LOCUS       NP_035075                920 aa            linear   ROD 14-JUN-2024
DEFINITION  protein FAN isoform 1 [Mus musculus].
ACCESSION   NP_035075
VERSION     NP_035075.2
DBSOURCE    REFSEQ: accession NM_010945.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 920)
  AUTHORS   Nusshold,C., Uellen,A., Bernhart,E., Hammer,A., Damm,S.,
            Wintersperger,A., Reicher,H., Hermetter,A., Malle,E. and Sattler,W.
  TITLE     Endocytosis and intracellular processing of BODIPY-sphingomyelin by
            murine CATH.a neurons
  JOURNAL   Biochim Biophys Acta 1831 (12), 1665-1678 (2013)
   PUBMED   23973266
REFERENCE   2  (residues 1 to 920)
  AUTHORS   Boecke,A., Carstens,A.C., Neacsu,C.D., Baschuk,N., Haubert,D.,
            Kashkar,H., Utermohlen,O., Pongratz,C. and Kronke,M.
  TITLE     TNF-receptor-1 adaptor protein FAN mediates TNF-induced B16
            melanoma motility and invasion
  JOURNAL   Br J Cancer 109 (2), 422-432 (2013)
   PUBMED   23674089
  REMARK    GeneRIF: FAN through promoting melanoma cellular motility and
            tumour invasiveness is critical for the tumour-promoting action of
            tumor necrosis factor.
REFERENCE   3  (residues 1 to 920)
  AUTHORS   Mas,E., Danjoux,M., Garcia,V., Carpentier,S., Segui,B. and
            Levade,T.
  TITLE     The pro-inflammatory action of tumour necrosis factor-alpha in
            non-alcoholic steatohepatitis is independent of the NSMAF gene
            product
  JOURNAL   Dig Liver Dis 45 (2), 147-154 (2013)
   PUBMED   23044079
  REMARK    GeneRIF: FAN is not implicated in the development of methionine and
            choline deficient diet-induced non-alcoholic steatohepatitis.
REFERENCE   4  (residues 1 to 920)
  AUTHORS   Montfort,A., de Badts,B., Douin-Echinard,V., Martin,P.G.,
            Iacovoni,J., Nevoit,C., Therville,N., Garcia,V., Bertrand,M.A.,
            Bessieres,M.H., Trombe,M.C., Levade,T., Benoist,H. and Segui,B.
  TITLE     FAN stimulates TNF(alpha)-induced gene expression, leukocyte
            recruitment, and humoral response
  JOURNAL   J Immunol 183 (8), 5369-5378 (2009)
   PUBMED   19786552
  REMARK    GeneRIF: these results indicate the involvement of FAN in
            TNF-induced gene expression and leukocyte recruitment, contributing
            to the establishment of the specific immune response.
REFERENCE   5  (residues 1 to 920)
  AUTHORS   Palin,K., Bluthe,R.M., McCusker,R.H., Levade,T., Moos,F.,
            Dantzer,R. and Kelley,K.W.
  TITLE     The type 1 TNF receptor and its associated adapter protein, FAN,
            are required for TNFalpha-induced sickness behavior
  JOURNAL   Psychopharmacology (Berl) 201 (4), 549-556 (2009)
   PUBMED   18825372
  REMARK    GeneRIF: This is the first report to demonstrate that
            TNFalpha-induced sickness behavior is fully mediated by TNF-R1 and
            that the adaptor protein FAN is a necessary intracellular
            intermediate for sickness behavior
REFERENCE   6  (residues 1 to 920)
  AUTHORS   Tcherkasowa,A.E., Adam-Klages,S., Kruse,M.L., Wiegmann,K.,
            Mathieu,S., Kolanus,W., Kronke,M. and Adam,D.
  TITLE     Interaction with factor associated with neutral sphingomyelinase
            activation, a WD motif-containing protein, identifies receptor for
            activated C-kinase 1 as a novel component of the signaling pathways
            of the p55 TNF receptor
  JOURNAL   J Immunol 169 (9), 5161-5170 (2002)
   PUBMED   12391233
REFERENCE   7  (residues 1 to 920)
  AUTHORS   Alavizadeh,A., Kiernan,A.E., Nolan,P., Lo,C., Steel,K.P. and
            Bucan,M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
REFERENCE   8  (residues 1 to 920)
  AUTHORS   Kreder,D., Krut,O., Adam-Klages,S., Wiegmann,K., Scherer,G.,
            Plitz,T., Jensen,J.M., Proksch,E., Steinmann,J., Pfeffer,K. and
            Kronke,M.
