LOCUS       NM_001039386            2949 bp    mRNA    linear   ROD 19-FEB-2023
DEFINITION  Mus musculus NMDA receptor synaptonuclear signaling and neuronal
            migration factor (Nsmf), transcript variant 1, mRNA.
ACCESSION   NM_001039386
VERSION     NM_001039386.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2949)
  AUTHORS   Gomes GM, Bar J, Karpova A and Kreutz MR.
  TITLE     A Jacob/nsmf gene knockout does not protect against acute hypoxia-
            and NMDA-induced excitotoxic cell death
  JOURNAL   Mol Brain 16 (1), 23 (2023)
   PUBMED   36774487
  REMARK    GeneRIF: A Jacob/nsmf gene knockout does not protect against acute
            hypoxia- and NMDA-induced excitotoxic cell death.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2949)
  AUTHORS   Wu B, Zhang X, Chiang HC, Pan H, Yuan B, Mitra P, Qi L, Simonyan H,
            Young CN, Yvon E, Hu Y, Zhang N and Li R.
  TITLE     RNA polymerase II pausing factor NELF in CD8+ T cells promotes
            antitumor immunity
  JOURNAL   Nat Commun 13 (1), 2155 (2022)
   PUBMED   35444206
  REMARK    GeneRIF: RNA polymerase II pausing factor NELF in CD8(+) T cells
            promotes antitumor immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2949)
  AUTHORS   Ou J, Guan X, Wang J, Wang T, Zhang B, Li R, Xu H, Hu X and Guo XK.
  TITLE     Epithelial NELF guards intestinal barrier function to ameliorate
            colitis by maintaining junctional integrity
  JOURNAL   Mucosal Immunol 15 (2), 279-288 (2022)
   PUBMED   34697434
  REMARK    GeneRIF: Epithelial NELF guards intestinal barrier function to
            ameliorate colitis by maintaining junctional integrity.
REFERENCE   4  (bases 1 to 2949)
  AUTHORS   Ju MK, Shin KJ, Lee JR, Khim KW, A Lee E, Ra JS, Kim BG, Jo HS,
            Yoon JH, Kim TM, Myung K, Choi JH, Kim H and Chae YC.
  TITLE     NSMF promotes the replication stress-induced DNA damage response
            for genome maintenance
  JOURNAL   Nucleic Acids Res 49 (10), 5605-5622 (2021)
   PUBMED   33963872
  REMARK    GeneRIF: NSMF promotes the replication stress-induced DNA damage
            response for genome maintenance.
REFERENCE   5  (bases 1 to 2949)
  AUTHORS   Aoi Y, Smith ER, Shah AP, Rendleman EJ, Marshall SA, Woodfin AR,
            Chen FX, Shiekhattar R and Shilatifard A.
  TITLE     NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II
            Pause-Release
  JOURNAL   Mol Cell 78 (2), 261-274 (2020)
   PUBMED   32155413
  REMARK    GeneRIF: NELF Regulates a Promoter-Proximal Step Distinct from RNA
            Pol II Pause-Release.
REFERENCE   6  (bases 1 to 2949)
  AUTHORS   Xu N, Bhagavath B, Kim HG, Halvorson L, Podolsky RS, Chorich LP,
            Prasad P, Xiong WC, Cameron RS and Layman LC.
  TITLE     NELF is a nuclear protein involved in hypothalamic GnRH neuronal
            migration
  JOURNAL   Mol Cell Endocrinol 319 (1-2), 47-55 (2010)
   PUBMED   20025934
REFERENCE   7  (bases 1 to 2949)
  AUTHORS   Kindler S, Dieterich DC, Schutt J, Sahin J, Karpova A, Mikhaylova
            M, Schob C, Gundelfinger ED, Kreienkamp HJ and Kreutz MR.
  TITLE     Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced
            nuclear translocation after calpain-mediated proteolysis
  JOURNAL   J Biol Chem 284 (37), 25431-25440 (2009)
   PUBMED   19608740
  REMARK    GeneRIF: Calpain-mediated clipping of the myristoylated N terminus
            of Jacob is required for its nuclear translocation after
            N-methyl-d-aspartate receptor activation
REFERENCE   8  (bases 1 to 2949)
  AUTHORS   Dieterich DC, Karpova A, Mikhaylova M, Zdobnova I, Konig I,
            Landwehr M, Kreutz M, Smalla KH, Richter K, Landgraf P, Reissner C,
            Boeckers TM, Zuschratter W, Spilker C, Seidenbecher CI, Garner CC,
            Gundelfinger ED and Kreutz MR.
