LOCUS       NM_175331               5967 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 5'-nucleotidase domain containing 3 (Nt5dc3), mRNA.
ACCESSION   NM_175331
VERSION     NM_175331.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5967)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   3  (bases 1 to 5967)
  AUTHORS   van den Akker,E., Vankan-Berkhoudt,Y., Valk,P.J., Lowenberg,B. and
            Delwel,R.
  TITLE     The common viral insertion site Evi12 is located in the
            5'-noncoding region of Gnn, a novel gene with enhanced expression
            in two subclasses of human acute myeloid leukemia
  JOURNAL   J Virol 79 (9), 5249-5258 (2005)
   PUBMED   15827139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098720.1, AK147488.1 and CJ256052.1.
            
            On Aug 8, 2006 this sequence version replaced NM_175331.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147488.1, AK172248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CJ098720.1         2-33
            33-2787             AK147488.1         2-2756
            2788-5669           AK147488.1         2758-5639
            5670-5967           CJ256052.1         183-480
FEATURES             Location/Qualifiers
     source          1..5967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.11 cM"
     gene            1..5967
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /note="5'-nucleotidase domain containing 3"
                     /db_xref="GeneID:103466"
                     /db_xref="MGI:MGI:3513266"
     exon            1..307
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1746
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /EC_number="3.1.3.-"
                     /note="TU12B1-TY protein homolog"
                     /codon_start=1
                     /product="5'-nucleotidase domain-containing protein 3"
                     /protein_id="NP_780540.2"
                     /db_xref="CCDS:CCDS36020.1"
                     /db_xref="GeneID:103466"
                     /db_xref="MGI:MGI:3513266"
                     /translation="MATVAAAARGAGARAAAGLRSCGGAVARERPRSGCARRLCSAPA
                     APAAVDMKSYLWARYHEAKRSTDELVPSIMNNLLNPDAIFSNNEMSLSDIEIYGFDYD
                     YTLVFYSKHLHTLIFNAARDLLINEHRYPVEIRKYEYDPSFAIRGLHYDVQRAVLMKI
                     DAFHYIQMGTVYRGLSVVPDEEVIDMYEGSHVPLEQMSDFYGKSSHGNTMKQFMDIFS
                     LPEMTLLSCVNEHFLKNNIDYEPVHLYKDVKDSIRDVHIKGIMYRAIEADIEKYICYA
                     DQTRAVLAKLAAHGKKMFLITNSPSSFVDKGMRYIVGKDWRDLFDVVIVQAEKPNFFN
                     DKRRPFRKVNEKGVLLWDKIHKLQKGQIYKQGNLYEFLKLTGWRGSKVLYFGDHIYSD
                     LADLTLKHGWRTGAIIPELRSELRIMNTEQYIQTMTWLQTLTGLLEQMQVHRDAESQL
                     VLQEWKKERKEMREMTKSFFNAQFGSLFRTDQNPTYFLRRLSRFADIYMASLSCLLNY
                     DVHHTFYPRRTPLQHELPAWSDSPSAFKAPLLQEAQAK"
     exon            308..492
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            493..567
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            568..623
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            624..714
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            715..852
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            853..913
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1016
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1118
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1200
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1287
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1428
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1493
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..5952
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5926..5931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /note="hexamer: AATAAA"
     polyA_site      5949
                     /gene="Nt5dc3"
