LOCUS       NM_134029               1315 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus 5',3'-nucleotidase, mitochondrial (Nt5m), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_134029
VERSION     NM_134029.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1315)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   2  (bases 1 to 1315)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 1315)
  AUTHORS   Rampazzo,C., Kost-Alimova,M., Ruzzenente,B., Dumanski,J.P. and
            Bianchi,V.
  TITLE     Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA
            cloning of the mitochondrial enzyme, gene structures, chromosomal
            mapping and comparison with the human orthologs
  JOURNAL   Gene 294 (1-2), 109-117 (2002)
   PUBMED   12234672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068808.20.
            
            On Mar 18, 2023 this sequence version replaced NM_134029.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020084.1, AY061970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AC068808.20        106348-106656       c
            310-410             AC068808.20        101829-101929       c
            411-471             AC068808.20        93910-93970         c
            472-586             AC068808.20        80053-80167         c
            587-1315            AC068808.20        78187-78915         c
FEATURES             Location/Qualifiers
     source          1..1315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.8 cM"
     gene            1..1315
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /note="5',3'-nucleotidase, mitochondrial"
                     /db_xref="GeneID:103850"
                     /db_xref="MGI:MGI:1917127"
     exon            1..309
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..729
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /EC_number="3.1.3.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 5'(3')-deoxyribonucleotidase, mitochondrial;
                     deoxy-5'-nucleotidase 2"
                     /codon_start=1
                     /product="5'(3')-deoxyribonucleotidase, mitochondrial
                     isoform 1 precursor"
                     /protein_id="NP_598790.1"
                     /db_xref="CCDS:CCDS24779.1"
                     /db_xref="GeneID:103850"
                     /db_xref="MGI:MGI:1917127"
                     /translation="MHRLRGCCARPRGAPLRAERSRASSRALRVLVDMDGVLADFEGG
                     FLRKFRARFPDLPFVALEDRRGFWVSEQYGRLQPGLSEKAISIWESKDFFFELEPLPG
                     AVEAVKQMANLQNTDVFICTSPIKMFKYCPYEKYAWVEKHFGPDFLEQIVLTRDKTVI
                     SADLLIDDRPDITGAEPHPSWEHILFTSCHNYHLQLQPPRRRLHSWADDWKAILDSKR
                     LR"
     exon            310..410
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..471
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..586
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1315
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /note="hexamer: AATAAA"
     polyA_site      1315
                     /gene="Nt5m"
                     /gene_synonym="2010013E09Rik; dNT-2"
                     /note="major polyA site"
ORIGIN      
        1 agcctgcgcg tccgtgtccg cggtggaggc tgcgtctgcc gcgggccccg ggcgaggagc
       61 ggggcgatgc ataggctgcg cggctgctgt gcgcgtcccc gcggtgcccc gctacgggcc
      121 gagcggagcc gggcgagcag ccgcgccctg cgggtgctgg tggacatgga cggcgtgctg
      181 gcggactttg agggcggctt cctccggaag ttccgcgcgc gtttccccga cctgcccttc
      241 gtggcgctgg aggaccggcg cggcttctgg gtgtcggagc agtacggacg gctacagcct
      301 gggctaagcg agaaggcgat cagcatctgg gagtcaaagg atttcttctt tgaacttgag
      361 cctctccctg gagccgtgga agctgtgaag cagatggcca atctacagaa cactgatgtc
      421 ttcatctgta caagccccat caagatgttc aagtactgtc cctatgagaa gtatgcctgg
      481 gtggagaagc actttggccc tgactttctg gagcagattg tgttgaccag agacaagact
      541 gtgatctcag ccgaccttct catagatgac cggccagaca tcacaggggc tgagccacat
      601 cccagctggg agcacatcct ctttacctcc tgccacaact accacctgca gctgcagccc
      661 cctcgccgca ggctgcactc atgggcagac gactggaagg ccatcttgga cagcaagcgg
      721 ctccgctgag gactgtacta tggctctctc gtggttcagc atggggctca cagctcacaa
      781 ctggacagca ggcagcccac tgagggttat gctgcagttc cctggtactt cctggaggat
      841 cccagtgaac actttggtca aaacaacgtc tgacacactt cccttcttcc cctagcccag
      901 caaggcctta acctgatagt tgggacgggg ctagaagaaa gatgcgtgtt ctcagataag
      961 ttggtctgac ctcaggcaga tgccccatgc cactgcctct cactgtgtgc aataggggtt
     1021 ctctgagaca tggaagtacc ctgatccagg atctgcaaga cgaggggtgc cagggacaga
     1081 cagatgacaa cggttcccct ggcaggcatg taggtacctc tactgtagaa tcttgtccag
     1141 cttacatact tagtctttct ggatttccat ggccaccagg ctcttttgga ggccaccgag
     1201 accctcccta cggtctcttg ctctggtgtt cttagatccc attaacagcc cagaaaggag
     1261 tcagcaggtg tgaatatttg ttgccaatat gaaaaataaa tgctactcac acata
//
