LOCUS       NM_027588               1855 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus 5'-nucleotidase, cytosolic IB (Nt5c1b), transcript
            variant 1, mRNA.
ACCESSION   NM_027588
VERSION     NM_027588.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Nguyen,T.T.T., Tokuhiro,K., Shimada,K., Wang,H., Mashiko,D.,
            Tonai,S., Kiyozumi,D. and Ikawa,M.
  TITLE     Gene-deficient mouse model established by CRISPR/Cas9 system
            reveals 15 reproductive organ-enriched genes dispensable for male
            fertility
  JOURNAL   Front Cell Dev Biol 12, 1411162 (2024)
   PUBMED   38835510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Homola,M., Pfeffer,M., Robson,S.C., Fischer,C., Zimmermann,H. and
            Korf,H.W.
  TITLE     Melatonin receptor deficiency decreases and temporally shifts
            ecto-5'-nucleotidase mRNA levels in mouse prosencephalon
  JOURNAL   Cell Tissue Res 365 (1), 147-156 (2016)
   PUBMED   26917036
  REMARK    GeneRIF: Ecto-5'-nucleotidase mRNA levels were found to be
            diminished in both MT1 and MT1/2 knockout mice.
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Sala-Newby,G.B. and Newby,A.C.
  TITLE     Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new
            gene related to human autoimmune infertility-related protein
  JOURNAL   Biochim Biophys Acta 1521 (1-3), 12-18 (2001)
   PUBMED   11690631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB573272.1 and AK014892.1.
            
            On Nov 17, 2009 this sequence version replaced NM_027588.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ295253.1, SRR5189685.114982.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BB573272.1         6-8
            4-1484              AK014892.1         4-1484
            1485-1855           AK014892.1         1578-1948
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 5.27 cM"
     gene            1..1855
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /note="5'-nucleotidase, cytosolic IB"
                     /db_xref="GeneID:70881"
                     /db_xref="MGI:MGI:1918131"
     exon            1..125
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1814
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /EC_number="3.1.3.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic 5'-nucleotidase 1B; cytosolic 5'-nucleotidase
                     IB; autoimmune infertility-related protein;
                     5'nucleotidase"
                     /codon_start=1
                     /product="cytosolic 5'-nucleotidase 1B isoform 1"
                     /protein_id="NP_081864.2"
                     /db_xref="CCDS:CCDS25810.1"
                     /db_xref="GeneID:70881"
                     /db_xref="MGI:MGI:1918131"
                     /translation="MSQTSLKHKKKNEPGMRYSKESLDAEKRKDSDKTGARLSTQGSQ
                     ELPLHNTDSRGYVVRNQWSRTSRSPSTGAPSVDEPRSRNTAIKVEAPNSSTTSRTSSA
                     SPSQHETSPPPQTSEKSSIQQTPQNRPITQLESQPPTPPETEPNSRRTSAKMYTGSDP
                     WAHRENREPRDLQLRDYAYSCDSREGMPKTREYPRTPPTEWKPYAQRRLQYGTSVDME
                     PEYISDGPQQRQRQQTEEDEVDEAYWTSVSMLYEKIPSCARPRPPKPKHAITIAVSSR
                     ALFNMVDDRKIYEEEGLEKYMEYQLTNENVILTPGPAFRFVKALQHVNSRLRDLYPDE
                     QDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKSPIGYLKAYLTNLYLSAD
                     SEKVQEAIKEGIASATMYAGAKDMAYCDTQLRVAFDGDAVLFSDESEHIAKDHGLDKF
                     FQHETLFENKPLAQGPLKSFLEDLGKLQKKFYAKDERLLCPIRTYLVTARSAASSGAR
                     VLKTLRRWGLEIDEALFLAGAPKGPILVKIRPHIFFDDQMFHIESAQKFGTITAHVPY
                     GIAQKRN"
     exon            126..215
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     exon            216..359
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     exon            360..878
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1046
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1176
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1299
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1484
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1855
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /note="hexamer: AATAAA"
     polyA_site      1851
                     /gene="Nt5c1b"
                     /gene_synonym="4921514H13Rik; AIRP; CN-IB; cN1B"
                     /note="major polyA site"
ORIGIN      
        1 tcagagctag actgagccag cgaagtgata ggaaatggag ctggggagat gaagaccatc
       61 ataacaacaa acgaattcca tcagttgaag aaatgagtca aacatccttg aaacacaaaa
      121 agaaaaatga acctggaatg aggtactcaa aagagagtct agatgcagag aaaagaaagg
      181 attctgacaa aactggagct cgtctgagca ctcagggatc ccaagaatta cctctgcata
      241 atacagactc ccgaggttac gttgtacgaa atcagtggtc ccgaacatca cggagcccat
      301 ctactggagc tccatcagtg gatgagccca gaagcaggaa tactgccatc aaggtagagg
      361 cccctaacag ctccactacc tctcgaactt cctctgcctc ccccagtcaa cacgagacct
      421 cacctccacc tcagacatca gagaagtcct ccattcaaca gaccccccag aacagaccta
      481 tcacccagct tgaatcacaa cctcccacac ctccggaaac agagccaaac tcgagacgaa
      541 catcggcgaa gatgtatacg ggcagtgatc cgtgggcgca cagggaaaac agagagccta
      601 gagacttgca gctgagggac tatgcataca gctgtgactc acgagaaggg atgcccaaga
      661 cccgagagta tccgcgcact cctcctactg agtggaagcc ctatgcccag cgtcgcctcc
      721 agtatggcac ctctgtggac atggaaccgg aatatatatc cgatggcccg cagcagaggc
      781 agaggcagca gacagaggaa gatgaggtgg atgaggccta ctggacatct gtgagcatgc
      841 tgtatgagaa gatccccagc tgtgcacggc ccaggccgcc caaacccaag catgccatca
      901 ccattgccgt ctcttctcgg gcacttttca atatggtaga tgacaggaaa atctacgaag
      961 aggaaggtct ggagaagtac atggagtatc agctcaccaa cgagaacgtc atcctgacgc
     1021 cagggccagc gttccggttt gtcaaggcac tgcagcatgt caactctaga ctccgtgatc
     1081 tgtatcctga cgaacaggac ttattcgata tagtactgat gactaataac catgcccaag
     1141 tgggagtaag gcttataaac agcgtcaatc actatggtct actgattgac cgcttctgtt
     1201 tgacgggtgg gaaaagcccc attggatatt tgaaggcata tcttaccaac ctgtatcttt
     1261 ctgctgattc tgaaaaagta caagaagcaa taaaagaagg tattgcctct gcaaccatgt
     1321 atgctggagc caaagacatg gcttattgcg acacacagct acgcgtggcc tttgatgggg
     1381 atgctgtcct cttctcagat gaatctgaac atattgccaa ggatcatggg ctggacaaat
     1441 ttttccaaca tgaaacacta tttgagaata agcctcttgc tcagggtcct cttaaaagct
     1501 ttctggaaga tttagggaaa ctgcagaaaa aattctatgc caaagacgaa cgattgcttt
     1561 gccccatcag gacctacctg gttacagctc gtagtgcagc gagttcaggt gcccgtgtgc
     1621 tgaagaccct tcgccgatgg ggtctagaga tagatgaagc tcttttcctg gctggagccc
     1681 ctaaaggtcc catcttagtg aagattcggc cccacatctt cttcgacgac caaatgttcc
     1741 acattgaatc agcacagaaa tttggtacca tcacggccca tgtgccttat ggcattgctc
     1801 aaaaacgcaa ctagggatgg ggaggaaaaa taaacagtct ggtattacaa acggc
//
