LOCUS       NM_008742               1313 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus neurotrophin 3 (Ntf3), transcript variant 3, mRNA.
ACCESSION   NM_008742
VERSION     NM_008742.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1313)
  AUTHORS   Li,W., Lipsius,K., Burns,N.G., Sato,R., Rehman,A., Xue,H.,
            Combs,C., Minichiello,L., Gangrade,H., Tampakakis,E. and
            Mukouyama,Y.S.
  TITLE     Vascular smooth muscle cell-derived nerve growth factor regulates
            sympathetic collateral branching to innervate blood vessels in
            embryonic skin
  JOURNAL   Biol Open 13 (5) (2024)
   PUBMED   38639409
  REMARK    GeneRIF: Vascular smooth muscle cell-derived nerve growth factor
            regulates sympathetic collateral branching to innervate blood
            vessels in embryonic skin.
REFERENCE   2  (bases 1 to 1313)
  AUTHORS   Sharma,D., Feng,X., Wang,B., Yasin,B., Bekker,A., Hu,H. and
            Tao,Y.X.
  TITLE     NT-3 contributes to chemotherapy-induced neuropathic pain through
            TrkC-mediated CCL2 elevation in DRG neurons
  JOURNAL   EMBO Rep 25 (5), 2375-2390 (2024)
   PUBMED   38594391
  REMARK    GeneRIF: NT-3 contributes to chemotherapy-induced neuropathic pain
            through TrkC-mediated CCL2 elevation in DRG neurons.
REFERENCE   3  (bases 1 to 1313)
  AUTHORS   Tan,J.W., An,J.J., Deane,H., Xu,H., Liao,G.Y. and Xu,B.
  TITLE     Neurotrophin-3 from the dentate gyrus supports postsynaptic sites
            of mossy fiber-CA3 synapses and hippocampus-dependent cognitive
            functions
  JOURNAL   Mol Psychiatry 29 (4), 1192-1204 (2024)
   PUBMED   38212372
  REMARK    GeneRIF: Neurotrophin-3 from the dentate gyrus supports
            postsynaptic sites of mossy fiber-CA3 synapses and
            hippocampus-dependent cognitive functions.
REFERENCE   4  (bases 1 to 1313)
  AUTHORS   Trinh,V.Q., Lee,T.F., Lemoinne,S., Ray,K.C., Ybanez,M.D.,
            Tsuchida,T., Carter,J.K., Agudo,J., Brown,B.D., Akat,K.M.,
            Friedman,S.L. and Lee,Y.A.
  TITLE     Hepatic stellate cells maintain liver homeostasis through paracrine
            neurotrophin-3 signaling that induces hepatocyte proliferation
  JOURNAL   Sci Signal 16 (787), eadf6696 (2023)
   PUBMED   37253090
  REMARK    GeneRIF: Hepatic stellate cells maintain liver homeostasis through
            paracrine neurotrophin-3 signaling that induces hepatocyte
            proliferation.
REFERENCE   5  (bases 1 to 1313)
  AUTHORS   Cao,R., Chen,P., Wang,H., Jing,H., Zhang,H., Xing,G., Luo,B.,
            Pan,J., Yu,Z., Xiong,W.C. and Mei,L.
  TITLE     Intrafusal-fiber LRP4 for muscle spindle formation and maintenance
            in adult and aged animals
  JOURNAL   Nat Commun 14 (1), 744 (2023)
   PUBMED   36765071
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1313)
  AUTHORS   Leingartner,A. and Lindholm,D.
  TITLE     Two promoters direct transcription of the mouse NT-3 gene
  JOURNAL   Eur J Neurosci 6 (7), 1149-1159 (1994)
   PUBMED   7952296
REFERENCE   7  (bases 1 to 1313)
  AUTHORS   Ozcelik,T., Rosenthal,A. and Francke,U.
  TITLE     Chromosomal mapping of brain-derived neurotrophic factor and
            neurotrophin-3 genes in man and mouse
  JOURNAL   Genomics 10 (3), 569-575 (1991)
   PUBMED   1889807
REFERENCE   8  (bases 1 to 1313)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
REFERENCE   9  (bases 1 to 1313)
  AUTHORS   Maisonpierre,P.C., Belluscio,L., Friedman,B., Alderson,R.F.,
            Wiegand,S.J., Furth,M.E., Lindsay,R.M. and Yancopoulos,G.D.
  TITLE     NT-3, BDNF, and NGF in the developing rat nervous system: Parallel
            as well as reciprocal patterns of expression
  JOURNAL   Neuron 5 (4), 501-509 (1990)
   PUBMED   1688327
REFERENCE   10 (bases 1 to 1313)
  AUTHORS   Bothwell,M.A. and Shooter,E.M.
