LOCUS       NM_029810               5167 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus 5'-nucleotidase, cytosolic II (Nt5c2), transcript
            variant 3, mRNA.
ACCESSION   NM_029810
VERSION     NM_029810.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5167)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5167)
  AUTHORS   Tzoneva,G., Dieck,C.L., Oshima,K., Ambesi-Impiombato,A.,
            Sanchez-Martin,M., Madubata,C.J., Khiabanian,H., Yu,J.,
            Waanders,E., Iacobucci,I., Sulis,M.L., Kato,M., Koh,K., Paganin,M.,
            Basso,G., Gastier-Foster,J.M., Loh,M.L., Kirschner-Schwabe,R.,
            Mullighan,C.G., Rabadan,R. and Ferrando,A.A.
  TITLE     Clonal evolution mechanisms in NT5C2 mutant-relapsed acute
            lymphoblastic leukaemia
  JOURNAL   Nature 553 (7689), 511-514 (2018)
   PUBMED   29342136
REFERENCE   3  (bases 1 to 5167)
  AUTHORS   Kviklyte,S., Vertommen,D., Yerna,X., Andersen,H., Xu,X., Gailly,P.,
            Bohlooly-Y,M., Oscarsson,J. and Rider,M.H.
  TITLE     Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and
            NT5C2 on AMPK activation and nucleotide levels in contracting mouse
            skeletal muscles
  JOURNAL   Am J Physiol Endocrinol Metab 313 (1), E48-E62 (2017)
   PUBMED   28325731
  REMARK    GeneRIF: The results on muscles from the NT5C knockout mice
            contradict previous findings where AMP levels and AMPK activity
            were shown to be modulated by NT5C enzymes.
REFERENCE   4  (bases 1 to 5167)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (bases 1 to 5167)
  AUTHORS   Kulkarni,S.S., Karlsson,H.K., Szekeres,F., Chibalin,A.V., Krook,A.
            and Zierath,J.R.
  TITLE     Suppression of 5'-nucleotidase enzymes promotes AMP-activated
            protein kinase (AMPK) phosphorylation and metabolism in human and
            mouse skeletal muscle
  JOURNAL   J Biol Chem 286 (40), 34567-34574 (2011)
   PUBMED   21873433
REFERENCE   6  (bases 1 to 5167)
  AUTHORS   Sala-Newby,G.B. and Newby,A.C.
  TITLE     Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new
            gene related to human autoimmune infertility-related protein
  JOURNAL   Biochim Biophys Acta 1521 (1-3), 12-18 (2001)
   PUBMED   11690631
REFERENCE   7  (bases 1 to 5167)
  AUTHORS   Allegrini,S., Pesi,R., Tozzi,M.G., Fiol,C.J., Johnson,R.B. and
            Eriksson,S.
  TITLE     Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and
            expression of active enzyme in Escherichia coli
  JOURNAL   Biochem J 328 (Pt 2) (Pt 2), 483-487 (1997)
   PUBMED   9371705
REFERENCE   8  (bases 1 to 5167)
  AUTHORS   Magnusson,G.
  TITLE     Deoxyribonucleotide phosphatase from rat liver and cultured mouse
            fibroblasts
  JOURNAL   Eur J Biochem 20 (2), 225-230 (1971)
   PUBMED   5560407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108814.22 and AC122442.4.
