LOCUS       NM_001205234            6642 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus neurexin II (Nrxn2), transcript variant 1, mRNA.
ACCESSION   NM_001205234
VERSION     NM_001205234.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6642)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6642)
  AUTHORS   Brockhaus,J., Kahl,I., Ahmad,M., Repetto,D., Reissner,C. and
            Missler,M.
  TITLE     Conditional Knockout of Neurexins Alters the Contribution of
            Calcium Channel Subtypes to Presynaptic Ca2+ Influx
  JOURNAL   Cells 13 (11), 981 (2024)
   PUBMED   38891114
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6642)
  AUTHORS   Khoja,S. and Chen,L.Y.
  TITLE     Conditional deletion of neurexin-2 impaired behavioral flexibility
            to alterations in action-outcome contingency
  JOURNAL   Sci Rep 14 (1), 10187 (2024)
   PUBMED   38702381
  REMARK    GeneRIF: Conditional deletion of neurexin-2 impaired behavioral
            flexibility to alterations in action-outcome contingency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6642)
  AUTHORS   Chofflet,N., Naito,Y., Pastore,A.J., Padmanabhan,N., Nguyen,P.T.,
            Poitras,C., Feller,B., Yi,N., Van Prooijen,J., Khaled,H.,
            Coulombe,B., Clapcote,S.J., Bourgault,S., Siddiqui,T.J., Rudenko,G.
            and Takahashi,H.
  TITLE     Structural and functional characterization of the
            IgSF21-neurexin2alpha complex and its related signaling pathways in
            the regulation of inhibitory synapse organization
  JOURNAL   Front Mol Neurosci 17, 1371145 (2024)
   PUBMED   38571813
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6642)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 6642)
  AUTHORS   Tabuchi,K. and Sudhof,T.C.
  TITLE     Structure and evolution of neurexin genes: insight into the
            mechanism of alternative splicing
  JOURNAL   Genomics 79 (6), 849-859 (2002)
   PUBMED   12036300
REFERENCE   7  (bases 1 to 6642)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   8  (bases 1 to 6642)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexins: three genes and 1001 products
  JOURNAL   Trends Genet 14 (1), 20-26 (1998)
   PUBMED   9448462
  REMARK    Review article
REFERENCE   9  (bases 1 to 6642)
  AUTHORS   Andres,C., Beeri,R., Friedman,A., Lev-Lehman,E., Henis,S.,
            Timberg,R., Shani,M. and Soreq,H.
  TITLE     Acetylcholinesterase-transgenic mice display embryonic modulations
            in spinal cord choline acetyltransferase and neurexin Ibeta gene
            expression followed by late-onset neuromotor deterioration
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 8173-8178 (1997)
   PUBMED   9223334
REFERENCE   10 (bases 1 to 6642)
  AUTHORS   Puschel,A.W. and Betz,H.
  TITLE     Neurexins are differentially expressed in the embryonic nervous
            system of mice
  JOURNAL   J Neurosci 15 (4), 2849-2856 (1995)
   PUBMED   7722633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167245.2.
