LOCUS       NM_001400914            3734 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus NOL1/NOP2/Sun domain family, member 7 (Nsun7),
            transcript variant 4, mRNA.
ACCESSION   NM_001400914 XM_006504101
VERSION     NM_001400914.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3734)
  AUTHORS   Chi,L. and Delgado-Olguin,P.
  TITLE     Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase
            family genes in early mouse embryogenesis
  JOURNAL   Gene Expr Patterns 13 (8), 319-327 (2013)
   PUBMED   23816522
REFERENCE   6  (bases 1 to 3734)
  AUTHORS   Ching,Y.H., Munroe,R.J., Moran,J.L., Barker,A.K., Mauceli,E.,
            Fennell,T., Dipalma,F., Lindblad-Toh,K., Abcunas,L.M.,
            Gilmour,J.F., Harris,T.P., Kloet,S.L., Luo,Y., McElwee,J.L., Mu,W.,
            Park,H.K., Rogal,D.L., Schimenti,K.J., Shen,L., Shindo,M.,
            Shou,J.Y., Stenson,E.K., Stover,P.J. and Schimenti,J.C.
  TITLE     High resolution mapping and positional cloning of ENU-induced
            mutations in the Rw region of mouse chromosome 5
  JOURNAL   BMC Genet 11, 106 (2010)
   PUBMED   21118569
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3734)
  AUTHORS   Harris,T., Marquez,B., Suarez,S. and Schimenti,J.
  TITLE     Sperm motility defects and infertility in male mice with a mutation
            in Nsun7, a member of the Sun domain-containing family of putative
            RNA methyltransferases
  JOURNAL   Biol Reprod 77 (2), 376-382 (2007)
   PUBMED   17442852
  REMARK    GeneRIF: Sun domain containing protein Nsun7 mutant sperm exhibited
            depressed progressive motility associated with a rigid flagellar
            midpiece (but not principal piece) segment
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131752.3.
            
            On Jan 28, 2022 this sequence version replaced XM_006504101.5.
            
            Summary: This gene encodes a member of the NOL1/NOP2/sun domain RNA
            methyltransferase family. Mice with a mutation in this gene exhibit
            male sterility due to impaired sperm motility. Alternative splicing
            of this gene results in multiple transcript variants. [provided by
            RefSeq, Nov 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.182924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AC131752.3         161796-162220       c
            426-829             AC131752.3         160873-161276       c
            830-888             AC131752.3         158050-158108       c
            889-1019            AC131752.3         157496-157626       c
            1020-1172           AC131752.3         145450-145602       c
            1173-1356           AC131752.3         144957-145140       c
            1357-1567           AC131752.3         143277-143487       c
            1568-1711           AC131752.3         138382-138525       c
            1712-1813           AC131752.3         137828-137929       c
            1814-1931           AC131752.3         132581-132698       c
            1932-2055           AC131752.3         127205-127328       c
            2056-3734           AC131752.3         125055-126733       c
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 34.34 cM"
     gene            1..3734
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /note="NOL1/NOP2/Sun domain family, member 7"
                     /db_xref="GeneID:70918"
                     /db_xref="MGI:MGI:1918168"
     exon            1..425
