cctcggcgca cgacttcgac aactcgccgg tgctgcagga ctgggtcacg gccaccgaca
     1021 tccgcgtggc tttcagccgc ctgcacacgt tcggcgacga gaacgaagac gactcggagc
     1081 tggcgcgcga ctcctattac tatgcagtgt ctgacctgca ggttggcggc cgctgcaagt
     1141 gcaacggcca cgcggcgcgt tgcgtgcgcg accgagacga cagtctggtg tgtgactgta
     1201 ggcacaacac ggccggccct gaatgcgacc gttgcaagcc cttccactac gaccggccct
     1261 ggcagcgcgc cacggcccgc gaggccaacg agtgcgtggc ctgcaactgc aacctccatg
     1321 ctcggcgctg cagattcaac atggagctct ataagctatc agggcgcaag agcgggggag
     1381 tctgtctcaa ctgccgccac aacactgcgg gccgccactg ccactactgc aaggagggct
     1441 tctaccgaga catgggcaag cctatcaccc accggaaggc ttgcaaagcc tgtgattgcc
     1501 acccagtggg tgctgctggc aagacctgca atcaaaccac tggccaatgt ccctgcaagg
     1561 acggcgtgac gggcatcacc tgcaaccgat gtgccaaagg ctaccagcag agccgctccc
     1621 ccatcgcccc ttgcatcaag attcctgtgg cgccacccac cactgcagcc agcagcgtgg
     1681 aggaaccgga agactgtgac tcctattgca aggcctccaa aggcaagctg aagatgaaca
     1741 tgaagaaata ctgcaggaag gactatgctg tccagatcca catcctgaag gccgacaaag
     1801 caggggactg gtggaagttc accgtgaaca tcatctccgt gtacaagcag ggcacaagtc
     1861 gtattcgccg tggtgaccag agtttgtgga tccgctcacg agacatcgcc tgcaagtgtc
     1921 ccaaaatcaa gcccctcaag aagtacttgc tgttgggtaa tgccgaggac tcacctgacc
     1981 agagtggcat cgtggcagac aagagcagcc tggtgatcca gtggcgggac acatgggcac
     2041 ggcggctgcg caagttccag caacgggaga agaagggcaa gtgcaagaag gcctagcgcg
     2101 gaggtggcgc gggctccagg agggcgggca gggcgctggc aaaggctggc agccttggac
     2161 ttggccgtca ggggtttttt tgggagggtg ggggcggggc gaagtcgaag tggggcgggg
     2221 ccctcagcgg ctccgcccca gccccaccct cacacccctg gctgcgctct tatgcgcatg
     2281 gcagaaagca ccctgtattg acaggccagg ccctggagaa atgaggacaa gacatagcta
     2341 cctcacggcg ctccttccag aacagagatg cgcttcccta gggctaggtg ggggtcgccg
     2401 tggaggggtt agggaggtcc tgagaggcgg gaacagaatg gcacagtggt ctacagtcgc
     2461 tgtgtttgat ggttattgaa gggggatgta agaactgtga atttttgggc ctgcagcctg
     2521 ggcaggggca accaatccac caccagacac tagtcacgcc cccctccttt ctccatcacc
     2581 cgctgtctag gaattcccac aggactccag actctgacaa caggtcccta tgttagaggg
     2641 cccgatgaca ctgggatcag ccagctttgg tctccactgc cacctgctgg gctggtctcc
     2701 tgggtggagt tcaccatctg tagggagggg agagttctcc tggggcctgc tctactccag
     2761 tggggctggc ccaggctcct ggcccatcag agggcctagg gcctaaggac cctgaagtca
     2821 agccgggtgg tcactgcctc tgctggagct gcctgtggaa ggaggcattg caaaccaaaa
     2881 cctcccagag agtttccttg ctggaaactt ggaaacagcc ctttttatga cattttccag
     2941 gggaggggga ggggtactgg cgggggttta gggcagtgac actatttgtg taatgacatc
     3001 agctcccaca aggcctcaca gcaatgtcaa cagctggaga gggcctggtt aagtctggaa
     3061 tgccagcggc tgtctaggca gtttgaacca ggcttggggg aaggggcttg cctgagtcag
     3121 ggtagggtcg ctgctcagca aggtgcctgg cgtccaagct ggagggcaag gccaggaatg
     3181 gtcaggttct tggggtccaa gcattctgtg actgcttcct gctgccgccc tcactgctgg
     3241 ctccccagaa aagggacata gactccttgg ttaagaaacc cactctagct cccagctgtc
     3301 ttggtctagc ctgggcagtc tggtctattc ctttctggct gccttctttg tggaggtccc
