LOCUS       NM_008741               2308 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus neuron specific gene family member 2 (Nsg2),
            transcript variant 1, mRNA.
ACCESSION   NM_008741
VERSION     NM_008741.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Zimmerman,A.J., Serrano-Rodriguez,A., Sun,M., Wilson,S.J.,
            Linsenbardt,D.N., Brigman,J.L. and Weick,J.P.
  TITLE     Knockout of AMPA receptor binding protein Neuron-specific gene 2
            (NSG2) enhances associative learning and cognitive flexibility
  JOURNAL   Mol Brain 17 (1), 95 (2024)
   PUBMED   39695712
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Chander,P., Kennedy,M.J., Winckler,B. and Weick,J.P.
  TITLE     Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting
            Protein That Modulates Excitatory Neurotransmission
  JOURNAL   eNeuro 6 (1) (2019)
   PUBMED   30680309
  REMARK    GeneRIF: NSG2 is found in discrete punctae restricted to the
            somatodendritic arbors of developing mouse and human neurons, and a
            significant proportion of NSG2 punctae colocalize with postsynaptic
            HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs)
            at excitatory synapses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   7  (bases 1 to 2308)
  AUTHORS   Heanue,T.A. and Pachnis,V.
  TITLE     Expression profiling the developing mammalian enteric nervous
            system identifies marker and candidate Hirschsprung disease genes
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 6919-6924 (2006)
   PUBMED   16632597
REFERENCE   8  (bases 1 to 2308)
  AUTHORS   Abramova,N., Charniga,C., Goderie,S.K. and Temple,S.
  TITLE     Stage-specific changes in gene expression in acutely isolated mouse
            CNS progenitor cells
  JOURNAL   Dev Biol 283 (2), 269-281 (2005)
   PUBMED   15890332
REFERENCE   9  (bases 1 to 2308)
  AUTHORS   Saberan-Djoneidi,D., Marey-Semper,I., Picart,R., Studler,J.M.,
            Tougard,C., Glowinski,J. and Levi-Strauss,M.
  TITLE     A 19-kDa protein belonging to a new family is expressed in the
            Golgi apparatus of neural cells
  JOURNAL   J Biol Chem 270 (4), 1888-1893 (1995)
   PUBMED   7829526
REFERENCE   10 (bases 1 to 2308)
  AUTHORS   Diriong,S., Saberan-Djoneidi,D., Levi-Strauss,M., Bernheim,A. and
            Nguyen,V.C.
  TITLE     Assignment of the human 8.5 H gene to chromosome 5, region 5q35
  JOURNAL   Hum Genet 93 (6), 703-706 (1994)
   PUBMED   8005598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN176718.1, AK075612.1, BM114408.1 and CO040919.1.
            
            On Mar 19, 2014 this sequence version replaced NM_008741.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN176718.1, AK088499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DN176718.1         1-44
            45-1859             AK075612.1         2-1816
            1860-2283           BM114408.1         1-424               c
            2284-2308           CO040919.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.72 cM"
     gene            1..2308
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /note="neuron specific gene family member 2"
                     /db_xref="GeneID:18197"
                     /db_xref="MGI:MGI:1202070"
     exon            1..178
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /inference="alignment:Splign:2.1.0"
     exon            179..328
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..715
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuron-specific protein family member 2; protein 8.5;
                     protein p19; neuronal vesicle trafficking-associated
                     protein 2"
                     /codon_start=1
                     /product="neuronal vesicle trafficking-associated protein
                     2 isoform 1"
