LOCUS       NM_008738               1060 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus neurturin (Nrtn), mRNA.
ACCESSION   NM_008738
VERSION     NM_008738.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Gadomski,S., Fielding,C., Garcia-Garcia,A., Korn,C., Kapeni,C.,
            Ashraf,S., Villadiego,J., Toro,R.D., Domingues,O., Skepper,J.N.,
            Michel,T., Zimmer,J., Sendtner,R., Dillon,S., Poole,K.E.S.,
            Holdsworth,G., Sendtner,M., Toledo-Aral,J.J., De Bari,C.,
            McCaskie,A.W., Robey,P.G. and Mendez-Ferrer,S.
  TITLE     A cholinergic neuroskeletal interface promotes bone formation
            during postnatal growth and exercise
  JOURNAL   Cell Stem Cell 29 (4), 528-544 (2022)
   PUBMED   35276096
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Fielding,C., Garcia-Garcia,A., Korn,C., Gadomski,S., Fang,Z.,
            Reguera,J.L., Perez-Simon,J.A., Gottgens,B. and Mendez-Ferrer,S.
  TITLE     Cholinergic signals preserve haematopoietic stem cell quiescence
            during regenerative haematopoiesis
  JOURNAL   Nat Commun 13 (1), 543 (2022)
   PUBMED   35087060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1060)
  AUTHORS   Correia,J.C., Kelahmetoglu,Y., Jannig,P.R., Schweingruber,C.,
            Shvaikovskaya,D., Zhengye,L., Cervenka,I., Khan,N., Stec,M.,
            Oliveira,M., Nijssen,J., Martinez-Redondo,V., Ducommun,S.,
            Azzolini,M., Lanner,J.T., Kleiner,S., Hedlund,E. and Ruas,J.L.
  TITLE     Muscle-secreted neurturin couples myofiber oxidative metabolism and
            slow motor neuron identity
  JOURNAL   Cell Metab 33 (11), 2215-2230 (2021)
   PUBMED   34592133
  REMARK    GeneRIF: Muscle-secreted neurturin couples myofiber oxidative
            metabolism and slow motor neuron identity.
REFERENCE   4  (bases 1 to 1060)
  AUTHORS   Garcia-Garcia,A., Korn,C., Garcia-Fernandez,M., Domingues,O.,
            Villadiego,J., Martin-Perez,D., Isern,J., Bejarano-Garcia,J.A.,
            Zimmer,J., Perez-Simon,J.A., Toledo-Aral,J.J., Michel,T.,
            Airaksinen,M.S. and Mendez-Ferrer,S.
  TITLE     Dual cholinergic signals regulate daily migration of hematopoietic
            stem cells and leukocytes
  JOURNAL   Blood 133 (3), 224-236 (2019)
   PUBMED   30361261
  REMARK    Erratum:[Blood. 2020 Dec 17;136(25):2965. PMID: 33331935]
REFERENCE   5  (bases 1 to 1060)
  AUTHORS   Mabe,A.M. and Hoover,D.B.
  TITLE     Structural and functional cardiac cholinergic deficits in adult
            neurturin knockout mice
  JOURNAL   Cardiovasc Res 82 (1), 93-99 (2009)
   PUBMED   19176599
  REMARK    GeneRIF: Report structural and functional cardiac cholinergic
            deficits in adult neurturin knockout mice.
REFERENCE   6  (bases 1 to 1060)
  AUTHORS   Heuckeroth,R.O., Enomoto,H., Grider,J.R., Golden,J.P., Hanke,J.A.,
            Jackman,A., Molliver,D.C., Bardgett,M.E., Snider,W.D., Johnson,E.M.
            Jr. and Milbrandt,J.
  TITLE     Gene targeting reveals a critical role for neurturin in the
            development and maintenance of enteric, sensory, and
            parasympathetic neurons
  JOURNAL   Neuron 22 (2), 253-263 (1999)
   PUBMED   10069332
REFERENCE   7  (bases 1 to 1060)
  AUTHORS   Heuckeroth,R.O., Kotzbauer,P., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Zimonjic,D.B., Popescu,N.C., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Neurturin, a novel neurotrophic factor, is localized to mouse
            chromosome 17 and human chromosome 19p13.3
  JOURNAL   Genomics 44 (1), 137-140 (1997)
   PUBMED   9286710
REFERENCE   8  (bases 1 to 1060)
  AUTHORS   Klein,R.D., Sherman,D., Ho,W.H., Stone,D., Bennett,G.L., Moffat,B.,
            Vandlen,R., Simmons,L., Gu,Q., Hongo,J.A., Devaux,B., Poulsen,K.,
            Armanini,M., Nozaki,C., Asai,N., Goddard,A., Phillips,H.,
            Henderson,C.E., Takahashi,M. and Rosenthal,A.
