LOCUS       NM_010941               2218 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus NAD(P) dependent steroid dehydrogenase-like (Nsdhl),
            mRNA.
ACCESSION   NM_010941
VERSION     NM_010941.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2218)
  AUTHORS   Fan,Q., Gong,T., Zheng,C., Ng,J.M.Y., Chen,J., Myers,C.,
            Hensley,H., Curran,T. and Yang,Z.J.
  TITLE     Statins repress hedgehog signaling in medulloblastoma with no bone
            toxicities
  JOURNAL   Oncogene 40 (12), 2258-2272 (2021)
   PUBMED   33649536
  REMARK    GeneRIF: Statins repress hedgehog signaling in medulloblastoma with
            no bone toxicities.
REFERENCE   2  (bases 1 to 2218)
  AUTHORS   Gabitova-Cornell,L., Surumbayeva,A., Peri,S., Franco-Barraza,J.,
            Restifo,D., Weitz,N., Ogier,C., Goldman,A.R., Hartman,T.R.,
            Francescone,R., Tan,Y., Nicolas,E., Shah,N., Handorf,E.A.,
            Cai,K.Q., O'Reilly,A.M., Sloma,I., Chiaverelli,R., Moffitt,R.A.,
            Khazak,V., Fang,C.Y., Golemis,E.A., Cukierman,E. and Astsaturov,I.
  TITLE     Cholesterol Pathway Inhibition Induces TGF-beta Signaling to
            Promote Basal Differentiation in Pancreatic Cancer
  JOURNAL   Cancer Cell 38 (4), 567-583 (2020)
   PUBMED   32976774
REFERENCE   3  (bases 1 to 2218)
  AUTHORS   Zhang,H., Li,C., Xin,Y., Cui,X., Cui,J. and Zhou,G.
  TITLE     Suppression of NSDHL attenuates adipogenesis with a downregulation
            of LXR-SREBP1 pathway in 3T3-L1 cells
  JOURNAL   Biosci Biotechnol Biochem 84 (5), 980-988 (2020)
   PUBMED   31985358
  REMARK    GeneRIF: Suppression of NSDHL attenuates adipogenesis with a
            downregulation of LXR-SREBP1 pathway in 3T3-L1 cells.
REFERENCE   4  (bases 1 to 2218)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2218)
  AUTHORS   Xin,Y., Li,C., Guo,Y., Xiao,R., Zhang,H. and Zhou,G.
  TITLE     RNA-Seq analysis reveals a negative role of MSMO1 with a synergized
            NSDHL expression during adipogenesis of 3T3-L1
  JOURNAL   Biosci Biotechnol Biochem 83 (4), 641-652 (2019)
   PUBMED   30582412
  REMARK    GeneRIF: The findings indicate that MSMO1 and NSDHL are novel
            modulators of adipogenesis.
REFERENCE   6  (bases 1 to 2218)
  AUTHORS   Herman,G.E., Faust,C.J., Darlison,M.G. and Barnard,E.A.
  TITLE     Genetic mapping of the mouse X chromosome in the region homologous
            to human Xq27-Xq28
  JOURNAL   Genomics 9 (4), 670-677 (1991)
   PUBMED   1674728
REFERENCE   7  (bases 1 to 2218)
  AUTHORS   Herman,G.E. and Walton,S.J.
  TITLE     Close linkage of the murine locus bare patches to the X-linked
            visual pigment gene: implications for mapping human X-linked
            dominant chondrodysplasia punctata
  JOURNAL   Genomics 7 (3), 307-312 (1990)
   PUBMED   1973136
REFERENCE   8  (bases 1 to 2218)
  AUTHORS   Amar,L.C., Dandolo,L., Hanauer,A., Cook,A.R., Arnaud,D.,
            Mandel,J.L. and Avner,P.
  TITLE     Conservation and reorganization of loci on the mammalian X
            chromosome: a molecular framework for the identification of
            homologous subchromosomal regions in man and mouse
  JOURNAL   Genomics 2 (3), 220-230 (1988)
   PUBMED   2899541
REFERENCE   9  (bases 1 to 2218)
  AUTHORS   Brown,K.S.
  TITLE     The comparative biology of chondrodysplasias in mice
  JOURNAL   Pathol Immunopathol Res 7 (1-2), 55-61 (1988)
   PUBMED   3222208
REFERENCE   10 (bases 1 to 2218)
  AUTHORS   Evans,E.P. and Phillips,R.J.
  TITLE     Inversion heterozygosity and the origin of XO daughters of
            Bpa/+female mice
  JOURNAL   Nature 256 (5512), 40-41 (1975)
   PUBMED   1134578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671908.8 and AK140930.1.