            
            On Apr 8, 2019 this sequence version replaced NM_001205234.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147295.1, AK147665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC167245.2         79925-80141
            218-1191            AC167245.2         88974-89947
            1192-1209           AC167245.2         104800-104817
            1210-1239           AC167245.2         109424-109453
            1240-1311           AC167245.2         111697-111768
            1312-1613           AC167245.2         116148-116449
            1614-1637           AC167245.2         124993-125016
            1638-1799           AC167245.2         133427-133588
            1800-2238           AC167245.2         134487-134925
            2239-2625           AC167245.2         142279-142665
            2626-2829           AC167245.2         142841-143044
            2830-2856           AC167245.2         149953-149979
            2857-2976           AC167245.2         151236-151355
            2977-3358           AC167245.2         151703-152084
            3359-3549           AC167245.2         152653-152843
            3550-3723           AC167245.2         154005-154178
            3724-3843           AC167245.2         154505-154624
            3844-4025           AC167245.2         166044-166225
            4026-4197           AC167245.2         170947-171118
            4198-4287           AC167245.2         174885-174974
            4288-4613           AC167245.2         178092-178417
            4614-4692           AC167245.2         180418-180496
            4693-6642           AC167245.2         192437-194386
FEATURES             Location/Qualifiers
     source          1..6642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.65 cM"
     gene            1..6642
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /note="neurexin II"
                     /db_xref="GeneID:18190"
                     /db_xref="MGI:MGI:1096362"
     exon            1..217
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            218..1191
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..5573
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neurexin II beta; neurexin II alpha;
                     neurexin-2-alpha; neurexin-2-beta"
                     /codon_start=1
                     /product="neurexin-2 isoform 1 precursor"
                     /protein_id="NP_001192163.1"
                     /db_xref="CCDS:CCDS57132.1"
                     /db_xref="GeneID:18190"
                     /db_xref="MGI:MGI:1096362"
                     /translation="MALGSRWQPPPQLPPLLLLLALAAGVRGLEFGGGPGQWARYARW
                     AGAASTGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQ
                     LDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVR
                     LSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGAAADPLCAPARNPCANGGL
                     CTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAG
                     DVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSA
                     DYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAM
                     VTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYK
                     NNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTG
                     SISLDFRTTEPNGLLLFSQGRRAGAGVGSHSSTQRADYFAMELLDGYLYLLLDMGSGG
                     IKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGESEVLDLESELYLGGL
                     PEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRE
                     TLKQCASAPCRNGGICREGWNRFVCDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPT
                     AMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMRLTVNLDCLRVGCAP
