LOCUS       NM_001359091            2691 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuron specific gene family member 1 (Nsg1),
            transcript variant 3, mRNA.
ACCESSION   NM_001359091
VERSION     NM_001359091.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2691)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2691)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2691)
  AUTHORS   Austin,R., Chander,P., Zimmerman,A.J., Overby,M., Digilio,L.,
            Yap,C.C., Linsenbardt,D.N., Muller,H.K. and Weick,J.P.
  TITLE     Global loss of Neuron-specific gene 1 causes alterations in motor
            coordination, increased anxiety, and diurnal hyperactivity in male
            mice
  JOURNAL   Genes Brain Behav 21 (6), e12816 (2022)
   PUBMED   35577358
REFERENCE   4  (bases 1 to 2691)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2691)
  AUTHORS   Yap,C.C., Digilio,L., McMahon,L. and Winckler,B.
  TITLE     The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are
            itinerant, not resident proteins of dendritic endosomes
  JOURNAL   Sci Rep 7 (1), 10481 (2017)
   PUBMED   28874679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2691)
  AUTHORS   Debaigt,C., Hirling,H., Steiner,P., Vincent,J.P. and Mazella,J.
  TITLE     Crucial role of neuron-enriched endosomal protein of 21 kDa in
            sorting between degradation and recycling of internalized
            G-protein-coupled receptors
  JOURNAL   J Biol Chem 279 (34), 35687-35691 (2004)
   PUBMED   15187090
REFERENCE   7  (bases 1 to 2691)
  AUTHORS   Steiner,P., Sarria,J.C., Glauser,L., Magnin,S., Catsicas,S. and
            Hirling,H.
  TITLE     Modulation of receptor cycling by neuron-enriched endosomal protein
            of 21 kD
  JOURNAL   J Cell Biol 157 (7), 1197-1209 (2002)
   PUBMED   12070131
REFERENCE   8  (bases 1 to 2691)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
REFERENCE   9  (bases 1 to 2691)
  AUTHORS   Saberan-Djoneidi,D., Picart,R., Escalier,D., Gelman,M., Barret,A.,
            Tougard,C., Glowinski,J. and Levi-Strauss,M.
  TITLE     A 21-kDa polypeptide belonging to a new family of proteins is
            expressed in the Golgi apparatus of neural and germ cells
  JOURNAL   J Biol Chem 273 (7), 3909-3914 (1998)
   PUBMED   9461575
REFERENCE   10 (bases 1 to 2691)
  AUTHORS   Carlock,L., Vo,T., Lorincz,M., Walker,P.D., Bessert,D.,
            Wisniewski,D. and Dunbar,J.C.
  TITLE     Variable subcellular localization of a neuron-specific protein
            during NTera 2 differentiation into post-mitotic human neurons
  JOURNAL   Brain Res Mol Brain Res 42 (2), 202-212 (1996)
   PUBMED   9013775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115931.7.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.222834.1,
                                           SRR7652917.782867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-628               AC115931.7         56476-57103         c
            629-783             AC115931.7         56237-56391         c
            784-900             AC115931.7         52968-53084         c
            901-1011            AC115931.7         42069-42179         c
            1012-2691           AC115931.7         34553-36232         c
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.21 cM"
     gene            1..2691
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="neuron specific gene family member 1"
                     /db_xref="GeneID:18196"
                     /db_xref="MGI:MGI:109149"
     exon            1..628
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            629..783
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     CDS             655..1212
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="neuron-specific protein family member 1; brain
                     neuron cytoplasmic protein 1; neuron-enriched endosomal
                     protein of 21 kDa"
                     /codon_start=1
                     /product="neuronal vesicle trafficking-associated protein
                     1"
                     /protein_id="NP_001346020.1"
                     /db_xref="CCDS:CCDS19251.1"
                     /db_xref="GeneID:18196"
                     /db_xref="MGI:MGI:109149"
