LOCUS       NM_010942               2416 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuron specific gene family member 1 (Nsg1),
            transcript variant 2, mRNA.
ACCESSION   NM_010942
VERSION     NM_010942.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Austin,R., Chander,P., Zimmerman,A.J., Overby,M., Digilio,L.,
            Yap,C.C., Linsenbardt,D.N., Muller,H.K. and Weick,J.P.
  TITLE     Global loss of Neuron-specific gene 1 causes alterations in motor
            coordination, increased anxiety, and diurnal hyperactivity in male
            mice
  JOURNAL   Genes Brain Behav 21 (6), e12816 (2022)
   PUBMED   35577358
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Yap,C.C., Digilio,L., McMahon,L. and Winckler,B.
  TITLE     The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are
            itinerant, not resident proteins of dendritic endosomes
  JOURNAL   Sci Rep 7 (1), 10481 (2017)
   PUBMED   28874679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Debaigt,C., Hirling,H., Steiner,P., Vincent,J.P. and Mazella,J.
  TITLE     Crucial role of neuron-enriched endosomal protein of 21 kDa in
            sorting between degradation and recycling of internalized
            G-protein-coupled receptors
  JOURNAL   J Biol Chem 279 (34), 35687-35691 (2004)
   PUBMED   15187090
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Steiner,P., Sarria,J.C., Glauser,L., Magnin,S., Catsicas,S. and
            Hirling,H.
  TITLE     Modulation of receptor cycling by neuron-enriched endosomal protein
            of 21 kD
  JOURNAL   J Cell Biol 157 (7), 1197-1209 (2002)
   PUBMED   12070131
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Saberan-Djoneidi,D., Picart,R., Escalier,D., Gelman,M., Barret,A.,
            Tougard,C., Glowinski,J. and Levi-Strauss,M.
  TITLE     A 21-kDa polypeptide belonging to a new family of proteins is
            expressed in the Golgi apparatus of neural and germ cells
  JOURNAL   J Biol Chem 273 (7), 3909-3914 (1998)
   PUBMED   9461575
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Carlock,L., Vo,T., Lorincz,M., Walker,P.D., Bessert,D.,
            Wisniewski,D. and Dunbar,J.C.
  TITLE     Variable subcellular localization of a neuron-specific protein
            during NTera 2 differentiation into post-mitotic human neurons
  JOURNAL   Brain Res Mol Brain Res 42 (2), 202-212 (1996)
   PUBMED   9013775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076451.1, AK148941.1 and AC115931.7.
            
            On Dec 20, 2017 this sequence version replaced NM_010942.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008272.1, AK148941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AK076451.1         165-441
            278-1593            AK148941.1         2-1317
            1594-1870           AC115931.7         35099-35375         c
            1871-2416           AK148941.1         1596-2141
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.21 cM"
     gene            1..2416
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="neuron specific gene family member 1"
                     /db_xref="GeneID:18196"
                     /db_xref="MGI:MGI:109149"
     exon            1..353
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            354..508
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..937
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="neuron-specific protein family member 1; brain
                     neuron cytoplasmic protein 1; neuron-enriched endosomal
                     protein of 21 kDa"
                     /codon_start=1
                     /product="neuronal vesicle trafficking-associated protein
                     1"
                     /protein_id="NP_035072.2"
                     /db_xref="CCDS:CCDS19251.1"
                     /db_xref="GeneID:18196"
                     /db_xref="MGI:MGI:109149"