            
            On Jun 19, 2003 this sequence version replaced NM_010941.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF100198.1, AK140930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL671908.8         143807-143926
            121-1943            AK140930.1         2-1824
            1944-2218           AL671908.8         183540-183814
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.29 cM"
     gene            1..2218
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /note="NAD(P) dependent steroid dehydrogenase-like"
                     /db_xref="GeneID:18194"
                     /db_xref="MGI:MGI:1099438"
     exon            1..173
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     exon            174..290
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1304
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /EC_number="1.1.1.170"
                     /note="striated; bare patches; NAD(P)-dependent steroid
                     dehydrogenase-like protein"
                     /codon_start=1
                     /product="sterol-4-alpha-carboxylate 3-dehydrogenase,
                     decarboxylating"
                     /protein_id="NP_035071.3"
                     /db_xref="CCDS:CCDS30190.1"
                     /db_xref="GeneID:18194"
                     /db_xref="MGI:MGI:1099438"
                     /translation="MEQAVHGESKRGQVTGTHLTNDISKAKKCTVIGGSGFLGQHMVE
                     QLLERGYTVNVFDIHQGFDNPRVQFFIGDLCNQQDLYPALKGVSTVFHCASPPPYSNN
                     KELFYRVNFIGTKTVIETCREAGVQKLILTSSASVVFEGVDIKNGTEDLPYAMKPIDY
                     YTETKILQERAVLDANDPKKNFLTAAIRPHGIFGPRDPQLVPILIDAARKGKMKFMIG
                     NGENLVDFTFVENVVHGHILAAEHLSQDAALGGKAFHITNDEPIPFWTFLSRILTGLN
                     YEAPKYHIPYWMAYYLAFLLSLLVMVVSPLIQIQPTFTPIRVALAGTFHYYSCEKAKK
                     LFGYRPLVTMDEAVERTVQSFHHLRKDK"
     exon            291..449
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     exon            450..596
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     exon            597..725
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     exon            726..868
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     exon            869..971
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2218
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /note="hexamer: CATAAA"
     polyA_site      1822
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /note="major polyA site"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /note="hexamer: AATAAA"
     polyA_site      1948
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
     regulatory      2194..2199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
                     /note="hexamer: AATAAA"
     polyA_site      2213
                     /gene="Nsdhl"
                     /gene_synonym="Bpa; H105E3; Str; XAP104"
ORIGIN      
        1 gagcgtcaat tggttgcgcc agagccaagc tagaccaatc aacattatga aggaagctct
       61 gctgattgtg ggctcatatc tatcagtaga aaagggtggc gggtgttcag ccagacttct
      121 ctggttgccg gttgtctgca agctgaggtc gatcatttga gtgtctaaac cgggaagaag
      181 agttgattgc aaacgaaacc atactttgag ccataatgga acaagctgtt catggtgaat
      241 caaagcgagg ccaggtcaca ggaacacatt tgacaaatga catttccaaa gctaagaagt
      301 gcacagtgat tggaggctct gggttcctgg ggcagcacat ggtggagcag ttgctggagc
      361 gaggctatac tgtcaatgta tttgatatcc accaaggctt tgataacccc cgggtgcagt
      421 tctttatagg cgacctgtgc aaccaacagg acctgtaccc agctctcaaa ggtgtaagca
      481 cagttttcca ctgcgcgtcc cctccgccgt acagtaacaa caaggagctc ttttatagag
      541 tgaatttcat tggcaccaag actgtcattg aaacctgcag agaggccgga gttcagaaac
      601 tcattttaac cagcagtgcc agtgttgtct ttgagggtgt tgacataaaa aatggaactg
      661 aagacctccc ttacgccatg aagcctattg actattacac agagaccaag atcttgcagg
      721 agagagcagt actggatgcc aacgacccta agaagaattt tttaaccgca gccattcgtc
      781 ctcatggcat tttcggccca agggaccccc agttggtccc aatcctaatt gatgcagcta
      841 gaaagggcaa aatgaagttc atgattggaa atggggaaaa cctggtggac ttcaccttcg
      901 tggagaatgt ggttcatgga cacatcttag ccgctgagca cctctcccaa gatgcagctc
      961 taggtggaaa ggcatttcac atcaccaacg atgaaccaat ccctttctgg acgttcctgt
     1021 cccgcattct gacaggcctc aattatgagg cccctaagta ccacatcccc tactggatgg
     1081 cctattacct tgctttcctg ctatctctac tggtgatggt ggtcagccct ctcatccaaa
     1141 tccagccaac ctttacacca attcgagtgg cattggctgg aacattccac tattacagtt
     1201 gtgaaaaagc caaaaagctc tttgggtacc ggccactggt caccatggat gaagctgtgg
     1261 aaaggactgt gcagagtttc caccacctgc ggaaggacaa gtgaagttcc ccagtgccct
     1321 ccccagtaac tttctcctct ctgttctaaa gaacgcatat ccttaactga gtttctcttg
     1381 acctgtgtgt cccttgctgg ttagatggta gcatacctga caccctccat gacattggag
     1441 gtgacaacag gagacatttc tcccaggata gcattgaact tctcaggcag agtcataatc
     1501 tactgcttgg gtctttttct ctcccccaca cccctacttc tgtctcctgg gttcattatc
     1561 agaaagacag cactaaagtg aagtctttat ctggggtctt aaaaattgaa gcaaaaccag
     1621 aaattgtaaa cacacagtaa gccttcagac atacatttta tatgatcaca gtacaatagc
     1681 tcaaagtatt gatgaatgta atccccaatc cttaaggata aatccactgc tggttccttg
     1741 cccctcacat actgtctagg tctctttcaa agatggttgc agtgtctgcc tctattgttt
     1801 ttccataaat catttcaatt tatccacaga ctctggtgtg gtctttattg ctcagtgatg
     1861 gtgcaatgca atggtacagt gtgtgctgtg ttagctggtc agctcctaat aaacaggaga
     1921 tgatggctgc ttggcaataa gccaaaaaga gtggtctcct tcatcgacat gatgtttgag
     1981 tagaaactcc tccgtgagat ggggcagaat gggttacaga catctttgca gctcatttca
     2041 cagaacatta ttaggccact ttccaaagag tacaggccac taacaatcca gccatttctg
     2101 ttctctgaac tcattgaaat gtattcttga agaattctaa gttcttcttc atcactgttc
     2161 aacagtaaga tgattggggg aaaataacaa agaaataaaa gccatacagt ttgtgttg
//