                     /gene_synonym="C630002B14Rik; TU12B1-TY"
                     /note="major polyA site"
ORIGIN      
        1 ggttcttggg ccgcgccggc acttgctcag acgtaggaac tgccggcgtg cgtcccggag
       61 cctcgcgacg ctggccatcc gtgccactgg cagcttagag gcagcatggc cacggtggca
      121 gcggcggccc gcggggccgg ggcgagggcg gcggcagggc tgcggagttg cggcggggcc
      181 gtggctcgag aacgaccgcg ctcgggctgc gctcggcgcc tgtgctctgc cccggctgcc
      241 ccggctgccg tggacatgaa aagctacctg tgggcgcgct accacgaggc gaagaggagc
      301 acggacgaat tggttccatc catcatgaac aacttgctga atccagacgc cattttctcg
      361 aacaatgaga tgagcctgtc agacatcgaa atatatggct ttgattatga ttacaccctg
      421 gtattctatt ccaagcacct ccacacactc atcttcaatg ctgcccggga ccttctcatc
      481 aacgaacaca ggtatcctgt ggaaatcagg aagtatgagt atgacccaag ctttgccatc
      541 cggggactcc attacgacgt ccagcgggca gtgttgatga agatcgatgc ttttcattac
      601 atccagatgg ggacagtgta cagaggcctc agtgttgtcc ctgatgaaga agtcatagac
      661 atgtatgagg ggtcccacgt gcccttggag cagatgagtg acttctatgg aaagagttct
      721 catgggaaca ccatgaagca gttcatggat atcttctcgc tgcccgagat gaccctgctg
      781 tcctgtgtga acgagcactt cctgaagaac aacattgact atgaacctgt gcacctgtac
      841 aaagacgtca aggactccat aagggatgtc cacatcaaag ggataatgta ccgagcaatc
      901 gaagcggata ttgaaaagta catctgttat gctgatcaga cccgtgcagt gttggctaaa
      961 ctggctgccc acggcaagaa gatgttcctc attaccaata gcccaagtag ctttgtagac
     1021 aaagggatgc ggtacatcgt ggggaaggac tggcgagacc tgttcgatgt ggtcatagtt
     1081 caggccgaga aacccaactt cttcaatgac aagcggaggc ctttccgaaa ggtgaatgag
     1141 aaaggtgtcc tactctggga taaaatccac aagctgcaga aaggccagat ttacaagcag
     1201 ggcaatttgt atgaattttt gaagctcact ggatggagag gatccaaagt actgtatttt
     1261 ggtgaccaca tctacagcga tctggcggat ctgaccctca agcacggctg gcgcactgga
     1321 gcgatcatcc ccgagctccg ttccgagctc aggatcatga acacggagca gtacatccag
     1381 accatgacct ggctgcagac cttgacgggg ctcctggagc agatgcaggt ccacagagac
     1441 gccgagtcac agctggtttt acaggagtgg aaaaaggaga ggaaggagat gagagaaatg
     1501 accaaaagtt tcttcaacgc ccagtttggg agcttgttcc gaacagacca gaatccaacc
     1561 tacttcctga ggcggctgtc gaggttcgct gacatctaca tggcgtctct gagctgcctt
     1621 ctgaactacg acgtccacca cacattctac cccaggagga ctcctctgca acatgagctc
     1681 cctgcatggt cggacagccc gtctgccttc aaagcccctt tgctgcagga ggctcaggcc
     1741 aagtagtcct gtgtttgcct gaggcaaaag ccagaagcat tcgtggcctc acagagggtc
     1801 aggcagcctc agagttgctt cccagagtca gatgcgcctt ttgtattttt tctatcttac
     1861 tatgaatact gtcctgtcca ggttgaggca ggagctggcc gcctggggcc tcccggccct
     1921 tctccacaca acagtgttga aaccctgatg agaccttgct tatagtggaa ccagcaacgt
     1981 gggcctcttg atgagtgaga cctcttgatg gcttctgaca agtgagacct cttgatggct
     2041 gcctgtgttc cgtaggtgga gagtggacac ttcttgattc tgtgagacat ttcttggttg
     2101 tttacaagca gcactgggga ccgcaagggc gtggtgatct gcagcacacc aggaagcagg
     2161 ttcctgaggg agcagcccta cctgtggcca gttcccccat ctcctggtcc taggctttca
     2221 aggacatttt cccataaaat tcacagcctc ctggaatgac tttgttgagg gaaaacagga
     2281 agcatttgtc acagtggctt tgtctgcccc aaaggggtga tgggtgggct ccctcctccc
     2341 taggaaaagt gggagaagac agccactcgc actaaaattg cctttcagcc agtgttttgg
     2401 acattataga agacaagaaa gactcagcct gtggccaggg ctagcctgtg tgttagacat
     2461 ccagcacaga cagctcgctg tgggaatgcc acatttcatg ctgagagcca agctggggaa
     2521 attgcttctg tccttccccc tctggaggga tgaatccttg attacatctg attgtagtag
     2581 ctttgaacac ttttgctgct taggcaccac aggactggct gctctgttat caacagttct
     2641 gtttaatggc gttttcgttg cagacgccac gttcattgca aatgccacga aagtgctcgt
     2701 ggccagatta gccttgtcac ctggcctgac tcattttgtg ctcttgtggc gctgctgctg
     2761 ctgcttctgc tccccccccc cccccccgag tccccccagg tagggtcttg ctttggagcc
     2821 tgggctggcc ttggactcaa tcctccggcc tcagcctcct gcaactgtgt gtgtgtgcat
     2881 gcatgcagaa gtgtaaagaa aggcaggacc atgacggaga cttgtggcga gcgcttgcgc
