LOCUS       NM_001012309            3132 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus nuclear speckle regulatory protein 1 (Nsrp1), mRNA.
ACCESSION   NM_001012309 XM_110955
VERSION     NM_001012309.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3132)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3132)
  AUTHORS   Kim,C.H., Park,S.M., Lee,S.J., Kim,Y.D., Jang,S.H., Woo,S.M.,
            Kwon,T.K., Park,Z.Y., Chung,I.J., Kim,H.R. and Jun,C.D.
  TITLE     NSrp70 is a lymphocyte-essential splicing factor that controls
            thymocyte development
  JOURNAL   Nucleic Acids Res 49 (10), 5760-5778 (2021)
   PUBMED   34037780
  REMARK    GeneRIF: NSrp70 is a lymphocyte-essential splicing factor that
            controls thymocyte development.
REFERENCE   3  (bases 1 to 3132)
  AUTHORS   Kim,Y.D., Lee,J.Y., Oh,K.M., Araki,M., Araki,K., Yamamura,K. and
            Jun,C.D.
  TITLE     NSrp70 is a novel nuclear speckle-related protein that modulates
            alternative pre-mRNA splicing in vivo
  JOURNAL   Nucleic Acids Res 39 (10), 4300-4314 (2011)
   PUBMED   21296756
REFERENCE   4  (bases 1 to 3132)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 3132)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3132)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161058.1, AK078762.1, AL603842.9 and BF462050.1.
            
            On Feb 2, 2013 this sequence version replaced NM_001012309.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168573.1, AK078762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK161058.1         2-16
            16-1963             AK078762.1         2-1949
            1964-2641           AL603842.9         55887-56564
            2642-3132           BF462050.1         1-491               c
FEATURES             Location/Qualifiers
     source          1..3132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.21 cM"
     gene            1..3132
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /note="nuclear speckle regulatory protein 1"
                     /db_xref="GeneID:237859"
                     /db_xref="MGI:MGI:2144305"
     exon            1..59
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1668
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /note="coiled-coil domain-containing protein 55; nuclear
                     speckle-related protein 70; coiled-coil domain containing
                     55"
                     /codon_start=1
                     /product="nuclear speckle splicing regulatory protein 1"
                     /protein_id="NP_001012309.1"
                     /db_xref="CCDS:CCDS25075.1"
                     /db_xref="GeneID:237859"
                     /db_xref="MGI:MGI:2144305"
                     /translation="MAIPGRQYGLILPKKTQPLHRVLQKPSVFGSDSDDDETSVSESL
                     QREAAKKQAMKQTKLEIQKALAEDSTVYEYDSVYDEMQKKKEENNPKLLPGKDRKPKY
                     IHNLLKAVEIRKKEQEKRMEKKIQREREMENGEFDDKEAFVTSAYKKKLEERAEEEER
                     EKRAAALEAHLDVTKQKDLSGFYRHLLNQAVGEEAAPKSSFREARTVIKEEKLRGYPD
                     ETNSESRPPQQSCVLQRGAQEAEENPDADREFDDESSEDGEKRDHKVKSRGEDTGASM
                     KHPKHHKNRAHSRSSSEERGLGTKHHSRGSQSRGHEHQDRQSRDQESCHKDRSHREEK
                     SSHRHREASHKDHYWKKHEQEDKLKGREQEERQDREGKREKYSSREQERDRQRNDHDR
                     YSEKEKKRKEKEEHTKARRERCEDSGKHREREKPEGHGQSSERHRDRRESSPRSRPKD
                     DLDQERSSKARNTEKDKGEQGKPSHSETSLATKHRLAEERPEKGSEQERPPEAVSKFA
                     KRSNEETVMSARDRYLARQMARINAKTYIEKEDD"
     exon            60..150
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            151..207
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            208..336
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            337..544
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            545..653
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            654..3116
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /note="hexamer: AATAAA"
     polyA_site      1964
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /note="major polyA site"