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            426..829
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             514..2691
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /note="isoform 4 is encoded by transcript variant 4;
                     putative methyltransferase NSUN7"
                     /codon_start=1
                     /product="putative methyltransferase NSUN7 isoform 4"
                     /protein_id="NP_001387843.1"
                     /db_xref="GeneID:70918"
                     /db_xref="MGI:MGI:1918168"
                     /translation="MLDPTSERDLFDQENMEEISQLASLEMSGDVVANTNSSTVVLEK
                     PSYPDSVYVTAANIFQGIRIQRSPDKVIINYGSEPLQPSSSRSEDESFQRLSYELAFS
                     TLKYQDILESILIDSYIFSSTTIASQLNSLIIVMLYDFQDRKFQPRILSENEETIPEV
                     QEVENLLNGFKTKLAAALARCRIKHDALSIYHILPETVRKQEQRASTLPLYAWINTSK
                     ISLEEVYNNLRRKGYSKVKSITSVNEKVYAVDQHCFNVLIFPAHLKTDLLNIDLIKDY
                     KLIFQDKSRSLAVHSVKALINIDDDVLMVNTGSWYTVAHMSILTSGHTSKIFVCGIQQ
                     EEKDFNARKLFTRMGCQNIEILHETFLSIESKDHRLQNVKVILLLPRCSSLGVSNPVE
                     FILNEHEDKSLLQDLSQGGLPKDKLETLVQQQFEQLTHAMKFTKVQAIVYCTCSVSKE
                     ENEDVVEKALEYQSSGVKMQPYRLSPPVLPLCTLKEIELSMDRFFRLEPSDMNNGCFL
                     SILTRERDPSETVSVKDVLARAAAKGLLEGVEVGKTLKRDKKRKKSKALPSRAPHHGD
                     PLRDHLAVDGNDTSNVQMKISELLHRESKISTSTKMSAPAKTVSQAGTSSQVRKPSKP
                     LSTPLVRNFSRPVERPTNFVRARPEGKVIPLKPIEIVLPPVIFPLSSQGPRVQMPATH
                     FYYRFIGSKVGVPRYLTSSTSRRKEKVKESTTSSHVRHPRPWL"
     exon            830..888
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1019
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1172
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1356
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1567
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1711
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1813
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1931
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2055
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..3734
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3716..3721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="Nsun7"
                     /gene_synonym="4921525L17Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggacc cagctccttg ctccttgctg ccttacccac tagggctgcc tcacgagctc
       61 cgggacggtc acgagaagtg tccccttagg gacccagagc tccgctttct ttcagggacc
      121 cggagagagc cgagagctcg gcctgagcag tgtccccgga gcgcgagggc gagccccgag
      181 gaggcagcgt ctccctcagg gaccctggac gtagctggcg cgggcgccga gcgctttccc
      241 ccggccgaac ccggtgggtg gtgtggctgc acttaaacca aacggcctcc gcgggccgcg
      301 gcttcccggg gctcccgagg gcctgttacc tcctccatcg ccccaagtgc agaggctgcc
      361 gcgtcttcag ccccagagcc ccggaaaaca tcccaacccc agagaagggc ggattcgcgg
      421 agaagagacg atgcttaaga ctacaaggat agagatctcc ctggaccaca tgatttgaac
      481 ttgaagcttg agttattgac atcaggggca aacatgctgg acccaacgag tgaaagggac
      541 ctttttgacc aagaaaacat ggaggagatc tcccaactcg cttccctgga gatgtcgggg
      601 gatgtagtcg ccaatacaaa ctcttcaacc gtcgtcctag aaaaacccag ctacccagac
      661 tccgtgtacg ttacggcagc gaacattttt cagggtattc ggatccaaag gtcgccagac
      721 aaagtcataa taaattacgg aagtgaaccc ctgcagccct cctcctcccg ctccgaggat
      781 gaatctttcc agcgcttgtc ctatgagttg gctttcagta ccctgaagta tcaagatatt
      841 ttggaaagta tattaataga tagctatatc ttctcaagta ccacaatcgc aagtcagctg
      901 aacagtctta tcattgtgat gctgtatgac ttccaagaca gaaaattcca gccccgcatc
