LOCUS       NM_001164035            1339 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus neurotrophin 3 (Ntf3), transcript variant 2, mRNA.
ACCESSION   NM_001164035
VERSION     NM_001164035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Li,W., Lipsius,K., Burns,N.G., Sato,R., Rehman,A., Xue,H.,
            Combs,C., Minichiello,L., Gangrade,H., Tampakakis,E. and
            Mukouyama,Y.S.
  TITLE     Vascular smooth muscle cell-derived nerve growth factor regulates
            sympathetic collateral branching to innervate blood vessels in
            embryonic skin
  JOURNAL   Biol Open 13 (5) (2024)
   PUBMED   38639409
  REMARK    GeneRIF: Vascular smooth muscle cell-derived nerve growth factor
            regulates sympathetic collateral branching to innervate blood
            vessels in embryonic skin.
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Sharma,D., Feng,X., Wang,B., Yasin,B., Bekker,A., Hu,H. and
            Tao,Y.X.
  TITLE     NT-3 contributes to chemotherapy-induced neuropathic pain through
            TrkC-mediated CCL2 elevation in DRG neurons
  JOURNAL   EMBO Rep 25 (5), 2375-2390 (2024)
   PUBMED   38594391
  REMARK    GeneRIF: NT-3 contributes to chemotherapy-induced neuropathic pain
            through TrkC-mediated CCL2 elevation in DRG neurons.
REFERENCE   3  (bases 1 to 1339)
  AUTHORS   Tan,J.W., An,J.J., Deane,H., Xu,H., Liao,G.Y. and Xu,B.
  TITLE     Neurotrophin-3 from the dentate gyrus supports postsynaptic sites
            of mossy fiber-CA3 synapses and hippocampus-dependent cognitive
            functions
  JOURNAL   Mol Psychiatry 29 (4), 1192-1204 (2024)
   PUBMED   38212372
  REMARK    GeneRIF: Neurotrophin-3 from the dentate gyrus supports
            postsynaptic sites of mossy fiber-CA3 synapses and
            hippocampus-dependent cognitive functions.
REFERENCE   4  (bases 1 to 1339)
  AUTHORS   Trinh,V.Q., Lee,T.F., Lemoinne,S., Ray,K.C., Ybanez,M.D.,
            Tsuchida,T., Carter,J.K., Agudo,J., Brown,B.D., Akat,K.M.,
            Friedman,S.L. and Lee,Y.A.
  TITLE     Hepatic stellate cells maintain liver homeostasis through paracrine
            neurotrophin-3 signaling that induces hepatocyte proliferation
  JOURNAL   Sci Signal 16 (787), eadf6696 (2023)
   PUBMED   37253090
  REMARK    GeneRIF: Hepatic stellate cells maintain liver homeostasis through
            paracrine neurotrophin-3 signaling that induces hepatocyte
            proliferation.
REFERENCE   5  (bases 1 to 1339)
  AUTHORS   Cao,R., Chen,P., Wang,H., Jing,H., Zhang,H., Xing,G., Luo,B.,
            Pan,J., Yu,Z., Xiong,W.C. and Mei,L.
  TITLE     Intrafusal-fiber LRP4 for muscle spindle formation and maintenance
            in adult and aged animals
  JOURNAL   Nat Commun 14 (1), 744 (2023)
   PUBMED   36765071
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1339)
  AUTHORS   Leingartner,A. and Lindholm,D.
  TITLE     Two promoters direct transcription of the mouse NT-3 gene
  JOURNAL   Eur J Neurosci 6 (7), 1149-1159 (1994)
   PUBMED   7952296
REFERENCE   7  (bases 1 to 1339)
  AUTHORS   Ozcelik,T., Rosenthal,A. and Francke,U.
  TITLE     Chromosomal mapping of brain-derived neurotrophic factor and
            neurotrophin-3 genes in man and mouse
  JOURNAL   Genomics 10 (3), 569-575 (1991)
   PUBMED   1889807
REFERENCE   8  (bases 1 to 1339)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
REFERENCE   9  (bases 1 to 1339)
  AUTHORS   Maisonpierre,P.C., Belluscio,L., Friedman,B., Alderson,R.F.,
            Wiegand,S.J., Furth,M.E., Lindsay,R.M. and Yancopoulos,G.D.
  TITLE     NT-3, BDNF, and NGF in the developing rat nervous system: Parallel
            as well as reciprocal patterns of expression
  JOURNAL   Neuron 5 (4), 501-509 (1990)
   PUBMED   1688327
REFERENCE   10 (bases 1 to 1339)
  AUTHORS   Bothwell,M.A. and Shooter,E.M.
