LOCUS       NM_010945               3518 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus neutral sphingomyelinase (N-SMase) activation
            associated factor (Nsmaf), mRNA.
ACCESSION   NM_010945
VERSION     NM_010945.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Nusshold C, Uellen A, Bernhart E, Hammer A, Damm S, Wintersperger
            A, Reicher H, Hermetter A, Malle E and Sattler W.
  TITLE     Endocytosis and intracellular processing of BODIPY-sphingomyelin by
            murine CATH.a neurons
  JOURNAL   Biochim Biophys Acta 1831 (12), 1665-1678 (2013)
   PUBMED   23973266
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Boecke A, Carstens AC, Neacsu CD, Baschuk N, Haubert D, Kashkar H,
            Utermohlen O, Pongratz C and Kronke M.
  TITLE     TNF-receptor-1 adaptor protein FAN mediates TNF-induced B16
            melanoma motility and invasion
  JOURNAL   Br J Cancer 109 (2), 422-432 (2013)
   PUBMED   23674089
  REMARK    GeneRIF: FAN through promoting melanoma cellular motility and
            tumour invasiveness is critical for the tumour-promoting action of
            tumor necrosis factor.
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Mas E, Danjoux M, Garcia V, Carpentier S, Segui B and Levade T.
  TITLE     The pro-inflammatory action of tumour necrosis factor-alpha in
            non-alcoholic steatohepatitis is independent of the NSMAF gene
            product
  JOURNAL   Dig Liver Dis 45 (2), 147-154 (2013)
   PUBMED   23044079
  REMARK    GeneRIF: FAN is not implicated in the development of methionine and
            choline deficient diet-induced non-alcoholic steatohepatitis.
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Montfort A, de Badts B, Douin-Echinard V, Martin PG, Iacovoni J,
            Nevoit C, Therville N, Garcia V, Bertrand MA, Bessieres MH, Trombe
            MC, Levade T, Benoist H and Segui B.
  TITLE     FAN stimulates TNF(alpha)-induced gene expression, leukocyte
            recruitment, and humoral response
  JOURNAL   J Immunol 183 (8), 5369-5378 (2009)
   PUBMED   19786552
  REMARK    GeneRIF: these results indicate the involvement of FAN in
            TNF-induced gene expression and leukocyte recruitment, contributing
            to the establishment of the specific immune response.
REFERENCE   5  (bases 1 to 3518)
  AUTHORS   Palin K, Bluthe RM, McCusker RH, Levade T, Moos F, Dantzer R and
            Kelley KW.
  TITLE     The type 1 TNF receptor and its associated adapter protein, FAN,
            are required for TNFalpha-induced sickness behavior
  JOURNAL   Psychopharmacology (Berl) 201 (4), 549-556 (2009)
   PUBMED   18825372
  REMARK    GeneRIF: This is the first report to demonstrate that
            TNFalpha-induced sickness behavior is fully mediated by TNF-R1 and
            that the adaptor protein FAN is a necessary intracellular
            intermediate for sickness behavior
REFERENCE   6  (bases 1 to 3518)
  AUTHORS   Mohlig H, Mathieu S, Thon L, Frederiksen MC, Ward DM, Kaplan J,
            Schutze S, Kabelitz D and Adam D.
  TITLE     The WD repeat protein FAN regulates lysosome size independent from
            abnormal downregulation/membrane recruitment of protein kinase C
  JOURNAL   Exp Cell Res 313 (12), 2703-2718 (2007)
   PUBMED   17512928
  REMARK    GeneRIF: FAN mediates activation of N-SMase as well as regulation
            of lysosome size by signaling pathways that operate independent
            from activation/membrane recruitment of PKC.
REFERENCE   7  (bases 1 to 3518)
  AUTHORS   Malagarie-Cazenave S, Segui B, Leveque S, Garcia V, Carpentier S,
            Altie MF, Brouchet A, Gouaze V, Andrieu-Abadie N, Barreira Y,
            Benoist H and Levade T.
  TITLE     Role of FAN in tumor necrosis factor-alpha and
            lipopolysaccharide-induced interleukin-6 secretion and lethality in
            D-galactosamine-sensitized mice
  JOURNAL   J Biol Chem 279 (18), 18648-18655 (2004)
   PUBMED   14985352
  REMARK    GeneRIF: the role of FAN and IL-6 in the inflammatory response
            initiated by endotoxin, implicating TNFalpha
REFERENCE   8  (bases 1 to 3518)
  AUTHORS   Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP and Bucan M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
REFERENCE   9  (bases 1 to 3518)
  AUTHORS   Kreder D, Krut O, Adam-Klages S, Wiegmann K, Scherer G, Plitz T,
            Jensen JM, Proksch E, Steinmann J, Pfeffer K and Kronke M.
