LOCUS       NM_176968               2780 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 5'-nucleotidase domain containing 1 (Nt5dc1),
            transcript variant 1, mRNA.
ACCESSION   NM_176968
VERSION     NM_176968.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2780)
  AUTHORS   Bitto,E., Bingman,C.A., Wesenberg,G.E., McCoy,J.G. and
            Phillips,G.N. Jr.
  TITLE     Structure of pyrimidine 5'-nucleotidase type 1. Insight into
            mechanism of action and inhibition during lead poisoning
  JOURNAL   J Biol Chem 281 (29), 20521-20529 (2006)
   PUBMED   16672222
  REMARK    GeneRIF: Inhibited by lead which binds at the active site and my
            inhibit lead poisoning.
REFERENCE   3  (bases 1 to 2780)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618670.1, AK145666.1 and BC098476.1.
            
            On Nov 29, 2016 this sequence version replaced NM_176968.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145666.1, AK077876.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164134,
                                           SAMN01164143 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB618670.1         3-25
            24-2739             AK145666.1         2-2717
            2740-2780           BC098476.1         2677-2717
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.85 cM"
     gene            1..2780
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /note="5'-nucleotidase domain containing 1"
                     /db_xref="GeneID:319638"
                     /db_xref="MGI:MGI:2442446"
     exon            1..191
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..283
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..355
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..492
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..572
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..657
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..832
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..930
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1049
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1202
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1371
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..2742
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="Nt5dc1"
                     /gene_synonym="6030401B09Rik; Nt5c2l1"
                     /note="major polyA site"
ORIGIN      
        1 gctccgcgtc ctgcctgcga gttacgcttg tagagtcccg gcaacttctc gcatgctcta
       61 ccggccttcc ggtctgcgtt acccgccgct gccctgccat ggctcagcac ttctccctgg
      121 gcgcctgcga cgtggtcggc ttcgatctcg accacacgct gtgccgctac aacctgcccg
      181 agagcgcccg gctcatttat aacagctttg ctcagttctt agtcaaggag aaaggatatg
      241 atgaggggct gctcactctg actccagagg actgggattt ctgttgcaag ggtttggcat
      301 tggatctgga agatgggacc ttcattaaac ttgcagctga tggcactgtg ctcagggcaa
      361 gccacggcac caagatgatg actccagagg cactgactga agcctttggc aagaaggagt
      421 ggaggcactg tgtgtcagac aaacgctgta catcagacaa gcccggtgtg tccgacattc
      481 cttgctgctc aggaaagtgt tatttctatg ataactactt tgacctgccg ggggctcttc
      541 tgtgtgccag agtggtggac tctttaacaa agcagaacag aggtcaaaaa acatttgatt
      601 tttggaagga tgtagttgct ggtatacaac acaattttaa aatgtcagcc tttaaggaaa
      661 attgtggatt cttctttccg gaaataaaaa gaaatctagg caaatatgtg caccgctgtc
      721 ctgagtctgt aagaaagtgg cttcgacagc tgaaggacgc tgggaaaatt actatgttga
      781 taactagttc tcacagtgat tactgtaaac ttcttggcag ttacatcctt ggggaggatt
      841 ttgcagacct ttttgacatt gtgattacaa acgcattaaa gcctggattc ttctcacatt
      901 tcccaagcca gaggcctttc tacacactcg agaatgatga agagaaggat gagctgccgt
      961 ctctggataa accgggctgg tactcccaag ggaacgctgc ccacctttat gagcttctga
     1021 agaaaatgac cagcaagcct gaacccaagg tcgtttactt tggtgacagc atgcattcag
     1081 acattttccc agcccatcac tatactaact gggagactgt ccttattctc gaggagcttc
     1141 aggggccaga aatggaaaag cctgaggaag cagagcctct ggagaaaaga ggaaaatatg
     1201 aggcaccaat ggtaaagcct ctaaacacct tgtctaataa gtggggctca tactttattg
     1261 actcagtctc cggacggggg agggcagaag actctgtggt ttatacatgg tcctctaaga
     1321 gaatcagcac ctacagtacg attgcaattc caaacattga atctattgca gagttacccc
     1381 tggactacaa atttacaaga ttttctacaa acaattcaaa aatggctggt tactatccct
     1441 tggtccatca taccttgggt tctcaagaca cagacagcaa aataatatct actgaaaaat
     1501 gaaccaacct atgttcagta gacatactgt ttaaaaaatg ttagttttcc acaacaatgc
     1561 aaatgttttg taagaacaat ttttcaatga aaattgacca aatggacact tgtcagtctg
     1621 tctttttaaa atataagtaa ttttatataa atccttttaa tgtttaacag ttcttattat
     1681 attaatattt ttagtaccct agactaaaag agaacatgac tgatcttttc tatgctggcc
     1741 gttttgagga ttcttccaag gtgatagaca aatacatgca tctacctggt ccagcagttt
     1801 ccaagcctgt ccacagtcta atagcagagc agcatagaac ttgaaaatgc aaatctgagt
     1861 gcttcctccc aaacctacga aatcagaaac tttgggagtg gggccagcaa tggcttttaa
     1921 gcaaacttcc agtaaatcga atgctctatt atgatttgag acctagtaag taaaccctgt
     1981 tctgagtatt catactttta attgaaagtg taatctgaat tgataacacc aaagtctagg
     2041 ttattgttcc aggctattag gctttttgct atttcttttt tcccccaaaa tacataaaga
     2101 gacatgattt gttaagataa tattacctcg ttccttagta ttaatttctc acattaggaa
     2161 gagttaaatt tatacctatt aaattcagct ttgtccttgg aaagggagct ggaagacaca
     2221 gttgcttagg tacacttcag gttaggatat gttgtgctct gtgtggtttt gataagttaa
     2281 catgtgcatc agatcatgta tatataagat attcagattc agttgatgtt ttataagttc
     2341 ctgggtcctc ttttgcctgt taacttcact gtacataaat ggatgggatt agaaaatatt
     2401 atcattattt ttgtcttgga atttagcata ttaacatgtg cactgaaaat tttattttct
     2461 taaaatttcc aaatattcag ataaatccta actgtactat gaagatgtgt ttctcagggt
     2521 aattaaaaag gaaacagaac ttatttcttt actatcagta tatttgatat tgatcaataa
     2581 gaatacatat acagagatat atttgatatc caaaatgtca ttagagtatt ataatgagcg
     2641 catgcaatca agcctagggc caaataaatg ctcttatcta tctattatgt gctttaagta
     2701 gagaattcac tttgctttaa aataaagcta tttttcctta taaaaaaaaa aaaaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa
//
