LOCUS       NM_026004               1687 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 5'-nucleotidase, cytosolic III (Nt5c3), transcript
            variant 1, mRNA.
ACCESSION   NM_026004
VERSION     NM_026004.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Ipata,P.L. and Balestri,F.
  TITLE     The functional logic of cytosolic 5'-nucleotidases
  JOURNAL   Curr Med Chem 20 (34), 4205-4216 (2013)
   PUBMED   23992316
  REMARK    Review article
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Magni,G., Amici,A. and Orsomando,G.
  TITLE     The enzymology of cytosolic pyrimidine 5'-nucleotidases: functional
            analysis and physiopathological implications
  JOURNAL   Curr Med Chem 20 (34), 4304-4316 (2013)
   PUBMED   23992312
  REMARK    Review article
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Grobosky,C.L., Lopez,J.B., Rennie,S., Skopelitis,D.J., Wiest,A.T.,
            Bingman,C.A. and Bitto,E.
  TITLE     Structural basis of substrate specificity and selectivity of murine
            cytosolic 5'-nucleotidase III
  JOURNAL   J Mol Biol 423 (4), 540-554 (2012)
   PUBMED   22925580
  REMARK    GeneRIF: report describes the first X-ray structure of a
            catalytically inactivated variant of murine cN-III with a natural
            substrate, uridine 5'-monophosphate, in the active site at 1.74A
            resolution
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Lu,M.M., Chen,F., Gitler,A., Li,J., Jin,F., Ma,X.K. and
            Epstein,J.A.
  TITLE     Cloning and expression analysis of murine lupin, a member of a
            novel gene family that is conserved through evolution and
            associated with Lupus inclusions
  JOURNAL   Dev Genes Evol 210 (10), 512-517 (2000)
   PUBMED   11180800
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Rich,S.A., Bose,M., Tempst,P. and Rudofsky,U.H.
  TITLE     Purification, microsequencing, and immunolocalization of p36, a new
            interferon-alpha-induced protein that is associated with human
            lupus inclusions
  JOURNAL   J Biol Chem 271 (2), 1118-1126 (1996)
   PUBMED   8557639
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Swallow,D.M., Turner,V.S. and Hopkinson,D.A.
  TITLE     Isozymes of rodent 5'-nucleotidase: evidence for two independent
            structural loci Umph-1 and Umph-2
  JOURNAL   Ann Hum Genet 47 (1), 9-17 (1983)
   PUBMED   6301357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY261587.1, AK011525.1, AK011894.1 and BX527194.1.
            
            On Apr 4, 2008 this sequence version replaced NM_026004.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.117843.1, AK011894.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY261587.1         2-51
            51-653              AK011525.1         2-604
            654-816             AK011894.1         552-714
            817-1573            AK011525.1         768-1524
            1574-1687           BX527194.1         361-474
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.75 cM"
     gene            1..1687
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /note="5'-nucleotidase, cytosolic III"
                     /db_xref="GeneID:107569"
                     /db_xref="MGI:MGI:1927186"
     exon            1..261
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1119
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /EC_number="3.1.3.5"
                     /EC_number="3.1.3.91"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic 5'-nucleotidase 3; pyrimidine 5'-nucleotidase 1;
                     cytosolic 5'-nucleotidase III; 5'-nucleotidase,
                     pyrimidine; uridine monophosphatase 1; cytosolic
                     5'-nucleotidase 3A; 7-methylguanosine nucleotidase;
                     7-methylguanosine phosphate-specific 5'-nucleotidase"
                     /codon_start=1
