LOCUS       NM_198654               2973 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NSL1, MIS12 kinetochore complex component (Nsl1),
            mRNA.
ACCESSION   NM_198654 XM_355266
VERSION     NM_198654.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2973)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2973)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   3  (bases 1 to 2973)
  AUTHORS   Varma,D. and Salmon,E.D.
  TITLE     The KMN protein network--chief conductors of the kinetochore
            orchestra
  JOURNAL   J Cell Sci 125 (Pt 24), 5927-5936 (2012)
   PUBMED   23418356
  REMARK    Review article
REFERENCE   4  (bases 1 to 2973)
  AUTHORS   Lampert,F. and Westermann,S.
  TITLE     A blueprint for kinetochores - new insights into the molecular
            mechanics of cell division
  JOURNAL   Nat Rev Mol Cell Biol 12 (7), 407-412 (2011)
   PUBMED   21633384
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2973)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138229.16.
            
            On Nov 20, 2008 this sequence version replaced NM_198654.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029086.1, BU052992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC138229.16        90658-90909
            253-331             AC138229.16        92812-92890
            332-462             AC138229.16        97627-97757
            463-517             AC138229.16        98815-98869
            518-585             AC138229.16        108126-108193
            586-2973            AC138229.16        109808-112195
FEATURES             Location/Qualifiers
     source          1..2973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..2973
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /note="NSL1, MIS12 kinetochore complex component"
                     /db_xref="GeneID:381318"
                     /db_xref="MGI:MGI:2685830"
     exon            1..252
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..864
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /note="NSL1, MIND kinetochore complex component, homolog"
                     /codon_start=1
                     /product="kinetochore-associated protein NSL1 homolog"
                     /protein_id="NP_941056.3"
                     /db_xref="CCDS:CCDS15614.1"
                     /db_xref="GeneID:381318"
                     /db_xref="MGI:MGI:2685830"
                     /translation="MAAVSETVLVSAPQDHDAQAASDPQATAADSPLEDFRVRCTLKR
                     AVMEVMEMCGRFVQELGAVLPEDVRELALRDAQWTFESAVQENVSFNGQAWEEAKEHG
                     LMDSDIKVLEDEFDELIVDVATKRRQYPRRILESVIKTLKAQHASLKQYHPVVHPLDL
                     KCDPDPASRVEDLKCRGEAIAKEMSEAMKALPVLIEQGEGFSQVLKMRPVIQLQRINQ
                     EVFSSLYRKADSKPDTRVTHVETTPAETGARKASDIVLKRKKAPDCAQRKRYPLRLQR
                     INLDM"
     exon            253..331
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /inference="alignment:Splign:2.1.0"
     exon            332..462
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /inference="alignment:Splign:2.1.0"
     exon            463..517
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /inference="alignment:Splign:2.1.0"
     exon            518..585
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /inference="alignment:Splign:2.1.0"
     exon            586..2973
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2949..2954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /note="hexamer: AATAAA"
     polyA_site      2973
                     /gene="Nsl1"
                     /gene_synonym="4833432M17Rik; Gm105; Gm984"
                     /note="major polyA site"
ORIGIN      
        1 ttagtttaaa ccgggaagat ggcggctgtc tctgaaacag tgctcgtctc cgccccgcag