  TITLE     Dissociation equilibrium constant of beta nerve growth factor
  JOURNAL   J Biol Chem 252 (23), 8532-8536 (1977)
   PUBMED   925010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124188.5 and AC155837.7.
            
            On Jul 27, 2022 this sequence version replaced NM_001164035.1.
            
            Summary: This gene encodes a member of the neurotrophins that have
            a wide variety of functions in both neural and non-neural tissues.
            The encoded preproprotein undergoes proteolytic processing to
            generate a noncovalently linked homodimeric mature protein that can
            bind to the transmembrane receptor tyrosine kinases to initiate a
            series of signaling events. Mice lacking the encoded protein
            exhibit severe defects in the peripheral nervous system including a
            complete lack of spinal proprioceptive afferents and their
            peripheral sense organs. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065785.1, AK132586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC124188.5         188361-188587
            228-1339            AC155837.7         53874-54985
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 60.45 cM"
     gene            1..1339
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:18205"
                     /db_xref="MGI:MGI:97380"
     exon            1..227
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1025
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; neurotrophic factor; nerve growth factor 2"
                     /codon_start=1
                     /product="neurotrophin-3 isoform a precursor"
                     /protein_id="NP_001157507.1"
                     /db_xref="CCDS:CCDS51914.1"
                     /db_xref="GeneID:18205"
                     /db_xref="MGI:MGI:97380"
                     /translation="MVTSATILQVNKVMSILFYVIFLAYLRGIQGNSMDQRSLPEDSL
                     NSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPEQGEATRSEFQPMIATD
                     TELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGNPVVANRTSPRRKRYAEHKSHR
                     GEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNG
                     CRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT"
     exon            228..1339
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1318..1323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="hexamer: AGTAAA"
     polyA_site      1339
                     /gene="Ntf3"
                     /gene_synonym="HDNF; NGF-2; Nt3; Ntf-3"
                     /note="major polyA site"
ORIGIN      
        1 agagttgaag gctcctctcc ttacccagca gctccgcgca ccgccccgcg agatagcccg
       61 gcgcaacttt cttccctctt tctttcttcc cctcgttttt tcccaccgct gggtagtggc
      121 tgcggcaggg gtgggcgaga ctgaatgacc gaactcgagt ccacctttct cttcatgtcg
      181 acgtccctgg aaatagtcac acggatgcca tggttacttc tgccacgatc ttacaggtga
      241 acaaggtgat gtccatcttg ttttatgtga tatttcttgc ttatctccgt ggcatccaag
      301 gcaacagcat ggatcaaagg agtttgccgg aagactctct caattccctc atcatcaagc
      361 tgatccaggc ggatatcttg aaaaacaagc tttccaaaca gatggtggat gttaaggaaa
      421 attaccagag caccctgccc aaagcagagg cacccaggga accagagcag ggagaggcca
      481 ccaggtcaga gttccagcca atgattgcaa cggacacaga gctactacgg caacagagac
      541 gctacaattc gccccgggtc ctgctgagtg acagcacccc tttggagccc cctcccttat
      601 acctaatgga ggattatgtg ggcaacccgg tggtagccaa tagaacctca ccacggagga
      661 aacgctatgc agaacataag agtcaccgag gagagtactc agtgtgtgac agtgagagcc
      721 tgtgggtgac cgacaagtcc tcagccattg acattcgggg acaccaggtc acagtgctgg
      781 gggagatcaa aaccggtaac tctcctgtga aacaatattt ttatgaaacg agatgtaaag
      841 aagccaggcc ggtcaaaaac ggttgcaggg ggattgatga caaacactgg aactctcagt
      901 gcaaaacttc gcaaacctat gtccgagcac tgacttcaga aaacaacaaa ctcgtaggct
      961 ggcgctggat acgaatagac acttcctgtg tgtgtgcctt gtcgagaaaa attggaagaa
     1021 catgaattgg catctgtccc cacatataaa ttattacttt aaattatatg atatgcatgt
     1081 agcatataaa tgtttatatt gtttttatat attataagtt gacctttatt tattaaactt
     1141 cagcaaccct tacagtatat aagctttttt ctcaataaaa ttcgtgtgct tgccttccct
     1201 caggcctttc ccatctgtta accttgtttt gtgattgggc tctcgggaac ccttctgtaa
     1261 aacctgtgta caccagtatt tggcattcag tattgtcaag gccatgactg tggtttcagt
     1321 aaactttctt aaaatcgga
//
