LOCUS       NM_001357602            3783 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus neurotrimin (Ntm), transcript variant 6, mRNA.
ACCESSION   NM_001357602
VERSION     NM_001357602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3783)
  AUTHORS   Liau,E.S., Jin,S., Chen,Y.C., Liu,W.S., Calon,M., Nedelec,S.,
            Nie,Q. and Chen,J.A.
  TITLE     Single-cell transcriptomic analysis reveals diversity within
            mammalian spinal motor neurons
  JOURNAL   Nat Commun 14 (1), 46 (2023)
   PUBMED   36596814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3783)
  AUTHORS   Fearnley,S., Raja,R. and Cloutier,J.F.
  TITLE     Spatiotemporal expression of IgLON family members in the developing
            mouse nervous system
  JOURNAL   Sci Rep 11 (1), 19536 (2021)
   PUBMED   34599206
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3783)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3783)
  AUTHORS   Goodyer,W.R., Beyersdorf,B.M., Paik,D.T., Tian,L., Li,G.,
            Buikema,J.W., Chirikian,O., Choi,S., Venkatraman,S., Adams,E.L.,
            Tessier-Lavigne,M., Wu,J.C. and Wu,S.M.
  TITLE     Transcriptomic Profiling of the Developing Cardiac Conduction
            System at Single-Cell Resolution
  JOURNAL   Circ Res 125 (4), 379-397 (2019)
   PUBMED   31284824
REFERENCE   5  (bases 1 to 3783)
  AUTHORS   Telley,L., Agirman,G., Prados,J., Amberg,N., Fievre,S., Oberst,P.,
            Bartolini,G., Vitali,I., Cadilhac,C., Hippenmeyer,S., Nguyen,L.,
            Dayer,A. and Jabaudon,D.
  TITLE     Temporal patterning of apical progenitors and their daughter
            neurons in the developing neocortex
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073041
REFERENCE   6  (bases 1 to 3783)
  AUTHORS   Singh,R., Hoogaars,W.M., Barnett,P., Grieskamp,T., Rana,M.S.,
            Buermans,H., Farin,H.F., Petry,M., Heallen,T., Martin,J.F.,
            Moorman,A.F., 't Hoen,P.A., Kispert,A. and Christoffels,V.M.
  TITLE     Tbx2 and Tbx3 induce atrioventricular myocardial development and
            endocardial cushion formation
  JOURNAL   Cell Mol Life Sci 69 (8), 1377-1389 (2012)
   PUBMED   22130515
REFERENCE   7  (bases 1 to 3783)
  AUTHORS   da Silva,S., Hasegawa,H., Scott,A., Zhou,X., Wagner,A.K., Han,B.X.
            and Wang,F.
  TITLE     Proper formation of whisker barrelettes requires periphery-derived
            Smad4-dependent TGF-beta signaling
  JOURNAL   Proc Natl Acad Sci U S A 108 (8), 3395-3400 (2011)
   PUBMED   21300867
REFERENCE   8  (bases 1 to 3783)
  AUTHORS   Gu,W.X. and Kania,A.
  TITLE     Identification of genes controlled by LMX1B in E13.5 mouse limbs
  JOURNAL   Dev Dyn 239 (8), 2246-2255 (2010)
   PUBMED   20589901
REFERENCE   9  (bases 1 to 3783)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 3783)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162927.3, AC155928.2 and AC154494.2.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_001357602.2.