            
            On Dec 12, 2019 this sequence version replaced NM_029810.4.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (3) is shorter than isoform 1. Variants 3 and 5-7 all encode the
            same isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132384.1, AK147901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC108814.22        96559-96595
            38-157              AC108814.22        107902-108021
            158-231             AC108814.22        134532-134605
            232-349             AC108814.22        153775-153892
            350-445             AC108814.22        154894-154989
            446-537             AC122442.4         177030-177121       c
            538-595             AC122442.4         176849-176906       c
            596-689             AC122442.4         175803-175896       c
            690-743             AC122442.4         174735-174788       c
            744-827             AC122442.4         172748-172831       c
            828-869             AC122442.4         171746-171787       c
            870-977             AC122442.4         170732-170839       c
            978-1044            AC122442.4         170462-170528       c
            1045-1215           AC122442.4         169736-169906       c
            1216-1267           AC122442.4         168473-168524       c
            1268-1328           AC122442.4         168296-168356       c
            1329-1505           AC122442.4         167997-168173       c
            1506-5167           AC122442.4         163617-167278       c
FEATURES             Location/Qualifiers
     source          1..5167
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.97 cM"
     gene            1..5167
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="5'-nucleotidase, cytosolic II"
                     /db_xref="GeneID:76952"
                     /db_xref="MGI:MGI:2178563"
     exon            1..37
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            38..157
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1739
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /EC_number="3.1.3.5"
                     /EC_number="3.1.3.99"
                     /EC_number="2.7.1.77"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cytosolic purine 5'-nucleotidase; cytosolic
                     5'-nucleotidase II; cytosolic nucleoside
                     phosphotransferase 5'N"
                     /codon_start=1
                     /product="cytosolic purine 5'-nucleotidase isoform 3"
                     /protein_id="NP_084086.3"
                     /db_xref="CCDS:CCDS29883.1"
                     /db_xref="GeneID:76952"
                     /db_xref="MGI:MGI:2178563"
                     /translation="MTTSWSDRLQNAADVPANMDKHALKKYRREAYHRVFVNRSLAME
                     KIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVF
                     DTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLP
                     ETYLLACLVDFFTNCPRYTSCDTGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKT
                     VENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSH
                     RPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDT
                     ICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEEL
                     QSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLF
                     ASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRN
                     RTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEE"
     exon            158..231
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            232..349
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            350..445
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            446..537
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            538..595
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..689
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            690..743
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            744..827
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            828..869