  TITLE     Impaired neutral sphingomyelinase activation and cutaneous barrier
            repair in FAN-deficient mice
  JOURNAL   EMBO J 18 (9), 2472-2479 (1999)
   PUBMED   10228161
REFERENCE   10 (bases 1 to 3518)
  AUTHORS   Adam-Klages S, Schwandner R, Adam D, Kreder D, Bernardo K and
            Kronke M.
  TITLE     Distinct adapter proteins mediate acid versus neutral
            sphingomyelinase activation through the p55 receptor for tumor
            necrosis factor
  JOURNAL   J Leukoc Biol 63 (6), 678-682 (1998)
   PUBMED   9620659
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729997.1, BC145963.1 and CO043098.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_010945.3.
            
            On Apr 2, 2008 this sequence version replaced NM_010945.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013632.1, BC145961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               BY729997.1         2-187
            187-3370            BC145963.1         1-3184
            3371-3518           CO043098.1         1-148               c
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..3518
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /note="neutral sphingomyelinase (N-SMase) activation
                     associated factor"
                     /db_xref="GeneID:18201"
                     /db_xref="MGI:MGI:1341864"
     exon            1..287
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2991
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /note="factor associated with neutral sphingomyelinase
                     activation; factor associated with N-SMase activation"
                     /codon_start=1
                     /product="protein FAN"
                     /protein_id="NP_035075.2"
                     /db_xref="CCDS:CCDS17952.1"
                     /db_xref="GeneID:18201"
                     /db_xref="MGI:MGI:1341864"
                     /translation="MAFTRKRQREQQLQLYSKERFSLLLLNLEEYYFEQHTAFHVQHQ
                     GSQEERKIRGSLKICSKSVIFEPDAISQPILKIPLRDCLKIGKHGENGANKHFAKAKS
                     WGISLIFSQIYFIKEHNIVAPYKIERGKMEYVFELEVSGKVEDVVETLLQLHRASCLD
                     KLGDQMAMITAILQSRLARTSFDKNRFQSVSEKLHMECKAEMVTPLVTNPGHVCITDT
                     SLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTDDDLCSDIYLKFYEPQ
                     DRDDLYFYIATYLEHHAAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYP
                     VFPWIISDYSSPELDLSNPATFRDLSKPVGALNAERLERLLTRYQEMPEPRFMYGSHY
                     SSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFY
                     DEDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWASSPQDFLQKNKDALESGYVSEHLHE
                     WIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTPKQ
                     LFVTPHPRRITPKFKSLSQASSYNASLTDSPVSPGEESFEDLTEESRTLAWSNIAKLQ
                     LHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCL
                     LLPGDTTVISSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHNDRLYSGSWDSTVK
                     VWSGVPAEMPGTKRHQFDLLAELEHDVSVNTINLNAVSTLLVSGTKEGMVNIWDLTTA
                     TLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSMASEEPQRCFV
                     WDGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIM
                     FWKLQY"
     exon            288..377
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            378..456
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            457..524
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            525..561
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            562..612
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            613..684
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            685..732
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            733..785
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            786..915
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            916..987
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1096
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1273
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1353
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1444
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1508
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1560
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1681
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1813
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1856
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2020
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2129
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2188
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2256
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2324
