LOCUS       NM_001009948            1422 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neurensin 2 (Nrsn2), transcript variant 1, mRNA.
ACCESSION   NM_001009948 XM_130718
VERSION     NM_001009948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1422)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1422)
  AUTHORS   Umschweif,G., Medrihan,L., McCabe,K.A., Sagi,Y. and Greengard,P.
  TITLE     Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin
            interneurons mediates the response to chronic antidepressants
  JOURNAL   Mol Psychiatry 26 (7), 3350-3362 (2021)
   PUBMED   33723417
  REMARK    GeneRIF: Activation of the p11/SMARCA3/Neurensin-2 pathway in
            parvalbumin interneurons mediates the response to chronic
            antidepressants.
REFERENCE   3  (bases 1 to 1422)
  AUTHORS   Tiklova,K., Bjorklund,A.K., Lahti,L., Fiorenzano,A., Nolbrant,S.,
            Gillberg,L., Volakakis,N., Yokota,C., Hilscher,M.M., Hauling,T.,
            Holmstrom,F., Joodmardi,E., Nilsson,M., Parmar,M. and Perlmann,T.
  TITLE     Single-cell RNA sequencing reveals midbrain dopamine neuron
            diversity emerging during mouse brain development
  JOURNAL   Nat Commun 10 (1), 581 (2019)
   PUBMED   30718509
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1422)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   5  (bases 1 to 1422)
  AUTHORS   Nakanishi,K., Ida,M., Suzuki,H., Kitano,C., Yamamoto,A., Mori,N.,
            Araki,M. and Taketani,S.
  TITLE     Molecular characterization of a transport vesicle protein
            Neurensin-2, a homologue of Neurensin-1, expressed in neural cells
  JOURNAL   Brain Res 1081 (1), 1-8 (2006)
   PUBMED   16527258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928568.17.
            
            On May 28, 2019 this sequence version replaced NM_001009948.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088982.1, AK140190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL928568.17        50628-50685         c
            59-253              AL928568.17        48176-48370         c
            254-1422            AL928568.17        42835-44003         c
FEATURES             Location/Qualifiers
     source          1..1422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.89 cM"
     gene            1..1422
                     /gene="Nrsn2"
                     /gene_synonym="Gm123; Neurensin-2"
                     /note="neurensin 2"
                     /db_xref="GeneID:228777"
                     /db_xref="MGI:MGI:2684969"
     exon            1..58
                     /gene="Nrsn2"
                     /gene_synonym="Gm123; Neurensin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            59..253
                     /gene="Nrsn2"
                     /gene_synonym="Gm123; Neurensin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..676
                     /gene="Nrsn2"
                     /gene_synonym="Gm123; Neurensin-2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="neurensin-2 isoform 1"
                     /protein_id="NP_001009948.1"
                     /db_xref="CCDS:CCDS16882.1"
                     /db_xref="GeneID:228777"
                     /db_xref="MGI:MGI:2684969"
                     /translation="MSCSRPCVCSHGTSVEESTWYGFDFYPNLFYNDWLGTTTLPYNP
                     ERIPIRYINRPWPSLCWKVTVAVASLFLLLGVAALTTGYAVPPKLELVNESKFSSMED
                     PVADYNQALMTCRVVGATLCGVAGIMLAVCLFLIASGWMFQDIKAEPLVTETDSPVEV
                     FRDEPEKLSPAFHETSSQSPFLTPPSPFGQQSVQTSQPQRDL"
     exon            254..1422
                     /gene="Nrsn2"
                     /gene_synonym="Gm123; Neurensin-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1401..1406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrsn2"
                     /gene_synonym="Gm123; Neurensin-2"
                     /note="hexamer: AATAAA"
     polyA_site      1422
                     /gene="Nrsn2"
                     /gene_synonym="Gm123; Neurensin-2"
                     /note="major polyA site"
ORIGIN      
        1 gctctgctct gctccagctc cgacagcttc tgttggctcc ggagacgcag gtccagaggg
       61 atccgtgatg agctgcagtc gcccctgtgt ctgtagtcat ggcaccagtg tggaggaaag
      121 tacatggtat gggtttgact tctatcctaa tctcttctac aatgactggc tgggcaccac
      181 cactctcccc tataacccag agagaatccc cattcggtat atcaaccgac cctggccctc
      241 actgtgttgg aaggtcaccg tggccgtggc ctctctgttt ctcctgctgg gtgtggcagc
      301 cttgaccact ggctatgcag tgccccccaa actagagctt gttaatgaaa gtaagttctc
      361 atcgatggag gatccagtag ccgactacaa ccaagccctc atgacctgcc gtgtggtagg
      421 agcgacgctg tgcggagtag cggggatcat gctggctgtc tgcctcttct tgatcgcctc
      481 tggttggatg ttccaggaca tcaaggcaga gcccctcgtc actgaaactg acagccccgt
      541 ggaagtattc agggatgagc ctgagaagct gtccccggcc ttccatgaga ccagtagtca
      601 gtcgccgttc ttgaccccgc ccagcccttt tgggcagcag tctgtgcaga ccagccagcc
      661 ccagcgggac ttgtaagtct gcaggctgga gaagtcagac ccttcccgcc tggcactcct
      721 tgctttcatc accttgactt cttcctctca gtagtgccaa tctctctagg acccttatag
      781 ctccccactc cccccaaatc aagtcccatg ctccaatctc acccctgtcc aggataggag
      841 caaactcaac caagaactgc tcattcagac tcgtgaaacg acccagagag ggctcagaaa
      901 cggcccagga aggcccaggg ccttcctggc gtgattgacg atctgagttt tatctctcac
      961 acctacaagg tggaagagga gaactggctc cccacagttg tcccctgacc ctcaccccta
     1021 acccccaatc acaaagaaag gtaataaaaa tataaattcc aaggattagg aaaagtggaa
     1081 tgtttttgcc cctcaaagtc caccccctag acagcaatgc cctctggact tgatcctgag
     1141 cctaataaac ctgtgtgcac tcctttaggt cccagcactt tcttcctatg ggtggtccag
     1201 acaaaagtat gtcctcctgt aggacgctag agggcgctct aggacagcgt cggatcctgt
     1261 ctctggcaac cccttgcaag cccacggggc ttcctgggtg ggaggaagag ggttcaggca
     1321 cttcccacca cctttgtgcc ccctctggtt gtactttcca ggtccctgct tctcacctcc
     1381 tccatcttgc ttcgcctttc aataaacagt tgatgcatac ca
//
