LOCUS       NM_001198587            7933 bp    mRNA    linear   ROD 02-MAY-2023
DEFINITION  Mus musculus neurexin III (Nrxn3), transcript variant 1, mRNA.
ACCESSION   NM_001198587
VERSION     NM_001198587.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7933)
  AUTHORS   Kamal N, Jafari Khamirani H, Dara M and Dianatpour M.
  TITLE     NRXN3 mutations cause developmental delay, movement disorder, and
            behavioral problems: CRISPR edited cells based WES results
  JOURNAL   Gene 867, 147347 (2023)
   PUBMED   36898513
  REMARK    GeneRIF: NRXN3 mutations cause developmental delay, movement
            disorder, and behavioral problems: CRISPR edited cells based WES
            results.
REFERENCE   2  (bases 1 to 7933)
  AUTHORS   Trotter JH, Wang CY, Zhou P, Nakahara G and Sudhof TC.
  TITLE     A combinatorial code of neurexin-3 alternative splicing controls
            inhibitory synapses via a trans-synaptic dystroglycan signaling
            loop
  JOURNAL   Nat Commun 14 (1), 1771 (2023)
   PUBMED   36997523
  REMARK    GeneRIF: A combinatorial code of neurexin-3 alternative splicing
            controls inhibitory synapses via a trans-synaptic dystroglycan
            signaling loop.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7933)
  AUTHORS   Han P, She Y, Yang Z, Zhuang M, Wang Q, Luo X, Yin C, Zhu J,
            Jaffrey SR and Ji SJ.
  TITLE     Cbln1 regulates axon growth and guidance in multiple neural regions
  JOURNAL   PLoS Biol 20 (11), e3001853 (2022)
   PUBMED   36395107
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7933)
  AUTHORS   Missler M, Zhang W, Rohlmann A, Kattenstroth G, Hammer RE, Gottmann
            K and Sudhof TC.
  TITLE     Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
  JOURNAL   Nature 423 (6943), 939-948 (2003)
   PUBMED   12827191
REFERENCE   5  (bases 1 to 7933)
  AUTHORS   Tabuchi K and Sudhof TC.
  TITLE     Structure and evolution of neurexin genes: insight into the
            mechanism of alternative splicing
  JOURNAL   Genomics 79 (6), 849-859 (2002)
   PUBMED   12036300
REFERENCE   6  (bases 1 to 7933)
  AUTHORS   Missler M, Hammer RE and Sudhof TC.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
  REMARK    GeneRIF: N-terminal sequencing of rat neurexin III alpha provides
            evidence for signal peptide
REFERENCE   7  (bases 1 to 7933)
  AUTHORS   Missler M and Sudhof TC.
  TITLE     Neurexins: three genes and 1001 products
  JOURNAL   Trends Genet 14 (1), 20-26 (1998)
   PUBMED   9448462
  REMARK    Review article
REFERENCE   8  (bases 1 to 7933)
  AUTHORS   Andres C, Beeri R, Friedman A, Lev-Lehman E, Henis S, Timberg R,
            Shani M and Soreq H.
  TITLE     Acetylcholinesterase-transgenic mice display embryonic modulations
            in spinal cord choline acetyltransferase and neurexin Ibeta gene
            expression followed by late-onset neuromotor deterioration
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 8173-8178 (1997)
   PUBMED   9223334
REFERENCE   9  (bases 1 to 7933)
  AUTHORS   Puschel AW and Betz H.
  TITLE     Neurexins are differentially expressed in the embryonic nervous
            system of mice
  JOURNAL   J Neurosci 15 (4), 2849-2856 (1995)
   PUBMED   7722633
REFERENCE   10 (bases 1 to 7933)
  AUTHORS   Ushkaryov YA, Hata Y, Ichtchenko K, Moomaw C, Afendis S, Slaughter
            CA and Sudhof TC.
  TITLE     Conserved domain structure of beta-neurexins. Unusual cleaved
            signal sequences in receptor-like neuronal cell-surface proteins
  JOURNAL   J Biol Chem 269 (16), 11987-11992 (1994)
   PUBMED   8163501
  REMARK    GeneRIF: N-terminal sequencing of cow neurexin III beta provides
            evidence for signal peptide
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK082055.1, BC060719.1,
            AK034555.1, AK162558.1 and BM942887.1.
            
            [WARNING] On Jun 9, 2023 this sequence was replaced by
            NM_001198587.4.
            
            On Dec 28, 2012 this sequence version replaced NM_001198587.2.