                     /translation="MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKV
                     VVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVV
                     YKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNVAKQSITRS
                     VSPWMSVLSEEKLSEQETEAAEKSA"
     exon            509..625
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            626..736
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            737..2416
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="hexamer: ATTAAA"
     polyA_site      1905
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="major polyA site"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="hexamer: ATTAAA"
     polyA_site      1951
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
ORIGIN      
        1 cgggtattcc cttagtcggg cattgggagt ctcaggttct ccttcctccg gtcggggagc
       61 gcgcggggtc cccgggggac ccccactgca gtcgcgtgct cctttgtgcg accgatccgc
      121 gcgcgggcgg cgctgcgtca aggcggaggc gcatccgcgc ggccccacgc gcactcccgc
      181 gcgcggcccc cgggaacggc aggaaggagg cggcgcgcgg aggcgggagg cacagaaccc
      241 aatcgccgat cccccggccg cggcgccgcc tccgccattg ctgtgcgcgg gagcgggcga
      301 cactgagcct cggagcgcgc ttggagccca gatcttccgg agccaggcgt ggggccgcag
      361 cctcgtgtct ttcgcaacca tggtgaagtt ggggaataat ttcgcagaga agggcaccaa
      421 gcagccactg ctggaggatg gcttcgacac cattcctttg atgacgcccc tcgatgtcaa
      481 ccagctgcag ttcccacccc cagataaggt cgtggtgaaa actaagactg aatatgaacc
      541 tgatcgcaaa aaaggaaaag cacgtcctcc caagatagcc gagttcaccg tcagcatcac
      601 cgagggtgtc accgagaggt ttaaggtctc cgtgctggtc ctctttgccc tggccttcct
      661 cacctgtgtc gtcttcctgg ttgtctacaa agtgtacaag tatgaccgcg cctgccctga
      721 tgggtttgtc ttgaagaaca cccagtgcat cccagaaggc ttggagagct actacacgga
      781 gcaagactcc agtgcccggg agaaatttta cactgtcata aaccactaca acgtggccaa
      841 gcagagcatc acccgctccg tgtcgccatg gatgtcagtt ctgtcagaag agaagctgtc
      901 ggaacaggag accgaagctg cagagaagtc agcttagcga gcagggcagg ttccttacga
      961 tgtgtcactt gaaggcaaca aggggacttt gagggacatt tcattaaata taattaccga
     1021 taatttagag attactcatt tacggtgcaa ttgcttctgt ttgctaatgc tgctttgcaa
     1081 attaaacttg ctgcggacca cccacaggcg taagaacaag agcatctcag cattgcttag
     1141 agagctggat gccactgtcc acgctgagga gtcttcattt agctccttcc ctgggattca
     1201 ctggatactg tcaaaaggta atctacactg gctatgccag gggtctggcc gtcagaacag
     1261 cacagctgct ggtttcctgt tttcttttct gcccctttgc tatctgcaga ccttactcca
     1321 tagccatatc tagagtgatc ccgtgctttt gctggtggca gtgctgactg tcaacatgca
     1381 ctgttgagcg gcgcagagaa ggggacgtgg gcaccacgac gcagccctgc caggcaattc
     1441 tgggaggttc tctttggtat gtcccctgag cagagcacaa ggatggggtg gggaagagct
     1501 ggctctgggc tagggggtcg ccgagcctgt ttctctgtgg gtgggctgtc tgctggtaat
     1561 gtgctaggta ggaagaaagc ccactggttc ttttctttcc tgttatgaat atatttgcac
     1621 gtacagccct gaatgcaggt gcagtttggg ttttttgttt tgttttgttt tgttttatta
     1681 gccagtgggc aaagtgaaat gtaattttgg gtaagccagg gctactttag cttttcttct
     1741 gtgaacagat gtgactcctg tgctgtggga aggggcagga cggctggtgg ggggggctga
     1801 tgtggcacct tgcaaataga atatctaagt ccacaatctt tgtaagaaaa gtatgtttat
     1861 gtttcaatct gaatcttgac attaaagtat atgtttacaa aatcaccagt aggtaaacta
     1921 aatgtgtaag acaattaaat agaaaaagct attcctgatt gttttcttcc atgttctcag
     1981 aatgtgttgt ttctggtggg catgtcagaa gtctcggcgt cctttagtag gtcagaaata
     2041 aatggcaaat agtctgagac ctttgtgaac aagcatggtg gccaccatca gctccactgc
     2101 tgcttcctga ggtgtgctac tgagacaaca tcatgtattg ttgaggtgtt ctaaaacaaa
     2161 gggcatgagc tcagcacagg gggaggggcc acacagtcac gagcttgaag tgcattggaa
     2221 agctgcgagg aatgcgcaaa gagcaataca catgtgccaa aacttgtctg tagagggatc
     2281 cgactcatgg gccgtgtgcg tgcagtaggc aggccctctg tgttttctaa cgtagccctt
     2341 tacccactgt gaactctccc aatgtaattt ctcattttta ctctacaaat aaagagctcg
     2401 tgggtactta agccgc
//