                     /translation="MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKV
                     VVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVV
                     YKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNVAKQSITRS
                     VSPWMSVLSEEKLSEQETEAAEKSA"
     exon            784..900
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1011
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2691
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="hexamer: ATTAAA"
     polyA_site      2180
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="major polyA site"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
                     /note="hexamer: ATTAAA"
     polyA_site      2226
                     /gene="Nsg1"
                     /gene_synonym="m234; Neep21; p21"
ORIGIN      
        1 cgggtattcc cttagtcggg cattgggagt ctcaggttct ccttcctccg gtcggggagc
       61 gcgcggggtc cccgggggac ccccactgca gtcgcgtgct cctttgtgcg accgatccgc
      121 gcgcgggcgg cgctgcgtca aggcggaggc gcatccgcgc ggccccacgc gcactcccgc
      181 gcgcggcccc cgggaacggc aggaaggagg cggcgcgcgg aggcgggagg cacagaaccc
      241 aatcgccgat cccccggccg cggcgccgcc tccgccattg ctgtgcgcgg gagcgggcga
      301 cactgagcct cggagcgcgc ttggagccca gatcttccgg agccaggcgt ggggtgagtg
      361 cgggtggcga acggggaggg cagaggagca tctctcaagc agagggccgc gggagacctg
      421 caggaggcca gtgccacccg acagggtacg cgtccagaaa ggctgggcac gggtagcgtc
      481 cccttacccg gccgtgatgc gccctgcggg atgggagtct agaaatgtta gtcaatacac
      541 agcctgagac tctgatctgg ctagatcgcc gcgtccctgc tacctctctg gggagataag
      601 gcggggacag cgaccgcgga gacagcgggc cgcagcctcg tgtctttcgc aaccatggtg
      661 aagttgggga ataatttcgc agagaagggc accaagcagc cactgctgga ggatggcttc
      721 gacaccattc ctttgatgac gcccctcgat gtcaaccagc tgcagttccc acccccagat
      781 aaggtcgtgg tgaaaactaa gactgaatat gaacctgatc gcaaaaaagg aaaagcacgt
      841 cctcccaaga tagccgagtt caccgtcagc atcaccgagg gtgtcaccga gaggtttaag
      901 gtctccgtgc tggtcctctt tgccctggcc ttcctcacct gtgtcgtctt cctggttgtc
      961 tacaaagtgt acaagtatga ccgcgcctgc cctgatgggt ttgtcttgaa gaacacccag
     1021 tgcatcccag aaggcttgga gagctactac acggagcaag actccagtgc ccgggagaaa
     1081 ttttacactg tcataaacca ctacaacgtg gccaagcaga gcatcacccg ctccgtgtcg
     1141 ccatggatgt cagttctgtc agaagagaag ctgtcggaac aggagaccga agctgcagag
     1201 aagtcagctt agcgagcagg gcaggttcct tacgatgtgt cacttgaagg caacaagggg
     1261 actttgaggg acatttcatt aaatataatt accgataatt tagagattac tcatttacgg
     1321 tgcaattgct tctgtttgct aatgctgctt tgcaaattaa acttgctgcg gaccacccac
     1381 aggcgtaaga acaagagcat ctcagcattg cttagagagc tggatgccac tgtccacgct
     1441 gaggagtctt catttagctc cttccctggg attcactgga tactgtcaaa aggtaatcta
     1501 cactggctat gccaggggtc tggccgtcag aacagcacag ctgctggttt cctgttttct
     1561 tttctgcccc tttgctatct gcagacctta ctccatagcc atatctagag tgatcccgtg
     1621 cttttgctgg tggcagtgct gactgtcaac atgcactgtt gagcggcgca gagaagggga
     1681 cgtgggcacc acgacgcagc cctgccaggc aattctggga ggttctcttt ggtatgtccc
     1741 ctgagcagag cacaaggatg gggtggggaa gagctggctc tgggctaggg ggtcgccgag
     1801 cctgtttctc tgtgggtggg ctgtctgctg gtaatgtgct aggtaggaag aaagcccact
     1861 ggttcttttc tttcctgtta tgaatatatt tgcacgtaca gccctgaatg caggtgcagt
     1921 ttgggttttt tgttttgttt tgttttgttt tattagccag tgggcaaagt gaaatgtaat
     1981 tttgggtaag ccagggctac tttagctttt cttctgtgaa cagatgtgac tcctgtgctg
     2041 tgggaagggg caggacggct ggtggggggg gctgatgtgg caccttgcaa atagaatatc
     2101 taagtccaca atctttgtaa gaaaagtatg tttatgtttc aatctgaatc ttgacattaa
     2161 agtatatgtt tacaaaatca ccagtaggta aactaaatgt gtaagacaat taaatagaaa
     2221 aagctattcc tgattgtttt cttccatgtt ctcagaatgt gttgtttctg gtgggcatgt
     2281 cagaagtctc ggcgtccttt agtaggtcag aaataaatgg caaatagtct gagacctttg
     2341 tgaacaagca tggtggccac catcagctcc actgctgctt cctgaggtgt gctactgaga
     2401 caacatcatg tattgttgag gtgttctaaa acaaagggca tgagctcagc acagggggag
     2461 gggccacaca gtcacgagct tgaagtgcat tggaaagctg cgaggaatgc gcaaagagca
     2521 atacacatgt gccaaaactt gtctgtagag ggatccgact catgggccgt gtgcgtgcag
     2581 taggcaggcc ctctgtgttt tctaacgtag ccctttaccc actgtgaact ctcccaatgt
     2641 aatttctcat ttttactcta caaataaaga gctcgtgggt acttaagccg c
//