  TITLE     A GPI-linked protein that interacts with Ret to form a candidate
            neurturin receptor
  JOURNAL   Nature 387 (6634), 717-721 (1997)
   PUBMED   9192898
  REMARK    Erratum:[Nature 1998 Mar 12;392(6672):210]
REFERENCE   9  (bases 1 to 1060)
  AUTHORS   Baloh,R.H., Tansey,M.G., Golden,J.P., Creedon,D.J.,
            Heuckeroth,R.O., Keck,C.L., Zimonjic,D.B., Popescu,N.C.,
            Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     TrnR2, a novel receptor that mediates neurturin and GDNF signaling
            through Ret
  JOURNAL   Neuron 18 (5), 793-802 (1997)
   PUBMED   9182803
REFERENCE   10 (bases 1 to 1060)
  AUTHORS   Kotzbauer,P.T., Lampe,P.A., Heuckeroth,R.O., Golden,J.P.,
            Creedon,D.J., Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     Neurturin, a relative of glial-cell-line-derived neurotrophic
            factor
  JOURNAL   Nature 384 (6608), 467-470 (1996)
   PUBMED   8945474
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT010491.8, BF471904.1 and
            BM899804.1.
            
            [WARNING] On Jul 23, 2024 this sequence was replaced by
            NM_008738.4.
            
            On Aug 4, 2016 this sequence version replaced NM_008738.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. The
            encoded preproprotein is proteolytically processed to generate the
            mature protein. This protein signals through the RET receptor
            tyrosine kinase and a GPI-linked coreceptor, and promotes survival
            of neuronal populations. Homozygous knockout mice for this gene
            exhibit defects in the development of the retina and enteric
            nervous system, and reduced cholinergic innervation of the heart
            and lacrimal glands. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002508.1, BC057993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CT010491.8         112294-112302       c
            10-633              BF471904.1         1-624
            634-1060            BM899804.1         1-427               c
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.49 cM"
     gene            1..1060
                     /gene="Nrtn"
                     /gene_synonym="NTN"
                     /note="neurturin"
                     /db_xref="GeneID:18188"
                     /db_xref="MGI:MGI:108417"
     exon            1..353
                     /gene="Nrtn"
                     /gene_synonym="NTN"
                     /inference="alignment:Splign:2.1.0"
     exon            354..535
                     /gene="Nrtn"
                     /gene_synonym="NTN"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..954
                     /gene="Nrtn"
                     /gene_synonym="NTN"
                     /codon_start=1
                     /product="neurturin preproprotein"
                     /protein_id="NP_032764.1"
                     /db_xref="CCDS:CCDS28913.1"
                     /db_xref="GeneID:18188"
                     /db_xref="MGI:MGI:108417"
                     /translation="MRRWKAAALVSLICSSLLSVWMCQEGLLLGHRLGPALAPLRRPP
                     RTLDARIARLAQYRALLQGAPDAVELRELSPWAARIPGPRRRAGPRRRRARPGARPCG
                     LRELEVRVSELGLGYTSDETVLFRYCAGACEAAIRIYDLGLRRLRQRRRVRRERARAH
                     PCCRPTAYEDEVSFLDVHSRYHTLQELSARECACV"
     exon            536..1043
                     /gene="Nrtn"
                     /gene_synonym="NTN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1022..1027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrtn"
                     /gene_synonym="NTN"
                     /note="hexamer: CATAAA"
     polyA_site      1043
                     /gene="Nrtn"
                     /gene_synonym="NTN"
                     /note="major polyA site"
ORIGIN      
        1 gaggtgcgcg gcgggagcgg agggagagcg cgcggtggct tcgtccgtgt gccccgcgcc
       61 cggcgctcct cgcgtggccc cgcgtcctga gcgcgctcca gcctcccacg cgcgccaccc
      121 cggggttcac tgagcccggc gagcccgggg aagacagaga aagagaggcc agggggggaa
      181 ccccatggcc cggcccgtgt cccgcaccct gtgcggtggc ctcctccggc acggggtccc
      241 cgggtcgcct ccggtccccg cgatccggat ggcgcacgca gtggctgggg ccgggccggg
      301 ctcgggtggt cggaggagtc accactgacc gggtcatctg gagcccgtgg caggccgagg
      361 cccaggatga ggcgctggaa ggcagcggcc ctggtgtcgc tcatctgcag ctccctgcta
      421 tctgtctgga tgtgccagga gggtctgctc ttgggccacc gcctgggacc cgcgcttgcc
      481 ccgctacgac gccctccacg caccctggac gcccgcatcg cccgcctggc ccagtatcgc
      541 gctctgctcc agggcgcccc cgacgcggtg gagcttcgag aactttctcc ctgggctgcc
      601 cgcatcccgg gaccgcgccg tcgagcgggt ccccggcgtc ggcgggcgcg gccgggggct
      661 cggccttgtg ggctgcgcga gctcgaggtg cgcgtgagcg agctgggcct gggctacacg
      721 tcggatgaga ccgtgctgtt ccgctactgc gcaggcgcgt gcgaggcggc catccgcatc
      781 tacgacctgg gccttcggcg cctgcgccag cggaggcgcg tgcgcagaga gcgggcgcgg
      841 gcgcacccgt gttgtcgccc gacggcctat gaggacgagg tgtccttcct ggacgtgcac
      901 agccgctacc acacgctgca agagctgtcg gcgcgggagt gcgcgtgcgt gtgatgctac
      961 ctcacgcccc ccgacctgcg aaagggccct ccctgccgac cctcgctgag aactgacttc
     1021 acataaagtg tgggaactcc cgaaaaaaaa aaaaaaaaaa
//
