LOCUS       NM_001410129            1317 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus neurotrophin 3 (Ntf3), transcript variant 5, mRNA.
ACCESSION   NM_001410129 XM_006505715
VERSION     NM_001410129.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Li,W., Lipsius,K., Burns,N.G., Sato,R., Rehman,A., Xue,H.,
            Combs,C., Minichiello,L., Gangrade,H., Tampakakis,E. and
            Mukouyama,Y.S.
  TITLE     Vascular smooth muscle cell-derived nerve growth factor regulates
            sympathetic collateral branching to innervate blood vessels in
            embryonic skin
  JOURNAL   Biol Open 13 (5) (2024)
   PUBMED   38639409
  REMARK    GeneRIF: Vascular smooth muscle cell-derived nerve growth factor
            regulates sympathetic collateral branching to innervate blood
            vessels in embryonic skin.
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Sharma,D., Feng,X., Wang,B., Yasin,B., Bekker,A., Hu,H. and
            Tao,Y.X.
  TITLE     NT-3 contributes to chemotherapy-induced neuropathic pain through
            TrkC-mediated CCL2 elevation in DRG neurons
  JOURNAL   EMBO Rep 25 (5), 2375-2390 (2024)
   PUBMED   38594391
  REMARK    GeneRIF: NT-3 contributes to chemotherapy-induced neuropathic pain
            through TrkC-mediated CCL2 elevation in DRG neurons.
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Tan,J.W., An,J.J., Deane,H., Xu,H., Liao,G.Y. and Xu,B.
  TITLE     Neurotrophin-3 from the dentate gyrus supports postsynaptic sites
            of mossy fiber-CA3 synapses and hippocampus-dependent cognitive
            functions
  JOURNAL   Mol Psychiatry 29 (4), 1192-1204 (2024)
   PUBMED   38212372
  REMARK    GeneRIF: Neurotrophin-3 from the dentate gyrus supports
            postsynaptic sites of mossy fiber-CA3 synapses and
            hippocampus-dependent cognitive functions.
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Trinh,V.Q., Lee,T.F., Lemoinne,S., Ray,K.C., Ybanez,M.D.,
            Tsuchida,T., Carter,J.K., Agudo,J., Brown,B.D., Akat,K.M.,
            Friedman,S.L. and Lee,Y.A.
  TITLE     Hepatic stellate cells maintain liver homeostasis through paracrine
            neurotrophin-3 signaling that induces hepatocyte proliferation
  JOURNAL   Sci Signal 16 (787), eadf6696 (2023)
   PUBMED   37253090
  REMARK    GeneRIF: Hepatic stellate cells maintain liver homeostasis through
            paracrine neurotrophin-3 signaling that induces hepatocyte
            proliferation.
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   Cao,R., Chen,P., Wang,H., Jing,H., Zhang,H., Xing,G., Luo,B.,
            Pan,J., Yu,Z., Xiong,W.C. and Mei,L.
  TITLE     Intrafusal-fiber LRP4 for muscle spindle formation and maintenance
            in adult and aged animals
  JOURNAL   Nat Commun 14 (1), 744 (2023)
   PUBMED   36765071
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1317)
  AUTHORS   Leingartner,A. and Lindholm,D.
  TITLE     Two promoters direct transcription of the mouse NT-3 gene
  JOURNAL   Eur J Neurosci 6 (7), 1149-1159 (1994)
   PUBMED   7952296
REFERENCE   7  (bases 1 to 1317)
  AUTHORS   Ozcelik,T., Rosenthal,A. and Francke,U.
  TITLE     Chromosomal mapping of brain-derived neurotrophic factor and
            neurotrophin-3 genes in man and mouse
  JOURNAL   Genomics 10 (3), 569-575 (1991)
   PUBMED   1889807
REFERENCE   8  (bases 1 to 1317)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
REFERENCE   9  (bases 1 to 1317)
  AUTHORS   Maisonpierre,P.C., Belluscio,L., Friedman,B., Alderson,R.F.,
            Wiegand,S.J., Furth,M.E., Lindsay,R.M. and Yancopoulos,G.D.
  TITLE     NT-3, BDNF, and NGF in the developing rat nervous system: Parallel
            as well as reciprocal patterns of expression
  JOURNAL   Neuron 5 (4), 501-509 (1990)
   PUBMED   1688327
REFERENCE   10 (bases 1 to 1317)
  AUTHORS   Bothwell,M.A. and Shooter,E.M.
