LOCUS       NM_021552               2686 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NSA2 ribosome biogenesis homolog (Nsa2), mRNA.
ACCESSION   NM_021552 XM_914319 XM_923170
VERSION     NM_021552.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2686)
  AUTHORS   Shahni,R., Gnudi,L., King,A., Jones,P. and Malik,A.N.
  TITLE     Elevated levels of renal and circulating Nop-7-associated 2 (NSA2)
            in rat and mouse models of diabetes, in mesangial cells in vitro
            and in patients with diabetic nephropathy
  JOURNAL   Diabetologia 55 (3), 825-834 (2012)
   PUBMED   22095236
  REMARK    GeneRIF: Data suggest that renal and circulating NSA2 levels are
            increased in hyperglycemia in experimental models of diabetes, and
            that circulating NSA2 is elevated in diabetic nephropathy patients
            with albuminuria.
REFERENCE   3  (bases 1 to 2686)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
REFERENCE   4  (bases 1 to 2686)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   5  (bases 1 to 2686)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ132894.1, AK078457.1 and AC154620.2.
            
            On Mar 26, 2009 this sequence version replaced NM_021552.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017605.1, AK078457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142, SAMN02415126
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CJ132894.1         2-50
            50-1589             AK078457.1         3-1542
            1590-2686           AC154620.2         50823-51919
FEATURES             Location/Qualifiers
     source          1..2686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.66 cM"
     gene            1..2686
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /note="NSA2 ribosome biogenesis homolog"
                     /db_xref="GeneID:59050"
                     /db_xref="MGI:MGI:1913883"
     exon            1..172
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..952
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /note="L-name related protein; L-name-related protein 42;
                     TGF-beta-inducible nuclear protein 1"
                     /codon_start=1
                     /product="ribosome biogenesis protein NSA2 homolog"
                     /protein_id="NP_067527.3"
                     /db_xref="CCDS:CCDS36756.1"
                     /db_xref="GeneID:59050"
                     /db_xref="MGI:MGI:1913883"
                     /translation="MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIG
                     LKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKDDEKTPQGAVPAYLLDREGQSRAKVL
                     SNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGF
                     TRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGT
                     VIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV"
     exon            173..360
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /inference="alignment:Splign:2.1.0"
     exon            361..511
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /inference="alignment:Splign:2.1.0"
     exon            512..691
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /inference="alignment:Splign:2.1.0"
     exon            692..884
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /inference="alignment:Splign:2.1.0"
     exon            885..2686
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1097..1102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /note="major polyA site"
     regulatory      1156..1161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