       61 gaccacgatg cccaggccgc ctcagaccct caggccacgg cagcagactc tcccctagag
      121 gacttccgag tgcgctgcac cttgaagagg gcggtgatgg aagtgatgga gatgtgcggt
      181 cgcttcgtgc aggagctcgg ggccgtgctg ccggaggacg tccgcgagct cgcgctgcgg
      241 gacgcacagt ggacatttga gtcggctgtg caggagaacg tcagctttaa cggacaggcc
      301 tgggaggaag ctaaagagca tggcttaatg gattctgaca tcaaagtgct tgaagatgaa
      361 tttgatgagc tcatagtaga tgtggcaacc aaacggaggc agtatcccag aaggatcctt
      421 gagagtgtca tcaaaacctt gaaagcacag cacgcgagtc tgaagcagta tcaccctgtt
      481 gtacatcctc tggacctgaa atgtgaccct gacccagctt ctcgtgtaga agatttgaaa
      541 tgccgcggag aagccatagc taaggaaatg agtgaggcca tgaaggcttt gcctgtgcta
      601 attgaacaag gagaaggctt ttcccaggtc ttaaagatgc gacctgtcat ccagctacag
      661 aggatcaacc aggaagtctt ctccagcctc tacaggaaag ctgactccaa gcctgacaca
      721 cgtgtgacac acgtagaaac cacaccagcc gagactggag ccaggaaggc ctccgacatt
      781 gtgctaaaga gaaagaaagc cccagactgt gcccagagaa agcgctaccc gctgcggctg
      841 cagagaatta atctcgatat gtgagctctg tttgttgagg agctgaaagt cagtgttgtc
      901 aacatttggg tcacagtctg atgcctgagt gacttcatga aagtgagtgg ctctgtccag
      961 gcactgtaca ggtgcagtgc gctgctgtga atcctggaat acggctgagt gcctagcttc
     1021 ttcccttgag tccctgtgca gtaggtgaag acttcccagt cctgcacaga cctgtcggta
     1081 gcctccgatg acaccagctc ttggctttgg ctgccttgca gctttgaggc atcccaggga
     1141 tgtgctctga ggggttttgt ttttagcaca gctttctgtg aggctctgag gtggttccct
     1201 gtggctggat agctggcatt ggctctgcgt ggccgtgtgt gcatttccag gcaggttttc
     1261 agatgaatgc acagaaaatg ggcctggcct taagtttgct ccatggtcat tcatttgagg
     1321 ttttagagtt ttgtaagata aatgagaagg ctattatttg tgcaggaaat gttcttaaaa
     1381 agaaaatctg gggcacggag cctctatttc ttgcctacgt ttttatttcc ataaatcttt
     1441 ttttttgttt tttggttttt ggtttttttg ttttgttttt ttcgagacag ggtttctctg
     1501 tatagccctg gctgtcctgg aactcacttt gtagaccagg ctggcctcga actcagaaat
     1561 ctgcctgcct ctgcctccca agtgctggga ttaaaggcat gcaccaccac gcctggctaa
     1621 tttccataaa tctttgaaca taatttgact ggaaactgat ggcttctttt aaagtcctta
     1681 tttccaaata gatccttcta gttcaaagta catattagga ttgatggacg tgtcatttac
     1741 cacagatcta agcagagtaa gtgtcagact caggccgtgt cagcaaacct acactgagat
     1801 ttcaacacag cctcttgcag tgtgcctgtg tctcttacct ggtgcgtcat aggcggggcc
     1861 gccgaacttg ccatctattt cccttttggg tgctcaccct tgtggccatt ttcaggggag
     1921 ttgactgatc atgactcggg aatctgtgtt gcctttgctc actgtgtcct gatgatcaca
     1981 agcatcttgg tttctctgct tttctcagct gggaagcttc atggccacgc tgctttgtgg
     2041 agctcgggtt ctgttttact taagttaatg attgcatggg ggagtgtttg ggtctttaaa
     2101 gtaatgtata aagaccagaa tcttggcact gtgcctgttc cacctaacaa ggcattcttg
     2161 gtgctggctt tcgtgggaga gcagggtggc gctctgcatt tcagcgtgag ctagctctca
     2221 ccctgaaacc aatgtgcgac tccagaaggt gactgctcgc actgtgcctt tccaggcatt
     2281 aaagcgctgt gactgatttt gcttgggaag tgcccaaaga ggcaaggcta gagagcagac
     2341 tgggaggcag catggtggga ttccactgaa gcaagagctg tgcagcagga tgggagcgtg
     2401 ggcttggggc atcctccagg cgactctggc tggacccata aagtcaaatt gtgaaaggcc
     2461 tctttccaca catgggctgt gacttaaagc actcgcttag tagtaagctc tgagaggtgt
     2521 tcgtcctcag tgcagaagct aggtgatcag agaactgcaa gcatccttgg ggccggctca
     2581 attcaacagg agttcttcat gggggttctc ttcccagcag gcctgtggta attgtgaaga
     2641 tgtttttttc ctatcataac ttaaggtgtg tgtggcgggg gttgaggtag cggtgtgtca
     2701 tcatctagtg atagatgtcc cgatggctgg cacagctaac catctgcccc aaggcagtga
     2761 tgctgtggtg gagaagccga ggggagagca gaccagcagc ataatgtggt gtggccatta
     2821 cagctctccc agcctgtgtg ggaaatgctg tttgtcttgg ttgtagttac cacttgtcca
     2881 cataccccac tgtcagtctt cataagacaa actgcaatgt atgaacttat tatataaaac
     2941 aatccacaaa taaaaaggaa atgttaattg taa
//