                     SKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHTRLEFHNIETG
                     IMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVT
                     FKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVF
                     DLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKG
                     ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDG
                     PSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWP
                     PNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDI
                     TIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPY
                     RLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAES
                     DPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTM
                     RDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFV
                     PPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVF
                     DSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPRPNLRTDGATGAPGVLFAPSAPAPNLP
                     AGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSAPGFPRLPTANPTGPGE
                     RGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYI
                     SNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV"
     exon            1192..1209
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1239
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1311
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1613
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1637
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1799
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2238
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2625
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2829
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2856
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2976
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3358
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3549
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3723
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3843
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..4025
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4197
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4287
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4613
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4692
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..6642
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6621..6626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /note="hexamer: AACAAA"
     polyA_site      6642
                     /gene="Nrxn2"
                     /gene_synonym="6430591O13Rik; mKIAA0921"
                     /note="major polyA site"
ORIGIN      
        1 agtcggtgtt gcagggatgc ggcggcggga gcagccgccc tgactctcag agcatcctcc
       61 tcggagcggc accgcggcgg ggcgggcggg gacgcggcgg ggaccaggag gcgcgaggca
      121 gccgatatcg ctggcccagg atctgttacc tgccgtagac ccagcggtct ctaggctcgg
      181 atccctaccc ttcagctcct ggcgccccca aaaccaggcg tccctccccc accttccata
      241 cgagcccgcc gcgggggagg ggctccacca ccgcagccgc cgtcgttgcc ttccggggac
      301 gtggacacgt gagccccggc tactgagtcc atggcactgt gaatcggcga gggagccccg
      361 ctccgcgcga ggggcgcccg gccccctccc cgccccatgc gcccgcggct ctgaagcctg
      421 agcggggccg ggggccgggc ggcgtcgggg ccgccggagg catggcgctc gggagtcggt
      481 ggcaaccgcc accccagctg ccgccgctgc tgttgctgct ggcgctggcg gcaggcgtcc
      541 gtggcttgga gttcggcggc ggccccgggc agtgggctcg ctacgcgcgt tgggcgggag
      601 cggcgagcac cggcgagctc agcttcagcc tgcgcaccaa cgccacgcgc gcgctgctgc
      661 tctacctgga cgacggcggc gactgcgact tcttggagct gctgctggtg gacgggcgcc
