LOCUS       NP_032770                604 aa            linear   ROD 06-MAY-2025
DEFINITION  netrin-1 precursor [Mus musculus].
ACCESSION   NP_032770
VERSION     NP_032770.2
DBSOURCE    REFSEQ: accession NM_008744.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 604)
  AUTHORS   Laumonnerie,C., Shamambo,M., Stabley,D.R., Lewis,T.L. Jr.,
            Trivedi,N., Howell,D. and Solecki,D.J.
  TITLE     Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to
            regulate cerebellar granule neuron germinal zone exit
  JOURNAL   Nat Commun 16 (1), 355 (2025)
   PUBMED   39774925
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 604)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   3  (residues 1 to 604)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 604)
  AUTHORS   Curran,B.M., Nickerson,K.R., Yung,A.R., Goodrich,L.V., Jaworski,A.,
            Tessier-Lavigne,M. and Ma,L.
  TITLE     Multiple guidance mechanisms control axon growth to generate
            precise T-shaped bifurcation during dorsal funiculus development in
            the spinal cord
  JOURNAL   Elife 13, 94109 (2024)
   PUBMED   39159057
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 604)
  AUTHORS   Yu,H.L., Liu,X., Yin,Y., Liu,X.N., Feng,Y.Y., Tahir,M.M.,
            Miao,X.Z., He,X.X., He,Z.X. and Zhu,X.J.
  TITLE     Netrin-1 Is an Important Mediator in Microglia Migration
  JOURNAL   Int J Mol Sci 25 (13), 7079 (2024)
   PUBMED   39000184
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 604)
  AUTHORS   Serafini,T., Colamarino,S.A., Leonardo,E.D., Wang,H.,
            Beddington,R., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Netrin-1 is required for commissural axon guidance in the
            developing vertebrate nervous system
  JOURNAL   Cell 87 (6), 1001-1014 (1996)
   PUBMED   8978605
REFERENCE   7  (residues 1 to 604)
  AUTHORS   Ang,S.L., Jin,O., Rhinn,M., Daigle,N., Stevenson,L. and Rossant,J.
  TITLE     A targeted mouse Otx2 mutation leads to severe defects in
            gastrulation and formation of axial mesoderm and to deletion of
            rostral brain
  JOURNAL   Development 122 (1), 243-252 (1996)
   PUBMED   8565836
REFERENCE   8  (residues 1 to 604)
  AUTHORS   Ishibashi,M., Ang,S.L., Shiota,K., Nakanishi,S., Kageyama,R. and
            Guillemot,F.
  TITLE     Targeted disruption of mammalian hairy and Enhancer of split
            homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix
            factors, premature neurogenesis, and severe neural tube defects
  JOURNAL   Genes Dev 9 (24), 3136-3148 (1995)
   PUBMED   8543157
REFERENCE   9  (residues 1 to 604)
  AUTHORS   Skarnes,W.C., Moss,J.E., Hurtley,S.M. and Beddington,R.S.
  TITLE     Capturing genes encoding membrane and secreted proteins important
            for mouse development
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6592-6596 (1995)
   PUBMED   7604039
REFERENCE   10 (residues 1 to 604)
  AUTHORS   Borit,A. and Sidman,R.L.
  TITLE     New mutant mouse with communicating hydrocephalus and secondary
            aqueductal stenosis
  JOURNAL   Acta Neuropathol 21 (4), 316-331 (1972)
   PUBMED   4116482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF537666.1, U65418.1, AI840271.1, BE652257.1, AL669842.11 and
            CF585515.1.
            
            On Aug 16, 2006 this sequence version replaced NP_032770.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.10822.1,
                                           SRR10223970.14020.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 41.45 cM"
     Protein         1..604
                     /product="netrin-1 precursor"
                     /calculated_mol_wt=65399
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2430
     mat_peptide     25..604
                     /product="Netrin-1. /id=PRO_0000017083"
                     /note="propagated from UniProtKB/Swiss-Prot (O09118.3)"
                     /calculated_mol_wt=65399
     Region          46..283
                     /region_name="LamNT"
                     /note="Laminin N-terminal domain (domain VI); smart00136"
                     /db_xref="CDD:214532"
     Site            95
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09118.3)"
     Site            116
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09118.3)"
     Site            131
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09118.3)"
     Region          284..329
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(285,287,297,304,306,315)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          341..401
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(341,343,350,368,371,380)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          404..>441
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(404,406,416,423,425,434)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Site            417
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09118.3)"
     Region          487..601
                     /region_name="NTR_netrin-1_like"
                     /note="NTR domain, Netrin-1-like subfamily; The C-terminal
                     NTR domain of netrins is also called domain C in the
                     context of C. elegans netrin UNC-6. Netrins are secreted
                     proteins that function as tropic cues in the direction of
                     axon growth and cell migration...; cd03579"
                     /db_xref="CDD:239634"
     Region          530..532
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O09118.3)"
     CDS             1..604
                     /gene="Ntn1"
                     /gene_synonym="Netrin-1"
                     /coded_by="NM_008744.2:282..2096"
                     /db_xref="CCDS:CCDS24864.1"
                     /db_xref="GeneID:18208"
                     /db_xref="MGI:MGI:105088"
ORIGIN      
        1 mmravweala alaavaclvg avrggpglsm fagqaaqpdp csdenghprr cipdfvnaaf
       61 gkdvrvsstc grpparycvv sergeerlrs chlcnssdpk kahppafltd lnnphnltcw
      121 qsenylqfph nvtltlslgk kfevtyvslq fcsprpesma iyksmdygrt wvpfqfystq
      181 crkmynrphr apitkqneqe avctdshtdm rplsggliaf stldgrpsah dfdnspvlqd
      241 wvtatdirva fsrlhtfgde neddselard syyyavsdlq vggrckcngh aarcvrdrdd
      301 slvcdcrhnt agpecdrckp fhydrpwqra tareanecva cncnlharrc rfnmelykls
      361 grksggvcln crhntagrhc hyckegfyrd mgkpithrka ckacdchpvg aagktcnqtt
      421 gqcpckdgvt gitcnrcakg yqqsrspiap cikipvappt taassveepe dcdsyckask
      481 gklkmnmkky crkdyavqih ilkadkagdw wkftvniisv ykqgtsrirr gdqslwirsr
      541 diackcpkik plkkylllgn aedspdqsgi vadksslviq wrdtwarrlr kfqqrekkgk
      601 ckka
//