  TITLE     Caldendrin-Jacob: a protein liaison that couples NMDA receptor
            signalling to the nucleus
  JOURNAL   PLoS Biol 6 (2), e34 (2008)
   PUBMED   18303947
  REMARK    Erratum:[PLoS Biol. 2009 Jan;7(1):e1000022]
REFERENCE   9  (bases 1 to 2949)
  AUTHORS   Kramer PR and Wray S.
  TITLE     Nasal embryonic LHRH factor (NELF) expression within the CNS and
            PNS of the rodent
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 23-26 (2001)
   PUBMED   15018815
REFERENCE   10 (bases 1 to 2949)
  AUTHORS   Kramer PR and Wray S.
  TITLE     Novel gene expressed in nasal region influences outgrowth of
            olfactory axons and migration of luteinizing hormone-releasing
            hormone (LHRH) neurons
  JOURNAL   Genes Dev 14 (14), 1824-1834 (2000)
   PUBMED   10898796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY259140.1, AK019560.1, AK053402.1 and AI850576.1.
            
            [WARNING] On May 25, 2023 this sequence was replaced by
            NM_001039386.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019560.1, AJ278902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY259140.1         2-35
            35-2162             AK019560.1         2-2129
            2163-2931           AK053402.1         2014-2782
            2932-2949           AI850576.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..2949
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /note="NMDA receptor synaptonuclear signaling and neuronal
                     migration factor"
                     /db_xref="GeneID:56876"
                     /db_xref="MGI:MGI:1861755"
     exon            1..293
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1821
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /note="isoform A is encoded by transcript variant 1; nasal
                     embryonic luteinizing hormone-releasing hormone factor;
                     juxtasynaptic attractor of caldendrin on dendritic boutons
                     protein; nasal embryonic LHRH factor"
                     /codon_start=1
                     /product="NMDA receptor synaptonuclear signaling and
                     neuronal migration factor isoform A"
                     /protein_id="NP_001034475.1"
                     /db_xref="CCDS:CCDS15745.1"
                     /db_xref="GeneID:56876"
                     /db_xref="MGI:MGI:1861755"
                     /translation="MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGA
                     DHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGRYEGSISDEAVSGKPAIEGPQPHVY
                     TISREPALLPGSEAEAIELAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWA
                     GSRQGSKECPGCAQLVPGPSSRAFGLEQPPLPEAPGRHKKLERMYSVDGVSDDVPIRT
                     WFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRV
                     KAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKG
                     LEAMACNTEGFLPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEE
                     IEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLM
                     SKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYKVTFESPLELSAQGKQMIETY
                     FDFRLYRLWKSRQHSKLLDFDDVL"
     exon            294..355
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            356..856
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            857..932
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            933..938
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1007
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1060
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1150
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1275
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1359
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1393
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1464
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1544
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1647