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            coding sequence and lacks two alternate in-frame exons compared to
            variant 1. The resulting isoform (6) has a distinct N-terminus and
            lacks an alternate internal segment compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.7981.1, AK158752.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1130              AC162927.3         176576-177705       c
            1131-1363           AC155928.2         96141-96373
            1364-1489           AC154494.2         13932-14057
            1490-1624           AC154494.2         109192-109326
            1625-1745           AC154494.2         111232-111352
            1746-1897           AC154494.2         114076-114227
            1898-3783           AC154494.2         126819-128704
FEATURES             Location/Qualifiers
     source          1..3783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 14.38 cM"
     gene            1..3783
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /note="neurotrimin"
                     /db_xref="GeneID:235106"
                     /db_xref="MGI:MGI:2446259"
     exon            1..1130
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             964..1998
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6"
                     /codon_start=1
                     /product="neurotrimin isoform 6 precursor"
                     /protein_id="NP_001344531.1"
                     /db_xref="CCDS:CCDS90526.1"
                     /db_xref="GeneID:235106"
                     /db_xref="MGI:MGI:2446259"
                     /translation="MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDN
                     VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI
                     QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIAT
                     GRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGEYECSASNDVAAPVVRRVKVT
                     VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWFKDDKRLVEGKKGVKVENRPF
                     LSKLTFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVNNGTSRRAGCIWLLP
                     LLVLHLLLKF"
     exon            1131..1363
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1489
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1624
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1745
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1897
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..3783
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2502..2507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /note="hexamer: AAGAAA"
     polyA_site      2516
                     /gene="Ntm"
                     /gene_synonym="6230410L23Rik; B230210G24Rik; Hnt; Igdcc2"
                     /note="major polyA site"
ORIGIN      
        1 acagtccgtg cctcccgcca gccggatcgc ttggagtcgg caaggagaga aagtggcggt
       61 cagggatgga gctgctgcca tgacaacccc ggcggtcggg gcccgcgcgc gtcggggctg
      121 ctcccgggag gaaggcagcg cggaggccgg gggcggccgc tgagcgtggc gtccgcggct
      181 ccggtggtgc cgactgcgct tcgtcttctg cagcgagcca gagagcgggc tagggaccgc
      241 tgcggtccgc ccctgccgcg ccgctccaac cttgctgctg cgctgcagag acagcccaag
      301 ctgcagcgcg aatctgggct ctgagcaagt tgaccgtggc tctgcggcag gattcccgag
      361 tccggattgc aggaagccgg cttagcaggc gcctccttgc tccctccgtg ccgcctcttg
      421 cgtgctctac tttccatctg ctattgttcc agattgtttc tggcgccgag ccttgctctg
      481 aaacttaaga aagtgctgga tttcctctcg ttcgactgag gaatcgtaga ccacatctgg
      541 gtagctggat tcaacccagc cacaaccccg ttggatacca aagtgcttac tcctgtccaa
      601 agtgccatgc ctgaactgct acggggaaga ggcagcttct gagacccgca cctgtgcgcc
      661 tgcttgcctg ccttgcgctt ctccttcctg gccaccttcc tggctacagg cagcacggag
      721 aaagtccgcc tcggatgtgt gtggaaactg gttctcggag gctgcgagct gaggctggat
