LOCUS       NP_001012309             542 aa            linear   ROD 03-JUN-2024
DEFINITION  nuclear speckle splicing regulatory protein 1 [Mus musculus].
ACCESSION   NP_001012309 XP_110955
VERSION     NP_001012309.1
DBSOURCE    REFSEQ: accession NM_001012309.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 542)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 542)
  AUTHORS   Kim,C.H., Park,S.M., Lee,S.J., Kim,Y.D., Jang,S.H., Woo,S.M.,
            Kwon,T.K., Park,Z.Y., Chung,I.J., Kim,H.R. and Jun,C.D.
  TITLE     NSrp70 is a lymphocyte-essential splicing factor that controls
            thymocyte development
  JOURNAL   Nucleic Acids Res 49 (10), 5760-5778 (2021)
   PUBMED   34037780
  REMARK    GeneRIF: NSrp70 is a lymphocyte-essential splicing factor that
            controls thymocyte development.
REFERENCE   3  (residues 1 to 542)
  AUTHORS   Kim,Y.D., Lee,J.Y., Oh,K.M., Araki,M., Araki,K., Yamamura,K. and
            Jun,C.D.
  TITLE     NSrp70 is a novel nuclear speckle-related protein that modulates
            alternative pre-mRNA splicing in vivo
  JOURNAL   Nucleic Acids Res 39 (10), 4300-4314 (2011)
   PUBMED   21296756
REFERENCE   4  (residues 1 to 542)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (residues 1 to 542)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (residues 1 to 542)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161058.1, AK078762.1, AL603842.9 and BF462050.1.
            
            On Feb 17, 2005 this sequence version replaced XP_110955.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168573.1, AK078762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.21 cM"
     Protein         1..542
                     /product="nuclear speckle splicing regulatory protein 1"
                     /note="coiled-coil domain-containing protein 55; nuclear
                     speckle-related protein 70; coiled-coil domain containing
                     55"
                     /calculated_mol_wt=63668
     Region          21..53
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Site            31
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Region          57..176
                     /region_name="NSRP1_N"
                     /note="Nuclear speckle splicing regulatory protein 1,
                     N-terminal; pfam09745"
                     /db_xref="CDD:462876"
     Region          105..169
                     /region_name="Necessary for alternative splicing activity.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Region          190..516
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Site            254
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Site            255
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H0G5; propagated from
                     UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Site            277
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q5NCR9.1)"
     Region          291..455
                     /region_name="NRP1_C"
                     /note="Nuclear speckle splicing regulatory protein 1,
                     RS-like domain; pfam20427"
                     /db_xref="CDD:466576"
     Region          416..>523
                     /region_name="U2AF_lg"
                     /note="U2 snRNP auxilliary factor, large subunit, splicing
                     factor; TIGR01642"
                     /db_xref="CDD:273727"
     Site            443
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q4FZU3; propagated from
                     UniProtKB/Swiss-Prot (Q5NCR9.1)"
     CDS             1..542
                     /gene="Nsrp1"
                     /gene_synonym="8030451K07; Ccdc55; NSpr70; NSrp70"
                     /coded_by="NM_001012309.2:40..1668"
                     /db_xref="CCDS:CCDS25075.1"
                     /db_xref="GeneID:237859"
                     /db_xref="MGI:MGI:2144305"
ORIGIN      
        1 maipgrqygl ilpkktqplh rvlqkpsvfg sdsdddetsv seslqreaak kqamkqtkle
       61 iqkalaedst vyeydsvyde mqkkkeennp kllpgkdrkp kyihnllkav eirkkeqekr
      121 mekkiqrere mengefddke afvtsaykkk leeraeeeer ekraaaleah ldvtkqkdls
      181 gfyrhllnqa vgeeaapkss freartvike eklrgypdet nsesrppqqs cvlqrgaqea
      241 eenpdadref ddessedgek rdhkvksrge dtgasmkhpk hhknrahsrs sseerglgtk
      301 hhsrgsqsrg hehqdrqsrd qeschkdrsh reeksshrhr eashkdhywk kheqedklkg
      361 reqeerqdre gkrekyssre qerdrqrndh drysekekkr kekeehtkar rercedsgkh
      421 rerekpeghg qsserhrdrr essprsrpkd dldqersska rntekdkgeq gkpshsetsl
      481 atkhrlaeer pekgseqerp peavskfakr sneetvmsar drylarqmar inaktyieke
      541 dd
//