     regulatory      3084..3089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /note="hexamer: AATAAA"
     polyA_site      3106
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /note="major polyA site"
ORIGIN      
        1 acgtccgcgt cgaccaggtc cagcggagac gggaacaaga tggcgatccc gggcaggcag
       61 tatgggctta ttttgccaaa gaaaacacag ccgttgcacc gagttttaca gaaaccgtca
      121 gtgtttggga gtgattctga tgacgatgag acttccgtga gcgaaagcct tcagagggaa
      181 gctgctaaga agcaggccat gaaacagacc aaattggaga ttcagaaagc tcttgcagaa
      241 gactccactg tgtatgagta tgacagcgtt tatgatgaga tgcagaaaaa gaaggaagaa
      301 aacaacccca agctgcttcc ggggaaggat cggaagccca aatatattca caacttacta
      361 aaagcagtcg agatcaggaa aaaggagcag gaaaagagaa tggaaaagaa aatacagaga
      421 gaacgagaga tggaaaacgg agaatttgat gataaagagg catttgtgac atctgcttat
      481 aaaaagaaac ttgaagagag agctgaagag gaggaaagag aaaagagggc agctgctctg
      541 gaagcacatt tggatgtgac caagcagaaa gatctcagtg gattttatcg gcatctatta
      601 aatcaagcag ttggtgagga ggcagctcct aaatccagct ttcgtgaagc caggactgtg
      661 ataaaagaag agaagctcag gggttaccct gatgaaacca attcagagag cagaccacca
      721 cagcagagct gcgtcctgca aaggggtgca caggaagcgg aggaaaaccc agatgctgac
      781 cgtgagtttg atgatgagag cagtgaggac ggtgaaaagc gagaccataa agtcaagtcc
      841 agaggagaag acaccggcgc ctccatgaaa caccccaagc atcacaagaa tcgcgcccac
      901 tcaagatcat ctagtgagga aagggggctc gggaccaagc accactcacg aggttcccag
      961 tcaagaggac atgagcacca ggacaggcag tccagagacc aagagagctg tcacaaggac
     1021 cgcagccacc gggaagaaaa gagttctcat aggcacagag aggccagtca taaagatcac
     1081 tactggaaga agcatgagca agaagataaa ctgaagggac gagaacagga agaaagacag
     1141 gacagagaag ggaagaggga aaaatattcc tcaagggaac aagaaagaga tagacaacgg
     1201 aatgatcacg accgatacag tgagaaagaa aagaaaagaa aagaaaaaga agagcacaca
     1261 aaagcaagga gggaaagatg tgaagacagt ggtaagcaca gagagaggga gaagccagaa
     1321 ggacatgggc agtcttcaga aagacatcga gacagaaggg aaagcagccc acggtctaga
     1381 ccaaaggacg accttgatca ggaaagatcc agcaaagcaa gaaacacgga gaaggacaaa
     1441 ggggaacaag ggaagccctc tcattctgaa acatcactag caacaaaaca cagactggca
     1501 gaggaaaggc cagagaaggg cagtgagcaa gagaggcccc ctgaggctgt gagcaagttt
     1561 gcaaaacgga gcaatgagga aactgtgatg tcagctagag acaggtattt ggccagacag
     1621 atggcgcgga taaacgcaaa gacttatatt gagaaagaag atgactaagg actgcccata
     1681 tctggagtcc cttgcaagcg tagagcattg taactcttga acttggttta agaaagcata
     1741 caactgttca tagaacagcg actggagagt attttttaaa atatattttc aaaatttgtt
     1801 aaatcaaaag tcagttcttt gagcttcagt gcttgtgagg tttttcctaa tgtatagcac
     1861 tttcttggtt ttactcaaga gtcaaaggtg ttaaatcttg tagattctct gtgaggaaaa
     1921 ttggcttcat gttataatgt taataaatag cttgtacaaa tgttgctttt gagttttttt
     1981 ggttttgtgt taactattac ctgggtggat gttttgccta catgtaagtc agtgcaccgg
     2041 gtggctgcct agtacccaca gagaaggcca gaagaaagca ctggatcccg ggaactgaag
     2101 tcatagatgg ctgtgaaccg ccttgtaggt gctaggaatt aaacctgggt cctccgtatg
     2161 ggcagccagt gctcttaacc atctctcagg ctctgaggag attttggttg ttgttgttgt
     2221 tgtttgtttt ttattatgtt ctgcttctgg tggggtgggg tggggattgt tgttatgctc
     2281 tgttgcccag gctgttctag aaatcctgtg ctcaagtgat ccttgtgtct cagcccctca
     2341 agtgctagaa ctgtaggcag tgaccagccc taggcccaat ttgtctcttg ttacagaaac
     2401 tgttttgtag atacttcctt tgagttaaaa tatatacatt ttggaaatag agaaaattgt
     2461 tttatgttct gaaatccctg ttaaaatgta acatagagat agatcatgtg tggttttttt
     2521 tttttttaaa gatttattta ttatgtgtaa gtaaactgta gctgtcttca gacactgcag
     2581 aagagggctt cagatcttat tacggatggt tgtgagccac catgtggttg ctgagatttg
     2641 aactcagaac ctttggagga gtagtcagtg cgcttaacca ctgagccatc tccccagccc
     2701 tagatcatgc atgtttaaac tttttgctcc acagcatact tggcttaaat aaaaataaag
     2761 atagtaatat gctactgcat ttaattcaac atttacttaa ctataaaggt gatttccagg
     2821 gtagggacaa agctcagtag tagagctctt gcctggcatg cacaaggtcc tggagttgat
     2881 gtccaagatt gaaaaaaagc aatcatttca ttcatgttca attctgggtt ttatttagaa
     2941 gacatcactt tttttttgta agtttgtatt ttgcaaatta ctaaattggt gtgtaactaa
     3001 atctgtcagc tgagaatgaa aaaaaaaagt tttatatact ccagcaagga gactgaagct
     3061 tgttaaaact atctctatgt tcaaataaaa ctagtttctg aactaagtca ttggaaaaaa
     3121 aaaaaaaaaa aa
//