     2941 tctggcatct taacccgcaa tgagtagatc ttaaccagct gttgagggct gctcccttgg
     3001 ccggttgctg actgcctggc aatgtgcaga agctaacgga gctgtgcagc attcactgta
     3061 atgctgtgtg ttagcatggg atctttgatg ttggtagtgt ttaacattgt tgtcaaggtg
     3121 acccttcagt ctcccttccc ccttcttgtg ttctaaacac gggggttcag tattctgctc
     3181 ctttttagaa tgagatgggc atttttctgt tcctgtgttc ccgttcccca gtgttagcca
     3241 tcgggggttt tggcagctgc tcagtgtcag ggtcctaaaa ggatgcatgc tgcccggatg
     3301 ccctaagccc taacttgtgc ttgtaggagg aatctttggt cgaattgtct actcttctgg
     3361 tgtggacagt ttcgagggtt tatttactca agattgaggt agcgatgttt tcttatgcct
     3421 acagtaggcg acctgagcct tgggggagga agacatctcc tgggtttgag aagtgaatct
     3481 tacagcctat tcctgtctgg aggatcacag tcccgaggtc tccaagcgtg gcagtactgg
     3541 gatcagcgag gctgtcgcac cagacatgca aactgtgatc tggctgcatg gctggcacgg
     3601 catccctgca ggaagaatgg ggcgttttcc ctgttactgt cctcatctag tgtagccagg
     3661 acaagtttta gcttgtccct gggactcttg gctggggtct gacctgctgc gctgtggtat
     3721 tttcttcttt ctagagtatt ctagagtatt tctagagtat ttttgtacac gttgagggca
     3781 gtacaagggg aggtgggtct ttttttcacc tttaaaaaaa tcaaattgta ggccgggtgt
     3841 ggtggcgcac gcctttaatc ccagcactcg ggaggcagag gcaggcggat ttctgagttc
     3901 aaggccagcc tggtctacaa agtgagttcc aggatagcca gagctataca gagaaaccct
     3961 gtctcggaaa aaaaaaatca aactgtaaac cgaacagtaa aattattttt aatatcttta
     4021 atttgtaggg ttttgttttt ttgacattgc ttagactgat tttcttagaa tcatgtgaac
     4081 aacaattcag tctaagggca atctctgcca gtctgatgtc cagcaaggtc atggtgccat
     4141 caggggccac tggagtagtt tgcactgctt ggggtttctc agttggtttt tcaggggaga
     4201 gctggcttta aaaatatctc aggttctgag tatttaaagc tcttgatttt cctcctaaga
     4261 tagcacaccc tcccctcccc tcccctcccc tcttccttcc ccctcccctg tccattcctc
     4321 cccttctctc ctcctccctg tttctctcct ccttccccct cccttcctct cctctcctcc
     4381 tttggctgtc tacccatgtc tgtctctgtc gtgctcccca cttcaccatt agtacacctg
     4441 ctgctgattt ggtcagatcc cagactaaat tataggttgc tttgaacaca tcagccctct
     4501 catttattgc aatgagggag aagtgaaaag ctctcgtgcc atctacctaa tttagctttg
     4561 ggtgaactaa atggctttcc cctcccttcg gcaagtgcta aacactacag ttccacttta
     4621 tccaaatgct cacttgctgc caaaacccta cttgggggct cttgactaaa atgctcaaga
     4681 gactacattt ggccagctgc agagctcctt ggtggttttc ttcagctgct tagggagccg
     4741 atccattctt tccctcctga ggaccttctt ttgtttgtta gtttgggaca gggtctcagt
     4801 gtgtagctct ggctggtcta gaagttacta tgttgagtgg gttggcctca aacttataga
     4861 gatctgcttg cctctgcccc cacagtgtgt tgggataaga ggagcatacc acccggcctg
     4921 gcatgatttc ctttcattgg gtggattttt ttctctctcc tttatttcct tgttatttat
     4981 ttatttgtgg ttttggcctt aatatttgtg agctaggttc ttgagttcag ctaacatttt
     5041 agaccacgga ttggttaagc aaagggaagg aagaggaggg ggcccttttc taataaggga
     5101 accattttca gctttgcagg ccattctggt tgccgcttct gtaggaatag acacactgtt
     5161 ccattgggat ttgattcatc agcacagggt gtggcttgct gcctcaggct gggatggcaa
     5221 gattctctgc ttagagccag tggagcagcc ttccagtttg gatagttagt gtgaggtcta
     5281 agccagcgtg ctgtgtcccc ttagctgccc tgtctaccat gtgtatctgt ttctgcacgg
     5341 ccagcgctaa gctgagattg cttcactgtg tggatttaag ctacgagttg ttgccccttt
     5401 tcgttactct gctggaccca ggactgaagg ccggctcatc ccaggggctg gagtgtggcc
     5461 ggctgatggg tttctctgcc ttgccccaga tcacatgcct ttcctggggg tgtatattcc
     5521 atgactgttc cctgtgaagg gtcgagagcc tggtctctcc aacactactt tggggacagc
     5581 tccagagctc cctttggggc tcctaagacc ttcctgtgct tgccctgcaa caactggtct
     5641 tcccctccca ggtgtccatc ccagcagtgt ccctcagaag gccttcctgc atgacacttt
     5701 tgtctccagt ctgctcctcc aaaagtgccc ctgtattctc ctgttagcac aggctagagc
     5761 tccaatgtag gcccatttcc tcactgtttc gtgtcgtggg atgactgtgc ctgtgtggta
     5821 tcaggcacaa taaatacaaa gtaggtttac tatttattcg gaatgtgaat ttgctattta
     5881 ttctacgtgt tgattgtcta tgttgtgata atgaacttaa agccaaataa aagcttgagt
     5941 tgtatctcct ggaaaaaaaa aaaaaaa
//