      721 tgcggctgcg cttcacgctg tcttgcgcgg agcccgccac gctgcagctg gacacgccgg
      781 tggccgacga ccgctggcac atggtgttgc tgacccgcga cgcgcggcgc acggcgctgg
      841 cggtggacgg cgaagcccgc gccgccgagg tccgctcaaa gcggcgcgag atgcaggtgg
      901 ccagcgacct gttcgtgggc ggcatccctc ccgacgtgcg cctatctgca ctcacgctca
      961 gcaccgtcaa gtacgagccg cctttccgcg gccttctggc caacctgaag ctgggcgagc
     1021 ggccgccggc gctgctgggt agccagggtc tgcgcggtgc ggccgccgac cctctgtgtg
     1081 cgcctgcgcg caatccctgc gccaacggcg gtctctgcac cgtgctagcc cccggcgagg
     1141 tgggctgcga ctgcagccac actggatttg gcggcaagtt ctgcagtgaa gaggaacacc
     1201 ccatggaagg tccggctcac ctgacgttaa acagcgaagt agggtcctta ctgttctccg
     1261 aggggggggc cgggagagga ggagccggcg atgtgcacca gccgacaaaa ggcaaggagg
     1321 aatttgtggc aaccttcaag ggcaatgagt tcttctgcta cgacctgtcc cacaacccga
     1381 tccagagcag cactgacgag atcacactgg ccttccgcac cctgcagcgc aacgggctga
     1441 tgctgcacac ggggaagtcg gctgactacg tcaacctgtc cctcaagtct ggggctgtct
     1501 ggctggtcat caacctaggc tcaggtgcct tcgaggccct cgtggaaccc gtcaatggca
     1561 agttcaacga caacgcctgg cacgacgtcc gggttacccg aaacctgcgc cagcacgcag
     1621 ggattggaca cgctatggtg accatctcgg tggacgggat cctgaccacc acaggctaca
     1681 cgcaggagga ttacaccatg ctgggctctg atgacttctt ctacattggg ggcagcccca
     1741 acacagccga cctgcctggc tcacctgtca gcaacaactt catgggctgc ctcaaggacg
     1801 tggtctacaa gaataatgac ttcaagctgg agctgtcccg actggctaag gaaggggacc
     1861 cgaagatgaa gctgcagggg gatttgtctt tccgttgtga ggatgtggct gccttggacc
     1921 ctgtgacctt tgagagtcct gaggcctttg tcgcactgcc ccgctggagc gccaagcgca
     1981 ctggttccat ctccctggac ttcagaacca ctgagcccaa tgggttgttg ctcttcagcc
     2041 agggccggcg ggctggggcc ggggtaggca gtcacagttc tacccagagg gccgactact
     2101 ttgccatgga gctgttggat ggctacctct accttctgct ggacatgggc tccgggggca
     2161 tcaagctgcg ggcgtctagc cgcaaggtca atgatggtga atggtgccac gtggacttcc
     2221 agagggacgg gcgcaaaggc tccatctctg tgaacagccg cagcacgcca ttcttggcca
     2281 caggagagag cgaggtcctg gacctggaga gtgagctgta cctgggcggt ctccccgagg
     2341 ggggacgagt ggacctgcca ctgccccctg aggtgtggac agctgctctc cgggctggct
     2401 acgtgggctg tgtgagagac ctcttcatcg atggacggag tcgagatctc cggggcctgg
     2461 ctgaggccca gggggctgtg ggcgttgctc ctttctgctc ccgggagacc ctgaagcagt
     2521 gtgcgtcggc cccttgtcga aacgggggca tctgtcgaga gggctggaac cggttcgtct
     2581 gtgactgcat cgggaccggc tttctgggtc gggtctgcga gagagaggcc acggtcttaa
     2641 gctatgacgg ctccatgtac atgaagatca tgctgcccac tgcgatgcac acggaagcag
     2701 aggatgtgtc cttacgcttc atgtctcaga gggcatatgg actcatgatg gccaccacct
     2761 ccagggagtc ggctgacact ctgcgtctcg agctggacgg ggggcagatg aggctcaccg
     2821 tcaacctcga ctgcctgcgc gtcggctgcg cacccagtaa aggccccgag acactgtttg
     2881 cggggcacaa gctgaatgac aatgaatggc acacggtgag ggtggtccgg cgtggcaaga
     2941 gcctgcagct gtccgtggac aacgtgactg tggagggaca gatggcagga gcccacactc
     3001 ggctggagtt ccacaacatt gagacgggca ttatgacaga gcggcggttt atctctgtgg
     3061 tgccctccaa cttcatcggg cacctgagtg ggctggtgtt caatggtcaa ccctacatgg
     3121 accaatgcaa agatggagac atcacctatt gtgagcttaa tgcccgcttt ggcctgcgtg
     3181 ccatcgtggc tgatcctgtc acgttcaaga gtcgcagcag ctacctggcg ttagccacgc
     3241 tgcaagccta tgcttccatg catctcttct tccagttcaa gaccacggcc ccagatggac
     3301 ttctgctgtt caactcaggc aacggcaacg acttcatcgt catcgagttg gtcaaggggt
     3361 acatccacta cgtgtttgac ctgggaaatg gcccgtcctt gatgaaggga aactcagaca
     3421 aaccagtcaa tgacaaccaa tggcacaatg tggtggtgtc cagggaccca ggcaacgtgc
     3481 acacactgaa gatcgactcc cgcacagtca cgcagcattc caacggtgcc cgaaatctgg
     3541 atctcaaagg ggagttgtat atcggtggcc tgagcaagaa tatgttcagc aacctgccca
     3601 agctggtggc ctctcgggat ggctttcaag gctgcttggc ttctgtggac ctcaacggac
