LOCUS       NM_026746               1159 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
            (Nsmce2), transcript variant 1, mRNA.
ACCESSION   NM_026746
VERSION     NM_026746.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Hwang,G., Sun,F., O'Brien,M., Eppig,J.J., Handel,M.A. and
            Jordan,P.W.
  TITLE     SMC5/6 is required for the formation of segregation-competent
            bivalent chromosomes during meiosis I in mouse oocytes
  JOURNAL   Development 144 (9), 1648-1660 (2017)
   PUBMED   28302748
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Jacome,A., Gutierrez-Martinez,P., Schiavoni,F., Tenaglia,E.,
            Martinez,P., Rodriguez-Acebes,S., Lecona,E., Murga,M., Mendez,J.,
            Blasco,M.A. and Fernandez-Capetillo,O.
  TITLE     NSMCE2 suppresses cancer and aging in mice independently of its
            SUMO ligase activity
  JOURNAL   EMBO J 34 (21), 2604-2619 (2015)
   PUBMED   26443207
  REMARK    GeneRIF: SUMO- and BLM-independent activities of NSMCE2 limit
            recombination and facilitate chromosome segregation.
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Gur,I., Fujiwara,K., Hasegawa,K. and Yoshikawa,K.
  TITLE     Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3
            ligase
  JOURNAL   PLoS One 9 (6), e99503 (2014)
   PUBMED   24911587
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Ishida,T., Fujiwara,S., Miura,K., Stacey,N., Yoshimura,M.,
            Schneider,K., Adachi,S., Minamisawa,K., Umeda,M. and Sugimoto,K.
  TITLE     SUMO E3 ligase HIGH PLOIDY2 regulates endocycle onset and meristem
            maintenance in Arabidopsis
  JOURNAL   Plant Cell 21 (8), 2284-2297 (2009)
   PUBMED   19666737
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV057668.1, AK003685.1 and AW489283.1.
            
            On Sep 3, 2009 this sequence version replaced NM_026746.2.
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009125.1, AK003685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               DV057668.1         21-332
            313-1140            AK003685.1         265-1092
            1141-1159           AW489283.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 25.19 cM"
     gene            1..1159
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /note="NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase"
                     /db_xref="GeneID:68501"
                     /db_xref="MGI:MGI:1915751"
     exon            1..158
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            159..329
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..916
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     SUMO-protein ligase NSE2; non-SMC element 2 homolog
                     (MMS21, S. cerevisiae); MMS21 homolog; non-structural
                     maintenance of chromosomes element 2 homolog; E3
                     SUMO-protein transferase NSE2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase NSE2 isoform 1"
                     /protein_id="NP_081022.2"
                     /db_xref="CCDS:CCDS27498.1"
                     /db_xref="GeneID:68501"
                     /db_xref="MGI:MGI:1915751"
                     /translation="MPGRSSTSSGSTRYISFSGIESALSSLKNFQSCISSGMDTVSSV
                     ALDLVETQTEVSSEYSMDKAMVEFAKMDRELSHYVKAVQSTINHVKEERPEKVPDLKL
                     LVEKKFLALQDKNSDADFKENEKFVQFKQQLRELKKQYGIHADRENDLTEGVDEDMIV
                     TQSQTNFICPITQLEMKKPVKNKMCGHTYEEEAIVRMIESKHKRKKKACCPKIGCSHT
                     DMRMSDLIPDEALRRAIESHNKKKKRHSE"
     exon            330..436
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            437..590
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            591..691
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            692..798
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1143
                     /gene="Nsmce2"
                     /gene_synonym="1110014D18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccgggcc cgggcatcat gtgatcgctc gcgggcgcca agtgatgacg cagagcgcgc
       61 gcgggtcgtt tcagccacag aagtgggctg aggaaaggag tcggggtctg ggcgtgcgac
      121 gttcggctag atatcaccga gctaggtggg acagccaggt aacaatttca agatgccagg
      181 acggtccagt acaagttcag gttctacccg ttacatatcc ttcagtggca tagagtcagc
      241 tctctcctcc ttaaaaaact tccaatcctg tatcagctct ggaatggaca cagtttctag
      301 tgttgccttg gaccttgtgg agactcaaac tgaagtgagt agtgagtaca gtatggacaa
      361 ggccatggtt gagtttgcta aaatggatcg agaactaagc cattatgtta aggctgtgca
      421 gtctacaatc aatcatgtaa aagaagaacg tccagaaaaa gtaccagatt taaaattact
      481 ggtagagaag aaatttttgg ctttacagga taagaactct gatgccgact ttaaagagaa
      541 tgaaaagttc gtgcagttca agcaacagct gagggagctg aagaagcaat atggtattca
      601 tgcagacaga gagaatgatc tgacagaagg agttgacgaa gatatgattg tgacccagag
      661 ccaaaccaat ttcatctgcc ccataacaca gctggaaatg aagaagccag tgaaaaataa
      721 aatgtgtggc catacatacg aagaggaagc cattgttcgc atgattgaat ccaagcataa
      781 gaggaagaag aaggcctgtt gccccaaaat tggctgtagc cacacagaca tgagaatgtc
      841 agatctcatt ccggatgaag ccctgagaag ggcaatcgag agccacaaca agaagaaaaa
      901 acgccactcc gaataggagc aagccacctg cccacaggga tgtcagcagc ctacctcccc
      961 gccagccacc agagagtgag ggatgccagc gataggcctg gccaagcagc gctgtttgcg
     1021 gtaacccttg aaggctaatt gtaattgaaa gcatttttta agttacacag taaaaacaca
     1081 agtacattat attctttatt ttcaagtgct ctgaaatttt aaataaaact ttgataatcc
     1141 tcaaaaaaaa aaaaaaaaa
//