            
            Summary: This gene encodes a member of a family of proteins that
            function in the nervous system as receptors and cell adhesion
            molecules. Extensive alternative splicing and the use of
            alternative promoters results in multiple transcript variants for
            this gene, but the full-length nature of many of these variants has
            not been determined. Transcripts that initiate from an upstream
            promoter encode alpha isoforms, which contain epidermal growth
            factor-like (EGF-like) sequences and laminin G domains. Transcripts
            initiating from the downstream promoter encode beta isoforms, which
            lack EGF-like sequences. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). This variant
            encodes an alpha isoform of neurexin 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: PMID: 12827191
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2724              AK082055.1         313-3036
            2725-5872           BC060719.1         2300-5447
            5873-7040           AK034555.1         347-1514
            7041-7918           AK162558.1         1058-1935
            7919-7933           BM942887.1         544-558
FEATURES             Location/Qualifiers
     source          1..7933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 42.94 cM"
     gene            1..7933
                     /gene="Nrxn3"
                     /note="neurexin III"
                     /db_xref="GeneID:18191"
                     /db_xref="MGI:MGI:1096389"
     exon            1..1390
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             682..5397
                     /gene="Nrxn3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neurexin-3-alpha"
                     /codon_start=1
                     /product="neurexin 3 isoform 1 precursor"
                     /protein_id="NP_001185516.2"
                     /db_xref="CCDS:CCDS56856.1"
                     /db_xref="GeneID:18191"
                     /db_xref="MGI:MGI:1096389"
                     /translation="MSFTLHSVFFTLKVSIFLGSLVGLCLGLEFMGLPNQWARYLRWD
                     ASTRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETTVLSNK
                     QVNDSSWHFLMVSRDRVRTGLVIDGEGQSGELRPQRPYMDVVSDLFLGGVPADIRPSA
                     LTLDGVQSMPGFKGLMLDLKYGNSEPRLLGSQSVQLEAEGPCGERPCENGGICFLLDG
                     HPTCDCSTTGYGGTLCSEDVSQGPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPI
                     QSSSDEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVN
                     GKFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL
                     PGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYGEVVFKCENVATLDPIN
                     FETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDVRSQKNTKVDFF
                     AVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT
                     ASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR
                     QLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCERE
                     ASILSYDGSMYMKVIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDG
                     GRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAE
                     GTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDY
                     CELKARFGLRNIIADPVTFKTKSSYLTLATLQAYTSMHLFFQFKTTSADGFILFNSGD
                     GNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDSSNTHSLKVD
                     TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPD
                     LINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDP
                     GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQL
                     HIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYP
                     TGNTDNERLQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQ
