LOCUS       NM_001374087            1812 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus 5'-nucleotidase domain containing 2 (Nt5dc2),
            transcript variant 1, mRNA.
ACCESSION   NM_001374087 XM_006519507
VERSION     NM_001374087.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Sang,R., Yu,X., Xia,H., Qian,X., Yong,J., Xu,Y., Sun,Y., Yao,Y.,
            Zhou,J. and Zhuo,S.
  TITLE     NT5DC2 knockdown suppresses progression, glycolysis, and
            neuropathic pain in triple-negative breast cancer by blocking the
            EGFR pathway
  JOURNAL   Mol Carcinog 63 (4), 785-796 (2024)
   PUBMED   38289126
  REMARK    GeneRIF: NT5DC2 knockdown suppresses progression, glycolysis, and
            neuropathic pain in triple-negative breast cancer by blocking the
            EGFR pathway.
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Choquet,H., Melles,R.B., Anand,D., Yin,J., Cuellar-Partida,G.,
            Wang,W., Hoffmann,T.J., Nair,K.S., Hysi,P.G., Lachke,S.A. and
            Jorgenson,E.
  CONSRTM   23andMe Research Team
  TITLE     A large multiethnic GWAS meta-analysis of cataract identifies new
            risk loci and sex-specific effects
  JOURNAL   Nat Commun 12 (1), 3595 (2021)
   PUBMED   34127677
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Kagami,Y. and Furuichi,T.
  TITLE     Investigation of differentially expressed genes during the
            development of mouse cerebellum
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 39-59 (2001)
   PUBMED   15018818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154446.2.
            
            On Sep 10, 2019 this sequence version replaced XM_006519507.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927937.2472321.1,
                                           SRR11927934.2223076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AC154446.2         95882-96169
            289-473             AC154446.2         99532-99716
            474-548             AC154446.2         99823-99897
            549-604             AC154446.2         100131-100186
            605-698             AC154446.2         100287-100380
            699-827             AC154446.2         100479-100607
            828-888             AC154446.2         100711-100771
            889-991             AC154446.2         100858-100960
            992-1093            AC154446.2         101061-101162
            1094-1175           AC154446.2         101389-101470
            1176-1262           AC154446.2         102917-103003
            1263-1403           AC154446.2         103125-103265
            1404-1468           AC154446.2         103402-103466
            1469-1812           AC154446.2         103574-103917
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..1812
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /note="5'-nucleotidase domain containing 2"
                     /db_xref="GeneID:70021"
                     /db_xref="MGI:MGI:1917271"
     exon            1..288
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1730
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /EC_number="3.1.3.5"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="5'-nucleotidase domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_001361016.1"
                     /db_xref="CCDS:CCDS88613.1"
                     /db_xref="GeneID:70021"
                     /db_xref="MGI:MGI:1917271"
                     /translation="MAGAGLRATARRLLLCRGHSGPRAASSSPSCPGCGPPGPGAHCP
                     STPRSAPADGADLSAHLWARYQDMRRLVHDLLPPEVCSLLNPAAIYANNEISLSDVEV
                     YGFDYDYTLAQYADALHPEIFNAARDILIEHYKYPEGIRKYDYDPSFAIRGLHYDIQK
                     SLLMKIDAFHYVQLGTAYRGLKPVPDDEVIDLYGGTQHIPLYQMSGFYGKGPSIKQFM
                     DIFSLPEMALLSCVVDYFLGHGLEFDQVHLYKDVTDAIRDVHVKGLMYQWIEQDMEKY
                     ILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADKP
                     NFFTDRRKPFRKLDEKGSLHWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDH
                     LYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDA
                     ESRQVLATWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSC
                     LLNYRVDFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLGDMAHIR"
     exon            289..473
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            474..548
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            549..604
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            605..698
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..827
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            828..888
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            889..991
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1093
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1175
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1262
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1403
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1468
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1812
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1786..1791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1812
                     /gene="Nt5dc2"
                     /gene_synonym="2510015F01Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcggagag cggcgggcag gcgggccagc ggacgggcgg agggcggccg gggcagcgcg
       61 cagggggcat ggcgggtgcc ggactgcggg cgacagctag gcgcttgctg ctgtgcagag
      121 gccacagcgg accgcgggcc gcctcgtcct caccctcctg ccctggctgc ggcccgccgg
      181 gtcccggagc ccactgcccc agcaccccgc gctcggcgcc cgcagacggc gcggacctca
      241 gcgcgcactt atgggctcgt taccaggaca tgcggaggct ggtgcacgac cttctgcccc
      301 ctgaggtctg cagcctccta aacccagcag ctatttatgc caacaatgag atcagcctga
      361 gtgacgtcga agtctatggc tttgactacg actacacgct ggcccagtat gcggatgcac
      421 tgcaccctga gatcttcaat gctgcccggg acatcttgat agagcactac aagtatcctg
      481 aggggatccg gaagtatgac tatgacccca gctttgccat ccgtggcctg cactacgaca
      541 ttcagaagag ccttctgatg aaaattgacg cttttcacta tgtacaactg ggaacggcct
      601 acaggggcct caagcctgtg ccggacgatg aagtgatcga cctgtacggc ggcacccagc
      661 acatcccact ctaccagatg agcggcttct atggcaaggg cccatctatc aagcagttca
      721 tggacatctt ctcgctccca gagatggctc tgctgtcctg tgtggtggac tactttctgg
      781 gccacggcct ggagtttgac caagtacatc tctacaagga tgtgacggat gctatccgcg
      841 atgtgcatgt aaagggcctc atgtaccagt ggatcgagca agacatggag aagtacatcc
      901 tgagaggaga tgagacattt gcggtgctga gccgcctggt ggcccatggg aaacagctgt
      961 tcctcattac caacagtccc ttcagctttg tggacaaagg tatgcggcac atggtaggtc
     1021 ccgattggcg ccaactcttc gacgtcgtca tcgtccaggc agacaagccc aactttttca
     1081 ccgacaggcg caagcctttt cgcaagcttg acgagaaggg ctccctccac tgggaccgta
     1141 tcactcgcct agagaagggc aagatctatc ggcagggaaa cctgtttgat tttcttcgtc
     1201 tgacggaatg gcgagggccg cgtgtgctct acttcggtga ccacctttac agtgacctgg
     1261 cggatctcat gctgcggcac ggctggcgca cgggagccat catccctgag ctggagcgcg
     1321 agatccgcat catcaacacg gagcagtaca tgcactcgct gacctggcag caggctctca
     1381 ctgggctgct ggagcgcatg cagacctatc aggatgcaga gtcacggcag gtgctggcta
     1441 cctggatgaa ggagcggcaa gaactgagat gcatcacaaa ggccctattc aacgcccagt
     1501 tcgggagcat cttccgcacc ttccacaacc ctacctactt ctcccggcgc ctcgtgcgct
     1561 tctccgacct ctacatggcc tcactcagct gcctgctcaa ctaccgcgta gacttcacct
     1621 tctacccgcg ccgcacaccc ctgcagcacg aggcacccct ctggatggac cagctgtgca
     1681 ctggctgcat gaagacaccc tttcttggtg acatggccca catccgctga gggcactttt
     1741 attgtcctgg acagaccatt ggccccctca gccaccctga caagcaataa aaatggtctg
     1801 tgtcttctca ga
//