  TITLE     Dissociation equilibrium constant of beta nerve growth factor
  JOURNAL   J Biol Chem 252 (23), 8532-8536 (1977)
   PUBMED   925010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124188.5 and AC155837.7.
            
            On Jul 27, 2022 this sequence version replaced NM_008742.3.
            
            Summary: This gene encodes a member of the neurotrophins that have
            a wide variety of functions in both neural and non-neural tissues.
            The encoded preproprotein undergoes proteolytic processing to
            generate a noncovalently linked homodimeric mature protein that can
            bind to the transmembrane receptor tyrosine kinases to initiate a
            series of signaling events. Mice lacking the encoded protein
            exhibit severe defects in the peripheral nervous system including a
            complete lack of spinal proprioceptive afferents and their
            peripheral sense organs. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (3) lacks a portion of the 5' UTR
            and 5' coding region, and uses a downstream translational start
            codon, compared to variant 1. The resulting isoform (b) is shorter
            at the N-terminus, compared to isoform a. Both variants 3 and 4
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ049238.1, SRR7345562.1654362.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC124188.5         186577-186777
            202-1313            AC155837.7         53874-54985
FEATURES             Location/Qualifiers
     source          1..1313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 60.45 cM"
     gene            1..1313
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:18205"
                     /db_xref="MGI:MGI:97380"
     exon            1..201
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /inference="alignment:Splign:2.1.0"
     exon            202..1313
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..999
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="isoform b preproprotein is encoded by transcript
                     variant 3; neurotrophic factor; nerve growth factor 2"
                     /codon_start=1
                     /product="neurotrophin-3 isoform b preproprotein"
                     /protein_id="NP_032768.1"
                     /db_xref="CCDS:CCDS20553.1"
                     /db_xref="GeneID:18205"
                     /db_xref="MGI:MGI:97380"
                     /translation="MSILFYVIFLAYLRGIQGNSMDQRSLPEDSLNSLIIKLIQADIL
                     KNKLSKQMVDVKENYQSTLPKAEAPREPEQGEATRSEFQPMIATDTELLRQQRRYNSP
                     RVLLSDSTPLEPPPLYLMEDYVGNPVVANRTSPRRKRYAEHKSHRGEYSVCDSESLWV
                     TDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQC
                     KTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="hexamer: AGTAAA"
     polyA_site      1313
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="major polyA site"
ORIGIN      
        1 aagccaaacc tccaaagtgc tgtgtggcag ggtgaagggg aaaactctgc agcctgatcg
       61 gatccggagg aagaagaaga tattttggca ggagggaagt ccttcaaagg gatcgttgga
      121 ggtgacgtcc ttggtgggcc tctgtgggtg ctgcaggcca ttttcgatgt ggcagccccc
      181 gtcagccagg ataatgatga gatcttacag gtgaacaagg tgatgtccat cttgttttat
      241 gtgatatttc ttgcttatct ccgtggcatc caaggcaaca gcatggatca aaggagtttg
      301 ccggaagact ctctcaattc cctcatcatc aagctgatcc aggcggatat cttgaaaaac
      361 aagctttcca aacagatggt ggatgttaag gaaaattacc agagcaccct gcccaaagca
      421 gaggcaccca gggaaccaga gcagggagag gccaccaggt cagagttcca gccaatgatt
      481 gcaacggaca cagagctact acggcaacag agacgctaca attcgccccg ggtcctgctg
      541 agtgacagca cccctttgga gccccctccc ttatacctaa tggaggatta tgtgggcaac
      601 ccggtggtag ccaatagaac ctcaccacgg aggaaacgct atgcagaaca taagagtcac
      661 cgaggagagt actcagtgtg tgacagtgag agcctgtggg tgaccgacaa gtcctcagcc
      721 attgacattc ggggacacca ggtcacagtg ctgggggaga tcaaaaccgg taactctcct
      781 gtgaaacaat atttttatga aacgagatgt aaagaagcca ggccggtcaa aaacggttgc
      841 agggggattg atgacaaaca ctggaactct cagtgcaaaa cttcgcaaac ctatgtccga
      901 gcactgactt cagaaaacaa caaactcgta ggctggcgct ggatacgaat agacacttcc
      961 tgtgtgtgtg ccttgtcgag aaaaattgga agaacatgaa ttggcatctg tccccacata
     1021 taaattatta ctttaaatta tatgatatgc atgtagcata taaatgttta tattgttttt
     1081 atatattata agttgacctt tatttattaa acttcagcaa cccttacagt atataagctt
     1141 ttttctcaat aaaattcgtg tgcttgcctt ccctcaggcc tttcccatct gttaaccttg
     1201 ttttgtgatt gggctctcgg gaacccttct gtaaaacctg tgtacaccag tatttggcat
     1261 tcagtattgt caaggccatg actgtggttt cagtaaactt tcttaaaatc gga
//