                     LSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSVSGTTQTTSMPPEMSTTVMETT
                     TTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTDKSLSTSIFEGGYK
                     AHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKP
                     QPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSS
                     TTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQ
                     ASSKSGHKKQKNKDKEYYV"
     exon            1391..1408
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1438
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1740
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1902
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2341
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2725
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2929
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..2956
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3076
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3458
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3649
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3823
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..3943
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4125
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4126..4297
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4387
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4695
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4696..4774
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4775..7922
                     /gene="Nrxn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7902..7907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrxn3"
     polyA_site      7922
                     /gene="Nrxn3"
ORIGIN      
        1 gtcttttctc tggagtcctg ggagctctgt tatgggcagc actgcctctg gccagcacca
       61 tgaagtctga atctgcttcc gctctgctct gggcctcact ccacctgagt cctcagttgt
      121 ttgcggttcc ccttcccagg gtctgctgct agaccgtcaa acctcagcac tgggccttgg
      181 cttgggcctg ccttttgcct ggctcacctc ccgattactc ctcctccatt acagcaccct
      241 gagccccagc cctgtccttg gtcttcctgg ctaggacgca tttgccggga ggaagacatt
      301 acggaaggct tattcccacc ctgggctcct tctcctcctt gaatcaaggc ctccggatcc
      361 acatggatag ctgagatctt ttcttggaga aagatacttc ttcctcgcct catccctgat
      421 ttgcctcacc cgacaaatcc cctgtctgtt tcgtctccct ctttatggga tttcttgctt
      481 gtgtgcctat ctagggccgt gttgtccttt ttcctctcct tcccctttcc tcctaacatt
      541 cctgtgtgtg ttcttcttgt gtcttctctt gtaccactct gttttccctc tttgccctca
      601 caatcaccta tcccctgcct cccgctccca cggctgatac ctggcctacc tgctcctctg
      661 tgctctgacc cagcaggcac catgagcttt accctccact cagttttctt caccttgaag
      721 gtgagcatct ttctgggctc cctggtgggg ctttgcctgg gtctggagtt catgggcctt
      781 cctaaccagt gggcccgcta cctgcgttgg gatgcaagca cgcgcagtga cctgagcttc
      841 cagttcaaga ccaatgtttc cactgggctg ctcctgtatt tggatgatgg tggtgtctgt
      901 gacttcctct gtctctccct ggtggatggc cgcgttcagc tccgctttag catggactgt
      961 gccgagacca ctgtgctatc caacaagcag gtgaacgaca gcagttggca cttcctcatg
     1021 gtgagccgtg atcgtgtgcg cactgggctg gtgattgatg gtgagggcca gtctggagag
     1081 ctacggcccc agcggcctta tatggatgtg gtcagtgatt tgttcctcgg tggcgtcccc
     1141 gctgacattc gaccttctgc cctgaccctc gatggagtac agagcatgcc tggctttaag
     1201 ggattaatgc tggatctcaa gtatggcaac tcggaacctc ggcttctggg gagccagagc
     1261 gtccagttag aagcagaggg accctgtggc gagcgtccct gtgaaaatgg tgggatctgc
     1321 ttcctcttgg atggtcatcc cacctgtgac tgttctacca ctggctatgg tggcacactc
     1381 tgctcagaag atgtcagtca aggtccaggc ctctcccatc ttatgatgag tgaacaagca
     1441 cgagaggaga acgtggccac cttccgaggc tcagagtatc tgtgctatga cctgtcccag
     1501 aaccccatcc agagcagcag cgacgaaatc accctttcct ttaagacctg gcaacgcaat
     1561 gggctcatcc tccacactgg caagtcggcc gactatgtta acctggctct gaaggatggt
     1621 gcggtctcct tggtcattaa cctggggtcc ggggcctttg aggccattgt ggagccagtg
     1681 aatgggaaat tcaacgacaa cgcctggcat gatgtcaaag tgacacgcaa tcttcggcag