                     /product="cytosolic 5'-nucleotidase 3A isoform 1"
                     /protein_id="NP_080280.3"
                     /db_xref="CCDS:CCDS20171.1"
                     /db_xref="GeneID:107569"
                     /db_xref="MGI:MGI:1927186"
                     /translation="MDRAAVARVGAVASASVCAVVAGVVLAQYIFTLKRKTGRKTKII
                     EMMPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYNGKRCPTCH
                     NIIDNCKLVTDECRRKLLQLKEQYYAIEVDPVLTVEEKFPYMVEWYTKSHGLLIEQGI
                     PKAKLKEIVADSDVMLKEGYENFFGKLQQHGIPVFIFSAGIGDVLEEVIRQAGVYHSN
                     VKVVSNFMDFDENGVLKGFKGELIHVFNKHDGALKNTDYFSQLKDNSNIILLGDSQGD
                     LRMADGVANVEHILKIGYLNDRVDELLEKYMDSYDIVLVKEESLEVVNSILQKTL"
     exon            262..360
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..430
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..477
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..563
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..653
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..816
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1017
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1676
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /note="hexamer: ATTAAA"
     polyA_site      1350
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /note="major polyA site"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /note="hexamer: AATACA"
     polyA_site      1578
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /note="hexamer: AAGAAA"
     polyA_site      1676
                     /gene="Nt5c3"
                     /gene_synonym="1600024P05Rik; 2610206B05Rik;
                     3110004A18Rik; cN-III; lupin; Nt5c3a; Nt5y; p36; P5'N-1;
                     P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcctcct cggtttcccc cgcgcggggc ggggctccgg ggaagtgtgc ggcttgcggc
       61 cgcgcccctg ggctcgtacc cgcggatccc gggcttccgc gccgagagca cgcgggcctg
      121 tcaatggacc gcgcggccgt ggcgcgagtg ggcgcggtgg cgagcgccag tgtgtgcgcg
      181 gtggtagcag gcgtggtgct ggcccagtac atattcacct tgaagagaaa aacgggccgc
      241 aagaccaaga tcatcgaaat gatgccagaa tttcagaaaa gctcagttcg tatcaagaac
      301 cctacaagag tagaagaaat tatctgtggt ctcattaaag gaggcgctgc caaacttcag
      361 ataataacag actttgacat gactctaagt aggttttcct acaatgggaa aagatgccca
      421 acgtgtcata atatcattga caactgtaag cttgttacag atgaatgtcg aagaaagtta
      481 ctgcagctaa aggagcagta ttatgctatt gaagttgatc ctgttctcac cgtggaagag
      541 aagttccctt acatggtaga gtggtatacc aaatctcacg gtttgcttat tgaacaaggc
      601 ataccaaaag ccaaacttaa agagattgtg gctgactctg acgttatgct caaggaagga
      661 tatgagaatt tcttcggtaa acttcaacag cacggtatcc ctgtgttcat attttctgct
      721 ggtattggtg atgtacttga agaagttatc cggcaggctg gagtttatca ctcaaacgtc
      781 aaagtagtgt caaacttcat ggattttgat gaaaatggag tgctgaaagg attcaaagga
      841 gagttaatcc acgtgttcaa caaacacgat ggtgccctga agaatacaga ctacttcagc
      901 cagctgaaag acaacagcaa catcattctg ctcggggact cccaaggaga cctaagaatg
      961 gccgatggcg tagccaatgt tgaacacatt ctgaaaattg gttatctgaa tgacagagta
     1021 gacgagcttt tagaaaaata catggactct tatgatattg ttttagtaaa agaagaatca
     1081 ttggaggttg tcaactcaat tttacagaag acattataaa caagccatcg tgagaagact
     1141 tcccccaggg gtacacctgg gtcaggcact gtccattttg aggaaagact ctttcttatt
     1201 tataaaacag tcttgctcct ggaacttttc ccttttccca acagacgatc ttcagacgtg
     1261 tggaacctgt gaaccacggc ccctcttccc acctccgtca ctatactcag cagaattttt
     1321 aagtcattaa aaattatctt aaagccaaaa ttagaaagat ggctcccttt tccaaagtga
     1381 gttttgtagt ttggtgttct gcagtttcta gggcattctc ccaggtgggt gtataagggc
     1441 gcagaagacg ctctctggat gtattatgtt cctgatttta accactgcta gctttgaaat
     1501 tggggtggag tatggagaca tcatcttctg aaattgtttt atttgtttat tttgtctata
     1561 aaatacattt gccaggaagt tgtgtcttaa aaactgttgg tgtccgcatc gctaacattg
     1621 caaatactct gtgtgaagca ctgagaataa accagaaaaa gaaagctttt ctaaaaaaaa
     1681 aaaaaaa
//
