LOCUS       NP_083226                476 aa            linear   ROD 06-JUN-2024
DEFINITION  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform a [Mus
            musculus].
ACCESSION   NP_083226 XP_001474818 XP_001476357
VERSION     NP_083226.3
DBSOURCE    REFSEQ: accession NM_028950.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 476)
  AUTHORS   Wang,W., Huang,H., Jiang,H., Tian,C., Tang,Y., Gan,D., Wen,X.,
            Song,Z., He,Y., Ou,X. and Fang,L.
  TITLE     A Cross-Tissue Investigation of Molecular Targets and Physiological
            Functions of Nsun6 Using Knockout Mice
  JOURNAL   Int J Mol Sci 23 (12), 6584 (2022)
   PUBMED   35743028
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 476)
  AUTHORS   Selmi,T., Hussain,S., Dietmann,S., Heiss,M., Borland,K., Flad,S.,
            Carter,J.M., Dennison,R., Huang,Y.L., Kellner,S., Bornelov,S. and
            Frye,M.
  TITLE     Sequence- and structure-specific cytosine-5 mRNA methylation by
            NSUN6
  JOURNAL   Nucleic Acids Res 49 (2), 1006-1022 (2021)
   PUBMED   33330931
  REMARK    GeneRIF: Sequence- and structure-specific cytosine-5 mRNA
            methylation by NSUN6.
REFERENCE   3  (residues 1 to 476)
  AUTHORS   Chi,L. and Delgado-Olguin,P.
  TITLE     Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase
            family genes in early mouse embryogenesis
  JOURNAL   Gene Expr Patterns 13 (8), 319-327 (2013)
   PUBMED   23816522
REFERENCE   4  (residues 1 to 476)
  AUTHORS   Vergnes,L., Lee,J.M., Chin,R.G., Auwerx,J. and Reue,K.
  TITLE     Diet1 functions in the FGF15/19 enterohepatic signaling axis to
            modulate bile acid and lipid levels
  JOURNAL   Cell Metab 17 (6), 916-928 (2013)
   PUBMED   23747249
REFERENCE   5  (residues 1 to 476)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928632.13.
            
            On Sep 30, 2009 this sequence version replaced NP_083226.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053751.1, AK132428.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 10.94 cM"
     Protein         1..476
                     /product="tRNA (cytosine(72)-C(5))-methyltransferase NSUN6
                     isoform a"
                     /note="NOL1/NOP2/Sun domain family 6; putative
                     methyltransferase NSUN6; tRNA
                     (cytosine(72)-C(5))-methyltransferase NSUN6"
                     /calculated_mol_wt=52148
     Region          113..202
                     /region_name="PUA_NSun6-like"
                     /note="PUA RNA-binding domain of the SAM-dependent
                     methyltransferase NSun6 and similar proteins; cd21150"
                     /db_xref="CDD:409292"
     Site            order(116,123,125..127,129..131,193..194,198..201)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:409292"
     Region          <195..465
                     /region_name="RsmB"
                     /note="16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF
                     family [Translation, ribosomal structure and biogenesis];
                     COG0144"
                     /db_xref="CDD:439914"
     Site            419
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q8TEA1; propagated from
                     UniProtKB/Swiss-Prot (Q7TS68.2)"
     CDS             1..476
                     /gene="Nsun6"
                     /gene_synonym="4933403D21Rik; 4933414E04Rik; NOPD1"
                     /coded_by="NM_028950.5:317..1747"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS15703.1"
                     /db_xref="GeneID:74455"
                     /db_xref="MGI:MGI:1921705"
ORIGIN      
        1 myvfpkislr pevenylkes flneeavsas srqeaerkfe tlllrlshpp smttvrvnth
       61 lgsvqhvrgl lleelqkqfg essipvvqhp alpdvllipm tgprknierq qgevivgaqc
      121 gnavlrgahv yvpgivsask fmkagdvisv ysdingkckk gakefdgtkv flgngisels
      181 rkdifnglpd lkgigirmte piylspsfdn vlpsyiflqn lpstvvahvl dpqpgekild
      241 mcaapggktt htaalmqdkg evialdkilt kvnklkqnas llglhsiraf cfdatkalkl
      301 dttdgieggp pflpesfdri ildapcsgmg qrpnmactwt lkevtsyqpl qrkllhvavq
      361 llkpggvlvy stctitlaen eeqvawalrt fpclqlqpqe pqiggegmvg agltleqlkq
      421 lqrfdpsvvp lqnmdtdslg earredmiwl ankdcigffi akflkcqstk akvsqk
//