     1741 gtgacaatct ctgtggatgg catcctaacc acaacgggct acactcaaga ggactacacc
     1801 atgctgggct cagatgactt cttctatgtt ggtggaagcc caagtaccgc agacttgcca
     1861 ggttcacctg tgagcaacaa cttcatgggc tgccttaaag aggttgttta taagaataat
     1921 gacatccgtc tagagctgtc tcgcttggcc cggattggag acaccaagat gaaaatctat
     1981 ggtgaagttg tgttcaagtg tgagaacgtg gccacactgg atcccatcaa ctttgagacc
     2041 ccagaggctt acatcagctt gcccaagtgg aacaccaaac gtatgggctc catttccttt
     2101 gactttcgca ccactgagcc caacggcctg attctcttca ctcacgggaa gcctcaagaa
     2161 aggaaagatg tccggagcca aaagaacaca aaagttgact tctttgctgt ggaacttctt
     2221 gatggcaacc tgtatttgct gcttgacatg ggctctggca ccatcaaagt gaaggccact
     2281 cagaagaagg ccaatgatgg ggaatggtac cacgtggata ttcagcgtga tggcagatca
     2341 ggtaccatat ctgtgaacag caggcgcacg ccattcaccg ccagtgggga gagtgaaatt
     2401 ctcgacctgg agggggacat gtatctgggc gggctgccag agaaccgagc tggcctcatc
     2461 ctccccacgg agctctggac cgccatgctc aactacggtt acgtgggctg catccgcgac
     2521 ctgttcatcg atgggcgcag caagaacatc cggcagctgg cggagatgca gaacgcagca
     2581 ggcgtcaagt cctcctgttc acgcatgagc gccaagcagt gtgacagcta cccctgcaag
     2641 aacaacgcgg tgtgcaagga cggctggaac cgcttcatct gcgactgcac tggcaccggc
     2701 tactggggga gaacctgcga aagagaggca tctatcctga gctatgacgg cagcatgtac
     2761 atgaaggtca tcatgcccat ggtgatgcac acggaggcag aggatgtgtc cttccgcttc
     2821 atgtcacagc gagcctatgg gctactggta gccacaacct ccagggattc tgcagataca
     2881 ctgcgtctag agttggatgg tgggcgtgtc aagctcatgg ttaacttaga ctgtatcagg
     2941 ataaactgta actccagcaa aggacctgag accctgtatg cagggcagaa gctcaatgac
     3001 aatgagtggc acaccgtccg ggtagtgcgg agaggaaaaa gccttaagct aacagtggat
     3061 gatgatgtgg ctgaggggac aatggtgggc gaccacaccc gcctggaatt ccacaatatt
     3121 gaaactggta tcatgactga gaagcgttac atctctgtgg tcccctccag tttcattggc
     3181 catctacaga gcctcatgtt caatggctta ctgtacattg atttgtgcaa aaatggcgac
     3241 atcgactact gtgaactgaa ggctcgcttt ggactgagaa acatcatcgc cgaccctgtc
     3301 acttttaaga ccaagagcag ctacctgacc ctcgccaccc tacaggctta cacctccatg
     3361 cacctcttct tccagttcaa gaccacttca gctgatggct tcattctctt caatagcgga
     3421 gatggcaatg attttattgc agttgagctg gtcaaggggt acatacacta tgtgtttgat
     3481 ctcggcaatg gtcccaatgt gatcaaaggc aacagtgacc gccccctgaa tgacaaccag
     3541 tggcacaacg tggtcatcac cagggacagc agtaacaccc acagtctgaa ggtggacacc
     3601 aaggtagtca ctcaggtcat caatggtgcc aaaaatctgg atttgaaagg tgacctctat
     3661 atggctggct tagcccaggg catgtacagc aaccttccca agcttgtggc ctccagggat
     3721 ggatttcagg gctgcctggc ctctgtggac ttgaatggac gcctgcctga tctcatcaac
     3781 gatgctctcc acaggagtgg acagatcgag cgaggctgtg aaggacccag tacaacctgt
     3841 caggaggatt catgcgccaa ccagggagtt tgcatgcagc agtgggaagg tttcacctgt
     3901 gactgctcca tgacatcata ttctggaaac cagtgcaatg accctggtgc aacatacatc
     3961 tttgggaaaa gcggtggcct catcctctat acctggccag caaatgacag acccagcaca
     4021 cgctctgacc gtctcgccgt gggcttcagc actactgtga aggatggtat cttagtacgc
     4081 attgacagcg cccctggact tggcgacttc ctccagcttc acatagaaca agggaaaatt
     4141 ggagttgtct tcaatattgg cacagttgac atctccatca aagaagagag aactcctgtc
     4201 aatgatggca aataccacgt tgtgcgcttc accaggaatg ggggaaatgc tacacttcag
     4261 gtggacaact ggccagtgaa tgagcactat cctacaggca acactgataa tgaacgcctc
     4321 caaatggtaa aacagaaaat ccccttcaaa tataaccggc ccgtagagga gtggctgcag
     4381 gaaaaaggcc ggcagctaac catcttcaac acccaggcgc aaatagccat cggaggaaag
     4441 gacaaaggac gtctcttcca aggtcaactc tctgggctct attatgatgg tttgaaagta
     4501 ctgaacatgg cagctgagaa caaccctaat attaaaatca atggaagtgt ccggctagtg
     4561 ggagaagtcc catcagtctc aggaacaaca cagacaacgt ccatgccacc tgaaatgtct
     4621 accaccgtca tggaaaccac caccaccatg gctacgacca ccacccgaaa gaaccgctct
     4681 acagccagca ttcagcccac gtcagatgat cttgtttcat ctgctgaatg ttcaagtgat
     4741 gatgaagact ttgtcgaatg tgaaccaagt acagataaga gtctttccac ttcaatcttc