                     /note="hexamer: AATAAA"
     polyA_site      1177
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
     polyA_site      1884
                     /gene="Nsa2"
                     /gene_synonym="5730427N09Rik; LNR42; Nsa2p; Tinp1; Yr29"
ORIGIN      
        1 agacgtcacg gaactgctgt gcggcgcttg cgctccactc ggccttctta aaggactacc
       61 ctttcccgtc ctgggctgaa cgaggcaggc tcgtggacca gtgacatcca gaaattaaga
      121 gttttttgag acccgggagg tcgcggaccg gtgctccgcg gctgtcatca tgccacaaaa
      181 tgaatatatt gaattgcacc gcaaacgata cggatatcgt ttggactacc atgagaaaaa
      241 gagaaagaaa gaaggtcggg aggcccatga acgttcaaag aaggcaaaaa aaatgattgg
      301 cctgaaggct aagctctacc ataaacagcg ccatgccgag aaaatacaaa tgaaaaagac
      361 tattaagatg catgagaaga gaaacaccaa gcagaaggat gatgagaaga cgccgcaggg
      421 agcagtccct gcctatctgc tggacagaga gggccagtcg agagcaaaag tcctttctaa
      481 catgattaag cagaaacgga aagaaaaggc gggaaaatgg gaggtccctc tacccaaagt
      541 tcgtgcccaa ggagaaacag aagtattgaa agttattcgg acaggaaaaa ggaaaaagaa
      601 ggcatggaag agaatggtta ctaaagtctg ttttgttggc gatggcttta caagaaaacc
      661 accgaaatat gaaaggttca ttaggcccat gggtctacgt ttcaaaaaag cccatgtcac
      721 acaccctgag ctgaaagcta ccttttgcct gcctattctc ggtgtgaaaa agaatccatc
      781 gtccccatta tatacaaccc tgggtgtgat caccaaaggt acagttattg aagtgaatgt
      841 gagcgagctg ggccttgtga cacaaggagg caaggtgatt tggggaaagt acgcccaagt
      901 taccaacaat cctgagaacg atgggtgcat aaatgcggtc ttgctggtct gacagtgacg
      961 tcactcatac acgtcattcc actcactgct gaagaccaca ccctgtcagg aaaacaccgt
     1021 ccctggggtc tttctgaacc accgagcagc cttacctcat gtgcagtcat caagcattta
     1081 ctaagttgta aaggaaaata aaactgccca gtttgacagt tggtctttag tttggggcat
     1141 aacggtttac atgttaataa aatttagtga ctgagtagcc aaggacacag aagcatacta
     1201 aaaactatgt atgcagcaat acaagtctgt cacaattgaa aagccatcag aatagttgaa
     1261 agttcctgta aaggtcaagt attttccatt gtgttgccat taatcctaaa atgtggaaca
     1321 ttttaaacac atggtagtgt ttaaattcat aaacaagtag attaaaagtc atagagaagg
     1381 taaattagat gaaaagagtg cacaattcag tgctttcact cataactaat accttatata
     1441 gtactgcagt gacctccagt gtacttcctc catttcctat attctaaaaa tagggagctc
     1501 gctcactact gctacaacaa tgtgaacaat tgggttagat aattctccac catgtaccag
     1561 tgacttgaga tgtggcaatt aattagattg aaaggtcatg atttggggtt ataacttaaa
     1621 tccacgttct taagagtgtc tgtatattaa tctgtaatca ccatattgct ttaaattgtt
     1681 tattttttaa atctactttc ataatacagg cagtgtgatt agctgtgcct ttaacagaat
     1741 cattcaatgt ctaatatcta agcacatctt catgaatgca actcagagga aaggaaattt
     1801 aaaacacaag actagaaaac aatcacaaaa cacaagttta attactattt taaacattaa
     1861 gggggaaaaa aaaaccctag caaagaaaca aaccataagt tctccataag acttggtatt
     1921 ctgaatattt tttttaaagt ttttagaaca tacaaagata ttaaaggaaa aggcgggcct
     1981 agttccttgg aaaggactga ccaggaaagg cagagtgact tcactttctt ataattagat
     2041 tttaacattg tctaccaatc agaacgggca atgtgtattt atctgcctga gttacggtga
     2101 aaggaagcct gactccaggt gatcagtggc tattgctgaa gtacatttgc ttattttttt
     2161 ttttaggatt gaaactagca aactgtcgta tactaaaaag tcatgggagg aagtattaaa
     2221 acaagcatga cttctgtaac agaccacgcc cagaaccacc agattgcaaa tggacatcaa
     2281 agcaaaagct gctctcttca aatagttaca tgagtagtat tagtacaaat tccttattta
     2341 catcaaaatc tgtttcagtt tgctggtgtg accacagctt aggtaattcc aaaggagaag
     2401 caacttcaga gatgtttagt tggtagaagg gcttaaaggt ctactaaagt cacaaaccac
     2461 taggtaacac tacactggtc acctgttcaa agtagaccat tagtgactag aagtcctcct
     2521 tagcctctgc aaatcaacgg taaaaggaaa gtagacacaa agtggaagaa tgtgaacaca
     2581 cagagaagac tgacattcta agtcatgcca tttgatttta ttttaaaaaa tcataataga
     2641 atctctttaa aagttttaaa ggagctttac aataaaattc ttaaat
//