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2448
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2532
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2683
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2786
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2896
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3507
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtaggac gcggctcccg cggcctcagg tcactgcgcg cccctcctcc gggcctgagt
       61 cacggcgtcg cccgagtccc cacgcgagga tgctgcggtg agcgccgtcc ggacgccgcg
      121 ggccctgggg cgcagcgtgg ggctcccggc cgcccgcccg cctgcccgcc cggtgcggcc
      181 gctcgggact gctcgggaca gtcggcggcc tgcgagccct gggcctccat ggcgttcacc
      241 cggaagaggc agcgcgagca gcagctgcag ctctactcca aggagaggtt ttccttactg
      301 cttctcaact tggaggagta ctactttgag cagcacacag cgttccatgt ccagcaccag
      361 ggcagccagg aagaaaggaa aatcagaggc tccttaaaga tatgttcaaa atcagtgatt
      421 tttgaaccag atgcaatatc tcagcccatt cttaagattc ctttgagaga ctgtttaaaa
      481 ataggaaaac atggagaaaa tggagccaat aaacactttg caaaggcaaa atcatggggt
      541 atttcactca ttttcagtca gatatacttt attaaggagc acaacattgt ggcaccgtat
      601 aagatagagc ggggaaaaat ggagtatgtc tttgaactgg aagtttctgg gaaggtggaa
      661 gatgttgtgg agacattgct acagctgcac agagcatcct gccttgataa acttggtgac
      721 caaatggcca tgataacagc tatcttgcag tcacgtctgg ctaggacatc atttgacaaa
      781 aacaggttcc aaagtgtttc tgaaaagctg cacatggagt gcaaagcaga gatggtaaca
      841 cctctagtga cgaaccctgg gcatgtgtgc attacagaca ccagcctgta tttccagcct
      901 ctcaatgggt acccgaaacc tgtggtccag ataacactgc aggatgtccg gcgcatttac
      961 aaaaggaggc acggcctcat gcctttgggc ttggaagtgt tttgcacaga tgacgacctg
     1021 tgttccgaca tatacctaaa gttctatgag cctcaagaca gagatgatct ctatttttat
     1081 atcgccacgt acctagaaca ccacgctgca gaacacactg cggagagcta catgctgcag
     1141 tggcagcgag ggcacctttc caactaccag tacctgctcc acctcaacaa cctggccgac
     1201 cgcagctgca atgacctgtc ccagtaccct gtgtttccat ggataataag tgattactcc
     1261 agcccagagc tagatttgtc aaatcctgca accttccgag atcttagtaa gccagtggga
     1321 gccctaaatg cggagcgact ggagagactg ctgactcgat accaggaaat gcctgagcca
     1381 agattcatgt atgggagtca ctactcttct ccaggctatg tgctctttta cctcgttagg
     1441 atcgcaccag agtatatgct gtgtctacaa aatggaagat ttgataatgc agataggatg
     1501 tttaacagta ttgcagaaac gtggaaaaac tgtttggatg gtgcaacgga ttttaaagag
     1561 ttgattccag aattctatga tgaagacgtc agctttttgg tcaatagtct gaagctggat
     1621 ctgggaaaga gacaaggcgg gcagatggtt gatgacgtgg accttccagc ctgggcctca
     1681 agtccccaag acttcctgca gaagaacaag gatgccttgg aaagcggtta cgtgtctgag
     1741 caccttcatg agtggattga tctgatattt ggctataagc aaaaagggag tgaggccata
     1801 ggggcccata acgtgtttca tcccctgacc tatgaaggtg gtgtagactt gaacagcatt
     1861 gaggatcctg atgaaaaagt agccatgctg acccaaattt tggaatttgg gcagacacca
     1921 aaacagctgt ttgtgacacc acatcctcga aggatcaccc ccaagtttaa aagtttgtcc
     1981 caagcctcca gctacaacgc ttctctgaca gactccccag tttctccagg ggaggagtcg
     2041 tttgaagacc tgactgagga aagcagaact ctggcctgga gtaatatcgc caagctgcag
     2101 ctacatgagc agtacaagat ccacaaagag gcggttacag ggatagcagt gtcttgcaat
     2161 ggctcttcag tctttaccac ctcccaagat tccactttga agatgttttc taaggaatcc
     2221 aaaatgctac aaagaagtat atcattttcc aatatggctt tatcctcttg tttactgttg
     2281 ccgggagaca ccactgtcat aagttcttct tgggataaca acgtctattt ttattccata
     2341 gcatttggaa gacgccaaga tacactgatg ggacatgacg atgctgtcag taagatctgt
     2401 tggcataacg acaggctgta ctctggatct tgggactcta ctgtgaaggt gtggtccggt
     2461 gttcctgcag aaatgccagg aacaaaaaga caccagtttg acttactggc tgagcttgaa
     2521 catgatgtca gcgtcaatac tatcaattta aatgctgtga gcacactgtt agtttctggc
     2581 accaaagaag gcatggtgaa tatttgggac ctcactacag ccactttatt acaccagact
     2641 tcatgccatt cagggacagt atgtgatgct gcttttagcc cagatagtcg ccacatcctc
     2701 agcacgggcg tagatggatg tctcaatgtg attgatgtgc agacgggcat gctcatctcc
     2761 tccatggcct cagaggagcc gcagaggtgc tttgtctggg atggaaattc tgtcttatct
     2821 ggaagtcggt ctggtgagct gcttgtttgg gacctccttg gagcaaaagt cagtgagcgg
     2881 attcagggcc acactggtgc tgtgacatgc atgtggatga acgaacagtg tagcagtatt
     2941 atcaccggag gggaagacag acaaattatg ttctggaaat tgcagtatta agtgcctttt
     3001 cctctccatc aagtacaatt ctacttaatg tattttaaac cagactttaa actggtgaat
     3061 gtgcaatgat agtacttaga agttttacca catgaagaat gtgtggtttc aacttcctaa
     3121 atcatggtga cttcattcag agccatttgt tgtcatccat taagcagata taacatggca
     3181 gtgttagggg aaaggacaga gaactatcaa ccatgacaac agtttgaaga ctactgggtg
     3241 ttcaggataa acccagtcgg actgaggaac actggccagc actggccagc tcagtcccca
     3301 agaggacagt ctgtattcaa gctgcccagg ttctgacggt aacacggttc tttgatgtgc
     3361 ggtcatggac tggttccttt cggcagtgct gcgtgcccag attcttaata acattaagtc
     3421 tgttactgtg tatagcaatg gtttatattt cattatgcta ctaaaggttc atcttttcta
     3481 cattaaaaat atttttctgt aatgaaaaaa aaaaaaaa
//