  TITLE     Dissociation equilibrium constant of beta nerve growth factor
  JOURNAL   J Biol Chem 252 (23), 8532-8536 (1977)
   PUBMED   925010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124188.5 and AC155837.7.
            
            On Jul 27, 2022 this sequence version replaced XM_006505715.4.
            
            Summary: This gene encodes a member of the neurotrophins that have
            a wide variety of functions in both neural and non-neural tissues.
            The encoded preproprotein undergoes proteolytic processing to
            generate a noncovalently linked homodimeric mature protein that can
            bind to the transmembrane receptor tyrosine kinases to initiate a
            series of signaling events. Mice lacking the encoded protein
            exhibit severe defects in the peripheral nervous system including a
            complete lack of spinal proprioceptive afferents and their
            peripheral sense organs. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.712380.1,
                                           SRR14995043.960651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC124188.5         186577-186781
            206-1317            AC155837.7         53874-54985
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 60.45 cM"
     gene            1..1317
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:18205"
                     /db_xref="MGI:MGI:97380"
     exon            1..205
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1003
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="isoform c precursor is encoded by transcript
                     variant 5; neurotrophic factor; nerve growth factor 2"
                     /codon_start=1
                     /product="neurotrophin-3 isoform c precursor"
                     /protein_id="NP_001397058.1"
                     /db_xref="GeneID:18205"
                     /db_xref="MGI:MGI:97380"
                     /translation="MWQPPSARIMMRQILQVNKVMSILFYVIFLAYLRGIQGNSMDQR
                     SLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPEQGEATRSEF
                     QPMIATDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGNPVVANRTSPRRKRY
                     AEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKE
                     ARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIG
                     RT"
     exon            206..1317
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="hexamer: AGTAAA"
     polyA_site      1317
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="major polyA site"
ORIGIN      
        1 aagccaaacc tccaaagtgc tgtgtggcag ggtgaagggg aaaactctgc agcctgatcg
       61 gatccggagg aagaagaaga tattttggca ggagggaagt ccttcaaagg gatcgttgga
      121 ggtgacgtcc ttggtgggcc tctgtgggtg ctgcaggcca ttttcgatgt ggcagccccc
      181 gtcagccagg ataatgatga ggcagatctt acaggtgaac aaggtgatgt ccatcttgtt
      241 ttatgtgata tttcttgctt atctccgtgg catccaaggc aacagcatgg atcaaaggag
      301 tttgccggaa gactctctca attccctcat catcaagctg atccaggcgg atatcttgaa
      361 aaacaagctt tccaaacaga tggtggatgt taaggaaaat taccagagca ccctgcccaa
      421 agcagaggca cccagggaac cagagcaggg agaggccacc aggtcagagt tccagccaat
      481 gattgcaacg gacacagagc tactacggca acagagacgc tacaattcgc cccgggtcct
      541 gctgagtgac agcacccctt tggagccccc tcccttatac ctaatggagg attatgtggg
      601 caacccggtg gtagccaata gaacctcacc acggaggaaa cgctatgcag aacataagag
      661 tcaccgagga gagtactcag tgtgtgacag tgagagcctg tgggtgaccg acaagtcctc
      721 agccattgac attcggggac accaggtcac agtgctgggg gagatcaaaa ccggtaactc
      781 tcctgtgaaa caatattttt atgaaacgag atgtaaagaa gccaggccgg tcaaaaacgg
      841 ttgcaggggg attgatgaca aacactggaa ctctcagtgc aaaacttcgc aaacctatgt
      901 ccgagcactg acttcagaaa acaacaaact cgtaggctgg cgctggatac gaatagacac
      961 ttcctgtgtg tgtgccttgt cgagaaaaat tggaagaaca tgaattggca tctgtcccca
     1021 catataaatt attactttaa attatatgat atgcatgtag catataaatg tttatattgt
     1081 ttttatatat tataagttga cctttattta ttaaacttca gcaaccctta cagtatataa
     1141 gcttttttct caataaaatt cgtgtgcttg ccttccctca ggcctttccc atctgttaac
     1201 cttgttttgt gattgggctc tcgggaaccc ttctgtaaaa cctgtgtaca ccagtatttg
     1261 gcattcagta ttgtcaaggc catgactgtg gtttcagtaa actttcttaa aatcgga
//