                     /protein_id="NP_032767.1"
                     /db_xref="CCDS:CCDS24516.1"
                     /db_xref="GeneID:18197"
                     /db_xref="MGI:MGI:1202070"
                     /translation="MVKLNSNPGEKGAKPPSVEDGFQTVPLITPLEVNHLQLAAPEKV
                     IVKTRTEYQPEQRNKGKFRVPKIAEFTVTILVSLALAFLACIVFLVVYKAFTYDHSCP
                     EGFVYKHKRCIPASLDAYYSSQDPSSRSRFYTVISHYSVAKQSTARAIGPWLSAAAVI
                     HEPKPPKTQGH"
     exon            329..412
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /inference="alignment:Splign:2.1.0"
     exon            413..523
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /inference="alignment:Splign:2.1.0"
     exon            524..2292
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /note="hexamer: AATAAA"
     polyA_site      2283
                     /gene="Nsg2"
                     /gene_synonym="P19"
                     /note="major polyA site"
ORIGIN      
        1 ctggcagctg ccagatcttc tctgcgcgct ggcgcctcgt tctcagaagc tccggatcca
       61 ggcacgcgag ggctgctttt ttcagcacca cgctctggct gaggagggag gactcctgtt
      121 tgtcctcctc ctctacatat tggcttgact ctgctctgac ccccaccagt gccgcacagt
      181 ctggaataaa agcagaagca tggtgaagct gaacagcaac cctggagaga agggggccaa
      241 gccgccttcc gtggaggatg gtttccagac cgtccctctc atcacgccct tggaggttaa
      301 tcatttgcag ctggctgctc ccgagaaggt gatcgtgaag acaagaacag aataccagcc
      361 ggaacagagg aacaaaggga agttccgggt gccaaagatc gctgaattta cggtcaccat
      421 tcttgtcagc ctggcccttg ccttccttgc ttgcattgtg ttcctggtgg tttacaaagc
      481 ctttacctat gaccacagct gtcctgaagg atttgtctac aagcacaagc gctgtatccc
      541 ggcctcgctg gatgcttact actcgtccca ggaccccagc tccaggagcc gcttctacac
      601 agtcatcagc cactacagtg tggccaagca gagcactgcc cgggccatcg ggccatggct
      661 gtcagcagct gctgtcatcc atgagcccaa gccacccaag acgcagggcc attagaggtc
      721 tgccccagct gggatggggg tgggtgggtg gagagggaaa cccccctccc cactagttaa
      781 gcaaggctgg agctacaaga caatactgta ctgctagggt acggggtggg ggcggggcag
      841 gatggggtct ggggagcact ccccaaaaat attgtgcact ggagttgtct gaatcgatct
      901 ttccttttgt tcttttgtat tgttgcttcg tacccaagtc aggctcgtgt acaaaggcat
      961 gtttcgcgtt gattgttccc atgtaagata ttttcaaagc cgccgcttat tctttgttag
     1021 gataatttag agacagaaag gggagccgga taaaatgaat ttaaaaagca tgaaacgggc
     1081 tccacgtgga agacacagca gggcagtaaa gagcagagtc tgtctgggac ttcttagata
     1141 aggccccatg gcttctgtgt gggcgtccga gtactgcgtg gcgaagggtg ggctgttcag
     1201 tttgcctgtg gtctgcagga gagaagcaca gcgatggcag gcaaggctga tttggagagg
     1261 aaggtgatgt tggcatttct caactaggaa tgcacagagt accactcaat ggtgagcttg
     1321 caagatttgc acaaactcat gggggaggca tccacgctca gccctgggca gcccatgggg
     1381 acctaggctc cgatgctcac agggcggctg ttgtgcctca gcaaacacag gcgtggatag
     1441 atgttgtctt tcttttgttt ttctaggtgt atccctagat gctgcccgtg ttttcaagat
     1501 ggcaggggtg ggaagggaga gaaaggaaga gaggtcaggc gggccgctct ggacccagct
     1561 aaaagcatag gcacccggtt tcacccgggt tttgcttttt ccccaaagcg ctaatgacag
     1621 caggaatgac aattgaattc tagttagttg aaatctgaca gccgggaaga aacttgaaga
     1681 ttgggcaggc agtgctcatt cctaaaagaa gctggagaag gtgactgttt gctcactgtg
     1741 ttgtgttgac agagttgtcc agacttccca gctaggttct agaagcacct gacagggagg
     1801 tgtggccaac atccttaggc ttctcactgg cactttagca agggcctcct gcttctcgcg
     1861 agcattccag gaaatccctt ttcttggagg tgctggcccc aggtccaaga gaatgagaac
     1921 tggccagggg aattgcccat ttggtctgca taggccgttt aagggtattt ttttgtggct
     1981 tgctatattg ctgaaattat tgtacacagc agctgggtaa taggaatagt atatctcaaa
     2041 ccatcctgcc agatactctc atctgatttc tcctccctcc ccccatcttc ccatcacctt
     2101 gagtcacctg taaattcatt tgtcatctga aacggatcaa caaatcttcc ctagcaaaac
     2161 cacagagcgc tttataattt tgtggtgtat ttttgtcagt aggtagcaga ggctgaagta
     2221 ttttttggtg taattcttga aattttctga caggaaaaaa aaataaacat agatgtgtct
     2281 gagtgtcctg acaaaaaaaa aaaaaaaa
//