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1723
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..2933
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsmf"
                     /gene_synonym="Jacob; Nelf"
                     /note="putative"
ORIGIN      
        1 agcgtcagga ggcggagcac cgcccccggg tccagccgcg ctctcctaca gtggctggac
       61 gcgctgggcg ctgggtgcgg ccatgcgggg cctgggccta agtctgaccc tgaccctgag
      121 gctgagacct agcgcgacct caggcgccgt acggctcccc cggcagaggc ggcgggcgcg
      181 aggcgcgctc tgaaatccgg gggatgcgcg ggcgccgtga ccatgggtgc cgccgcctcc
      241 aggaggaggg cgctgaggag cgaggccatg tcctcggtag cggccaaagt aagagcagcc
      301 cgagcgtttg gagagtacct gtcccagagt caccctgaga accgcaacgg tgcagaccac
      361 ctgctggctg acgcctactc tggccacgac gggtccccag agatgcaacc tgcaccccag
      421 aacaagcgcc gcctctccct cgtctccaat ggccgatatg agggcagcat ctcagatgag
      481 gcagtcagcg ggaagccggc tatagagggc ccccagcccc acgtgtacac catctctaga
      541 gagcccgccc tgctacctgg ctctgaagct gaagccattg agctagcagt ggtaaaaggg
      601 aggagacagc gggaacggca ccctcaccac cacagccagc ccctgcgtgc cagcccaggc
      661 agcagccggg aggacatcag caggccctgc caaagctggg caggaagccg ccagggctcc
      721 aaagagtgcc caggatgtgc ccagctggtc cctggtccct cttctcgggc ctttgggctg
      781 gagcagccac ctctacctga ggctcctggc cgccacaaga agctggaaag gatgtatagc
      841 gttgatggag tgtctgatga tgtccccatc cgtacctggt tccccaagga aaaccttttc
      901 agcttccaga cggcaaccac aactatgcaa gccatctcgg tattcagggg ctacgcggag
      961 aggaagcgtc ggaaacggga gaatgattcc gcgtctgtaa tccagaggaa cttccgcaaa
     1021 cacctgcgca tggttggcag tcggcgggtg aaggcccaga cgttcgctga gcgtcgcgaa
     1081 cggagcttca gccggtcctg gagcgacccc acccctatga aagccgacac ttcccacgac
     1141 tcccgagaca gcagtgacct acagagctca cactgcaccc tggatgaggc ttgtgaggac
     1201 ctggactggg acacagagaa aggtctggag gccatggcct gcaacaccga gggcttcttg
     1261 ccacccaagg tcatgctcat ctcctccaag gtgccaaagg ccgagtatat ccctactatc
     1321 atccgcagag atgacccgtc catcattccc atcctctacg accacgagca tgcaaccttc
     1381 gaggacatcc tggaggaaat agagaagaaa ttgaacatct atcacaaggg ggccaagatc
     1441 tggaagatgc tgattttctg ccagggcggc cctggacacc tttatttgct caagaacaag
     1501 gtggccacct ttgccaaagt ggagaaggaa gaggacatga tccacttctg gaagaggctg
     1561 agccgcctga tgagcaaggt gaaccccgag ccgaatgtca tccacatcat gggctgctac
     1621 attctgggga accctaacgg ggagaagcta ttccagaacc tcaggaccct catgacccct
     1681 tacaaggtta cctttgagtc gcctctcgag ctgtctgccc aagggaagca gatgattgag
     1741 acctactttg acttccggct gtaccgcctg tggaagagcc gccagcactc aaagctgctg
     1801 gactttgatg acgtcctgtg agaagcatgg gtcatgccca ggaaccacca ggccatttcc
     1861 tctgggctgg ggacctagag ctgggctgcc tcttgcaccc gggacagtgt ggccctgctc
     1921 ttgcccacag ccacttcagg gaccctcaga cgttgctcag gttctcgtag ggtctggtcc
     1981 tcactgcacc agtgggccac agaggccaca ctcctggtgg tccagattaa caatctcagc
     2041 ccatgaccag tggcctctca atggccaggg cattgacctg tcatgcctcg cctggaggca
     2101 gcagcattgg ggatcccctc catggggttc atagaaataa gtgcaatttt tttacacccc
     2161 tgaaacaatt tgaagggaag cagcattact aattaactag ttaagcactc tgctactagt
     2221 tacagtgtag acaaccagcc cagtgtgtgt tcaggtcctc ctgtccccca gcctctcagc
     2281 cctgctgtat ttgatcacca gcaccaggat ggcccataag tgtggggcta gctctgtcag
     2341 gctgcctagc ctggcccagt ctacactggc caaatctggc ctgctttcac ccttttgtca
     2401 cccctggctt actttgacct catcctggca aggggtaggc tgggcagtta ggagggaaga
     2461 gcctcactca ccctccctct tgtcagggga gcactgggtt gccatctgtt gcccacctcc
     2521 tcaagccaac ccatttccct ttgctgctgc tgaactcggc tttttctagc cttggtctgg
     2581 aagccacatc ccagcacagt ggcttagggg tgtggtgggg acagccgggg ctgggcctgg
     2641 gaaggcaaga acctcaccag cattgtggtg gggggcctag atctgtcacc ccaggctgga
     2701 gagtcaagta gctggtgaac tgtgaggtcc ccatgactcc cttcagtctt gtccagggtc
     2761 tagcagggtg ggctctcttg tacatagttg gagcttgggg gcaggccccc cttttgtaga
     2821 gcctggggtc tggggacacc tggccgtgtc cctgacccag gggagttagg attgggcact
     2881 gaacaatgta cgatatccct tagagtgacc attaaacttg accctctgct gcaaaaaaaa
     2941 aaaaaaaaa
//