     3361 caggccctcc tgtatgccta gctctctttt ctcttagaga cttaatgtcc tcacgcaggc
     3421 agctccaagc ttcccttctg gttgcttccc aggccccttt agcctttccc tgcctccctg
     3481 tactcgggcc tctagcctcg cgccccgcac actggatgag aggcctggcc ctctcagtca
     3541 ggaaattggt ttcatttctc ctgcccactt ggctgccctg aagggccata tgagggatga
     3601 agctcagccc ctcagtgaca cggctccctc tgcttctcca cttctgccca catcaccact
     3661 gccacttact gagcaccctc ttggtgccag gcactttacc catatgctcc tggcctgttt
     3721 tcaccacaaa cctgcgaggc agggattcac tcttgtcttc gtgttcacca gtaaaaagac
     3781 atgtccacgt gcccaaggtc acaccagcac cggtactcag actctgacct caccacagtt
     3841 gcacatcagc agttagccct cttgacactc ccacagtagg cgagggttgg gtgggatagt
     3901 ggttaccact gagacccagg cagcttgtct ctagagaact ctgaggatat gagcctggag
     3961 tatggtctgg gacagaccca gcaacacctc ctgaggaggc atcgggagtg gcggggaatg
     4021 aggaatggac tccctagtgg aaagccgcaa gatccaggaa gacaggcatg gccatctgag
     4081 agggcctgga gaggtggctt agctgcttcc ctagccggag gaagactaag gcttcagagg
     4141 gaggctggca tgagcacaca gacctaccct ggcaagggtc aggtggcttc cctggtccaa
     4201 gcttgagatt gagggcaagg tccactatcc aggagagcca gtatggtttg ttgggtacca
     4261 tctgtagcaa ataacatcca gctgtacagc aggggtctca tttctgtacc agcatgtcta
     4321 atgctctggc cagcttccac ccttgaaccc tggagtccag tctcacctgg tatccagcga
     4381 agtctcttaa ctagacttcc cccacgcccc tgctaagcaa cagagacgtc ttgttagaaa
     4441 tctaccaagg cctcctgccc tgccctctgt ggcctgctca atgggggcta cattaaatag
     4501 ccaaaatgag ccaagttgtg gataaggtca ttgctgaggg agcagggttt gtcacagcca
     4561 ccacctctgt ggaccagaat ccagcccacc tctcctctgc ctgagagcca gccttaggga
     4621 ggcagctgtc tcctacccac cctagggagg agatggaaag ggggaagaag acatcctctt
     4681 tgtacagtta ggaaggggtg caaaatggaa gtaggttttt gagtttgaga gtgtattaac
     4741 agagttgtga tatgtaggtc tttgaagaaa accataccag gttagtcact taccagtcaa
     4801 gatttcccag ctgtcccttt gcttaccatt tgggtagtct ggtcccctgt caccagaatg
     4861 cctcctttgc tgacacacag tggcacaaag gtatgtggtg aaggtgatga catgctccta
     4921 ggtacagctg tgagctgtgg tttctggcca gagcttctgt cccagaaagc agggcaggag
     4981 gcaggaccat ccggctcctt cagatgggag ggagggtcag atgccaaggg caaagcctag
     5041 ggaggctggg gtggcctctc cgagggcctt agggactttc tagaactctg cctcagtggt
     5101 tacatacagg cagtgggtac aggctgtctt agaattgccc ctgagctgga acaagactga
     5161 aatgaggaga cccttcagga ctgacctggg gaatggttcc tttagggtct caacacttga
     5221 aggactccat ccaggaaacc tagagagtgg gcaagatagg ctcactaatg ggccgtggtt
     5281 cacagacaga tattcctgtg gaccagagcc atgccatacc ccaggggtat caaaattgtc
     5341 tttgtggggc cttgcccctg ccaaaaacta agccagcctc acctcttgtg tcagcggact
     5401 tccttcccct ttccctgatc tgggtacacc cccccggcct ccctcctgtg tcaccgattc
     5461 tgctcacaca gaattgtaaa tgtttagttg tgaccatgac atattgtttg ggccagtgtt
     5521 cctttccaat gcatactaat atattatggt tattatatat gaatatattt aatgacatgg
     5581 agaaagttgt ggattttctt tctttttctt tctttttttt tttaaagttt ttttgttgtt
     5641 agagttgtaa tggacccaga cggaacttgt aacgtgggcc ctacatgata gaactaaatc
     5701 cagatatcat taaataaact cttgtatact gttctgtgaa aaaaaaaaaa aaaaaaa
//