     4801 gaaggtggct acaaagcaca tgcgcccaag tgggaatcca aggactttag acctaacaaa
     4861 gtctcggaaa ctagtagaac tacaaccacc tctttgtccc ctgagctgat ccgcttcaca
     4921 gcgtcctcct cgtctgggat ggtgcccaaa ttgccagctg gcaaaatgaa taaccgtgat
     4981 ctcaaacccc agcctgatat agtcttgctt ccgttgccca ctgcctatga gctagacagc
     5041 accaaactga agagcccact aattacttcc cccatgttcc gtaatgtgcc cacagcaaac
     5101 cccacggagc caggaatcag acgggttccg ggggcctcag aggtgatccg ggagtccagc
     5161 agtacaacag ggatggtcgt cggcattgtg gctgctgccg ccctctgcat cttgatcctc
     5221 ctgtacgcca tgtacaagta caggaacagg gacgaggggt cctatcaagt ggacgagacg
     5281 aggaactaca tcagcaactc ggcccagagc aacggcacgc tcatgaagga gaagcaagcc
     5341 agctccaaga gcggccataa gaaacagaaa aacaaggaca aggagtatta tgtgtaaaca
     5401 taacaccacc agtcgtatgc gaacttaaaa cagaattatt tctatacaca cacctgaata
     5461 ctttgacaat gagatttaac ttgttgaatg tgttctgtga gatggggtgt accacgacta
     5521 tggtgggaaa aaccattttt taaaggacac atacgatggt gtatctctct gtgtaatggt
     5581 gagccatgct gcaaggttgt agccttggcc cgaagacaga aaattctctc tgccctgctg
     5641 tatcataaag cacacactta gtgccctgga gcaagtccat gactccacat gaccttggaa
     5701 gctttcttct ctccagaaca tttggaaagg ggtagaagac catatggctt acttgttcca
     5761 tagctccaag tgagtctgta ataatgtttg tgaatcttga ctgtaacaat gttgggttat
     5821 tttttgtttg tttgtttgtt taattatgta aaaaaaaaca aaaacaaaaa aataagaaaa
     5881 gaaaaacgct taaaaaaaaa aaacacaaac aaaacaaaac aagaaaccca gaaataccct
     5941 tatctggttc tgaccagtgt gtgtgtaact ttccaagatc tgaggggaaa atagcttttg
     6001 ggttttcatt tatttttttg acaaagactg cacataagaa gaaaaggaaa aaaatatact
     6061 cagaaaaaaa gtatgagact cttgccatat gaactcaaaa tctaccatgg cattcactcc
     6121 atgtagcagg ttgtggtgtc tctagaacca attgttagtt tcctaatgct ttggtgaacc
     6181 catgtgggat gacaagccgt ttgaaaagca ggtccccaga tctaattcca atatttgcca
     6241 ttcaaacctg taacagatgg gtttggggct ggtgttatcg gagctattgg tttcacttaa
     6301 caaatactgt ccctgtccat caacccaaag tgtgtgaacg gggaaatgta acccccaaga
     6361 attaaagcag agcctttcta agggaaggaa aaaagggaaa gggggtggac tggatctgtg
     6421 aaatgcatgc aaacaaagaa aaaaaaaaac ccacaaaaaa gaaaagacaa tgttagcatc
     6481 tgtttcaaca gactgcaagg gagttcctaa cttgtaacac aaccacaagt ggtcacacaa
     6541 gcctagtcat ggccaagtgt gaaaaatcat agttacttcc ccacccccaa cataataacg
     6601 gtttccatat ggtttaactt tgtagcctga tgtgagtaaa tccttcccat ctcctcatgt
     6661 ctccttccgc ccatcttttt tttttaaaga caaataaata aatgagtaaa gctgctgtga
     6721 cacacacaca aaaggaattt aatagtataa tatatataaa taaatatata tacagatata
     6781 tttatcatgg tatgtttgat gggatgactg acacagaaat ctgttaaagt cttgaagtgg
     6841 aatgagaatg ttattttaaa agaaaaataa caaaacaaca aaaaagtaaa ccttaaaatg
     6901 tgaagaaagt gtgagttttc gttttgtcac agttaactgt gtcaaagaga atttaaacaa
     6961 caaacaacag aaacttctca gattttgttt acatatttta ctacattttt gctggtataa
     7021 tcccttagtc gtgtatgtac ctaccgcttt gagaactgtt atttcctttc tgtctgttta
     7081 tttggtttgt gtcccattct ctttctgtct tctttttgta aagaggaaac aatgtacaga
     7141 gtaattaaaa aaaaaaaaac aaacaaacaa actggtttca tggccatagc cattcaaaaa
     7201 gcaagaagat aaagcaagac acatactctc acagagggca atgtgtcatc tggaggggca
     7261 ggcatataca atttcttttg tacagatgaa aaccaatcag ctgtttagat ttagaaatct
     7321 actcttgctg gtctttgtaa gttgcatgaa tatttgactt tgaaaaaaca atatcttaca
     7381 gacatggggc agaaggcaca gtctaaaaca gtggtagcct ttactgatgt gtatggagag
     7441 cggtgttcct ccttatctga gatttcaatg ttttaagagt tttccttttt tttgttgttg
     7501 ttgtcattaa aaaagacagg actgtacaag gatatctaag cacgatttta gataaatggc
     7561 ccagcctata tgaagttgat tatatctcga tgtctgtgac agattgctgt tcttggagtc
     7621 gtgagatctt gtgaactgat attctccttt ctttctttcc actttttttt aaaaatcgga
     7681 gtaaatactc atttgttata ttccttttag tgtaagttaa tatttggaca gttttacggg
     7741 aacttgtgca ttctgtacga gagctttcat tggattcctg ttgtgttctt tgcagaccct
     7801 gaaagagatt ttttttcata atgttgcgat gttcctgctt ttttcttttt ccttttctct
     7861 ttgctttccc atttgctttt tcgttcatgg atatgcttag caataaaatg ttcttcccaa
     7921 aaaaaaaaaa aaa
//