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            870..977
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1044
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1215
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1267
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1328
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1505
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..5167
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1880..1885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="hexamer: AATAAT"
     polyA_site      1899
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="major polyA site"
     polyA_site      1987
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="major polyA site"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="hexamer: AATACA"
     polyA_site      2205
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="hexamer: AGTAAA"
     polyA_site      2731
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="major polyA site"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="hexamer: AATACA"
     polyA_site      2840
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
     polyA_site      2884
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="hexamer: AGTAAA"
     polyA_site      3728
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
     regulatory      5143..5148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
                     /note="hexamer: AATAAA"
     polyA_site      5167
                     /gene="Nt5c2"
                     /gene_synonym="2010002I23Rik; cN-II; CnII; Gm9751; Gmp;
                     Nt5b; Pnt5"
ORIGIN      
        1 agttgcgcgc taggattgct gccgtgcggt gcggccgaat tcatcctaca aataagatga
       61 cgacctcctg gagtgaccgc ttacagaatg cagcagatgt gcctgctaac atggataagc
      121 atgccttgaa aaagtaccgt cgagaagcct atcaccgggt gtttgtgaac cgaagtttag
      181 ccatggaaaa aataaagtgt tttggttttg atatggatta taccctagcc gtgtacaagt
      241 ctccagaata tgaatccctt ggctttgagc ttactgtgga gagattagtt tccattggct
      301 atcctcagga gctgctcagc tttgcatatg attctacatt ccctaccaga ggacttgtct
      361 ttgacacgct ctatggaaat cttttgaaag tcgatgccta tggaaacctc ttggtgtgtg
      421 cacatggatt taacttcata agaggaccag aaactagaga gcagtatcca aataaattta
      481 tccaacgaga tgacactgaa cggttttaca ttctgaacac actattcaat ctcccagaga
      541 cctacctgtt ggcctgcctc gtagattttt ttactaattg tcccagatac accagttgtg
      601 acacaggatt taaagatggg gacctcttca tgtcctaccg tagcatgttc caggacgtaa
      661 gagacgcagt ggactgggtc cattacaagg gctcccttaa ggagaagacg gttgaaaatc
      721 ttgagaagta tgtcgtcaag gatggcaagt tgccgttgct tctgagccga atgaaggaag
      781 tagggaaagt gtttctggct actaacagtg actataagta cacagataaa atcatgactt
      841 acctgtttga tttcccgcat ggccccaagc ccgggagctc ccaccggccg tggcagtcct
      901 actttgacct gattttggtg gatgctcgga aaccactctt ttttggagaa ggcacagtgc
      961 tgcgtcaggt ggacactaaa actggaaaac tgaaaattgg cacctacacg ggccccctgc
     1021 agcacggcat tgtctactca gggggttcat ctgatacaat ctgtgacctg ttgggagcta
     1081 agggcaaaga cattttgtat attggagatc acatttttgg agacattctg aagtcaaaga
     1141 aacggcaagg gtggaggact ttcttggtga ttcctgagct tgcgcaggag ctccacgtct
     1201 ggacggacaa gagttcactc tttgaagaac ttcaaagctt ggatattttc ttggctgaac
     1261 tctacaagca cctggacagc agtagcaatg agcgcccgga cattagttcc atccagagac
     1321 ggattaagaa agtaactcat gacatggaca tgtgctatgg gatgatggga agcctgttcc
     1381 gcagcggctc ccggcagaca ctctttgcca gccaagtgat gcgctatgca gatctctatg
     1441 cggcctcgtt catcaacctg ctgtactacc cattcagcta cctcttcaga gctgcccatg
     1501 tcctgatgcc gcacgagtca acggtggaac acacgcatgt ggatatcaat gagatggagt
     1561 cccctctcgc cacccggaac cgcacgtcag tggatttcaa agacactgac tataagcgac
     1621 accagcttac aaggtccatt agtgagatca agccccccaa cctcttcccg ctggcccccc
     1681 aggagatcac acactgccat gatgaagatg atgatgaaga ggaagaagag gaagaatagg
     1741 aaggcagact agaaaccgga gcacccatca agtctgtcag actcacgggg tgaggggtgg
     1801 cctgtttgga ttctgttagg gagggtggga ggactccatc agaagtcctg gaaagtttgg
     1861 aaagtttctc aaggctttaa ataattctaa tcatagctac ttcagttttg tgtatctgtt