  TITLE     Impaired neutral sphingomyelinase activation and cutaneous barrier
            repair in FAN-deficient mice
  JOURNAL   EMBO J 18 (9), 2472-2479 (1999)
   PUBMED   10228161
REFERENCE   9  (residues 1 to 920)
  AUTHORS   Adam-Klages,S., Schwandner,R., Adam,D., Kreder,D., Bernardo,K. and
            Kronke,M.
  TITLE     Distinct adapter proteins mediate acid versus neutral
            sphingomyelinase activation through the p55 receptor for tumor
            necrosis factor
  JOURNAL   J Leukoc Biol 63 (6), 678-682 (1998)
   PUBMED   9620659
  REMARK    Review article
REFERENCE   10 (residues 1 to 920)
  AUTHORS   Adam-Klages,S., Adam,D., Wiegmann,K., Struve,S., Kolanus,W.,
            Schneider-Mergener,J. and Kronke,M.
  TITLE     FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to
            neutral sphingomyelinase
  JOURNAL   Cell 86 (6), 937-947 (1996)
   PUBMED   8808629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX510318.4 and AL772306.10.
            
            On Apr 2, 2008 this sequence version replaced NP_035075.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.57289.1, BC145961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 2.91 cM"
     Protein         1..920
                     /product="protein FAN isoform 1"
                     /note="protein FAN; factor associated with neutral
                     sphingomyelinase activation; factor associated with
                     N-SMase activation"
                     /calculated_mol_wt=104415
     Region          192..285
                     /region_name="PH_BEACH"
                     /note="Pleckstrin homology domain in BEACH domain
                     containing proteins; cd01201"
                     /db_xref="CDD:275391"
     Region          304..575
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          <619..919
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          631..661
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35242.2)"
     Region          636..673
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          673..703
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O35242.2)"
     Region          679..715
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          715..743
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O35242.2)"
     Region          720..764
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          764..794
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35242.2)"
     Region          770..805
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          806..836
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (O35242.2)"
     Region          811..848
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          887..917
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (O35242.2)"
     Region          892..916
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..920
                     /gene="Nsmaf"
                     /gene_synonym="C630007J05; Fan"
                     /coded_by="NM_010945.3:238..3000"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17952.1"
                     /db_xref="GeneID:18201"
                     /db_xref="MGI:MGI:1341864"
ORIGIN      
        1 maftrkrqre qqlqlysker fsllllnlee yyfeqhtafh vqhqgsqeer kirgslkics
       61 ksvifepdai sqpilkiplr dclkigkhge ngankhfaka kswgislifs qiyfikehni
      121 vapykiergk meyvfelevs gkvedvvetl lqlhrascld klgdqmamit ailqsrlart
      181 sfdknrfqsv seklhmecka emvtplvtnp ghvcitdtsl yfqplngypk pvvqitlqdv
      241 rriykrrhgl mplglevfct dddlcsdiyl kfyepqdrdd lyfyiatyle hhaaehtaes
      301 ymlqwqrghl snyqyllhln nladrscndl sqypvfpwii sdysspeldl snpatfrdls
      361 kpvgalnaer lerlltryqe mpeprfmygs hysspgyvlf ylvriapeym lclqngrfdn
      421 adrmfnsiae twkncldgat dfkelipefy dedvsflvns lkldlgkrqg gqmvddvdlp
      481 awasspqdfl qknkdalesg yvsehlhewi dlifgykqkg seaigahnvf hpltyeggvd
      541 lnsiedpdek vamltqilef gqtpkqlfvt phprritpkf kslsqassyn asltdspvsp
      601 geesfedlte esrtlawsni aklqlheqyk ihkeavtgia vscngssvft tsqdstlkmf
      661 skeskmlqrs isfsnmalss clllpgdttv issswdnnvy fysiafgrrq dtlmghddav
      721 skicwhndrl ysgswdstvk vwsgvpaemp gtkrhqfdll aelehdvsvn tinlnavstl
      781 lvsgtkegmv niwdlttatl lhqtschsgt vcdaafspds rhilstgvdg clnvidvqtg
      841 mlissmasee pqrcfvwdgn svlsgsrsge llvwdllgak vseriqghtg avtcmwmneq
      901 cssiitgged rqimfwklqy
//
