LOCUS       NM_170592               1245 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Ntmt1),
            transcript variant 1, mRNA.
ACCESSION   NM_170592
VERSION     NM_170592.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Wang,F., Tan,P., Zhang,P., Ren,Y., Zhou,J., Li,Y., Hou,S., Li,S.,
            Zhang,L., Ma,Y., Wang,C., Tang,W., Wang,X., Huo,Y., Hu,Y., Cui,T.,
            Niu,C., Wang,D., Liu,B., Lan,Y. and Yu,J.
  TITLE     Single-cell architecture and functional requirement of alternative
            splicing during hematopoietic stem cell formation
  JOURNAL   Sci Adv 8 (1), eabg5369 (2022)
   PUBMED   34995116
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Kole,C., Berdugo,N., Da Silva,C., Ait-Ali,N., Millet-Puel,G.,
            Pagan,D., Blond,F., Poidevin,L., Ripp,R., Fontaine,V., Wincker,P.,
            Zack,D.J., Sahel,J.A., Poch,O. and Leveillard,T.
  TITLE     Identification of an Alternative Splicing Product of the Otx2 Gene
            Expressed in the Neural Retina and Retinal Pigmented Epithelial
            Cells
  JOURNAL   PLoS One 11 (3), e0150758 (2016)
   PUBMED   26985665
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Bonsignore,L.A., Tooley,J.G., Van Hoose,P.M., Wang,E., Cheng,A.,
            Cole,M.P. and Schaner Tooley,C.E.
  TITLE     NRMT1 knockout mice exhibit phenotypes associated with impaired DNA
            repair and premature aging
  JOURNAL   Mech Ageing Dev 146-148, 42-52 (2015)
   PUBMED   25843235
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Petkowski,J.J., Bonsignore,L.A., Tooley,J.G., Wilkey,D.W.,
            Merchant,M.L., Macara,I.G. and Schaner Tooley,C.E.
  TITLE     NRMT2 is an N-terminal monomethylase that primes for its homologue
            NRMT1
  JOURNAL   Biochem J 456 (3), 453-462 (2013)
   PUBMED   24090352
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Tooley,C.E., Petkowski,J.J., Muratore-Schroeder,T.L.,
            Balsbaugh,J.L., Shabanowitz,J., Sabat,M., Minor,W., Hunt,D.F. and
            Macara,I.G.
  TITLE     NRMT is an alpha-N-methyltransferase that methylates RCC1 and
            retinoblastoma protein
  JOURNAL   Nature 466 (7310), 1125-1128 (2010)
   PUBMED   20668449
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844532.18 and FO719547.1.
            
            On Oct 4, 2017 this sequence version replaced NM_170592.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154783.1, AK011888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AL844532.18        38979-39027
            50-743              FO719547.1         1-694
            744-1245            AL844532.18        53543-54044
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.74 cM"
     gene            1..1245
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /note="N-terminal Xaa-Pro-Lys N-methyltransferase 1"
                     /db_xref="GeneID:66617"
                     /db_xref="MGI:MGI:1913867"
     exon            1..116
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            117..320
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..830
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /EC_number="2.1.1.244"
                     /note="isoform a is encoded by transcript variant 1; alpha
                     N-terminal protein methyltransferase 1A;
                     methyltransferase-like protein 11A; X-Pro-Lys N-terminal
                     protein methyltransferase 1A; methyltransferase like 11A"
                     /codon_start=1
                     /product="N-terminal Xaa-Pro-Lys N-methyltransferase 1
                     isoform a"
                     /protein_id="NP_733480.1"
                     /db_xref="CCDS:CCDS15886.1"
                     /db_xref="GeneID:66617"
                     /db_xref="MGI:MGI:1913867"
                     /translation="MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISNIDLNS
                     SRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFRVVDMVDVTEDFLAKAKT
                     YLGEEGKRVRNYFCCGLQDFSPEPGSYDVIWIQWVIGHLTDQHLAEFLRRCKRGLRPN
                     GIIVIKDNMAQEGVILDDVDSSVCRDLEVVRRIIRTAGLSLLAEERQENLPDEIYHVY
                     SFALR"
     exon            321..573
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1245
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1208..1213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /note="hexamer: AATAAA"
     polyA_site      1232
                     /gene="Ntmt1"
                     /gene_synonym="2610205E22Rik; Mettl11a; NTM1A"
                     /note="major polyA site"
ORIGIN      
        1 agaggccgcg aggtgtctgg tccggtagag tggtggcggc tgctgtgggc tacggtcttt
       61 gccagcctcc ttctcaaccc gtccttttct ctcgggtccc tggagccccg acccagggga
      121 gcagcgcggt ggctggcgac ttcacggctg gtgacgtcat gacgagcgag gtgattgagg
      181 atgagaaaca gttttattcg aaggccaaga cctactggaa gcagatccca cccacggtgg
      241 acggcatgct cggggggtat ggccacatct ccaacatcga cctcaacagc tcccggaagt
      301 ttctgcagag gtttttaagg gaaggcccaa acaagacagg gacttcctgt gccttggact
      361 gtggcgctgg tattggaagg atcaccaagc gcctgctcct gccactcttc agggtggtcg
      421 acatggtcga cgtgacggaa gactttctgg ccaaagccaa gacctacctg ggggaagagg
      481 gcaagagggt gaggaactac ttctgctgtg ggctgcagga cttcagccct gagcctggct
      541 cctatgacgt gatctggatc cagtgggtga taggccacct gacggatcag cacctggctg
      601 agtttctgcg ccgctgcaag cggggcctgc gccccaatgg catcatcgtc atcaaggaca
      661 acatggccca ggagggtgtg atcctggacg atgtggacag cagtgtgtgc cgggaccttg
      721 aggtggtccg ccggatcatc cgcactgcag gcctcagcct cctggccgag gagcgccagg
      781 agaacctgcc agatgagatc taccatgtct acagctttgc cctgagatga agccagggcc
      841 agagctgggg gccagcagct ggcaggccaa gagacacacc attgactcca gtgggaaggg
      901 tcaagcccta ggggaggtgt gccctggatt ggggcactgc agccctgtca ctctaaagca
      961 ccctggcaac ttcccacagg gctatggaaa gcagagttgg tcaccgctgg tctagctgcc
     1021 tgaggggaaa gacttcactt ggttgcctag ggacctcaat gtgtggactg ctgtgttcca
     1081 ggacagccag gccacacatg gtacctgcca gacagtacca attacagaaa tggtcacagc
     1141 cccatatcct ctttggtgat gggtcacagc agcctgcagc tcctaggagc tcctctctga
     1201 cacagccaat aaaagggtga gtcctattct cagatgcccc aggca
//