     1921 ctctgcagat ggtttgaaac tgtataggaa gaacaggtaa aggcaggtgg agtgcacaca
     1981 gatcgcacca catggcttgt aatgattttc tgtgtctgtc atcgtcagcg tgtcatctgg
     2041 atgtacgaag gtagtaaaaa agggtttcag aacagagcca cgggactggt aggaagagga
     2101 gatccacaaa tgctgtatac aggctgtacc gctgcttcaa accccacttg tccagtgctt
     2161 cacagtgttg ctaatcagtg gagaaataca tgctttcatt atcaagtgta gtcagccgtc
     2221 tgttgaggtc aggtttcctt ccgttagctt ttgggtttcc tcggtggctc tggcaaggct
     2281 gctgctgtgt cattcggtgc ctttgtgagt ttccttgctg taggtgattc ttgactgtgg
     2341 ggattggaat ttgaggcaga agttaccatc cctactacat tttttaaagt tggtagcaca
     2401 aatgcttttt attctatgaa aacaatcctt ttggggaatg tacctgaaga gtacagagga
     2461 gcaagttccc agagcagcag ccacggcatc gtggcctgca ggtgcaccct cctcctcgcc
     2521 acagtcagtc agttcccgtg acaggaaacg accttgtgtt ctgaggagag cgtgaaggct
     2581 gtgcctgccc tgccagtgca gggagctgtc ccgcacttga gcagtgtcag agattcttgc
     2641 tttaactttg atttgctttc tcccattctt ggccctggtc actagggtcc tggctattct
     2701 agaactcagt aaaatgtatg tctaatgcta acattggccc ttgtgtagta caactattag
     2761 ccgtcacagc tattgctctt caaatggctt tagggttggt gttcttttta agggaaatac
     2821 attttcaaaa ttgctcacca tatctgtatc acttttagtt aaaaacatgc ttatatgtac
     2881 agtgtttcat gggtataagg attttttttc actgaggttt taggcatttt ttaaaaagac
     2941 aaattttctc tatgtagccc tggctgtcct gggacatgtt cagtatgtag agcagactgg
     3001 ccttgaactc aaagaggtgt gcctgtctct gcctcccggg tgctgggatt aaaggcgtgc
     3061 agcaccttgc ctggcttgtt ttaaagtaat cattgaaggt atggagcaca gccactgagc
     3121 caaggctgca gctgccagca ctcactgact ttacagtaag tcatttcaag taacgtgcat
     3181 tcggactgaa atttctggaa catgtacgtg gcctattagt tgtcatctct gtttttaaaa
     3241 tttagagact accgtattca ccctagttac tattctcatt taaattgtca ttgaggacat
     3301 tgcctagttt gacagtgtta agccttctca agcccagatc acctctgcgt ggcatgtgac
     3361 aactgcagag tcaccttgca ttagttcatt ccttagagca gaggtggata tcactcagtt
     3421 tgctttctat gttttactgt gttgtgtgga tacaacagtt tgttactggc cagatgacac
     3481 tgtcagccag gtgactcacc aggagagcta gcgagcgagc aagcacttca agtggctgtg
     3541 aaaagcacgc agttgcaaga actccacgtt aagtcaccag aaggagctgc taaggagctt
     3601 tgtgagagac cagctggtga tttcccacac gttcccagat gtgctgggag gtctgtctgg
     3661 ggcaggtgac tggacatttc agaatggaaa acagggattg tctgtcatca gtaaacttct
     3721 ccaccgtttt cctaagtctg aataatttag aggacagaaa tggcagcccg cccttccgtc
     3781 actcttcaga acctttccta ggagttctga aaacactcag ttttcaggct ttgtagagca
     3841 tcagaattta ggaatccttt cttcatgcta gactgagctc ccaagactgg agtgtgtgac
     3901 actagggagt ccggtgttcc cagtcctact gggtctcacg gccacagagg tgcgccagga
     3961 gaacaaacac ccaagtgtct cagaaacatc tggggcagag aaaattcaat gtttatttta
     4021 tacccaagat tctcctttac cataagcata gatctgcaga gatccatgga gtaagctatg
     4081 cgcccttcaa gttgctcttt aaattttgtt taaagtagaa atagaataac taaatgagct
     4141 acaaatctgt aagtcacatt ctatgggcag ttacaggtca gatttaaaag tagcttgccc
     4201 atgtttagat atttataaat cagacttgtt tgtttaacaa ctttaaagtc ctgcaagttt
     4261 tccagggctt ctggggcact tttaaatcct ctgcttattc accacaaata gcctgagata
     4321 aacaactgca tatttaagac tgtattagga caggaacttc gctcacattc catgttatgg
     4381 aaactattta agctctttct gacggtggga aagtggttac taagatccat ctattgctgt
     4441 gctgccagcc gccttcttcc ccatgtggtt tgagagttag gccctcaatc cttagtttct
     4501 catggcattc tttcttggtg actagaatta gcttctcttg cagtttttcc tcagagggaa
     4561 tgatttctaa tcatacactt gggatgccca agtctggagt ccttaccaaa gatgaaacaa
     4621 aagcatgcac tatagtaaga tgcatagagg atctacatgc atgtgacgtc aaaaagcaga
     4681 gcctgattgc agcccacatt gcctgccaca ctaacaggga accagcacct aagctcccca
     4741 ctgctgtcca gaagaagcaa gaagcagctc tagaaagaat attcagttac gaaacacgaa
     4801 acttttctcc tcattgcttt tccctgcttc tcaacctatg gagacaacag tgtaatggtg
     4861 tccagcaaaa cagtaatggc aagaagtgaa atgttgccat gtgccatacc aatgtgtcag
     4921 tcagcaacag accatgcata ttacggtggc cccataaggt gcagctgtct ggtttgtgag
     4981 tactcatgcc tgctgttccc gtgaggtcac ctcatgacac attcccactg tgaaatgatg
     5041 cacagctccc aagatccttt tagagccaaa acatgaaact gcaccagatt cacctctcag
     5101 gcttggacac cacatggaaa gtaagcagaa tttttccaac taaataaaat tcccagtttt
     5161 gagcctg
//