      961 ctttccgaga atgaagagac cataccagaa gttcaagaag tcgagaacct tctaaacggc
     1021 tttaagacaa aattggctgc agccttggcg agatgtcgaa tcaaacacga cgccctctcg
     1081 atttaccata ttctgccaga gacagttagg aaacaggaac aaagggcctc aactttgcct
     1141 ctttatgctt ggataaatac cagtaaaata agccttgaag aagtctataa taatttgagg
     1201 aggaaaggtt actctaaagt caagtctata acgagtgtca atgagaaagt ctatgcagta
     1261 gaccagcact gcttcaatgt cttaattttc ccagctcatc tcaaaacaga ccttttaaac
     1321 atagatctca taaaagacta taaacttatt ttccaggaca aatctcgaag tcttgccgtc
     1381 cactctgtga aggctttgat aaacatcgat gatgatgtcc taatggtcaa cacgggttcg
     1441 tggtacacag ttgcccatat gtccatctta acaagtggtc acacttcgaa aatctttgta
     1501 tgtggaatac aacaagaaga gaaggatttt aatgcgagga aactttttac aagaatggga
     1561 tgtcaaaata ttgaaatact tcacgaaaca tttcttagca ttgaatccaa agatcaccgg
     1621 ttacagaatg tgaaggtcat tctgttgcta cctcgctgtt ccagcctcgg tgtcagcaac
     1681 ccagtggaat tcattctaaa tgaacacgaa gataaaagtt tacttcaaga tctttctcaa
     1741 ggtggtctac cgaaagataa actcgagact ttggttcagc agcagtttga acagctaaca
     1801 cacgcaatga aatttaccaa agttcaagca attgtctatt gcacatgttc tgtttctaaa
     1861 gaggaaaatg aagacgttgt tgagaaagca ctggaatatc aaagctcagg ggttaaaatg
     1921 caaccttaca gactcagtcc tcctgttctc ccactgtgca ccctaaaaga gatagaactg
     1981 tctatggata gattcttcag attggaacca tctgatatga acaatggctg ttttctttct
     2041 atcttaacaa gagagcggga cccatctgag acagtgtcag tgaaagacgt tctggccagg
     2101 gcagcagcca aaggtctact ggaaggggtt gaggttggga agacgctcaa aagggacaag
     2161 aagaggaaaa aatcgaaagc actgccatcc agggctcctc accatgggga cccacttcgc
     2221 gaccatttgg cagtggatgg taacgacacc agcaacgtcc aaatgaaaat ctccgagctc
     2281 ttgcaccgag aaagcaagat aagtacttca acaaaaatgt ccgccccagc aaagactgtg
     2341 tctcaagccg gcacttcctc ccaagtcaga aagcccagca agcctttatc gaccccactg
     2401 gtgaggaatt tttccaggcc ggtagaaagg ccaacgaact ttgtgagagc gcggccagaa
     2461 ggcaaagtga ttcctttgaa accaattgaa atcgttctgc cgccagtgat attcccattg
     2521 agttcccagg ggcccagggt tcagatgcca gccacccatt tttattaccg cttcattgga
     2581 tcaaaggttg gtgtgccccg ctatcttaca tcctcaacat ccagaagaaa ggagaaggtt
     2641 aaggagagca caacttcctc ccacgtcagg caccctagac catggctctg actgtgtggc
     2701 ccttgtgaca gggtggctgg gctttgtcca gttttagata cggttacaca aggtgctggt
     2761 gcttgcggtt gcttagtgtc ctctagtgca atgtaacctc cagagagaat gaaagacagg
     2821 tgaggagtaa ccctggaggg gccgagctaa gccaagcttt cagcagtgct gtgctattaa
     2881 cctgttctag gaagtccagt tgcagactgg accagctgtt agaccttgtc tcactcttgg
     2941 gaggtttcaa gtatgggcgg agcatggctg tcttacctga agggaagcca ggaccccttc
     3001 cagtaggttg atttgcagac ctgaccgagg ggcttggtag aaagtcccga gacacaaagg
     3061 atgctgttct ttccagcctg ctccagctct agccaggaac ctgcgggcac tccttagcta
     3121 ggcagttact gtagctgaaa cctctccaaa gccaactgag gccagctttt tccttaagca
     3181 tcctactgct cctgagagag gacatgccag gaggttctct agtggcctga gctttgagta
     3241 cggtaggaag cccaggaaat cccaagtgtc agatgtgcac agtccagatg ttcattcaga
     3301 aactgtttct ggagagactc ctggatcccg agtagactaa gcatgataat ccctcccttc
     3361 tgtttaggcc aaacattgtt ggaaagagga cagcaagcaa gattccacct agggattctt
     3421 actctgagaa ataggtctca actgtcgaac agaagcagaa actcagaggt ttctgattct
     3481 acacgaagat caggtggcac agccaaacgt agacgtcatt tcaagggcac acggggacgg
     3541 aaccttgggg aactcatttc tgatgcacag ttagaataga ttgcagcact atgttaatta
     3601 cattaaatgt caccactctt agctatagta accattgcct agtaatactg acatgattat
     3661 catttctggg tcttaatttt ttttttatca tggcaacaga aattgtttga cgttaaataa
     3721 agttatgatt acaa
//
