LOCUS       NM_026330                963 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus NSE1 homolog, SMC5-SMC6 complex component (Nsmce1),
            transcript variant 1, mRNA.
ACCESSION   NM_026330
VERSION     NM_026330.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 963)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 963)
  AUTHORS   Gong,M., Wang,Z., Liu,Y., Li,W., Ye,S., Zhu,J., Zhang,H., Wang,J.
            and He,K.
  TITLE     A transcriptomic analysis of Nsmce1 overexpression in mouse
            hippocampal neuronal cell by RNA sequencing
  JOURNAL   Funct Integr Genomics 20 (3), 459-470 (2020)
   PUBMED   31792732
  REMARK    GeneRIF: A transcriptomic analysis of Nsmce1 overexpression in
            mouse hippocampal neuronal cell by RNA sequencing.
REFERENCE   4  (bases 1 to 963)
  AUTHORS   Hwang,G., Sun,F., O'Brien,M., Eppig,J.J., Handel,M.A. and
            Jordan,P.W.
  TITLE     SMC5/6 is required for the formation of segregation-competent
            bivalent chromosomes during meiosis I in mouse oocytes
  JOURNAL   Development 144 (9), 1648-1660 (2017)
   PUBMED   28302748
REFERENCE   5  (bases 1 to 963)
  AUTHORS   Pryzhkova,M.V. and Jordan,P.W.
  TITLE     Conditional mutation of Smc5 in mouse embryonic stem cells perturbs
            condensin localization and mitotic progression
  JOURNAL   J Cell Sci 129 (8), 1619-1634 (2016)
   PUBMED   26919979
REFERENCE   6  (bases 1 to 963)
  AUTHORS   Taniura,H., Tanabe,N., Bando,Y. and Arai,N.
  TITLE     Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in
            Dictyostelium development upon starvation
  JOURNAL   Dev Growth Differ 57 (6), 430-443 (2015)
   PUBMED   26036668
REFERENCE   7  (bases 1 to 963)
  AUTHORS   Gur,I., Fujiwara,K., Hasegawa,K. and Yoshikawa,K.
  TITLE     Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3
            ligase
  JOURNAL   PLoS One 9 (6), e99503 (2014)
   PUBMED   24911587
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 963)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011011.1 and BC049558.1.
            
            On Apr 4, 2019 this sequence version replaced NM_026330.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049558.1, AK011011.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               AK011011.1         5-498
            495-963             BC049558.1         587-1055
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 68.87 cM"
     gene            1..963
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /note="NSE1 homolog, SMC5-SMC6 complex component"
                     /db_xref="GeneID:67711"
                     /db_xref="MGI:MGI:1914961"
     exon            1..31
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            32..178
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..843
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-structural maintenance of chromosomes element 1
                     homolog; non-SMC element 1 homolog"
                     /codon_start=1
                     /product="non-structural maintenance of chromosomes
                     element 1 homolog isoform 1"
                     /protein_id="NP_080606.3"
                     /db_xref="GeneID:67711"
                     /db_xref="MGI:MGI:1914961"
                     /translation="MQGSTRRAGAMTDVHRRFLQLLMTHGVLEEWEVRRLQNHCYQVH
                     DRNATVDKLEDFINNINSVLESLYIEIKKGVTEDDGRPIYALVNLATTSVSKMATDFA
                     ENELDLFRKALELIVDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQSKWLI
                     EKEGEFTLHGRAILEMEQFIRESYPDSVKMCNICHGLLIQGQSCETCGIRMHLPCVAK
                     YFQSIPEPHCPHCNDYWPHDIPEVYNPEKEREAGISKSSRKSLRTRQH"
     exon            179..300
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..378
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            379..525
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            526..642
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..763
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            764..963
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      930..935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      963
                     /gene="Nsmce1"
                     /gene_synonym="2510027N19Rik"
                     /note="major polyA site"
ORIGIN      
        1 atggcttccg gcgtgatctc gctggtttgc gctccctcca acatgcaggg cagcacgagg
       61 agagcaggag ccatgacgga tgtgcaccgg cgcttcctcc agctgctcat gacccacggt
      121 gtgctggagg agtgggaggt tcggcgtctg cagaaccact gctaccaggt ccatgaccga
      181 aatgcgactg tagataagct ggaggacttc atcaacaaca tcaacagtgt cctggagtct
      241 ctgtatattg agataaagaa aggagtcacg gaagatgatg ggagacccat ttatgcactg
      301 gtgaatcttg ctacaacttc agtttccaaa atggctacgg attttgcaga gaacgagctg
      361 gatctgttta gaaaggctct ggaactgatc gttgactcag aaactggctt tgcttcttct
      421 acaaacattt tgaacctagt tgatcaactc aaagggaaaa agatgaggaa gaaggaggcc
      481 gagcaggtgc tgcagaagtt tgtgcagagc aagtggttga ttgagaagga gggagagttc
      541 accttgcatg gccgggctat cttggagatg gagcagttca tccgagagag ctacccagat
      601 tctgtgaaga tgtgcaacat ctgccacggc ctcctcatcc agggtcaaag ttgtgagacg
      661 tgtggaatta ggatgcattt gccttgtgtg gccaaatact tccagtccat ccctgaacca
      721 cactgccccc actgtaatga ctactggccc cacgatatac cagaagtcta caaccctgag
      781 aaggagaggg aagctggcat ctccaagtcg agcagaaagt ccttacggac ccggcagcac
      841 tagctgtgtc ctgcatcgtt ctgggctgac cctcacagtc catttaggac tgccgtgcct
      901 cctttgttat ttgttcttaa cacgttttta gtaaatgttt cctgatggcg ctgtgctctg
      961 taa
//