      781 ttaggggagg aatattagac ttggaggagt ctgcgcgctt ttctcctccc agtgcatcgc
      841 gcggtcgccg ctagttcatc gctgggtccc cgcgctcact ccccacccca cccacttcct
      901 gtgctcgccc ggggggcgtg tgcgtgccac taccggagtt ctgggaagtt gtggctgtcg
      961 agaatggggg tctgtgggta cctgttcctg ccctggaagt gcctcgtggt cgtgtctctc
     1021 aggctgctat tccttgtacc cacaggagtg ccggtgcgta gcggagatgc cacctttccc
     1081 aaagctatgg acaacgtgac ggtcaggcag ggggagagcg ccaccctcag gtgcacaatt
     1141 gacaaccgag tcacccgggt ggcctggcta aaccgcagta ccatcctcta tgctggaaat
     1201 gacaagtggt gcctagatcc tcgtgtggtc ctcctgagta acacccagac ccagtacagc
     1261 attgagatcc agaatgtgga tgtgtacgat gagggccctt atacctgctc ggtacagaca
     1321 gacaaccacc ctaagacctc cagggtccac ctcattgtac aagtatctcc caaaattgta
     1381 gagatttctt cagatatctc cattaatgaa gggaacaaca tcagcctcac ttgcatagcc
     1441 acaggtagac cggagcctac agtaacctgg agacatattt ctcccaaggc cgttggcttt
     1501 gtgagtgagg atgagtacct ggagatccag ggcatcactc gggaacagtc aggcgagtac
     1561 gagtgcagcg cctccaacga cgtggcggca ccagtggtac gaagagtgaa ggtcaccgtg
     1621 aactatccac catacatctc agaagctaag ggcacaggtg tccccgtggg gcagaagggg
     1681 actctgcagt gtgaagcttc cgcagtccct tcagcagaat ttcaatggtt caaggatgac
     1741 aaaagactgg tcgaaggaaa gaagggagtc aaagtggaaa acagaccttt cctttcaaaa
     1801 ctcacctttt tcaacgtctc tgaacatgac tatgggaact acacatgtgt ggcctccaac
     1861 aagctgggtc acaccaacgc cagcatcatg ctatttggtc ccggtgctgt cagtgaggtc
     1921 aacaatggga catcaaggag ggcaggctgc atttggctcc tccctcttct ggtcttacac
     1981 ctgctcctca aattttgatg tgagtgcccc ttccctgctg gggagagctg ctgccaccgc
     2041 atctcaatac aacagcactg caaaatgaag caacaagtca gaatcaaatg aaattccgag
     2101 aatcacagcc aatgagacag aaattcgagg gagggggaca aagcatactg tggtaaaggg
     2161 gaaaaaaagg tttaagaaaa ggaaatttgg aaattgcctt gcagatattt cggtaccgct
     2221 gagttttctt tcttttccca agtgggaaga aggcacacct agcttggacc cacccacaag
     2281 ctgcactgtg tgacctctct gttgccaggg tgggcaaggg ctcagccact ctgcccacta
     2341 aagtgcccca ccatgaaaca ttctggagtt ggccatccca aatttcatcg gtccatagac
     2401 acaagcacag agcaagaaac aagggcctta gatgtgccac gaagggccct ttggtgggct
     2461 gtgtgacagt cgcgtgtgtc atgaagtgtg aaatctggag gaagaaaaaa aaacaagagc
     2521 aaaagaaaag aaaagaaaag aagagaagag aagagaagag aagagaagag aagagaagag
     2581 aagagaagag aagagaagag aagagaagag aagagaaaag aaagaacaaa caaacgaaac
     2641 aagacagcct gacagcacca taaccccaca agcaacagtc acaaaagata ccattaagct
     2701 tttgtttttc attttaccac atggacatca cggataataa gggattctga ttcattatta
     2761 attttattaa ttatattttc tgatatgagt ctagagctta gggtaaaaaa agagagagag
     2821 agacaagact aaaactacac aggcaagggc gatgggaagt gtgtttaagt attaaaagcg
     2881 aatagtgtac ttcttaccta agtttacatc tggtggacca ttcaccaggc attaatcacc
     2941 tggtgaggat ttggcaaatc caccagaaac acatgtgatt taacaaacac ctccaccagc
     3001 gttacagatt cctcctcatc tcttgcagac agtactatgc tatccataca ctacttagac
     3061 acagaaggtt ggtctgcacc tctatcttgg tttgttggct atgcttcctt tgatgacata
     3121 tattatacag tatatatata tacatatatt ttttttgtta gagttctagc cattttcttt
     3181 ctcagcaggg tccttctcag acattactgc atgctgtata tggcgttagc tgtgtgttga
     3241 tcttctaaaa gatgatagag tttaccggta attgtgtaat cagctccttc cttccttttt
     3301 tttttccctt tgggttattt acatgtcaga gacatttcta caaagcagaa aggacaacag
     3361 aaacaataac taataccagg cgcagcatct ttccaggtgt ggctctctga ggaggaggcc
     3421 tccagcttgg cttctccatc acaccttggg gcattaacgg acagcaagca actgaaacaa
     3481 ctaaaccaac agtaatcact tgcttaagcc cattgtggga atccctgatg cctttttgac
     3541 tactggagaa cataatcctc ttggtttatt tttatttaat tttccacctt tgtgtgagtg
     3601 tgtatgaaag agaagaaaaa aaaatgcagt ttttaggtaa ccattttttc ccttcccgaa
     3661 gtctggggac cagagaggcc tcggggaggg gtcctggatg tgatgaggga aactgggatg
     3721 ggggataggg gagggaaggg ttgtctctga cttgacatta aaaagtgttc catgtccctc
     3781 ttc
//