     3661 gcctcccaga cctcatcgct gacgccctgc accgcatcgg gcaggtggag aggggctgtg
     3721 atggccctag caccacctgc accgaagagt cttgtgccaa ccagggcgtc tgtctgcagc
     3781 agtgggatgg ttttacctgt gactgtacta tgacttccta tggaggccct gtctgcaatg
     3841 accctgggac cacatacatc ttcgggaagg ggggagcgct catcacctat acatggcctc
     3901 ccaatgaccg gcccagtaca cggatggacc gcctggccgt aggcttcagc acacaccagc
     3961 ggagcgctgt gctggtgcga gtggacagtg cctccggcct cggggactac ttgcagctgc
     4021 acattgacca gggcactgtt ggggtgattt ttaatgtggg cacggacgac attacaattg
     4081 atgagcccaa cgccatcgtg agcgacggca aatatcacgt ggtgcgcttt actcgaagtg
     4141 gtggcaatgc caccttgcaa gtggacagct ggccagtcaa cgagaggtac ccggcaggaa
     4201 actttgataa cgagcgcctg gcgattgcta gacagagaat cccctaccgg cttggtcgag
     4261 tagtagatga gtggctgctc gacaaaggac gccagctgac catcttcaac agccaggctg
     4321 ccatcaagat agggggccgg gatcagggcc gccccttcca gggccaggtg tccggcctct
     4381 actacaatgg gctcaaggta ctggcgctgg ccgccgagag cgaccccaat gtgcggaccg
     4441 aaggccacct acggctagta ggggaggggc cgtccgtgct gctcagtgct gagaccactg
     4501 ccaccactct gctggccgac atggccacca ccatcatgga gaccaccacc accatggcca
     4561 ccaccactac tcgccggggc cgttccccca caatgaggga cagcaccacc cagaacacag
     4621 atgacctcct ggtggcctcg gctgagtgtc caagtgatga tgaggaccta gaggagtgtg
     4681 agcctagtac tggaggagag ttaatattgc ccattatcac ggaggactcc ttagaccctc
     4741 ctcccgtggc cacccgatcc cccttcgtgc ccccaccccc caccttctac ccctttctca
     4801 cgggcgtggg tgccacccaa gacaccctgc ctccgcccgc cgcgcgccgc ccgtcctcgg
     4861 ggggcccgtg tcaggccgag cgcgacgaca gcgactgcga ggagcccgtg gaagcctcgg
     4921 gcttcgcctc cggggaggtc tttgactcca gcctcccccc cacggacgac gaggactttt
     4981 acactacttt ccccttggtc acggaccgca ccaccctcct gtcgccccgc aagccccgac
     5041 ccaacctcag gacagatggg gccacgggcg cccccggggt gctatttgcg ccctccgccc
     5101 cagcccccaa cctgcccgcg ggcaaaatga accaccgaga cccactgcag ccgctgctgg
     5161 agaacccacc cctggggcct ggggtcccca cggccttcga gccgcggcgg ccgcctcccc
     5221 tgcgccccgg cgtgacctca gcccccggtt tcccccgtct gcccacagcc aaccccacgg
     5281 gtccggggga gcgcggcccg ccaggtgcag tggaggtgat ccgcgaatcc agcagcacca
     5341 cgggcatggt ggtgggcatc gtggcggcgg cggcgctctg catcctcatt ctcctctacg
     5401 ccatgtacaa gtaccgcaac cgcgacgagg gctcctacca ggtggaccag agccggaatt
     5461 acatcagtaa ctcggcccag agcaatgggg cggtggtgaa ggagaaggcc cctgctgccc
     5521 ccaagacgcc aagcaaggcc aagaagaaca aagacaaaga gtattacgtc tgagcaccca
     5581 gtccaggcac cccactgcca gctgctcctc ccaggaggga ggagggtgcg gccctctccc
     5641 tgcaggggga tctggggacc ctctccccgg ctgcctcagg cttctcccac gaagaggaaa
     5701 cgcaaaaaaa gaaaaagaaa aggaatataa ctactacgtg ctcatcccct tccctcccgc
     5761 tgccctcggc gccgcactgt cagctctggg gctggctgtc ctccgctctg cgcctgtcag
     5821 gcagggcacg tgctcacagc cctgggttga tttatttttt taaggggggt agttttattt
     5881 tggtggggct gggcgggaag gaaggctggg gttttgtaaa gtgtccactg cgccgttcgt
     5941 ttatttccct cgattttctt cttcctctcg ccttccttct tcgcagccct cctgtcccgg
     6001 ttcaggcttg ctgtctcttg tccctaccct cctccgcccc actccctttc ttttctcttc
     6061 ttttctttat ttttcttttc ttttcctttc ctttcttttc tttctttttt aaactctctt
     6121 ttctctgctt cccttccttt gggtttccag agtctctggg agaagaaggg tgggcgggtg
     6181 gacccagagc gacccagatt gggtggctgg ggcggggcag tagggttcat tctcctagtg
     6241 ccccaagtcc cctcctgcct ggggctgccc agggattgga cctggacctg gccaaggcct
     6301 tttgtgtgtg tcgctgctgc cgggcaacgt gcattgctgg gaagccgaag ccgctggagg
     6361 agcgggtggg ggggcggggg gaggggaaag gcaaatgcag atatatatta aaaacaaata
     6421 atcgaggtac cagagctgcg tctgtggcac cagctagctg caggtgcagg ggatggcggg
     6481 agtgaggctg tgtctgcgga tggctggggt cacttctctg cccatgggct ccctgctccc
     6541 ccagtttttt ttctctttgt taacaaatgt gtctgagtct tggaaaacac cccaaacccg
     6601 gaaatgtgtg ggaaaaagaa aacaaaaact ttccaaattc ca
//
